This 319.2-mile journey from Biloxi to Mikoma, Mississippi, is designed for a single day, taking an estimated 6 hours and 23 minutes to complete. You'll spend nearly all of your time on major highways, with 99% of the route being on established roads like US 49, I-55, and MS 32. The estimated fuel cost for this drive is around $48, making it an economical option. Given its duration, it's a manageable day trip, though you could opt to break it up if you prefer a more relaxed pace. This highway-focused drive keeps you moving efficiently through the Southeast region of Mississippi.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
159.6 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 3h 18m into the drive
.
Main Roads
Road
Distance
Duration
US 49
135 mi
2h 46m
I 55
131.7 mi
2h 23m
MS 32
24.8 mi
36m
MS 15
20.7 mi
24m
I 110
3.1 mi
4m
Clay Street
1.6 mi
2m
Main Street
0.8 mi
1m
Division Street
0.5 mi
1m
Longest stretch:
US 49
— 135 mi, about 2h 46m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Mikoma, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Turn straight onto US 49
10 mi·16 min·US 49
Use the straight lane.
12
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
13
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
14
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
15
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
16
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
17
Take the exit onto US 49
0.2 mi·21 sec·US 49
18
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
19
Keep slight right at fork onto US 49
0.9 mi·1 min·US 49
20
Merge onto I 55
132 mi·2 hr 23 min·I 55
21
Take the exit
0.2 mi·32 sec
Toward Oakland, Water Valley
22
Turn sharp left onto MS 32; MS 32 Scenic
12 mi·17 min·MS 32; MS 32 Scenic
23
Continue on MS 32
0.3 mi·36 sec·Main Street
24
Turn left onto MS 32; MS 35
1.6 mi·2 min·Clay Street
25
Turn right onto MS 32
13 mi·19 min·MS 32
26
Arrive at destination
MS 32
Trip Plan
To make the most of this 6-hour and 23-minute drive, consider an early morning departure from Biloxi to avoid any potential traffic and maximize daylight hours. With only one recommended stop and a substantial 135-mile stretch on US 49, plan your fuel and rest breaks accordingly. The $48 fuel estimate is helpful for budgeting, but always keep an eye on your gauge, especially during that long segment. This route is well-suited for a single-day adventure, offering flexibility in when and where you choose to pause.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 159.6 miles from Biloxi, MS, or about 3h 18m into the drive.
The longest continuous stretch on this route runs about 135 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 70 miles or 1h 26m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 159.6 miles or 3h 18m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 9m
Traffic, exits, and arrival timing usually matter more near Mikoma, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 319.2 miles and 6h 23m.
Your first comfortable stop window is around 70 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 135 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 15
5 decision points cluster between mile 25.1 and 292.4 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
5
25.5 mi into trip|~33m in|US 49
Merge onto US 49
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
5
158.9 mi into trip|~3h 17m in|US 49
Keep slight left at fork onto US 49 toward Jackson
Highway fork - watch signs carefully
Toward Jackson
5
292.2 mi into trip|~5h 42m in
Take the exit toward Oakland, Water Valley
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward Oakland, Water Valley
5
292.4 mi into trip|~5h 43m in|MS 32; MS 32 Scenic
Turn sharp left onto MS 32; MS 32 Scenic
Sharp turn - reduce speed on approach
Fuel & Cost
Regular Gas
$48.21 one way
$96.41 round trip
$3.84/gal25.4 MPG avg112 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$52.92
$105.84
premium
$4.56
$57.29
$114.59
diesel
$5.61
$70.48
$140.95
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$48
Meals
$25–$50
Total
$73–$98
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 111.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $34 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
95.8
1
$33.52
$15.32
Efficient EV
79.8
0
$27.93
$12.77
EV Truck/SUV
127.7
1
$44.69
$20.43
Gas CO2
112 kg
EV CO2
37 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Biloxi, MS
Evening
in Biloxi on Saturday
Local time
8:26 PM
CDT
Current temp
61°F
Unavailable
Live forecast
Destination
Mikoma, MS
Evening
in Mikoma on Saturday
Local time
8:26 PM
CDT
Current temp
62°F
Unavailable
Live forecast
55°F
Florence, MS
160 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 23m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
3 mi from route
~8 min detour
Free
near mile 165.1
Emmett Till and Mamie Till-Mobley National Monument
National Monument
In 1955, 14-year-old Emmett Till traveled to Money, Mississippi, to visit relatives. He was kidnapped, tortured, and murdered after reportedly whistling at a white woman. His mother, Mamie Till-Mobley...
5 mi from route
~13 min detour
Free
near mile 319.2
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a highway-focused drive for the vast majority of this trip, with 99% of the route utilizing major roads. You'll experience a significant stretch of 135 miles on US 49, which will be your longest uninterrupted segment. While primarily on highways, the route incorporates I-55 and MS 32, offering a consistent pace for most of the 319.2 miles. The personality of the drive is one of steady progress rather than winding backroads or particularly scenic detours.
99% highway — fuel and pacing are the main things to plan.
26 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 135 mi on US 49.
How Hard Is This Drive?
8/10
This is a straightforward highway drive that stays mostly on US 49 and I 55. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 15 significant decision points across 319.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 158.9 miles (US 49): Highway fork - watch signs carefully.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and Mikoma, MS, road signs point toward Jackson, Oakland and Water Valley.
Jackson
25.1 mi in|~32m
Oakland
292.2 mi in|~5h 42m
Water Valley
292.2 mi in|~5h 42m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 6h 23m. Total distance: 319.2 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 23m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 135 miles on US 49. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Mikoma, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 158.9 miles (US 49): Highway fork - watch signs carefully.
Yes — Medgar and Myrlie Evers Home National Monument and Emmett Till and Mamie Till-Mobley National Monument. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.4 hours each way, a round trip means 12.8 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Mikoma, MS before the return drive.
