Biloxi to Louisville is 225.8 miles and takes about 4h 42m via Lance Corporal Roy M Wheat Memorial Highway and US 49, with a fuel budget near $33 and enough daylight to finish in a day. This trip takes you from the Southeast region of Mississippi to another part of the same state, offering a relatively straightforward drive. With a recommended one-day duration, it's a manageable route for those looking to cover ground without an overnight stay. Consider this drive if you need a direct path between these two Mississippi locations and prefer a route with a significant portion on main highways.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
112.9 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 2h 13m into the drive
.
Main Roads
Road
Distance
Duration
Lance Corporal Roy M Wheat Memorial Highway
88.4 mi
1h 35m
US 49
42.2 mi
49m
MS 15
40.8 mi
54m
MS 19
36.7 mi
54m
US 98
3.3 mi
4m
I 110
3.1 mi
4m
South Church Avenue
2.5 mi
4m
I 59
2 mi
2m
Longest stretch:
Lance Corporal Roy M Wheat Memorial Highway
— 88.4 mi, about 1h 35m
Traffic on I-59
Hour-of-day weekday pattern from 24 FHWA count stations on your route.
Peak
4 PM
~969 veh/hr typical
· worst 1,202
Quietest
1 AM
~89 veh/hr
Peak-to-quiet ratio
10.9×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 103 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Louisville, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Take the exit
0.3 mi·51 sec
12
Merge onto US 98
2.5 mi·2 min·US 98
Use the straight / slight right lanes.
13
Take the exit onto US 98
0.8 mi·1 min·US 98
Toward I 59 North, US 98 West: Columbia, LaurelUse the straight / slight right lanes.
14
Merge onto I 59; US 98
88 mi·1 hr 35 min·Lance Corporal Roy M Wheat Memorial Highway
Use the straight / slight right lanes.
15
Keep slight right at fork onto I 59
2.0 mi·2 min·I 59
Toward I 59 North, I 20 East: Meridian, TuscaloosaUse the straight lane.
16
Take the exit
0.4 mi·44 sec
Toward South US 11, North Mississippi 19: Philadelphia, Meridian AirportUse the straight / slight right lanes.
17
Turn left onto US 11
1.2 mi·1 min·US 11
18
Turn left onto MS 19
37 mi·54 min·MS 19
19
At end of road, turn left onto MS 16; MS 19
0.1 mi·15 sec·Beacon Street
20
Turn right onto MS 21
1.8 mi·2 min·Pecan Avenue
21
Turn straight onto County Road 561
1.3 mi·1 min·County Road 561
22
Turn right onto MS 15
20 mi·30 min·MS 15
23
Turn right onto MS 15 Business
2.5 mi·4 min·South Church Avenue
24
Turn right onto MS 14
98 ft·1 sec·MS-14/West Main Street
25
Arrive at destination
MS 14
Trip Plan
Given the 4h 42m drive time, leaving Biloxi in the morning should allow you ample time to reach Louisville before evening. The route is manageable in a single day, so you have flexibility in planning your stops. Keep an eye on your fuel gauge, especially during the 88.4-mile stretch on Lance Corporal Roy M Wheat Memorial Highway, as services might be less frequent. While there's only one recommended stop, planning for a brief break midway can help keep you refreshed for the latter half of the drive.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 112.9 miles from Biloxi, MS, or about 2h 13m into the drive.
The longest continuous stretch on this route runs about 88.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 50 miles or 1h 1m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 112.9 miles or 2h 13m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 41m
Traffic, exits, and arrival timing usually matter more near Louisville, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 225.8 miles and 4h 42m.
Your first comfortable stop window is around 50 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Lance Corporal Roy M Wheat Memorial Highway for about 88.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 19
5 decision points cluster between mile 25.1 and 161.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
5
25.5 mi into trip|~33m in|US 49
Merge onto US 49
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
7
70.4 mi into trip|~1h 26m in|US 98
Take the exit onto US 98 toward I 59 North, US 98 West: Columbia, Laurel
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 59 North, US 98 West: Columbia, Laurel
8
159.6 mi into trip|~3h 3m in|I 59
Keep slight right at fork onto I 59 toward I 59 North, I 20 East: Meridian, Tuscaloosa
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Toward I 59 North, I 20 East: Meridian, Tuscalo...
7
161.7 mi into trip|~3h 5m in
Take the exit toward South US 11, North Mississippi 19: Philadelphia, Meridian Airport
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward South US 11, North Mississippi 19: Phila...
Fuel & Cost
Regular Gas
$35.15 one way
$70.30 round trip
$3.95/gal25.4 MPG avg79 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$38.75
$77.50
premium
$4.71
$41.88
$83.76
diesel
$6.18
$54.93
$109.86
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$35
Meals
$25–$50
Total
$60–$85
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 79 kg one way.
Prices: EIA weekly data, 2026-10-12.
EV Charging Along Route
8 DC fast chargers
· Coverage: excellent
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Electric Vehicle Charging Station
Biloxi, Mississippi
Other
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Tesla Destination Charger
Biloxi, Mississippi
Tesla Destination
1 DCFC
Electric Vehicle Charging Station
Biloxi, Mississippi
Other
1 DCFC
Eaton Charging Station
Ocean Springs, Mississippi
Other
1 DCFC
ChargePoint Charging Station
D'Iberville, Mississippi
ChargePoint
1 DCFC
Tesla Destination: 4
Other: 3
ChargePoint: 1
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $24 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
67.7
0
$23.71
$10.84
Efficient EV
56.5
0
$19.76
$9.03
EV Truck/SUV
90.3
1
$31.61
$14.45
Gas CO2
79 kg
EV CO2
26 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Oct 19, 2026
Origin
Biloxi, MS
Morning
in Biloxi on Monday
Local time
7:58 AM
CDT
Current temp
55°F
Mostly Clear
NE 10 mph0% chanceLive forecast
Destination
Louisville, MS
Morning
in Louisville on Monday
Local time
7:58 AM
CDT
Current temp
44°F
Clear
ESE 5 mph0% chanceLive forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
11 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 42m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
You'll spend about 57% of this 225.8-mile route on highways. The longest continuous stretch on a single highway is 88.4 miles, which occurs on Lance Corporal Roy M Wheat Memorial Highway. After this, the profile shifts to mixed highway and surface roads, so expect a change in driving conditions. You'll notice the transition from higher-speed highway cruising to more varied surface road driving as you progress.
57% highway, the rest on surface roads — varied driving throughout.
25 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 88.4 mi on Lance Corporal Roy M Wheat Memorial Highway.
How Hard Is This Drive?
9/10
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 25.1 miles in.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 225.8 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
568 ft20 ft
Total Climb
867 ft
Total Descent
319 ft
Highest Point
568 ft
~225.8 mi in
Elevation Range
548 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Biloxi, MS and Louisville, MS, road signs point toward Jackson, Laurel, Tuscaloosa, Mississippi 19: Philadelphia and Meridian Airport.
Biloxi is a city in Harrison County, on the Gulf Coast of Mississippi. It's well known for its beaches and nine casinos. It is also home to the "Jefferson Davis Presidential Library and Museum", which serves as a museum of the Confederacy.
Top landmarks
•Jefferson Davis Presidential Library and Museum — presidential library and museum for Confederate States President Jefferson Davis...
•Beauvoir — post-war home of the former President of the Confederate States of America, Jeff...
•Biloxi Light — lighthouse in Mississippi, United States
Doable as a same-day drive at 4h 42m. Total distance: 225.8 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 42m drive, comfortable solo distance.
Scenic Drive
Mixed highway & surface route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 88.4 miles on Lance Corporal Roy M Wheat Memorial Highway. The full list of main roads is in the Roads section above.
Yes — we found about 9 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Louisville, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 9 rest areas along the route for bathroom stops.
The main spots that need attention: at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here; at 70.4 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Possible but tiring. At 4.7 hours each way, an in-and-out day trip would put you behind the wheel for 9.4 hours — manageable with a long break at Louisville, MS, but most travelers stay overnight.
