Saint Joseph, MO to Clayton, MO is 299.6 miles and takes about 5h 42m via Dwight D. Eisenhower Highway, with a fuel budget near $53 and enough daylight to finish in a day. This trip stays within Missouri, traversing the Midwest region from one side to the other. Given the 5-hour drive time, it's a manageable one-day excursion, perfect for getting from point A to point B without much fuss. You'll primarily be on surface roads, so expect a more local feel rather than high-speed interstate travel.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
149.8 miles from Saint Joseph, MO
A natural place for your longest stop of the day
, about 2h 45m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
135.3 mi
2h 34m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
I 29
28.4 mi
30m
I 435
28 mi
30m
Avenue of the Saints
27.7 mi
33m
Truman/Eisenhower Presidential Highway
5.6 mi
6m
I 229
4.5 mi
4m
Daniel Boone Expressway
3.2 mi
3m
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Traffic on I-70
Hour-of-day weekday pattern from 23 FHWA count stations on your route.
Peak
4 PM
~3,281 veh/hr typical
· worst 3,830
Quietest
1 AM
~292 veh/hr
Peak-to-quiet ratio
11.2×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Saint Joseph, MO and Clayton, MO.
1
Start on Walter Welsh Avenue
417 ft·8 sec·Walter Welsh Avenue
2
Turn right onto North 12th Street
297 ft·10 sec·North 12th Street
3
Turn right onto Francis Street
0.2 mi·37 sec·Francis Street
4
Turn left onto I 29 Business
1.2 mi·2 min·North 9th Street
5
Take the ramp
0.1 mi·15 sec
6
Merge onto US 36
0.2 mi·19 sec·US 36
7
Take the exit
0.2 mi·21 sec
Toward I 229 South, US 59 South: Kansas City
8
Merge onto I 229; US 59
4.5 mi·4 min·I 229; US 59
9
Keep slight right at fork
0.3 mi·29 sec
Toward I 29 South, US 71 South: Kansas City
10
Merge onto I 29; US 71
26 mi·27 min·I 29; US 71
11
Merge onto I 29; I 435; US 71
2.2 mi·2 min·I 29; I 435; US 71
Use the straight / slight right lanes.
12
Keep slight right at fork onto I 435
28 mi·30 min·I 435
Exit 14Toward I 435 East: Saint LouisUse the straight / slight right lanes.
13
Keep slight right at fork onto US 24
0.3 mi·23 sec·US 24
Exit 63Toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
14
Keep slight left at fork
1.2 mi·1 min
Toward I 70 East: Saint LouisUse the straight / slight right lanes.
15
Keep slight left at fork
469 ft·11 sec
Toward I 70 East: Saint LouisUse the slight left / straight lanes.
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
22
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
23
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
24
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
25
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
26
Continue on I 70; US 40
81 mi·1 hr 35 min·Dwight D. Eisenhower Highway
27
Take the exit onto US 40
0.3 mi·33 sec·US 40
Exit 210AToward I 64 East, US 40 East, US 61 South: Chesterfield
28
Merge onto I 64; US 40; US 61
28 mi·33 min·Avenue of the Saints
Use the straight / slight left lanes.
29
Continue on I 64; US 40
3.2 mi·3 min·Daniel Boone Expressway
Use the straight lane.
30
Take the exit
0.2 mi·12 sec
Exit 31B-AToward I 170 NorthUse the slight right lane.
31
Keep slight left at fork
0.3 mi·42 sec
Exit 31BToward Brentwood Boulevard, Hanley RoadUse the straight lane.
32
Continue on South Service Road
0.6 mi·1 min·South Service Road
Toward Hanley Road
33
Turn left onto South Hanley Road
1.0 mi·1 min·South Hanley Road
Use the left / straight lanes.
34
Turn right onto Wydown Boulevard
0.6 mi·1 min·Wydown Boulevard
35
Turn right onto Hillvale Drive
178 ft·7 sec·Hillvale Drive
36
Arrive at destination
Hillvale Drive
Trip Plan
To make the most of this drive, consider an early morning departure from Saint Joseph to maximize daylight for the 5h 42m estimated travel time. With 299.6 miles and a fuel cost around $53, planning one stop for fuel and a quick break should suffice. Pay attention to the transition from I-29 to surface roads; the route data indicates a significant shift away from highway driving, so be ready to adjust your speed and awareness. This route is well within a single day's driving capacity, offering flexibility for when you depart.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 149.8 miles from Saint Joseph, MO, or about 2h 45m into the drive.
The longest continuous stretch on this route runs about 135.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 66 miles or 1h 14m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 149.8 miles or 2h 45m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 35m
Traffic, exits, and arrival timing usually matter more near Clayton, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Saint Joseph, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Saint Joseph, MO
This is one driving day of about 299.6 miles and 5h 42m.
Your first comfortable stop window is around 66 miles from Saint Joseph, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 135.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 22
5 decision points cluster between mile 35.2 and 297.1 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
35.2 mi into trip|~39m in|I 435
Keep slight right at fork onto I 435 toward I 435 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Exit 14
Toward I 435 East: Saint Louis
7
63.2 mi into trip|~1h 10m in|US 24
Keep slight right at fork onto US 24 toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 63
Toward I 70, US 24 West, US 40: Saint Louis, Ka...
7
63.5 mi into trip|~1h 11m in
Keep slight left at fork toward I 70 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Toward I 70 East: Saint Louis
7
64.7 mi into trip|~1h 12m in
Keep slight left at fork toward I 70 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left / straight lanes.
Toward I 70 East: Saint Louis
9
297.1 mi into trip|~5h 37m in
Keep slight left at fork toward Brentwood Boulevard, Hanley Road
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Exit 31B
Toward Brentwood Boulevard, Hanley Road
Fuel & Cost
Regular Gas
$49.81 one way
$99.62 round trip
$4.22/gal25.4 MPG avg105 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.60
$54.26
$108.52
premium
$5.18
$61.13
$122.27
diesel
$5.35
$63.10
$126.21
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$50
Meals
$25–$50
Total
$75–$100
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 104.8 kg one way.
Prices: EIA weekly data, 2026-06-01.
Driving Electric?
About $31 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
89.9
1
$31.46
$14.38
Efficient EV
74.9
0
$26.22
$11.98
EV Truck/SUV
119.8
1
$41.94
$19.17
Gas CO2
105 kg
EV CO2
35 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jun 1, 2026
Origin
Saint Joseph, MO
Afternoon
in Saint Joseph on Wednesday
Local time
2:01 PM
CDT
Current temp
66°F
Slight Chance Rain Showers
ENE 3 mph15% chanceLive forecast
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued June 1 at 4:06AM CDT until June 1 at 4:45AM CDT by NWS Kansas City/Pleasant Hill MO
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued June 1 at 4:04AM CDT until June 1 at 4:30AM CDT by NWS St Louis MO
Destination
Clayton, MO
Afternoon
in Clayton on Wednesday
Local time
2:01 PM
CDT
Current temp
65°F
Showers And Thunderstorms
S 5 mph92% chanceLive forecast
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued June 1 at 4:06AM CDT until June 1 at 4:45AM CDT by NWS Kansas City/Pleasant Hill MO
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued June 1 at 4:04AM CDT until June 1 at 4:30AM CDT by NWS St Louis MO
86°F
Centralia, MO
150 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 42m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Gateway Arch National Park
National Park
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
7 mi from route
~18 min detour
$19
near mile 299.6
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route features a 22% highway share, meaning you'll spend the majority of your time on surface roads. The longest stretch on a limited-access highway is 135.3 miles, primarily on the Dwight D. Eisenhower Highway and I-29. After this initial highway segment, expect a more relaxed pace with more frequent intersections and local traffic as you transition to surface streets. You'll notice the landscape change as you move from the northwestern part of the state towards the St. Louis area.
Only 22% highway — the rest is turn-by-turn surface driving.
36 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 135.3 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
10/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 35.2 miles in near I 435.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 22 significant decision points across 299.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 35.2 miles (I 435): Highway fork - watch signs carefully. Lane positioning matters here; at 63.2 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 63.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Elevation Profile
Mostly flat terrain
994 ft564 ft
Total Climb
368 ft
Total Descent
697 ft
Highest Point
994 ft
~42.8 mi in
Elevation Range
430 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Saint Joseph, MO and Clayton, MO, road signs point toward Kansas City and Sports Complex.
Doable as a same-day drive at 5h 42m. Total distance: 299.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 42m drive, comfortable solo distance.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 135.3 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
Yes — we found about 42 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Clayton, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 42 rest areas along the route for bathroom stops.
The main spots that need attention: at 35.2 miles (I 435): Highway fork - watch signs carefully. Lane positioning matters here; at 63.2 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 63.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Yes — Gateway Arch National Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.7 hours each way, a round trip means 11.4 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Clayton, MO before the return drive.
