Spanning 391.2 miles across Tennessee, this cross-state journey takes you from Memphis to Knoxville in approximately 5 hours and 44 minutes. You will primarily navigate via I-40 East, utilizing the Downtown Loop and North B to transition between cities. Because the total drive time is under six hours, it is very manageable as a single-day trip without requiring an overnight stay. Expect to budget around $59 for fuel to cover the distance. Both your start and end points are located within the Southeast, offering a consistent regional feel as you traverse the state from west to east.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
195.6 miles from Memphis, TN
A natural place for your longest stop of the day
, about 3h 34m into the drive
.
Main Roads
Road
Distance
Duration
I 40
386.5 mi
7h 2m
Downtown Loop
2.9 mi
4m
Henley Street
0.3 mi
<1m
North B. B. King Boulevard
0.2 mi
<1m
Poplar Avenue
<0.1 mi
<1m
Longest stretch:
I 40
— 386.5 mi, about 7h 2m
Turn-by-Turn Driving Directions
Step-by-step road directions between Memphis, TN and Knoxville, TN.
1
Start on Poplar Avenue
190 ft·11 sec·Poplar Avenue
2
Turn left onto North B. B. King Boulevard
0.2 mi·33 sec·North B. B. King Boulevard
Use the left lane.
3
Take the ramp
0.1 mi·13 sec
Toward I 40 EastUse the right lane.
4
Merge onto I 40
12 mi·14 min·I 40
Use the straight lane.
5
Keep slight left at fork onto I 40
198 mi·3 hr 34 min·I 40
Toward I 40 East: Nashville, KnoxvilleUse the slight left / straight lanes.
6
Keep slight right at fork
0.2 mi·24 sec
Exit 208AToward I 40 East, I 65 South: Knoxville, HuntsvilleUse the slight left / slight right lanes.
7
Merge onto I 40; I 65
2.4 mi·3 min·Downtown Loop
Use the straight / slight right lanes.
8
Continue on I 40
0.5 mi·42 sec·Downtown Loop
Exit 211B; 211AToward I 24 West, I 40 East, I 24 East: Clarksville, Louisville, Knoxville, ChattanoogaUse the straight / slight right lanes.
9
Keep slight right at fork onto I 40
174 mi·3 hr 9 min·I 40
Exit 211AToward I 40 East, I 24 East: Knoxville, ChattanoogaUse the slight left / slight right lanes.
10
Keep slight left at fork onto I 40
2.9 mi·3 min·I 40
11
Take the exit
0.4 mi·27 sec
Exit 388Toward Convention Center, East Tennessee History Center, Museum of Art
12
Keep slight left at fork
0.5 mi·56 sec
Exit 388Toward Convention Center, East Tennessee History Center, Museum of Art
13
Continue on US 441
0.2 mi·27 sec·Henley Street
Use the straight lane.
14
Continue on US 441
255 ft·11 sec·Henley Street
15
Arrive at destination
US 441
Trip Plan
For the best experience, plan your departure to avoid peak congestion in the urban centers you will be passing through. Since the drive is roughly 5 hours and 44 minutes, you can easily complete it in one go, but incorporating at least one planned stop will help you stay refreshed. Keep your $59 fuel budget in mind as you monitor your gauge, especially since local road driving can sometimes impact fuel efficiency compared to steady highway cruising. Given the turn-heavy nature of the route, double-check your navigation settings before you pull away from Memphis to ensure you are comfortable with the transitions between the Downtown Loop and I-40 East.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 195.6 miles from Memphis, TN, or about 3h 34m into the drive.
The longest continuous stretch on this route runs about 386.5 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 86 miles or 1h 35m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 195.6 miles or 3h 34m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 6h 3m
Traffic, exits, and arrival timing usually matter more near Knoxville, TN than in the middle of the route.
Before You Leave
+
Open the route before leaving Memphis, TN so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
Day 1
Settle into the route from Memphis, TN
This is one driving day of about 391.2 miles and 7h 9m.
Your first comfortable stop window is around 86 miles from Memphis, TN.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on I 40 for about 386.5 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 11
5 decision points cluster between mile 0 and 213.4 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
7
0 mi into trip|~0m in|North B. B. King Boulevard
Turn left onto North B. B. King Boulevard
Lane positioning matters here
Use the left lane.
8
0.3 mi into trip|~0m in
Take the ramp toward I 40 East
Lane positioning matters here
Use the right lane.
Toward I 40 East
8
12.3 mi into trip|~15m in|I 40
Keep slight left at fork onto I 40 toward I 40 East: Nashville, Knoxville
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / straight lanes.
Toward I 40 East: Nashville, Knoxville
9
210.2 mi into trip|~3h 50m in
Keep slight right at fork toward I 40 East, I 65 South: Knoxville, Huntsville
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Exit 208A
Toward I 40 East, I 65 South: Knoxville, Huntsv...
9
213.4 mi into trip|~3h 54m in|I 40
Keep slight right at fork onto I 40 toward I 40 East, I 24 East: Knoxville, Chattanooga
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Exit 211A
Toward I 40 East, I 24 East: Knoxville, Chattan...
Fuel & Cost
Regular Gas
$61.16 one way
$122.32 round trip
$3.97/gal25.4 MPG avg137 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$67.15
$134.30
premium
$4.89
$75.28
$150.57
diesel
$5.61
$86.37
$172.74
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$61
Meals
$25–$50
Total
$86–$111
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 136.9 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $41 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
117.4
1
$41.08
$18.78
Efficient EV
97.8
1
$34.23
$15.65
EV Truck/SUV
156.5
1
$54.77
$25.04
Gas CO2
137 kg
EV CO2
46 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 16, 2026
Origin
Memphis, TN
Night
in Memphis on Saturday
Local time
9:51 PM
CDT
Current temp
82°F
Chance Showers And Thunderstorms
SW 10 mph60% chanceLive forecast
Destination
Knoxville, TN
Night
in Knoxville on Saturday
Local time
10:51 PM
EDT
Current temp
74°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
1 hour later
The destination clock does not match departure time, so double-check hotel check-in windows and late arrival plans.
Temperature spread
8 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
7h 9m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Stones River National Battlefield
National Battlefield
The Battle of Stones River began on the last day of 1862 and became one of the bloodiest conflicts of the Civil War. The battle produced important military and political gains for the Union, and it ch...
21 mi from route
~52 min detour
Free
near mile 229.3
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Prepare for a turn-heavy local drive that demands your full attention behind the wheel. Unlike a standard interstate cruise, this route features a unique profile that prioritizes local connections over high-speed highway stretches. While you will spend time on I-40 East, the path requires navigating through the Downtown Loop and North B, adding a technical element to your travel. You should remain alert as the road transitions through these various segments, ensuring you stay focused on the changing traffic patterns. This isn't a monotonous grind; rather, it is a dynamic drive that keeps you engaged until you reach your destination.
99% highway — fuel and pacing are the main things to plan.
15 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 386.5 mi on I 40.
How Hard Is This Drive?
8/10
This is a straightforward highway drive that stays mostly on I 40 and Downtown Loop. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near North B. B. King Boulevard.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 11 significant decision points across 391.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: near the start (North B. B. King Boulevard): Lane positioning matters here; at 0.3 miles: Lane positioning matters here; at 12.3 miles (I 40): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Memphis, TN and Knoxville, TN, road signs point toward Huntsville, Louisville and Chattanooga.
Memphis is the second largest city in the state of Tennessee, after Nashville. The state rests in the southeastern portion of the United States. Memphis, with a population of more than 651,000 (2019), is also the county seat for Shelby County. The city's claims to fame include Graceland, the mansion Elvis Presley lived in during his later years. Perhaps more importantly, Memphis is considered by many to be the home of blues music.
Knoxville, in Knox County, is the third-largest city in Tennessee. It is the home of the University of Tennessee's primary campus (UTK) and site of the 1982 World's Fair.
Doable as a same-day drive at 7h 9m. Total distance: 391.2 miles.
Family Friendly
Moderate complexity with 2 natural rest stops along the way.
Solo Traveler
7h 9m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 386.5 miles on I 40. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Knoxville, TN before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 2 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: near the start (North B. B. King Boulevard): Lane positioning matters here; at 0.3 miles: Lane positioning matters here; at 12.3 miles (I 40): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Stones River National Battlefield. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 7.2 hours each way, a round trip means 14.3 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Knoxville, TN before the return drive.
