Connecting Kansas City to Perryville, this 313.9-mile journey across Missouri takes approximately 6 hours and 1 minute of driving time. Because the route is categorized as a turn-heavy local drive, it is best suited for a single-day trip if you are comfortable with a full day behind the wheel. You should budget about $48 for fuel to complete the trek between these two Midwest locations. While the trip is manageable in one go, you will need to account for at least one planned stop to maintain your energy. It is a straightforward transit across the state, perfect for travelers who want to get from the western edge to the eastern side of Missouri efficiently.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
157 miles from Kansas City, MO
A natural place for your longest stop of the day
, about 2h 56m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
135.3 mi
2h 34m
Police Officer Steven Jarvis Memorial Highway
57.5 mi
1h 1m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Avenue of the Saints
25.1 mi
30m
I 270
11.5 mi
14m
George Brett Super Highway
6.9 mi
9m
Truman/Eisenhower Presidential Highway
5.6 mi
6m
US 61
5.3 mi
7m
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Turn-by-Turn Driving Directions
Step-by-step road directions between Kansas City, MO and Perryville, MO.
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
11
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
12
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
13
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
14
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
15
Continue on I 70; US 40
81 mi·1 hr 35 min·Dwight D. Eisenhower Highway
16
Take the exit onto US 40
0.3 mi·33 sec·US 40
Exit 210AToward I 64 East, US 40 East, US 61 South: Chesterfield
17
Merge onto I 64; US 40; US 61
25 mi·30 min·Avenue of the Saints
Use the straight / slight left lanes.
18
Take the exit
0.3 mi·38 sec
Exit 25Toward I 270: Chicago, MemphisUse the slight right lane.
19
Keep slight right at fork
0.3 mi·31 sec
Toward I 270 South: MemphisUse the slight right lane.
20
Merge onto I 270
11 mi·14 min·I 270
Use the straight lane.
21
Take the exit
0.4 mi·27 sec
Exit 1AToward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry RoadUse the straight / slight right lanes.
22
Keep slight right at fork
0.4 mi·43 sec
Toward I 55 South: Memphis
23
Merge onto I 55
1.5 mi·1 min·Rosa Parks Highway
24
Continue on I 55
1.8 mi·2 min·Officer Thomas G. Smith, Jr. Memorial Highway
25
Continue on I 55
57 mi·1 hr 1 min·Police Officer Steven Jarvis Memorial Highway
Use the straight / slight right lanes.
26
Take the exit
0.2 mi·29 sec
Exit 135Toward MO M: Brewer
27
Turn left onto MO M
0.6 mi·1 min·MO M
28
At end of road, turn right onto US 61; MO M
5.3 mi·7 min·US 61; MO M
29
Enter roundabout onto MO B
55 ft·0 sec·North Main Street
30
Continue on MO B
0.5 mi·1 min·North Main Street
31
Turn left onto East Saint Joseph Street
365 ft·18 sec·East Saint Joseph Street
32
Turn right onto South Spring Street
221 ft·9 sec·South Spring Street
33
Arrive at destination
South Spring Street
Trip Plan
To make the most of this 6-hour drive, try departing early in the morning to beat local traffic patterns and ensure you arrive in Perryville before sunset. Since you will be navigating a route with significant turn-heavy sections, keep your navigation system updated to avoid missing key exits on the memorial highways. Factor in at least one substantial break to stretch your legs, especially given the technical nature of the local road segments. With a $48 fuel estimate, consider topping off your tank before leaving Kansas City to avoid unnecessary stops during the longest 135.3-mile stretch. Flexibility is your biggest advantage here, so use your single planned stop strategically to break up the monotony of the winding local roads.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 157 miles from Kansas City, MO, or about 2h 56m into the drive.
The longest continuous stretch on this route runs about 135.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 69 miles or 1h 17m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 157 miles or 2h 56m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 56m
Traffic, exits, and arrival timing usually matter more near Perryville, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Kansas City, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Kansas City, MO
This is one driving day of about 313.9 miles and 6h 1m.
Your first comfortable stop window is around 69 miles from Kansas City, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 135.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 19
5 decision points cluster between mile 0 and 245.6 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0 mi into trip|~0m in|East 12th Street
Turn right onto East 12th Street
Navigation decision point
6
208.1 mi into trip|~3h 56m in|US 40
Take the exit onto US 40 toward I 64 East, US 40 East, US 61 South: Chesterfield
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 210A
Toward I 64 East, US 40 East, US 61 South: Ches...
8
233.5 mi into trip|~4h 27m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 25
Toward I 270: Chicago, Memphis
7
233.8 mi into trip|~4h 27m in
Keep slight right at fork toward I 270 South: Memphis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Toward I 270 South: Memphis
8
245.6 mi into trip|~4h 42m in
Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis...
Fuel & Cost
Regular Gas
$46.60 one way
$93.21 round trip
$3.77/gal25.4 MPG avg110 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.25
$52.56
$105.12
premium
$4.65
$57.52
$115.03
diesel
$5.30
$65.55
$131.10
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$47
Meals
$25–$50
Total
$72–$97
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 109.8 kg one way.
Driving Electric?
About $33 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
94.2
1
$32.96
$15.07
Efficient EV
78.5
0
$27.47
$12.56
EV Truck/SUV
125.6
1
$43.95
$20.09
Gas CO2
110 kg
EV CO2
37 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 16, 2026
Origin
Kansas City, MO
Evening
in Kansas City on Saturday
Local time
8:12 PM
CDT
Current temp
83°F
Sunny
SSW 3 to 10 mph2% chanceLive forecast
Destination
Perryville, MO
Evening
in Perryville on Saturday
Local time
8:12 PM
CDT
Current temp
56°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
27 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 1m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Ste. Geneviève National Historical Park
National Historical Park
Established by 1750, Ste. Geneviève was the first permanent European settlement in Missouri. Early French Canadian settlers were drawn here by the rich agricultural land known as Le Grand Champ (the B...
5 mi from route
~13 min detour
Free
near mile 292.3
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
14 mi from route
~35 min detour
$19
near mile 238.2
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a varied experience as you transition from major thoroughfares to more localized roads. Only 5% of this journey is spent on major highways, meaning you will spend the vast majority of your time navigating secondary routes. The longest uninterrupted section spans 135.3 miles along the Dwight D. Eisenhower Highway, providing a significant stretch of consistent driving. Following that, you will navigate segments of the Police Officer Steven Jarvis Memorial Highway and the U.S. Submarine Veterans' Memorial Highway. Prepare for a turn-heavy environment that demands more attention than a typical interstate grind, as the road profile shifts significantly from high-speed corridors to local navigation.
Only 5% highway — the rest is turn-by-turn surface driving.
33 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 135.3 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
10/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near East 12th Street.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 313.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: near the start (East 12th Street): Navigation decision point; at 208.1 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 233.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Kansas City, MO to Perryville, MO, road signs begin pointing toward Memphis along the way.
Kansas City is a major Midwestern metropolitan area that spreads across the border of Missouri and Kansas. It is a city that tends to hide itself from tourists. Reputed to have more boulevards than Paris and more fountains than any other city in the world except for Rome, it can be a beautiful city, too. It is unique in that it is split down the middle by the state line of Kansas and Missouri.
Doable as a same-day drive at 6h 1m. Total distance: 313.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 1m drive, plan rest stops for pacing.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 135.3 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Perryville, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: near the start (East 12th Street): Navigation decision point; at 208.1 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 233.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Ste. Geneviève National Historical Park and Gateway Arch National Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.0 hours each way, a round trip means 12.0 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Perryville, MO before the return drive.
