Spanning 297 miles across the Missouri Midwest, this cross-state journey takes approximately 5 hours and 41 minutes to complete. You will primarily navigate via the Dwight D. Eisenhower Highway, the Police Officer Steven Jarvis Memorial Highway, and the U.S. Submarine Veterans' Memorial Highway. Because the total duration is manageable, this trip works perfectly as a single-day excursion. Budgeting roughly $45 for fuel covers the expenses for the drive, though you should factor in at least one planned stop. It is a straightforward trip that keeps you within the state from start to finish, offering a reliable path for travelers moving between the western and eastern sides of Missouri.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
148.5 miles from Blue Springs, MO
A natural place for your longest stop of the day
, about 2h 46m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
131.6 mi
2h 29m
Police Officer Steven Jarvis Memorial Highway
57.5 mi
1h 1m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Avenue of the Saints
25.1 mi
30m
I 270
11.5 mi
14m
US 61
5.3 mi
7m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
Officer Thomas G. Smith, Jr. Memorial Highway
1.8 mi
2m
Longest stretch:
Dwight D. Eisenhower Highway
— 131.6 mi, about 2h 29m
Turn-by-Turn Driving Directions
Step-by-step road directions between Blue Springs, MO and Perryville, MO.
1
Start on Southwest 15th Street
0.5 mi·1 min·Southwest 15th Street
2
Turn right onto Northwest R D Mize Road
0.5 mi·1 min·Northwest R D Mize Road
3
Turn left onto MO 7
0.4 mi·1 min·MO 7
4
Turn slight right onto MO 7
84 ft·2 sec·MO 7
5
Keep slight right at fork
0.2 mi·26 sec
Toward I 70 East: Columbia
6
Merge onto I 70
49 mi·52 min·Dwight D. Eisenhower Highway
7
Continue on I 70; US 40
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
8
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
9
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
10
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
11
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
12
Continue on I 70; US 40
81 mi·1 hr 35 min·Dwight D. Eisenhower Highway
13
Take the exit onto US 40
0.3 mi·33 sec·US 40
Exit 210AToward I 64 East, US 40 East, US 61 South: Chesterfield
14
Merge onto I 64; US 40; US 61
25 mi·30 min·Avenue of the Saints
Use the straight / slight left lanes.
15
Take the exit
0.3 mi·38 sec
Exit 25Toward I 270: Chicago, MemphisUse the slight right lane.
16
Keep slight right at fork
0.3 mi·31 sec
Toward I 270 South: MemphisUse the slight right lane.
17
Merge onto I 270
11 mi·14 min·I 270
Use the straight lane.
18
Take the exit
0.4 mi·27 sec
Exit 1AToward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry RoadUse the straight / slight right lanes.
19
Keep slight right at fork
0.4 mi·43 sec
Toward I 55 South: Memphis
20
Merge onto I 55
1.5 mi·1 min·Rosa Parks Highway
21
Continue on I 55
1.8 mi·2 min·Officer Thomas G. Smith, Jr. Memorial Highway
22
Continue on I 55
57 mi·1 hr 1 min·Police Officer Steven Jarvis Memorial Highway
Use the straight / slight right lanes.
23
Take the exit
0.2 mi·29 sec
Exit 135Toward MO M: Brewer
24
Turn left onto MO M
0.6 mi·1 min·MO M
25
At end of road, turn right onto US 61; MO M
5.3 mi·7 min·US 61; MO M
26
Enter roundabout onto MO B
55 ft·0 sec·North Main Street
27
Continue on MO B
0.5 mi·1 min·North Main Street
28
Turn left onto East Saint Joseph Street
365 ft·18 sec·East Saint Joseph Street
29
Turn right onto South Spring Street
221 ft·9 sec·South Spring Street
30
Arrive at destination
South Spring Street
Trip Plan
To make the most of your 5-hour and 41-minute trek, plan your departure early to avoid peak traffic and allow for a relaxed pace. Since you only have one designated stop, use that time effectively to stretch and refuel your vehicle, keeping your $45 fuel budget in mind throughout the day. Because this is a turn-heavy local drive, stay alert during the transitions between the major memorial highways, as these segments can be more demanding than standard interstate cruising. Flexibility is your biggest advantage here, as the one-day duration leaves you plenty of room to adjust your schedule based on road conditions or personal energy levels.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 148.5 miles from Blue Springs, MO, or about 2h 46m into the drive.
The longest continuous stretch on this route runs about 131.6 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 65 miles or 1h 11m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 148.5 miles or 2h 46m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 39m
Traffic, exits, and arrival timing usually matter more near Perryville, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Blue Springs, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Blue Springs, MO
This is one driving day of about 297 miles and 5h 41m.
Your first comfortable stop window is around 65 miles from Blue Springs, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 131.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 18
5 decision points cluster between mile 1.4 and 228.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
1.4 mi into trip|~3m in
Keep slight right at fork toward I 70 East: Columbia
Highway fork - watch signs carefully
Toward I 70 East: Columbia
6
191.1 mi into trip|~3h 36m in|US 40
Take the exit onto US 40 toward I 64 East, US 40 East, US 61 South: Chesterfield
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 210A
Toward I 64 East, US 40 East, US 61 South: Ches...
8
216.5 mi into trip|~4h 7m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 25
Toward I 270: Chicago, Memphis
7
216.8 mi into trip|~4h 8m in
Keep slight right at fork toward I 270 South: Memphis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Toward I 270 South: Memphis
8
228.7 mi into trip|~4h 23m in
Take the exit toward I 55, US 61, US 67: Saint Louis, Memphis, Lemay Ferry Road
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 1A
Toward I 55, US 61, US 67: Saint Louis, Memphis...
Fuel & Cost
Regular Gas
$46.43 one way
$92.87 round trip
$3.97/gal25.4 MPG avg104 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$50.98
$101.96
premium
$4.89
$57.15
$114.31
diesel
$5.61
$65.57
$131.15
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$46
Meals
$25–$50
Total
$71–$96
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 103.9 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $31 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
89.1
1
$31.18
$14.26
Efficient EV
74.3
0
$25.99
$11.88
EV Truck/SUV
118.8
1
$41.58
$19.01
Gas CO2
104 kg
EV CO2
35 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Blue Springs, MO
Late night
in Blue Springs on Sunday
Local time
1:03 AM
CDT
Current temp
56°F
Unavailable
Live forecast
Destination
Perryville, MO
Late night
in Perryville on Sunday
Local time
1:03 AM
CDT
Current temp
56°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
5h 41m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a varied experience behind the wheel, as this route is characterized as a turn-heavy local drive rather than a simple interstate sprint. While you spend time on major thoroughfares, only about 6% of your journey is strictly highway driving, meaning you will encounter more frequent transitions and winding segments. Your longest uninterrupted stretch occurs on the Dwight D. Eisenhower Highway, covering 131.6 miles of the total distance. As you move through these different road types, the character of the drive shifts from high-speed highway segments to more technical local stretches that require your focused attention.
Only 6% highway — the rest is turn-by-turn surface driving.
30 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 131.6 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
10/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 1.4 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 18 significant decision points across 297 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 1.4 miles: Highway fork - watch signs carefully; at 191.1 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 216.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Blue Springs, MO to Perryville, MO, road signs begin pointing toward Memphis along the way.
Memphis
216.5 mi in|~4h 7m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 5h 41m. Total distance: 297 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 41m drive, comfortable solo distance.
Scenic Drive
Mostly surface roads route profile.
Frequently Asked Questions
The longest stretch is about 131.6 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Perryville, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 1.4 miles: Highway fork - watch signs carefully; at 191.1 miles (US 40): Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 216.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Not recommended in a single day. At 5.7 hours each way, a round trip means 11.4 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Perryville, MO before the return drive.
