Independence, MO to Saint Charles, MO is 221.1 miles and takes about 4h 16m via Dwight D. Eisenhower Highway, with a fuel budget near $34 and enough daylight to finish in a day. This trip stays within the Midwest region, moving from one part of Missouri to another. Expect to spend most of your time on surface roads, so plan for a more relaxed pace than a pure interstate drive. With only one recommended stop and a manageable duration, this route is ideal for a single-day excursion.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
110.6 miles from Independence, MO
A natural place for your longest stop of the day
, about 2h 2m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
153.3 mi
2h 56m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
South Noland Road
3.1 mi
5m
Truman/Eisenhower Presidential Highway
2.6 mi
3m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi
1m
Clifton J. Scott Memorial Highway
1.5 mi
1m
First Capitol Drive
0.9 mi
2m
Longest stretch:
Dwight D. Eisenhower Highway
— 153.3 mi, about 2h 56m
Traffic on I-70
Hour-of-day weekday pattern from 23 FHWA count stations on your route.
Peak
4 PM
~3,281 veh/hr typical
· worst 3,830
Quietest
1 AM
~292 veh/hr
Peak-to-quiet ratio
11.2×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Independence, MO and Saint Charles, MO.
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
10
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
11
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
12
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
13
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
14
Continue on I 70; US 40
99 mi·1 hr 57 min·Dwight D. Eisenhower Highway
Use the straight / slight right lanes.
15
Take the exit
0.1 mi·14 sec
Exit 228Toward I 70 Business, MO 94: First Capitol Drive, Lewis and Clark TrailUse the slight right lane.
16
Keep slight left at fork
0.1 mi·14 sec
Toward I 70 Business, MO 94 East: First Capitol Drive, Lindenwood University, SSM Health Saint Joseph HospitalUse the slight left / slight right lanes.
17
Turn straight onto I 70 Business; MO 94
0.9 mi·2 min·First Capitol Drive
18
Turn slight right onto I 70 Business; MO 94
0.9 mi·2 min·I 70 Business; MO 94
Toward MO 94
19
Turn left onto South Second Street
0.3 mi·56 sec·South Second Street
20
Arrive at destination
North Second Street
Trip Plan
Given the 4h 16m estimated drive time, leaving Independence, MO in the morning will give you ample time to reach Saint Charles, MO before evening. Since this is a single-day trip with a low highway percentage, you have flexibility in your departure time. Plan for your single stop to break up the 153.3-mile stretch on Dwight D. Eisenhower Highway. Keep an eye on your fuel gauge, as navigating surface roads can sometimes be less predictable for fuel availability compared to major interstates, and budget around $34 for gas.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 110.6 miles from Independence, MO, or about 2h 2m into the drive.
The longest continuous stretch on this route runs about 153.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 49 miles or 55m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 110.6 miles or 2h 2m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 25m
Traffic, exits, and arrival timing usually matter more near Saint Charles, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Independence, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Independence, MO
This is one driving day of about 221.1 miles and 4h 16m.
Your first comfortable stop window is around 49 miles from Independence, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 153.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 9
5 decision points cluster between mile 0 and 218.9 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0 mi into trip|~0m in|South Lynn Street
Turn right onto South Lynn Street
Navigation decision point
5
0.1 mi into trip|~0m in|East Walnut Street
Turn left onto East Walnut Street
Navigation decision point
6
3.3 mi into trip|~6m in
Turn left toward I 70 East: Columbia, Saint Louis
Multiple destination signs - pick the right one
Toward I 70 East: Columbia, Saint Louis
8
218.8 mi into trip|~4h 10m in
Take the exit toward I 70 Business, MO 94: First Capitol Drive, Lewis and Clark Trail
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 228
Toward I 70 Business, MO 94: First Capitol Driv...
9
218.9 mi into trip|~4h 10m in
Keep slight left at fork toward I 70 Business, MO 94 East: First Capitol Drive, Lindenwood University, SSM Health Saint Joseph Hospital
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 70 Business, MO 94 East: First Capitol...
Fuel & Cost
Regular Gas
$32.65 one way
$65.30 round trip
$3.75/gal25.4 MPG avg77 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.14
$36.05
$72.09
premium
$4.72
$41.05
$82.10
diesel
$4.80
$41.75
$83.50
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$33
Meals
$25–$50
Total
$58–$83
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 77.4 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $23 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
66.3
0
$23.22
$10.61
Efficient EV
55.3
0
$19.35
$8.84
EV Truck/SUV
88.4
1
$30.95
$14.15
Gas CO2
77 kg
EV CO2
26 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 18, 2026
Origin
Independence, MO
Late night
in Independence on Sunday
Local time
5:50 AM
CDT
Current temp
92°F
Chance Showers And Thunderstorms
SW 6 mph28% chanceLive forecast
Special Weather Statement
Special Weather Statement issued July 18 at 3:52PM CDT by NWS Paducah KY
Special Weather Statement
Special Weather Statement issued July 18 at 3:42PM CDT by NWS Paducah KY
Destination
Saint Charles, MO
Late night
in Saint Charles on Sunday
Local time
5:50 AM
CDT
Current temp
95°F
Isolated Showers And Thunderstorms
W 9 mph21% chanceLive forecast
Special Weather Statement
Special Weather Statement issued July 18 at 3:52PM CDT by NWS Paducah KY
Special Weather Statement
Special Weather Statement issued July 18 at 3:42PM CDT by NWS Paducah KY
91°F
Columbia, MO
111 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
3 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 16m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Gateway Arch National Park
National Park
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
19 mi from route
~48 min detour
$19
near mile 221.1
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route is primarily surface roads, with 0% highway share. You'll be on local roads for the majority of the 221.1 miles. The longest stretch without a significant break is 153.3 miles along Dwight D. Eisenhower Highway. Be prepared for frequent intersections and traffic signals as you navigate through towns and populated areas.
Only 0% highway — the rest is turn-by-turn surface driving.
20 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 153.3 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
5/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. You will hit about 9 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near South Lynn Street.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 221.1 miles you will encounter 9 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (South Lynn Street): Navigation decision point; at 0.1 miles (East Walnut Street): Navigation decision point; at 3.3 miles: Multiple destination signs - pick the right one.
Independence, known as the Queen City of the Trails, is a city in western Missouri just east of Kansas City with a population of approximately 110,000. Independence's founding predates that of Kansas City, and it was home to U.S. President Harry S. Truman and the legendary actress Ginger Rogers, as well as the starting point of three of America's great Westward Trails: the Santa Fe Trail, the California Trail, and the Oregon Trail. The city also hosts numerous historical sites related to the Community of Christ (formerly RLDS), Church of Jesus Christ of Latter-day Saints (the "Mormons"), American Civil War and Western history.
While offering a full range of entertainment and lodging options for visitors, Independence generally tends to be more "quiet" than its larger neighbor to the west.
Top landmarks
•Harry S. Truman Presidential Library and Museum — presidential library and museum for U.S. President Harry S. Truman, located in I...
•Temple Lot — Geographical location important in Latter Day Saint history
•Harry S. Truman National Historic Site — national Historic Site of the United States in Missouri
St. Charles, Missouri is outside of St. Louis on the bank of the Missouri River. It was Missouri's first state capital and was one of the first stops by Lewis and Clark on their journey to explore Louisiana Territory. The historic Main Street has largely been restored to its 1812-era appearance including gas lights a boardwalk and is lined with shops selling artwork, handicrafts, home decorations, antiques. There are also many restaurants.
Top landmarks
•First Missouri State Capitol State Historic Site — historic site in Missouri, United States
•African Church — church building in Missouri, United States of America
•Frenchtown Historic District — historic district in St. Charles County, Missouri
Doable as a same-day drive at 4h 16m. Total distance: 221.1 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 16m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (0%). Some complex stretches to watch for.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 153.3 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: near the start (South Lynn Street): Navigation decision point; at 0.1 miles (East Walnut Street): Navigation decision point; at 3.3 miles: Multiple destination signs - pick the right one.
Yes — Gateway Arch National Park. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.3 hours each way, an in-and-out day trip would put you behind the wheel for 8.5 hours — manageable with a long break at Saint Charles, MO, but most travelers stay overnight.
