Harrisonville, MO to O'Fallon, MO is 223.9 miles and takes about 4h 30m via Dwight D. Eisenhower Highway, with a fuel budget near $35 and enough daylight to finish in a day. This trip stays within Missouri, traversing the Midwest region on a route that primarily uses surface roads. With only one recommended stop and a manageable duration, it's a straightforward drive for a single day. Consider this if you're looking for a direct connection between these two points without extensive highway time.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
111.9 miles from Harrisonville, MO
A natural place for your longest stop of the day
, about 2h 18m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
131 mi
2h 30m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
East Mechanic Street
13.2 mi
21m
South Outer Belt Road
7.4 mi
10m
MO VV
4.9 mi
8m
MO E
3.2 mi
5m
South Broadway Street
2.7 mi
5m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
Longest stretch:
Dwight D. Eisenhower Highway
— 131 mi, about 2h 30m
Traffic on I-70
Hour-of-day weekday pattern from 20 FHWA count stations on your route.
Peak
3 PM
~2,340 veh/hr typical
· worst 2,883
Quietest
1 AM
~235 veh/hr
Peak-to-quiet ratio
10×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Harrisonville, MO and O'Fallon, MO.
1
Start on South Independence Street
76 ft·6 sec·South Independence Street
2
Turn left onto MO 7
13 mi·21 min·East Mechanic Street
3
Turn right onto MO VV
0.5 mi·50 sec·MO VV
4
Enter roundabout onto MO VV
88 ft·1 sec·MO VV
5
Continue on MO VV
4.4 mi·7 min·MO VV
6
At end of road, turn left onto MO E
3.2 mi·5 min·MO E
7
Take the ramp
0.2 mi·28 sec
Toward US 50 East: Warrensburg, Sedalia
8
Merge onto US 50
1.9 mi·2 min·US 50
9
Take the exit
348 ft·10 sec
10
Turn left onto MO F
7.4 mi·10 min·South Outer Belt Road
11
Continue on MO F
2.7 mi·5 min·South Broadway Street
12
Take the ramp
0.3 mi·34 sec
Toward I 70 East, US 40 East: Columbia
13
Merge onto I 70; US 40
41 mi·43 min·Dwight D. Eisenhower Highway
14
Continue on I 70; US 40
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
15
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
16
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
17
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
18
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
19
Continue on I 70; US 40
88 mi·1 hr 44 min·Dwight D. Eisenhower Highway
Use the straight / slight right lanes.
20
Take the exit
0.3 mi·43 sec
Toward MO K: O'FallonUse the straight / slight right lanes.
21
Turn straight onto Drennen Parkway
150 ft·3 sec·Drennen Parkway
Toward MO K: O'Fallon
22
Keep slight right at fork onto Drennen Parkway
166 ft·5 sec·Drennen Parkway
Toward MO K: O'Fallon
23
Turn slight left
62 ft·2 sec
Toward MO K: O'Fallon
24
Continue on South Main Street
0.6 mi·1 min·South Main Street
25
Turn right
25 ft·1 sec
26
Arrive at destination
Trip Plan
Since this drive is only 4.5 hours and can be completed in a single day, you have flexibility with your departure time. Leaving in the morning allows you to reach O'Fallon with plenty of daylight remaining. With one stop suggested and a fuel cost estimated at $35, plan your stops accordingly for fuel or a quick break. Keep an eye out for transitions between different highway designations, as the route profile indicates a significant portion will be on surface roads, which may involve more varied speed limits and traffic.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 111.9 miles from Harrisonville, MO, or about 2h 18m into the drive.
The longest continuous stretch on this route runs about 131 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 49 miles or 1h 11m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 111.9 miles or 2h 18m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 41m
Traffic, exits, and arrival timing usually matter more near O'Fallon, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Harrisonville, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Harrisonville, MO
This is one driving day of about 223.9 miles and 4h 30m.
Your first comfortable stop window is around 49 miles from Harrisonville, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 131 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 15
5 decision points cluster between mile 0 and 223.2 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
4
0 mi into trip|~0m in|MO 7 / East Mechanic Street
Turn left onto MO 7 / East Mechanic Street
Navigation decision point
4
13.7 mi into trip|~22m in|MO VV
Enter roundabout onto MO VV
Roundabout - know your exit number before entering
5
21.4 mi into trip|~35m in
Take the ramp toward US 50 East: Warrensburg, Sedalia
Multiple destination signs - pick the right one
Toward US 50 East: Warrensburg, Sedalia
6
222.9 mi into trip|~4h 28m in
Take the exit toward MO K: O'Fallon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Toward MO K: O'Fallon
6
223.2 mi into trip|~4h 28m in|Drennen Parkway
Keep slight right at fork onto Drennen Parkway toward MO K: O'Fallon
Highway fork - watch signs carefully
Toward MO K: O'Fallon
Fuel & Cost
Regular Gas
$33.06 one way
$66.13 round trip
$3.75/gal25.4 MPG avg78 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.14
$36.50
$73.01
premium
$4.72
$41.57
$83.14
diesel
$4.80
$42.28
$84.55
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$33
Meals
$25–$50
Total
$58–$83
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 78.3 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $24 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
67.2
0
$23.51
$10.75
Efficient EV
56
0
$19.59
$8.96
EV Truck/SUV
89.6
1
$31.35
$14.33
Gas CO2
78 kg
EV CO2
26 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 18, 2026
Origin
Harrisonville, MO
Late night
in Harrisonville on Monday
Local time
12:54 AM
CDT
Current temp
92°F
Chance Showers And Thunderstorms
WSW 7 mph27% chanceLive forecast
Heat Advisory
Heat Advisory issued July 18 at 12:07PM CDT until July 18 at 8:00PM CDT by NWS Memphis TN
Heat Advisory
Heat Advisory issued July 18 at 12:07PM CDT until July 19 at 9:00PM CDT by NWS Memphis TN
Destination
O'Fallon, MO
Late night
in O'Fallon on Monday
Local time
12:54 AM
CDT
Current temp
94°F
Slight Chance Showers And Thunderstorms
W 8 mph21% chanceLive forecast
Heat Advisory
Heat Advisory issued July 18 at 12:07PM CDT until July 18 at 8:00PM CDT by NWS Memphis TN
Heat Advisory
Heat Advisory issued July 18 at 12:07PM CDT until July 19 at 9:00PM CDT by NWS Memphis TN
92°F
Marshall, MO
112 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 30m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This route has a 100% highway share, meaning you'll be on highways for the entire 223.9 miles. The longest continuous stretch you'll experience is 131 miles on the Dwight D. Eisenhower Highway. Given the 'Mostly surface roads' profile, expect frequent exits and entrances as you navigate through towns and more developed areas rather than open interstate cruising.
Only 1% highway — the rest is turn-by-turn surface driving.
26 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 131 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
5/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. You will hit about 15 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near MO 7 / East Mechanic Street.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 223.9 miles you will encounter 15 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (MO 7 / East Mechanic Street): Navigation decision point; at 13.7 miles (MO VV): Roundabout - know your exit number before entering; at 21.4 miles: Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
959 ft546 ft
Total Climb
405 ft
Total Descent
812 ft
Highest Point
959 ft
~16 mi in
Elevation Range
413 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Harrisonville, MO to O'Fallon, MO, road signs begin pointing toward Sedalia along the way.
St. Charles, Missouri is outside of St. Louis on the bank of the Missouri River. It was Missouri's first state capital and was one of the first stops by Lewis and Clark on their journey to explore Louisiana Territory. The historic Main Street has largely been restored to its 1812-era appearance including gas lights a boardwalk and is lined with shops selling artwork, handicrafts, home decorations, antiques. There are also many restaurants.
Doable as a same-day drive at 4h 30m. Total distance: 223.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 30m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (1%). Some complex stretches to watch for.
Scenic Drive
Mostly surface roads route profile.
Frequently Asked Questions
The longest stretch is about 131 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
Yes — we found about 30 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: near the start (MO 7 / East Mechanic Street): Navigation decision point; at 13.7 miles (MO VV): Roundabout - know your exit number before entering; at 21.4 miles: Multiple destination signs - pick the right one.
Possible but tiring. At 4.5 hours each way, an in-and-out day trip would put you behind the wheel for 9.0 hours — manageable with a long break at O'Fallon, MO, but most travelers stay overnight.
