Spanning 208.3 miles across Mississippi, this drive from Greenville to West Hattiesburg typically takes about 4 hours and 20 minutes of travel time. Because the trip is manageable in a single day, you can easily complete it without needing an overnight stay, leaving you with plenty of flexibility. Expect to budget approximately $32 for fuel depending on your vehicle's efficiency. You will navigate through the Southeast region, transitioning from Greenville onto Main Street and North Martin Luther King Drive before settling onto US 49 South. It is a straightforward journey that serves as a practical connection between these two Mississippi hubs, perfect for travelers who prefer a direct, purposeful route.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
104.1 miles from Greenville, MS
A natural place for your longest stop of the day
, about 2h 10m into the drive
.
Main Roads
Road
Distance
Duration
Highway 49 South
80.3 mi
1h 37m
North Martin Luther King Drive
46.2 mi
55m
Jerry Clower Boulevard
38.8 mi
47m
US 82
15.8 mi
19m
US 49
11.5 mi
15m
MS 182
9.2 mi
13m
Lance Corporal Roy M Wheat Memorial Highway
1.9 mi
1m
I 20
1.2 mi
1m
Longest stretch:
Highway 49 South
— 80.3 mi, about 1h 37m
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenville, MS and West Hattiesburg, MS.
1
Start on MS 814
10 ft·7 sec·South Broadway Street
2
Turn left onto Main Street
0.9 mi·2 min·Main Street
3
Turn left onto MS 182
9.2 mi·13 min·MS 182
4
Turn left onto US 82; US 278
16 mi·19 min·US 82; US 278
Use the straight lane.
5
Turn right onto US 49W
46 mi·55 min·North Martin Luther King Drive
6
Keep slight right at fork onto US 49W
0.5 mi·53 sec·US 49W
Toward US 49 South: Jackson
7
Merge onto US 49
39 mi·47 min·Jerry Clower Boulevard
8
Take the exit onto US 49
4.9 mi·5 min·US 49
9
Keep slight left at fork onto US 49
3.8 mi·5 min·US 49
10
Merge onto I 20; I 55; US 49
1.1 mi·1 min·I 20; I 55; US 49
11
Keep slight right at fork onto I 20; US 49
347 ft·4 sec·I 20; US 49
Toward Meridian, Hattiesburg
12
Take the exit onto US 49
0.6 mi·42 sec·US 49
Toward Hattiesburg
13
Keep slight right at fork onto US 49
0.7 mi·1 min·US 49
Toward Richland, Hattiesburg
14
Merge onto US 49
80 mi·1 hr 37 min·Highway 49 South
Use the straight lane.
15
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
16
Continue on US 49; MS 42
1.1 mi·1 min·US 49; MS 42
Use the straight lane.
17
Take the exit
0.4 mi·36 sec
Toward I 59 South: New Orleans, Gulf CoastUse the slight right lane.
18
Merge onto I 59
1.9 mi·1 min·Lance Corporal Roy M Wheat Memorial Highway
Toward Mississippi Gulf Coast
19
Take the exit
0.2 mi·21 sec
Toward US 98 West: Columbia, Hardy StreetUse the slight right lane.
20
Keep slight left at fork
236 ft·8 sec
Toward US 98 West: Hardy Street, University of Southern Mississippi, Columbia
21
Turn right onto US 98
1.2 mi·2 min·Hardy Street
Toward US 98 West: ColumbiaUse the straight / right lanes.
22
Turn left onto Weathersby Road
0.2 mi·35 sec·Weathersby Road
Use the left lane.
23
Turn right onto North Lane
0.1 mi·23 sec·North Lane
24
Arrive at destination
McKenzie Circle
Trip Plan
For the most efficient trip, plan your departure early in the morning to avoid local traffic congestion on the surface streets. You should budget for at least one stop during your 4-hour and 20-minute journey to stretch your legs and refresh. Since the route relies heavily on local roads, keep a close eye on your fuel gauge before leaving Greenville to ensure you stay within your $32 budget. Given the turn-heavy nature of the drive, having a reliable navigation system active is essential to manage the transitions between Main Street, North Martin Luther King Drive, and US 49 South. Use that single planned stop as a mid-point reset to maintain focus during the more technical sections of the drive.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 104.1 miles from Greenville, MS, or about 2h 10m into the drive.
The longest continuous stretch on this route runs about 80.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 46 miles or 59m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 104.1 miles or 2h 10m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 33m
Traffic, exits, and arrival timing usually matter more near West Hattiesburg, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Greenville, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Greenville, MS
This is one driving day of about 208.3 miles and 4h 20m.
Your first comfortable stop window is around 46 miles from Greenville, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Highway 49 South for about 80.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 19
5 decision points cluster between mile 121.2 and 206.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
121.2 mi into trip|~2h 32m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward Meridian, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Meridian, Hattiesburg
6
121.8 mi into trip|~2h 32m in|US 49
Keep slight right at fork onto US 49 toward Richland, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Richland, Hattiesburg
7
204.3 mi into trip|~4h 14m in
Take the exit toward I 59 South: New Orleans, Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward I 59 South: New Orleans, Gulf Coast
7
206.5 mi into trip|~4h 16m in
Take the exit toward US 98 West: Columbia, Hardy Street
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Toward US 98 West: Columbia, Hardy Street
7
206.7 mi into trip|~4h 17m in
Keep slight left at fork toward US 98 West: Hardy Street, University of Southern Mississippi, Columbia
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 98 West: Hardy Street, University of...
Fuel & Cost
Regular Gas
$31.46 one way
$62.92 round trip
$3.84/gal25.4 MPG avg73 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$34.53
$69.07
premium
$4.56
$37.39
$74.77
diesel
$5.61
$45.99
$91.98
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$31
Meals
$25–$50
Total
$56–$81
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 72.9 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $22 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
62.5
0
$21.87
$10.00
Efficient EV
52.1
0
$18.23
$8.33
EV Truck/SUV
83.3
1
$29.16
$13.33
Gas CO2
73 kg
EV CO2
24 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 16, 2026
Origin
Greenville, MS
Night
in Greenville on Saturday
Local time
11:44 PM
CDT
Current temp
86°F
Mostly Sunny
SSW 10 to 15 mph13% chanceLive forecast
Destination
West Hattiesburg, MS
Night
in West Hattiesburg on Saturday
Local time
11:44 PM
CDT
Current temp
54°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
32 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 20m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
3 mi from route
~7 min detour
Free
near mile 114.9
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a turn-heavy, local-style drive that requires your full attention rather than a monotonous interstate cruise. Since the route has a highway share of 0%, you should prepare for a more involved experience behind the wheel as you navigate surface streets and local roads. The path shifts from the local corridors of Greenville onto the broader stretch of US 49 South, creating a varied driving environment. You will not encounter long, uninterrupted highway stretches here, so remain alert for changing speed limits and intersection traffic. The character of this drive is defined by its local pacing, making it a distinct change of pace from standard highway travel.
57% highway, the rest on surface roads — varied driving throughout.
24 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 80.3 mi on Highway 49 South.
How Hard Is This Drive?
10/10
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 121.2 miles in near I 20; US 49.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 208.3 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 121.2 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 121.8 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 204.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Greenville, MS and West Hattiesburg, MS, road signs point toward Meridian, Hattiesburg and Richland.
Greenville is a city in Washington County, Mississippi, United States. The population was 30,000 in 2020, making it the ninth largest city in the state. It is the county seat of Washington County.
Doable as a same-day drive at 4h 20m. Total distance: 208.3 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 20m drive, comfortable solo distance.
Scenic Drive
Mixed highway & surface route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 80.3 miles on Highway 49 South. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at West Hattiesburg, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 121.2 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 121.8 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 204.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.3 hours each way, an in-and-out day trip would put you behind the wheel for 8.7 hours — manageable with a long break at West Hattiesburg, MS, but most travelers stay overnight.
