Connecting the Gulf Coast to the state capital, this 162.7-mile journey from Biloxi to Jackson is a straightforward trek across Mississippi. You can expect about 3 hours and 23 minutes of drive time, making this a very manageable day trip that doesn't require an overnight stay. Your primary path involves navigating I-110, MS 15, and the extensive US 49 corridor. With an estimated fuel budget of $25, the route is as economical as it is efficient. Whether you are heading inland for business or leisure, the drive keeps you firmly within the Southeast region for the duration of the trip.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
81.3 miles from Biloxi, MS
A natural place for your longest stop of the day
, about 1h 43m into the drive
.
Main Roads
Road
Distance
Duration
US 49
135.1 mi
2h 46m
MS 15
20.7 mi
24m
I 110
3.1 mi
4m
South State Street
1.3 mi
2m
Division Street
0.5 mi
1m
Main Street
0.5 mi
1m
I 20
0.3 mi
<1m
East Pearl Street
0.2 mi
<1m
Longest stretch:
US 49
— 135.1 mi, about 2h 46m
Turn-by-Turn Driving Directions
Step-by-step road directions between Biloxi, MS and Jackson, MS.
1
Start on Howard Avenue
91 ft·6 sec·Howard Avenue
2
Turn right onto Main Street
0.5 mi·1 min·Main Street
3
Turn left onto Division Street
0.5 mi·1 min·Division Street
4
Take the ramp onto Bohn Street
139 ft·3 sec·Bohn Street
5
Turn straight
0.3 mi·37 sec
6
Merge onto I 110
3.1 mi·4 min·I 110
7
Continue on MS 15; MS 67
21 mi·24 min·MS 15; MS 67
Use the straight lane.
8
Keep slight right at fork
0.4 mi·47 sec
Toward US 49 North: Hattiesburg, Jackson
9
Merge onto US 49
40 mi·46 min·US 49
Use the straight lane.
10
Continue on US 49
2.4 mi·2 min·US 49
Use the straight / slight right lanes.
11
Turn straight onto US 49
10 mi·16 min·US 49
Use the straight lane.
12
Continue on US 49; MS 42
5.4 mi·6 min·US 49; MS 42
Use the straight lane.
13
Continue on US 49
5.3 mi·6 min·US 49
Use the straight lane.
14
Continue on US 49
0.2 mi·14 sec·US 49
Use the straight lane.
15
Continue on US 49
4.2 mi·4 min·US 49
Use the straight lane.
16
Continue on US 49
66 mi·1 hr 20 min·US 49
Use the straight lane.
17
Take the exit onto US 49
0.2 mi·21 sec·US 49
18
Keep slight left at fork onto US 49
0.7 mi·1 min·US 49
Toward Jackson
19
Keep slight left at fork onto US 49
1.0 mi·1 min·US 49
20
Merge onto I 20; I 55; US 49
0.3 mi·25 sec·I 20; I 55; US 49
21
Take the exit
0.3 mi·37 sec
Toward US 51 North
22
Turn straight onto US 51
1.3 mi·2 min·South State Street
23
Turn left onto East Pearl Street
0.2 mi·32 sec·East Pearl Street
24
Arrive at destination
East Pearl Street
Trip Plan
Since the trip takes less than four hours, you have plenty of flexibility to plan your departure around your personal schedule. You only need to account for one stop to comfortably break up the 162.7-mile distance. Keep a close eye on your fuel gauge before starting the long 135.1-mile stretch on US 49 to ensure you aren't caught off guard between service points. Because this route is almost entirely highway-based, check traffic reports for any unexpected congestion on the primary corridors before you leave. Planning your single stop near the midpoint of the US 49 stretch is the best way to maintain your energy for the final leg into Jackson.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 81.3 miles from Biloxi, MS, or about 1h 43m into the drive.
The longest continuous stretch on this route runs about 135.1 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 36 miles or 45m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 81.3 miles or 1h 43m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 46m
Traffic, exits, and arrival timing usually matter more near Jackson, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Biloxi, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Biloxi, MS
This is one driving day of about 162.7 miles and 3h 23m.
Your first comfortable stop window is around 36 miles from Biloxi, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 49 for about 135.1 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 13
5 decision points cluster between mile 1 and 159.5 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
4
1 mi into trip|~3m in|Bohn Street
Take the ramp onto Bohn Street
Navigation decision point
6
25.1 mi into trip|~32m in
Keep slight right at fork toward US 49 North: Hattiesburg, Jackson
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 49 North: Hattiesburg, Jackson
5
25.5 mi into trip|~33m in|US 49
Merge onto US 49
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
5
158.9 mi into trip|~3h 17m in|US 49
Keep slight left at fork onto US 49 toward Jackson
Highway fork - watch signs carefully
Toward Jackson
4
159.5 mi into trip|~3h 18m in|US 49
Keep slight left at fork onto US 49
Highway fork - watch signs carefully
Fuel & Cost
Regular Gas
$24.57 one way
$49.14 round trip
$3.84/gal25.4 MPG avg57 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$26.97
$53.95
premium
$4.56
$29.20
$58.41
diesel
$5.61
$35.92
$71.84
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$25
Meals
$25–$50
Total
$50–$75
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 56.9 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $17 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
48.8
0
$17.08
$7.81
Efficient EV
40.7
0
$14.24
$6.51
EV Truck/SUV
65.1
0
$22.78
$10.41
Gas CO2
57 kg
EV CO2
19 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 17, 2026
Origin
Biloxi, MS
Late night
in Biloxi on Tuesday
Local time
3:45 AM
CDT
Current temp
79°F
Sunny
S 10 mph0% chanceLive forecast
Destination
Jackson, MS
Late night
in Jackson on Tuesday
Local time
3:45 AM
CDT
Current temp
88°F
Sunny
S 10 mph0% chanceLive forecast
58°F
Sumrall, MS
81 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
9 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
3h 23m on the road
The weather snapshot is not static. If you are leaving later, give both cities one more quick forecast check before departure.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
3 mi from route
~8 min detour
Free
near mile 162.7
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This is a highway-focused drive, with 98% of your time spent on major roads rather than local streets. You will spend the bulk of your journey on US 49, which features a long, uninterrupted stretch of 135.1 miles. Because the route relies heavily on high-speed thoroughfares, it favors steady cruising over technical maneuvering. Expect a consistent pace as you move from the coastal environment toward the center of the state. It is a functional, efficient drive that prioritizes speed and directness over winding backroads.
98% highway — fuel and pacing are the main things to plan.
24 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 135.1 mi on US 49.
How Hard Is This Drive?
8/10
This is a straightforward highway drive that stays mostly on US 49 and MS 15. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 1 miles in near Bohn Street.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 13 significant decision points across 162.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 1 miles (Bohn Street): Navigation decision point; at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here.
Biloxi is a city in Harrison County, on the Gulf Coast of Mississippi. It's well known for its beaches and nine casinos. It is also home to the "Jefferson Davis Presidential Library and Museum", which serves as a museum of the Confederacy.
Jackson is the capital of the state of Mississippi. While it may not offer much in terms of tourism today, Jackson can be used as a stopover for getting to other parts of the state or further.
Doable as a same-day drive at 3h 23m. Total distance: 162.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
3h 23m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (98%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 135.1 miles on US 49. The full list of main roads is in the Roads section above.
Yes — we found about 7 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Jackson, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 7 rest areas along the route for bathroom stops.
The main spots that need attention: at 1 miles (Bohn Street): Navigation decision point; at 25.1 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 25.5 miles (US 49): Merge point - match speed before joining. Lane positioning matters here.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 3.4 hours each way, an in-and-out day trip would put you behind the wheel for 6.8 hours — manageable with a long break at Jackson, MS, but most travelers stay overnight.
