Slater, MO to O'Fallon, MO is 145 miles and takes about 3h 4m via Dwight D. Eisenhower Highway, with a fuel budget near $23 and enough daylight to finish in a day. This drive stays within Missouri, connecting two points in the Midwest. Expect a local feel with frequent turns rather than a straight shot on the interstate. It's a manageable one-day trip, perfect for a quick journey with minimal fuss.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
72.5 miles from Slater, MO
A natural place for your longest stop of the day
, about 1h 37m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
90 mi
1h 46m
Industrial Boulevard
13.2 mi
19m
North Church Street
12.8 mi
19m
MO 240
12.2 mi
15m
MO 5
12 mi
16m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi
1m
South Main Street
0.6 mi
1m
Longest stretch:
Dwight D. Eisenhower Highway
— 90 mi, about 1h 46m
Turn-by-Turn Driving Directions
Step-by-step road directions between Slater, MO and O'Fallon, MO.
1
Start on Porter Street
72 ft·5 sec·Porter Street
2
Turn right onto MO O
468 ft·14 sec·West Maple Street
3
Turn right onto MO C
0.2 mi·21 sec·North Broadway Street
4
Continue on South Broadway Street
70 ft·4 sec·South Broadway Street
5
Turn left onto MO 240
13 mi·19 min·Industrial Boulevard
6
Turn left onto MO 5; MO 240
12 mi·16 min·MO 5; MO 240
7
Continue on MO 240
13 mi·19 min·North Church Street
8
Keep slight left at fork onto MO 240
12 mi·15 min·MO 240
9
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
10
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
11
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
12
Continue on I 70; US 40
88 mi·1 hr 44 min·Dwight D. Eisenhower Highway
Use the straight / slight right lanes.
13
Take the exit
0.3 mi·43 sec
Toward MO K: O'FallonUse the straight / slight right lanes.
14
Turn straight onto Drennen Parkway
150 ft·3 sec·Drennen Parkway
Toward MO K: O'Fallon
15
Keep slight right at fork onto Drennen Parkway
166 ft·5 sec·Drennen Parkway
Toward MO K: O'Fallon
16
Turn slight left
62 ft·2 sec
Toward MO K: O'Fallon
17
Continue on South Main Street
0.6 mi·1 min·South Main Street
18
Turn right
25 ft·1 sec
19
Arrive at destination
Trip Plan
Given the 3h 4m duration and 145-mile distance, this is an easy one-day trip. You could leave in the morning and arrive by lunchtime, or depart after lunch and be there before dinner. With only one stop suggested and a fuel cost around $23, planning is straightforward. Keep an eye out for changes in speed limits as you transition between highway and local roads; this is where most of your navigation will be focused.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 72.5 miles from Slater, MO, or about 1h 37m into the drive.
The longest continuous stretch on this route runs about 90 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 32 miles or 46m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 72.5 miles or 1h 37m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 32m
Traffic, exits, and arrival timing usually matter more near O'Fallon, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Slater, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Slater, MO
This is one driving day of about 145 miles and 3h 4m.
Your first comfortable stop window is around 32 miles from Slater, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 90 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 9
5 decision points cluster between mile 0 and 144.3 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0 mi into trip|~0m in|MO O / West Maple Street
Turn right onto MO O / West Maple Street
Navigation decision point
5
0.1 mi into trip|~0m in|MO C / North Broadway Street
Turn right onto MO C / North Broadway Street
Navigation decision point
4
13.5 mi into trip|~19m in|MO 5; MO 240
Turn left onto MO 5; MO 240
Navigation decision point
6
144 mi into trip|~3h 1m in
Take the exit toward MO K: O'Fallon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Toward MO K: O'Fallon
6
144.3 mi into trip|~3h 2m in|Drennen Parkway
Keep slight right at fork onto Drennen Parkway toward MO K: O'Fallon
Highway fork - watch signs carefully
Toward MO K: O'Fallon
Fuel & Cost
Regular Gas
$22.67 one way
$45.34 round trip
$3.97/gal25.4 MPG avg51 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$24.89
$49.78
premium
$4.89
$27.90
$55.81
diesel
$5.61
$32.01
$64.03
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$23
Meals
$25–$50
Total
$48–$73
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 50.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $15 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
43.5
0
$15.23
$6.96
Efficient EV
36.3
0
$12.69
$5.80
EV Truck/SUV
58
0
$20.30
$9.28
Gas CO2
51 kg
EV CO2
17 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Slater, MO
Morning
in Slater on Sunday
Local time
9:17 AM
CDT
Current temp
73°F
Unavailable
Live forecast
Destination
O'Fallon, MO
Morning
in O'Fallon on Sunday
Local time
9:17 AM
CDT
Current temp
57°F
Unavailable
Live forecast
74°F
Columbia, MO
73 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
16 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
3h 4m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This route is characterized as a 'turn-heavy local drive,' with only 17% of the journey on the highway. You'll experience a mix of speeds and road types, so be prepared for adjustments. The longest uninterrupted stretch is 90 miles on the Dwight D. Eisenhower Highway, offering a period of more consistent travel. Outside of that, anticipate navigating local roads and making frequent turns as you make your way to O'Fallon.
Only 17% highway — the rest is turn-by-turn surface driving.
19 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 90 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
4/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. There are only a few real navigation decisions along the way. The trickiest moment comes early in the drive near MO O / West Maple Street.
Driving Effort4/10
Easy - simple navigation with a manageable amount of wheel time
Balances navigation complexity with total wheel time.
This is a straightforward 3h 4m drive. You will face about 9 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
The main spots that need attention: near the start (MO O / West Maple Street): Navigation decision point; at 0.1 miles (MO C / North Broadway Street): Navigation decision point; at 13.5 miles (MO 5; MO 240): Navigation decision point.
St. Charles, Missouri is outside of St. Louis on the bank of the Missouri River. It was Missouri's first state capital and was one of the first stops by Lewis and Clark on their journey to explore Louisiana Territory. The historic Main Street has largely been restored to its 1812-era appearance including gas lights a boardwalk and is lined with shops selling artwork, handicrafts, home decorations, antiques. There are also many restaurants.
The longest stretch is about 90 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: near the start (MO O / West Maple Street): Navigation decision point; at 0.1 miles (MO C / North Broadway Street): Navigation decision point; at 13.5 miles (MO 5; MO 240): Navigation decision point.
Possible but tiring. At 3.1 hours each way, an in-and-out day trip would put you behind the wheel for 6.1 hours — manageable with a long break at O'Fallon, MO, but most travelers stay overnight.
