Connecting Saltillo to Southaven, this 102.2-mile journey across Mississippi is a straightforward trek that typically takes about two hours of drive time. Because of its manageable length, the route is perfectly suited for a single-day trip, requiring no overnight stays. You should budget roughly $16 for fuel to cover the distance between these two Southeast locations. Navigating primarily via I-22, you will find the transition between these points efficient and predictable. Whether you are traveling for business or a change of scenery, this path offers a reliable, no-fuss connection across the state.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Midpoint
51.1 miles from Saltillo, MS
A natural place for your longest stop of the day
, about 59m into the drive
.
Main Roads
Road
Distance
Duration
I 22
82.3 mi
1h 28m
Goodman Road
8.3 mi
12m
Natchez Trace Parkway
6.6 mi
10m
I 55
1.4 mi
1m
East Mobile Street
1.2 mi
2m
Stateline Road West
0.4 mi
<1m
Millbranch Road
0.2 mi
<1m
Haleville Drive
0.2 mi
<1m
Longest stretch:
I 22
— 82.3 mi, about 1h 28m
Turn-by-Turn Driving Directions
Step-by-step road directions between Saltillo, MS and Southaven, MS.
1
Start on MS 363
1.2 mi·2 min·East Mobile Street
2
Turn right
0.1 mi·30 sec
3
At end of road, turn right onto Natchez Trace Parkway
6.6 mi·10 min·Natchez Trace Parkway
4
Take the ramp
0.4 mi·47 sec
Toward Memphis
5
Merge onto I 22; US 78
82 mi·1 hr 28 min·I 22; US 78
Use the straight / slight right lanes.
6
Take the exit
0.2 mi·23 sec
Toward MS 302: Olive Branch Southaven
7
Keep slight left at fork
195 ft·10 sec
8
Turn left onto MS 302
8.3 mi·12 min·Goodman Road
Use the straight / right lanes.
9
Take the ramp
0.3 mi·42 sec
Toward Memphis
10
Merge onto I 55; I 69
1.4 mi·1 min·I 55; I 69
11
Take the exit
0.3 mi·43 sec
Toward Southaven, Horn Lake
12
Turn left onto Stateline Road West
0.4 mi·53 sec·Stateline Road West
13
Turn left onto Millbranch Road
0.2 mi·36 sec·Millbranch Road
14
Turn right onto Haleville Drive
0.2 mi·53 sec·Haleville Drive
15
Turn left onto Five Oaks Drive North
0.1 mi·28 sec·Five Oaks Drive North
16
Arrive at destination
Five Oaks Drive West
Trip Plan
Since this is a relatively short trip, you have plenty of flexibility regarding your departure time. Aim to leave during off-peak hours to avoid potential congestion as you near the Southaven area. Because there are no mandatory stops scheduled, feel free to pace the two-hour drive according to your own comfort. Keep in mind that the majority of your travel occurs on I-22, so stay alert for changing traffic patterns as you transition toward local roads like Goodman Road. Carrying a little extra cash for fuel is always a smart move, though $16 should cover your primary transit costs comfortably.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
You may only need one short stretch break if traffic stays light.
The halfway point lands around 51.1 miles from Saltillo, MS, or about 59m into the drive.
The longest continuous stretch on this route runs about 82.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 22 miles or 28m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 51.1 miles or 59m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 1h 34m
Traffic, exits, and arrival timing usually matter more near Southaven, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Saltillo, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Saltillo, MS
This is one driving day of about 102.2 miles and 2h.
Your first comfortable stop window is around 22 miles from Saltillo, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
The longest stretch is on I 22 for about 82.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 13
5 decision points cluster between mile 8.3 and 102 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
8.3 mi into trip|~13m in|I 22; US 78
Merge onto I 22; US 78
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
5
90.8 mi into trip|~1h 42m in
Keep slight left at fork
Highway fork - watch signs carefully
5
90.9 mi into trip|~1h 42m in|MS 302 / Goodman Road
Turn left onto MS 302 / Goodman Road
Lane positioning matters here
Use the straight / right lanes.
5
100.9 mi into trip|~1h 57m in
Take the exit toward Southaven, Horn Lake
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward Southaven, Horn Lake
5
102 mi into trip|~2h in|Five Oaks Drive North
Turn left onto Five Oaks Drive North
Navigation decision point
Fuel & Cost
Regular Gas
$15.43 one way
$30.87 round trip
$3.84/gal25.4 MPG avg36 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$16.94
$33.89
premium
$4.56
$18.34
$36.69
diesel
$5.61
$22.56
$45.13
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$15
Meals
$25–$50
Total
$40–$65
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 35.8 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $11 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
30.7
0
$10.73
$4.91
Efficient EV
25.6
0
$8.94
$4.09
EV Truck/SUV
40.9
0
$14.31
$6.54
Gas CO2
36 kg
EV CO2
12 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Saltillo, MS
Night
in Saltillo on Saturday
Local time
11:34 PM
CDT
Current temp
77°F
Unavailable
Live forecast
Destination
Southaven, MS
Night
in Southaven on Saturday
Local time
11:34 PM
CDT
Current temp
56°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
21 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
2h on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Natchez Trace National Scenic Trail
National Scenic Trail
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
1 mi from route
~3 min detour
Free
near mile 7
Park Closure: Partial Closure of Rocky Springs Trail
Park Closure: Temporary Blackland Prairie Trail Closure to Equestrians
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a highway-focused drive, as 88 percent of your journey is spent on major thoroughfares. The core of your trip involves a significant 82.3-mile stretch on I-22, which serves as the backbone of the route. As you move away from the Saltillo area, the road maintains a consistent pace, eventually transitioning onto Goodman Road as you approach Southaven. While the drive is characterized by these fast-moving highway segments, the lack of required stops makes it a streamlined experience. You will spend the vast majority of your time cruising on high-speed infrastructure designed for efficiency.
88% highway — fuel and pacing are the main things to plan.
16 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 82.3 mi on I 22.
How Hard Is This Drive?
5/10
This is a straightforward highway drive that stays mostly on I 22 and Goodman Road. You will hit about 13 points where you need to pay attention to lane position or signs. The trickiest moment comes around 8.3 miles in near I 22; US 78.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 102.2 miles you will encounter 13 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 8.3 miles (I 22; US 78): Merge point - match speed before joining. Lane positioning matters here; at 90.8 miles: Highway fork - watch signs carefully; at 90.9 miles (MS 302 / Goodman Road): Lane positioning matters here.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Saltillo, MS to Southaven, MS, road signs begin pointing toward Memphis along the way.
Memphis
7.9 mi in|~12m
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 2h. Total distance: 102.2 miles.
Family Friendly
Moderate complexity with 0 natural rest stops along the way.
Solo Traveler
2h drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (88%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 82.3 miles on I 22. The full list of main roads is in the Roads section above.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: at 8.3 miles (I 22; US 78): Merge point - match speed before joining. Lane positioning matters here; at 90.8 miles: Highway fork - watch signs carefully; at 90.9 miles (MS 302 / Goodman Road): Lane positioning matters here.
Yes — Natchez Trace National Scenic Trail and Tupelo National Battlefield. See the National Parks section for detour distances and tips on detours.
Yes. A round trip is manageable in a single day if you plan a break at Southaven, MS before heading back.
