Saint Joseph, MO to Hillsboro, MO is 322.4 miles and takes about 6h 13m via Dwight D. Eisenhower Highway, with a fuel budget near $49 and enough daylight to finish in a day. This trip stays within Missouri, moving from the Midwest region to another part of the Midwest. With a recommended one-day drive, you'll mostly be on surface roads, offering a more grounded perspective of the landscape. It's a straightforward drive for those looking to cover ground efficiently within the state.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
161.2 miles from Saint Joseph, MO
A natural place for your longest stop of the day
, about 2h 57m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
135.3 mi
2h 34m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
I 29
28.4 mi
30m
I 435
28 mi
30m
Avenue of the Saints
22 mi
26m
Veterans Memorial Highway
17.1 mi
19m
MO 141
14.9 mi
23m
Truman/Eisenhower Presidential Highway
5.6 mi
6m
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Traffic on I-70
Hour-of-day weekday pattern from 23 FHWA count stations on your route.
Peak
4 PM
~3,281 veh/hr typical
· worst 3,830
Quietest
1 AM
~292 veh/hr
Peak-to-quiet ratio
11.2×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Saint Joseph, MO and Hillsboro, MO.
1
Start on Walter Welsh Avenue
417 ft·8 sec·Walter Welsh Avenue
2
Turn right onto North 12th Street
297 ft·10 sec·North 12th Street
3
Turn right onto Francis Street
0.2 mi·37 sec·Francis Street
4
Turn left onto I 29 Business
1.2 mi·2 min·North 9th Street
5
Take the ramp
0.1 mi·15 sec
6
Merge onto US 36
0.2 mi·19 sec·US 36
7
Take the exit
0.2 mi·21 sec
Toward I 229 South, US 59 South: Kansas City
8
Merge onto I 229; US 59
4.5 mi·4 min·I 229; US 59
9
Keep slight right at fork
0.3 mi·29 sec
Toward I 29 South, US 71 South: Kansas City
10
Merge onto I 29; US 71
26 mi·27 min·I 29; US 71
11
Merge onto I 29; I 435; US 71
2.2 mi·2 min·I 29; I 435; US 71
Use the straight / slight right lanes.
12
Keep slight right at fork onto I 435
28 mi·30 min·I 435
Exit 14Toward I 435 East: Saint LouisUse the straight / slight right lanes.
13
Keep slight right at fork onto US 24
0.3 mi·23 sec·US 24
Exit 63Toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
14
Keep slight left at fork
1.2 mi·1 min
Toward I 70 East: Saint LouisUse the straight / slight right lanes.
15
Keep slight left at fork
469 ft·11 sec
Toward I 70 East: Saint LouisUse the slight left / straight lanes.
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
22
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
23
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
24
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
25
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
26
Continue on I 70; US 40
81 mi·1 hr 35 min·Dwight D. Eisenhower Highway
27
Take the exit onto US 40
0.3 mi·33 sec·US 40
Exit 210AToward I 64 East, US 40 East, US 61 South: Chesterfield
28
Merge onto I 64; US 40; US 61
22 mi·26 min·Avenue of the Saints
Use the straight / slight left lanes.
29
Take the exit
0.3 mi·33 sec
Exit 22Toward MO 141Use the slight right lane.
30
Turn right
185 ft·5 sec
Toward MO 141: Manchester
31
Merge onto MO 141
11 mi·17 min·MO 141
Use the right lane.
32
Keep slight left at fork onto MO 141
4.0 mi·5 min·MO 141
Use the left / straight lanes.
33
Take the exit
0.2 mi·13 sec
Toward MO 21 South: Hillsboro
34
Merge onto MO 21
17 mi·19 min·Veterans Memorial Highway
35
Take the exit
0.3 mi·45 sec
Toward MO A
36
Turn left onto MO A
0.2 mi·20 sec·MO A
37
Turn straight
205 ft·9 sec
Toward MO 21 Business
38
Turn slight right onto MO 21 Business
1.2 mi·2 min·Old State Highway 21
39
Arrive at destination
MO 21 Business
Trip Plan
Given the 6h 13m estimated drive time, starting your day in Saint Joseph, MO, shortly after sunrise should allow you to reach Hillsboro, MO, with plenty of daylight to spare. The route includes only one recommended stop, so plan your breaks accordingly, perhaps for a meal or to stretch your legs. Keep an eye on your fuel gauge, as the estimated cost is $49, and it’s always wise to top off before you leave or when you see a cluster of stations. Since this is a one-day trip, you have the flexibility to adjust your departure time slightly based on traffic or weather.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 161.2 miles from Saint Joseph, MO, or about 2h 57m into the drive.
The longest continuous stretch on this route runs about 135.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 71 miles or 1h 20m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 161.2 miles or 2h 57m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 57m
Traffic, exits, and arrival timing usually matter more near Hillsboro, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Saint Joseph, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Saint Joseph, MO
This is one driving day of about 322.4 miles and 6h 13m.
Your first comfortable stop window is around 71 miles from Saint Joseph, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 135.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 26
5 decision points cluster between mile 35.2 and 288.1 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
35.2 mi into trip|~39m in|I 435
Keep slight right at fork onto I 435 toward I 435 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Exit 14
Toward I 435 East: Saint Louis
7
63.2 mi into trip|~1h 10m in|US 24
Keep slight right at fork onto US 24 toward I 70, US 24 West, US 40: Saint Louis, Kansas City, Sports Complex
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Exit 63
Toward I 70, US 24 West, US 40: Saint Louis, Ka...
7
63.5 mi into trip|~1h 11m in
Keep slight left at fork toward I 70 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
Toward I 70 East: Saint Louis
7
64.7 mi into trip|~1h 12m in
Keep slight left at fork toward I 70 East: Saint Louis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left / straight lanes.
Toward I 70 East: Saint Louis
7
288.1 mi into trip|~5h 26m in
Take the exit toward MO 141
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 22
Toward MO 141
Fuel & Cost
Regular Gas
$53.60 one way
$107.20 round trip
$4.22/gal25.4 MPG avg113 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.60
$58.39
$116.77
premium
$5.18
$65.79
$131.57
diesel
$5.35
$67.91
$135.81
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$54
Meals
$25–$50
Total
$79–$104
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 112.8 kg one way.
Prices: EIA weekly data, 2026-06-01.
Driving Electric?
About $34 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
96.7
1
$33.85
$15.48
Efficient EV
80.6
0
$28.21
$12.90
EV Truck/SUV
129
1
$45.14
$20.63
Gas CO2
113 kg
EV CO2
38 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jun 1, 2026
Origin
Saint Joseph, MO
Afternoon
in Saint Joseph on Wednesday
Local time
2:01 PM
CDT
Current temp
66°F
Slight Chance Rain Showers
ENE 3 mph15% chanceLive forecast
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued June 1 at 4:06AM CDT until June 1 at 4:45AM CDT by NWS Kansas City/Pleasant Hill MO
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued June 1 at 4:04AM CDT until June 1 at 4:30AM CDT by NWS St Louis MO
Destination
Hillsboro, MO
Afternoon
in Hillsboro on Wednesday
Local time
2:01 PM
CDT
Current temp
63°F
Showers And Thunderstorms
S 1 mph86% chanceLive forecast
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued June 1 at 4:06AM CDT until June 1 at 4:45AM CDT by NWS Kansas City/Pleasant Hill MO
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued June 1 at 4:04AM CDT until June 1 at 4:30AM CDT by NWS St Louis MO
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
3 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 13m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Gateway Arch National Park
National Park
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
16 mi from route
~40 min detour
$19
near mile 300.1
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This drive is primarily on surface roads, with highway driving accounting for 24% of the total mileage. You'll encounter 135.3 miles on the Dwight D. Eisenhower Highway, which will likely feel like a significant stretch of consistent travel. After that, expect a shift to more varied road conditions, potentially with more frequent intersections and lower speed limits as you transition to non-highway routes.
Only 24% highway — the rest is turn-by-turn surface driving.
39 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 135.3 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
10/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 35.2 miles in near I 435.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 26 significant decision points across 322.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 35.2 miles (I 435): Highway fork - watch signs carefully. Lane positioning matters here; at 63.2 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 63.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Elevation Profile
Mostly flat terrain
1,029 ft432 ft
Total Climb
719 ft
Total Descent
819 ft
Highest Point
1,029 ft
~46.1 mi in
Elevation Range
597 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Saint Joseph, MO and Hillsboro, MO, road signs point toward Kansas City and Sports Complex.
Doable as a same-day drive at 6h 13m. Total distance: 322.4 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 13m drive, plan rest stops for pacing.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 135.3 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
Yes — we found about 42 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Hillsboro, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 42 rest areas along the route for bathroom stops.
The main spots that need attention: at 35.2 miles (I 435): Highway fork - watch signs carefully. Lane positioning matters here; at 63.2 miles (US 24): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 63.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Yes — Gateway Arch National Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.2 hours each way, a round trip means 12.5 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Hillsboro, MO before the return drive.
