Pulaski County, IN to Jeffersonville, IN is 213.6 miles and takes about 4h 42m via I 65 and SR 29, with a fuel budget near $29 and enough daylight to finish in a day. This drive primarily stays within Indiana, moving from the Midwest region to another part of the Midwest. With most of the route on the highway, expect a fairly straightforward trip. It's a manageable distance for a single day, making it a practical option for getting from point A to point B without much fuss.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
106.8 miles from Pulaski County, IN
A natural place for your longest stop of the day
, about 2h 42m into the drive
.
Main Roads
Road
Distance
Duration
I 65
110.3 mi
2h 1m
SR 29
30.7 mi
44m
South Huddleston Road
25.3 mi
37m
US 421
17.5 mi
25m
South Michigan Road
15.9 mi
26m
SR 14
4.9 mi
8m
Kenneth "Babyface" Edmonds Highway
3.6 mi
5m
North Monticello Street
1.1 mi
2m
Longest stretch:
I 65
— 110.3 mi, about 2h 1m
Traffic on I-65
Hour-of-day weekday pattern from 132 FHWA count stations on your route.
Peak
4 PM
~3,745 veh/hr typical
· worst 4,455
Quietest
1 AM
~405 veh/hr
Peak-to-quiet ratio
9.2×
busier at peak than in the quiet hours
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Averaged across 99 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Pulaski County, IN and Jeffersonville, IN.
1
Start on 500 W
0.9 mi·3 min·500 W
2
Turn right onto SR 14
4.9 mi·8 min·SR 14
3
Turn right onto US 35
1.1 mi·2 min·North Monticello Street
4
Continue on US 35
25 mi·37 min·South Huddleston Road
5
At end of road, turn right onto SR 29
31 mi·44 min·SR 29
6
Continue on US 421; SR 28
17 mi·25 min·US 421; SR 28
7
Enter roundabout onto US 421
130 ft·2 sec·South Michigan Road
8
Continue on US 421
16 mi·25 min·South Michigan Road
Use the left lane.
9
Continue on Dr Martin Luther King Jr Street
1.0 mi·1 min·Dr Martin Luther King Jr Street
10
Take the ramp
0.2 mi·21 sec
Toward I 65 South
11
Merge onto I 65
3.6 mi·5 min·Kenneth "Babyface" Edmonds Highway
Use the straight / slight right lanes.
12
Continue on I 65
1.9 mi·2 min·I 65
Exit 112AToward I 70 East: Dayton
13
Keep slight left at fork onto I 65
108 mi·1 hr 58 min·I 65
Use the slight left lane.
14
Take the exit
0.3 mi·32 sec
Exit 1Toward US 31 South: Jeffersonville, Clarksville
15
Turn straight onto US 31
0.7 mi·1 min·US 31
16
Turn slight right
0.5 mi·1 min
17
Continue on East 10th Street
419 ft·12 sec·East 10th Street
18
Turn right onto Wall Street
0.2 mi·38 sec·Wall Street
19
Turn left onto East 8th Street
0.2 mi·32 sec·East 8th Street
20
Turn right onto Watt Street
0.2 mi·34 sec·Watt Street
21
Arrive at destination
Watt Street
Trip Plan
Given the 4h 42m estimated drive time, leaving in the morning should allow ample time to reach Jeffersonville before evening. The longest stretch without a break is over 110 miles on I 65, so plan for a stop around that point for fuel or a stretch. The fuel cost is estimated at $29, so factor that into your budget. Since this is a one-day trip, you have flexibility; consider an early start to avoid potential traffic around the destination.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 106.8 miles from Pulaski County, IN, or about 2h 42m into the drive.
The longest continuous stretch on this route runs about 110.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 47 miles or 1h 13m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 106.8 miles or 2h 42m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 57m
Traffic, exits, and arrival timing usually matter more near Jeffersonville, IN than in the middle of the route.
Before You Leave
+
Open the route before leaving Pulaski County, IN so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Pulaski County, IN
This is one driving day of about 213.6 miles and 4h 42m.
Your first comfortable stop window is around 47 miles from Pulaski County, IN.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 65 for about 110.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 12
5 decision points cluster between mile 97.5 and 213.4 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
97.5 mi into trip|~2h 30m in|I 65 / Kenneth "Babyface" Edmonds Highway
Merge onto I 65 / Kenneth "Babyface" Edmonds Highway
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
6
103.1 mi into trip|~2h 38m in|I 65
Keep slight left at fork onto I 65
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left lane.
6
211.4 mi into trip|~4h 37m in
Take the exit toward US 31 South: Jeffersonville, Clarksville
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 1
Toward US 31 South: Jeffersonville, Clarksville
5
213.2 mi into trip|~4h 41m in|East 8th Street
Turn left onto East 8th Street
Navigation decision point
5
213.4 mi into trip|~4h 42m in|Watt Street
Turn right onto Watt Street
Navigation decision point
Fuel & Cost
Regular Gas
$35.63 one way
$71.26 round trip
$4.24/gal25.4 MPG avg75 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.61
$38.73
$77.45
premium
$5.26
$44.23
$88.45
diesel
$6.18
$51.96
$103.92
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$36
Meals
$25–$50
Total
$61–$86
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 74.7 kg one way.
Prices: EIA weekly data, 2026-10-12.
Driving Electric?
About $22 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
64.1
0
$22.43
$10.25
Efficient EV
53.4
0
$18.69
$8.54
EV Truck/SUV
85.4
1
$29.90
$13.67
Gas CO2
75 kg
EV CO2
25 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Oct 18, 2026
Origin
Pulaski County, IN
Morning
in Pulaski County on Monday
Local time
9:25 AM
EDT
Current temp
64°F
Widespread Frost then Sunny
S 5 to 15 mph0% chanceLive forecast
Freeze Warning
Freeze Warning issued October 18 at 4:25AM EDT until October 18 at 9:00AM EDT by NWS Indianapolis IN
Freeze Warning
Freeze Warning issued October 18 at 2:57AM EDT until October 18 at 9:00AM EDT by NWS Wilmington OH
Destination
Jeffersonville, IN
Morning
in Jeffersonville on Monday
Local time
9:25 AM
EDT
Current temp
66°F
Areas Of Frost then Sunny
E 5 mph0% chanceLive forecast
Freeze Warning
Freeze Warning issued October 18 at 4:25AM EDT until October 18 at 9:00AM EDT by NWS Indianapolis IN
Freeze Warning
Freeze Warning issued October 18 at 2:57AM EDT until October 18 at 9:00AM EDT by NWS Wilmington OH
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 42m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This route is mostly highway, with 77% of it on major roads like I 65. You'll experience a long stretch of 110.3 miles on I 65 without needing to exit. The transition to surface roads begins after that, with SR 29 and South Huddleston Road making up the remainder. Expect frequent exits as you approach more populated areas towards the end of your drive.
77% highway — fuel and pacing are the main things to plan.
21 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 110.3 mi on I 65.
How Hard Is This Drive?
4/10
This is a straightforward highway drive that stays mostly on I 65 and SR 29. There are only a few real navigation decisions along the way. The trickiest moment comes around 97.5 miles in near I 65 / Kenneth "Babyface" Edmonds Highway.
Driving Effort4/10
Easy - simple navigation with a manageable amount of wheel time
Balances navigation complexity with total wheel time.
This is a straightforward 4h 42m drive. You will face about 12 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
The main spots that need attention: at 97.5 miles (I 65 / Kenneth "Babyface" Edmonds Highway): Merge point - match speed before joining. Lane positioning matters here; at 103.1 miles (I 65): Highway fork - watch signs carefully. Lane positioning matters here; at 211.4 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Jeffersonville, often called "Jeff" by locals, is the county seat of Clark County in Southern Indiana, on the opposite side of the Ohio River from Louisville, Kentucky and connected to Louisville by the Kennedy, Lincoln, and Lewis and Clark Bridges. It has a population of 48,000 (2019).
Top landmarks
•George Rogers Clark Memorial Bridge — crossing of the Ohio River between Louisville, Kentucky, and Jeffersonville, Ind...
•Spring Street Freight House — constructed in 1925
The longest stretch is about 110.3 miles on I 65. The full list of main roads is in the Roads section above.
Yes — we found about 10 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: at 97.5 miles (I 65 / Kenneth "Babyface" Edmonds Highway): Merge point - match speed before joining. Lane positioning matters here; at 103.1 miles (I 65): Highway fork - watch signs carefully. Lane positioning matters here; at 211.4 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Possible but tiring. At 4.7 hours each way, an in-and-out day trip would put you behind the wheel for 9.4 hours — manageable with a long break at Jeffersonville, IN, but most travelers stay overnight.
