Traveling from Orangeburg to Conway covers 127.3 miles across the Southeast, making for a straightforward journey that typically takes 2 hours and 38 minutes. This route is perfectly suited as a one-day trip, allowing you to reach your destination without the need for an overnight stay. You can expect to spend approximately $20 on fuel for the trek, depending on your vehicle's efficiency. By utilizing a mix of I-95, Turbeville Highway, and Highway 378, you transition smoothly between regions within South Carolina. It is a practical, manageable drive that offers enough variety to keep you engaged while remaining efficient for those on a schedule.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
63.7 miles from Orangeburg, SC
A natural place for your longest stop of the day
, about 1h 14m into the drive
.
Main Roads
Road
Distance
Duration
I 95
38.5 mi
41m
Turbeville Highway
36.1 mi
43m
Highway 378
22.9 mi
32m
Five Chop Road
21.3 mi
26m
Clarence Coker Highway
3.5 mi
4m
Wright Boulevard
1.2 mi
2m
John C Calhoun Drive
1.2 mi
1m
Myrtle Beach Highway
0.9 mi
1m
Longest stretch:
I 95
— 38.5 mi, about 41m
Turn-by-Turn Driving Directions
Step-by-step road directions between Orangeburg, SC and Conway, SC.
1
Start on Whitman Street
165 ft·12 sec·Whitman Street
2
Turn right onto US 601; US 21 Business
336 ft·13 sec·Magnolia Street
3
Turn left onto US 301
1.2 mi·1 min·John C Calhoun Drive
4
Turn right onto US 301
21 mi·26 min·Five Chop Road
5
Take the exit onto US 15; US 301
0.3 mi·33 sec·US 15; US 301
Use the right lane.
6
Merge onto I 95
38 mi·41 min·I 95
Use the straight / slight right lanes.
7
Take the exit
0.3 mi·36 sec
Toward US 378: Turbeville, Sumter
8
Keep slight right at fork
288 ft·7 sec
Toward US 378 East: Turbeville, Lake City, Myrtle Beach
9
Merge onto US 378
0.9 mi·1 min·Myrtle Beach Highway
10
Continue on US 378
3.5 mi·4 min·Clarence Coker Highway
11
Continue on US 301; US 378
0.5 mi·1 min·Main Street
12
Continue on US 301; US 378
36 mi·43 min·Turbeville Highway
13
Continue on US 378
23 mi·32 min·Highway 378
14
Continue on US 378
1.2 mi·2 min·Wright Boulevard
15
Turn left onto SC 905
0.6 mi·1 min·4th Avenue
16
Arrive at destination
SC 905
Trip Plan
Planning for this 127.3-mile trip is simple, as you only need to account for one planned stop to keep your energy up. Given the total duration of 2 hours and 38 minutes, you have plenty of flexibility to depart when it best suits your schedule. Since the route involves shifting from major interstates to Highway 378 and Turbeville Highway, stay alert for changing speed limits as you leave the highway stretches. Budgeting around $20 for fuel should keep you covered for the duration of the trip. Since the drive is relatively short, try to time your departure to avoid peak local traffic hours to ensure a smoother transition onto the secondary roads.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 63.7 miles from Orangeburg, SC, or about 1h 14m into the drive.
The longest continuous stretch on this route runs about 38.5 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 28 miles or 35m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 63.7 miles or 1h 14m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 4m
Traffic, exits, and arrival timing usually matter more near Conway, SC than in the middle of the route.
Before You Leave
+
Open the route before leaving Orangeburg, SC so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Orangeburg, SC
This is one driving day of about 127.3 miles and 2h 38m.
Your first comfortable stop window is around 28 miles from Orangeburg, SC.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 95 for about 38.5 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 7
5 decision points cluster between mile 0 and 61.6 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0 mi into trip|~0m in|US 601; US 21 Business / Magnolia Street
Turn right onto US 601; US 21 Business / Magnolia Street
Navigation decision point
5
22.6 mi into trip|~28m in|US 15; US 301
Take the exit onto US 15; US 301
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the right lane.
5
22.9 mi into trip|~29m in|I 95
Merge onto I 95
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
5
61.3 mi into trip|~1h 10m in
Take the exit toward US 378: Turbeville, Sumter
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward US 378: Turbeville, Sumter
7
61.6 mi into trip|~1h 11m in
Keep slight right at fork toward US 378 East: Turbeville, Lake City, Myrtle Beach
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 378 East: Turbeville, Lake City, Myrt...
Fuel & Cost
Regular Gas
$19.91 one way
$39.81 round trip
$3.97/gal25.4 MPG avg45 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.34
$21.77
$43.53
premium
$4.70
$23.56
$47.12
diesel
$5.61
$28.11
$56.21
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$20
Meals
$25–$50
Total
$45–$70
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 44.5 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $13 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
38.2
0
$13.37
$6.11
Efficient EV
31.8
0
$11.14
$5.09
EV Truck/SUV
50.9
0
$17.82
$8.15
Gas CO2
45 kg
EV CO2
15 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 20, 2026
Origin
Orangeburg, SC
Late night
in Orangeburg on Tuesday
Local time
4:08 AM
EDT
Current temp
87°F
Unavailable
Live forecast
Destination
Conway, SC
Late night
in Conway on Tuesday
Local time
4:08 AM
EDT
Current temp
83°F
Unavailable
Live forecast
85°F
Lake City, SC
64 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
4 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
2h 38m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Congaree National Park
National Park
Astonishing biodiversity exists in Congaree National Park, the largest intact expanse of old growth bottomland hardwood forest remaining in the southeastern United States. Waters from the Congaree and...
22 mi from route
~54 min detour
Free
Caution: Backcountry Trail Conditions
Park Closure: Boardwalk Partially Closed for Construction
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This trip offers a mixed drive experience, balancing about 48% highway travel with local road segments. You will spend your longest uninterrupted stretch covering 38.5 miles on I-95 before transitioning onto the secondary highways. Expect the road's personality to shift as you move away from the interstate and navigate the more localized paths of Turbeville Highway and Highway 378. The contrast between the high-speed interstate sections and the more measured pace of the state highways keeps the drive dynamic. You will feel the transition from major transit corridors to the specific regional roads that lead you directly to Conway.
48% highway, the rest on surface roads — varied driving throughout.
16 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 38.5 mi on I 95.
How Hard Is This Drive?
3/10
This route mixes highway mileage with some local-road sections near the start or finish. There are only a few real navigation decisions along the way. The trickiest moment comes early in the drive near US 601; US 21 Business / Magnolia Street.
Driving Effort3/10
Easy - simple navigation with a manageable amount of wheel time
Balances navigation complexity with total wheel time.
This is a straightforward 2h 38m drive. You will face about 7 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
The main spots that need attention: near the start (US 601; US 21 Business / Magnolia Street): Navigation decision point; at 22.6 miles (US 15; US 301): Exit ramp - move to the correct lane early. Lane positioning matters here; at 22.9 miles (I 95): Merge point - match speed before joining. Lane positioning matters here.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Orangeburg, SC and Conway, SC, road signs point toward Sumter, Lake City and Myrtle Beach.
Orangeburg is a city in South Carolina. This town that started as a trading post between settlers and Native Americans in 1704 became a hotbed of tension and activism during the Civil Rights movement, culminating in the infamous Orangeburg Massacre on February 8, 1968 when local police opened fire and killed three students and injured many others. On a positive note, today the town boasts two historically black colleges, one of which (Claflin College) holds a designation as one of the top liberal arts colleges in the state and premier historic black colleges in the country.
Orangeburg has a little bit of a crime problem, so do not be too lax about reckless decisions in your affairs.
Mixed highway & surface route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 38.5 miles on I 95. The full list of main roads is in the Roads section above.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: near the start (US 601; US 21 Business / Magnolia Street): Navigation decision point; at 22.6 miles (US 15; US 301): Exit ramp - move to the correct lane early. Lane positioning matters here; at 22.9 miles (I 95): Merge point - match speed before joining. Lane positioning matters here.
Yes — Congaree National Park. See the National Parks section for detour distances and tips on detours.
Yes. A round trip is manageable in a single day if you plan a break at Conway, SC before heading back.
