South Carolina Road Trips
South Carolina has 63 mapped road trip routes covering cities across the state. Major departure hubs include Hilton Head Island, SC, Anderson County Airport, SC and Anderson, SC. The average drive from a South Carolina city covers about 327 miles, with options ranging from quick day trips to multi-day cross-state adventures.
Routes
63
Avg Distance
327 mi
Longest Drive
2487.5 mi
Hilton Head Island, SC → Huston, ID
Quickest Drive
4h 44m
Hilton Head, SC → Lyman, SC
South Carolina Route Map
Featured South Carolina Trips
Hand-picked routes for the best South Carolina driving experiences.
Major Hubs in South Carolina
Browse city-level route pages with detailed trip planning for each hub.
Hilton Head Island, SC
12 routes
Anderson County Airport, SC
6 routes
Anderson, SC
4 routes
Clemson, SC
3 routes
Westminster, SC
3 routes
Walhalla, SC
2 routes
Homeland Park, SC
2 routes
Greenville, SC
2 routes
Mount Pleasant, SC
2 routes
Belton, SC
2 routes
Greer, SC
2 routes
Hilton Head, SC
2 routes
Cross-State Routes
Longer drives heading out of South Carolina — fuel planning and overnight stops recommended.
All Routes from South Carolina
Hilton Head Island, SC → Huston, ID
Hilton Head Island, SC → Fashing, TX
Hilton Head Island, SC → Farmers Branch, TX
Walhalla, SC → Hilton Head Island, SC
Walhalla, SC → Myrtle Beach, SC
Clemson, SC → Hilton Head Island, SC
Anderson County Airport, SC → Little River, SC
Hilton Head Island, SC → Westminster, SC
Clemson, SC → Hilton Head, SC
Clemson, SC → Myrtle Beach, SC
Anderson, SC → North Myrtle Beach, SC
Liberty, SC → Hilton Head Island, SC
Anderson County Airport, SC → Garden City, SC
Pickens, SC → Hilton Head, SC
Hilton Head Island, SC → Landrum, SC
Easley, SC → Hilton Head Island, SC
Homeland Park, SC → Hilton Head, SC
Anderson County Airport, SC → Loris, SC
Anderson County Airport, SC → Socastee, SC
Hilton Head Island, SC → Travelers Rest, SC
Greenville, SC → Little River, SC
Homeland Park, SC → Myrtle Beach, SC
Hilton Head Island, SC → Welcome, SC
Blacksburg, SC → Hilton Head Island, SC
Anderson, SC → Myrtle Beach, SC
Hilton Head Island, SC → Dunean, SC
Westminster, SC → Mount Pleasant, SC
Mount Pleasant, SC → Walhalla, SC
Greenville, SC → North Myrtle Beach, SC
Hilton Head Island, SC → Judson, SC
Belton, SC → Hilton Head Island, SC
Greer, SC → North Myrtle Beach, SC
Anderson County Airport, SC → Port Royal, SC
Chesterfield, SC → Anderson County Airport, SC
Charleston, SC → Walhalla, SC
Bluffton, SC → Easley, SC
Hilton Head, SC → Welcome, SC
Westminster, SC → Charleston, SC
Travelers Rest, SC → Myrtle Beach, SC
Anderson County Airport, SC → Red Hill, SC
Greer, SC → Hilton Head Island, SC
Gantt, SC → Hilton Head Island, SC
Hilton Head Island, SC → Williamston, SC
Hilton Head Island, SC → East Gaffney, SC
Gaffney, SC → Hilton Head Island, SC
Hilton Head Island, SC → Lyman, SC
Welcome, SC → Myrtle Beach, SC
Parker, SC → Myrtle Beach, SC
Mount Pleasant, SC → Seneca, SC
Anderson, SC → Port Royal, SC
Dunean, SC → Myrtle Beach, SC
Westminster, SC → North Charleston, SC
Belton, SC → Myrtle Beach, SC
Clover, SC → Hilton Head Island, SC
Myrtle Beach, SC → Powdersville, SC
Gantt, SC → Hilton Head, SC
Anderson, SC → Red Hill, SC
North Myrtle Beach, SC → Spartanburg, SC
Myrtle Beach, SC → Piedmont, SC
Hilton Head, SC → Lyman, SC
Routes to South Carolina
Walhalla, SC → Hilton Head Island, SC
Walhalla, SC → Myrtle Beach, SC
Clemson, SC → Hilton Head Island, SC
Anderson County Airport, SC → Little River, SC
Hilton Head Island, SC → Westminster, SC
Clemson, SC → Hilton Head, SC
Clemson, SC → Myrtle Beach, SC
Anderson, SC → North Myrtle Beach, SC
Liberty, SC → Hilton Head Island, SC
Anderson County Airport, SC → Garden City, SC
Pickens, SC → Hilton Head, SC
Hilton Head Island, SC → Landrum, SC
Easley, SC → Hilton Head Island, SC
Homeland Park, SC → Hilton Head, SC
Anderson County Airport, SC → Loris, SC
Anderson County Airport, SC → Socastee, SC
Hilton Head Island, SC → Travelers Rest, SC
Greenville, SC → Little River, SC
Homeland Park, SC → Myrtle Beach, SC
Hilton Head Island, SC → Welcome, SC
Blacksburg, SC → Hilton Head Island, SC
Anderson, SC → Myrtle Beach, SC
Hilton Head Island, SC → Dunean, SC
Westminster, SC → Mount Pleasant, SC
South Carolina Road Trip Guides
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