This 296-mile journey from Mayfield to Pittsburgh, Pennsylvania, is a solid day trip, estimated to take about 6 hours and 3 minutes of driving time. You'll navigate a mix of roads, including sections of the Keystone Shortway, William Penn Highway, and American Legion Memorial Highway. With a fuel cost estimated at $49, this trip is budget-friendly for a single day of travel. The route is characterized as a 'turn-heavy local drive,' suggesting a need for attention rather than a relaxing cruise. It's a feasible drive for one day, keeping in mind the numerous turns involved.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
148 miles from Mayfield, PA
A natural place for your longest stop of the day
, about 2h 50m into the drive
.
Main Roads
Road
Distance
Duration
Keystone Shortway
98.5 mi
1h 47m
William Penn Highway
61.2 mi
1h 25m
American Legion Memorial Highway
35 mi
42m
I 99
33.8 mi
36m
Jacksonville Road
24.2 mi
28m
Penn-Lincoln Parkway East
13.5 mi
18m
Admiral Peary Highway
13.4 mi
19m
Governor Robert P. Casey Highway
10 mi
11m
Longest stretch:
Keystone Shortway
— 98.5 mi, about 1h 47m
Traffic on I-80
Hour-of-day weekday pattern from 36 FHWA count stations on your route.
Peak
3 PM
~1,120 veh/hr typical
· worst 1,611
Quietest
2 AM
~194 veh/hr
Peak-to-quiet ratio
5.8×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 104 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Mayfield, PA and Pittsburgh, PA.
1
Start on Maple Street
109 ft·6 sec·Maple Street
2
Turn right onto Hill Street
0.2 mi·45 sec·Hill Street
3
Turn right onto Poplar Street
0.2 mi·42 sec·Poplar Street
4
Turn left onto Main Street
0.3 mi·26 sec·Main Street
5
Continue on Washington Avenue
0.2 mi·21 sec·Washington Avenue
6
Turn left onto PA 107
0.7 mi·1 min·Rushbrook Street
7
Take the ramp
0.4 mi·47 sec
Toward US 6 West: Scranton
8
Merge onto US 6
10 mi·11 min·Governor Robert P. Casey Highway
Use the straight lane.
9
Keep slight left at fork
1.2 mi·2 min
Toward I 81 South: Wilkes-BarreUse the slight left lane.
10
Merge onto I 81
35 mi·42 min·American Legion Memorial Highway
11
Take the exit
0.7 mi·1 min
Exit 151BToward I-80 West: Bloomsburg
12
Merge onto I 80
99 mi·1 hr 47 min·Keystone Shortway
13
Take the exit
0.3 mi·53 sec
Exit 161Toward I 99 South, US 220 South, PA 26: Bellefonte
14
Turn left onto US 220; PA 26
24 mi·28 min·Jacksonville Road
Use the straight lane.
15
Keep slight left at fork onto I 99; US 220
34 mi·36 min·I 99; US 220
Toward I 99 South, US 220 South: Port Matilda, Altoona
16
Take the exit
0.8 mi·1 min
Toward US 22: Ebensburg, Hollidaysburg
17
Continue on this road
0.5 mi·43 sec·this road
18
Continue on US 22
16 mi·19 min·William Penn Highway
19
Continue on US 22
13 mi·19 min·Admiral Peary Highway
Use the straight lane.
20
Continue on US 22
45 mi·1 hr 6 min·William Penn Highway
Use the straight / right lanes.
21
Keep slight right at fork onto I 376; US 22
13 mi·18 min·Penn-Lincoln Parkway East
Toward I 376 West, US 22 West: PittsburghUse the slight left lane.
22
Take the exit
0.2 mi·38 sec
Exit 71BToward Second AvenueUse the straight / slight right lanes.
23
Turn straight onto Second Avenue
0.3 mi·41 sec·Second Avenue
24
At end of road, turn right onto Ross Street
0.2 mi·32 sec·Ross Street
25
Turn left onto Fifth Avenue
352 ft·10 sec·Fifth Avenue
26
Turn right onto Grant Street
513 ft·21 sec·Grant Street
Use the right lane.
27
Arrive at destination
Grant Street
Trip Plan
Given the 6-hour duration and the 'turn-heavy local drive' profile, starting your trip from Mayfield early in the morning is advisable to maximize daylight and minimize traffic. You'll have one recommended stop on this route, so plan your break strategically. Keep an eye on your fuel gauge, especially as you move away from highway stretches, and be aware that the longest uninterrupted stretch is under 100 miles. The route's nature suggests that paying close attention to navigation and road signs will be key to a smooth transition between the different main roads like the Keystone Shortway and William Penn Highway.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 148 miles from Mayfield, PA, or about 2h 50m into the drive.
The longest continuous stretch on this route runs about 98.5 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 65 miles or 1h 20m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 148 miles or 2h 50m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 45m
Traffic, exits, and arrival timing usually matter more near Pittsburgh, PA than in the middle of the route.
Before You Leave
+
Open the route before leaving Mayfield, PA so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Mayfield, PA
This is one driving day of about 296 miles and 6h 3m.
Your first comfortable stop window is around 65 miles from Mayfield, PA.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Keystone Shortway for about 98.5 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 19
5 decision points cluster between mile 11.9 and 295.9 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
7
11.9 mi into trip|~16m in
Keep slight left at fork toward I 81 South: Wilkes-Barre
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left lane.
Toward I 81 South: Wilkes-Barre
6
147.4 mi into trip|~2h 49m in
Take the exit toward I 99 South, US 220 South, PA 26: Bellefonte
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 161
Toward I 99 South, US 220 South, PA 26: Bellefo...
8
281.7 mi into trip|~5h 42m in|I 376; US 22 / Penn-Lincoln Parkway East
Keep slight right at fork onto I 376; US 22 / Penn-Lincoln Parkway East toward I 376 West, US 22 West: Pittsburgh
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Toward I 376 West, US 22 West: Pittsburgh
7
295.2 mi into trip|~6h 1m in
Take the exit toward Second Avenue
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Exit 71B
Toward Second Avenue
7
295.9 mi into trip|~6h 3m in|Grant Street
Turn right onto Grant Street
Lane positioning matters here
Use the right lane.
Fuel & Cost
Regular Gas
$49.46 one way
$98.92 round trip
$4.24/gal25.4 MPG avg104 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.67
$54.43
$108.87
premium
$5.01
$58.41
$116.82
diesel
$5.60
$65.25
$130.50
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$49
Meals
$25–$50
Total
$74–$99
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 103.6 kg one way.
Prices: EIA weekly data, 2026-08-31.
Driving Electric?
About $31 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
88.8
1
$31.08
$14.21
Efficient EV
74
0
$25.90
$11.84
EV Truck/SUV
118.4
1
$41.44
$18.94
Gas CO2
104 kg
EV CO2
35 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Aug 20, 2026
Origin
Mayfield, PA
Late night
in Mayfield on Wednesday
Local time
3:55 AM
EDT
Current temp
60°F
Partly Cloudy then Patchy Fog
W 1 to 5 mph9% chanceLive forecast
Flood Watch
Flood Watch issued August 19 at 5:16PM EDT until August 20 at 2:00PM EDT by NWS Pittsburgh PA
Flood Watch
Flood Watch issued August 19 at 2:08PM EDT until August 21 at 2:00AM EDT by NWS Mount Holly NJ
Destination
Pittsburgh, PA
Late night
in Pittsburgh on Wednesday
Local time
3:55 AM
EDT
Current temp
64°F
Chance Showers And Thunderstorms
NW 1 to 7 mph57% chanceLive forecast
Flood Watch
Flood Watch issued August 19 at 5:16PM EDT until August 20 at 2:00PM EDT by NWS Pittsburgh PA
Flood Watch
Flood Watch issued August 19 at 2:08PM EDT until August 21 at 2:00AM EDT by NWS Mount Holly NJ
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
4 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 3m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Johnstown Flood National Memorial
National Memorial
The South Fork Dam failed on Friday, May 31, 1889, and unleashed 20,000,000 tons of water that devastated Johnstown, PA. The flood killed 2,209 people but it brought the nation and the world together...
9 mi from route
~23 min detour
Free
near mile 224.5
On Tuesday morning, September 11, 2001, the U.S. came under attack when four commercial airliners were hijacked and used to strike targets on the ground. Nearly 3,000 people tragically lost their live...
26 mi from route
~65 min detour
Free
near mile 234.8
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a varied driving experience on this route, with only 16% of the drive on highways. The profile indicates a 'turn-heavy local drive,' so be prepared for frequent changes in direction. The longest uninterrupted stretch you'll encounter is 98.5 miles on the Keystone Shortway, offering a period of more consistent travel before transitioning back to local roads. This mix means you'll likely experience a dynamic journey, shifting between more open stretches and more intricate, winding segments as you make your way across Pennsylvania.
Only 16% highway — the rest is turn-by-turn surface driving.
27 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 98.5 mi on Keystone Shortway.
How Hard Is This Drive?
9/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 11.9 miles in.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 296 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 11.9 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 147.4 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 281.7 miles (I 376; US 22 / Penn-Lincoln Parkway East): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Gently rolling terrain
2,136 ft524 ft
Total Climb
2,709 ft
Total Descent
2,899 ft
Highest Point
2,136 ft
~232.6 mi in
Elevation Range
1,612 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Mayfield, PA and Pittsburgh, PA, road signs point toward Altoona and Hollidaysburg.
The pleasure of Pittsburgh remains a well-kept secret. Though not built up by reputation, the city's unique combination of bridges, steep hills, and broad rivers make it one of the most naturally scenic cities in the country. Cheap food and beer abound in this true sports town and the locals are amazingly friendly. A city of about 303,000 (2021) in Allegheny County, at the center of a metro area of about 2.4 million in southwestern Pennsylvania, Pittsburgh is situated at the confluence of three rivers: the Monongahela and Allegheny Rivers, which meet to form the Ohio River. The city's unique terrain has resulted in an unusual city design and a hodge-podge of unique neighborhood "pockets" with diverse ethnic and architectural heritage.
Top landmarks
•Carnegie Museum of Natural History — natural history museum in Pittsburgh, Pennsylvania, United States
•Allegheny Observatory — historic observatory of the University of Pittsburgh
•Carnegie Museum of Art — museum in Pittsburgh, Pennsylvania
Doable as a same-day drive at 6h 3m. Total distance: 296 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 3m drive, plan rest stops for pacing.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 98.5 miles on Keystone Shortway. The full list of main roads is in the Roads section above.
Yes — we found about 24 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Pittsburgh, PA before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 24 rest areas along the route for bathroom stops.
The main spots that need attention: at 11.9 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 147.4 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 281.7 miles (I 376; US 22 / Penn-Lincoln Parkway East): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Johnstown Flood National Memorial and Flight 93 National Memorial. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.1 hours each way, a round trip means 12.1 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Pittsburgh, PA before the return drive.
