Spanning 147.6 miles across the Missouri Midwest, this trip connects Macon to O'Fallon in approximately 2 hours and 14 minutes. Because the drive is relatively short, it is perfectly suited for a single-day excursion without the need for an overnight stay. You can expect to spend about $22 on fuel for the journey, making it a budget-friendly option for your travel plans. Navigating through local streets like East Washington, North Rollins, and South Missouri provides a different experience than a standard interstate trek. Whether you are heading out for business or visiting family, this route offers a straightforward path between these two Missouri cities. It is an ideal choice if you prefer staying off the major highways and sticking to local roads.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
73.7 miles from Macon, MO
A natural place for your longest stop of the day
, about 1h 24m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
88.2 mi
1h 44m
South Missouri Street
55.5 mi
1h
North Rollins Street
1.3 mi
3m
South Main Street
0.6 mi
1m
US 63 Conn
0.4 mi
<1m
Drennen Parkway
<0.1 mi
<1m
Walker Street
<0.1 mi
<1m
East Washington Street
<0.1 mi
<1m
Longest stretch:
Dwight D. Eisenhower Highway
— 88.2 mi, about 1h 44m
Turn-by-Turn Driving Directions
Step-by-step road directions between Macon, MO and O'Fallon, MO.
1
Start on Walker Street
157 ft·8 sec·Walker Street
2
Turn right onto East Washington Street
154 ft·11 sec·East Washington Street
3
Turn left onto North Rollins Street
1.3 mi·3 min·North Rollins Street
4
At end of road, turn right onto US 63
55 mi·1 hr·South Missouri Street
5
Take the exit
0.5 mi·56 sec
Toward MO PP, I 70, US 40: Kansas City, Saint Louis
6
Turn straight onto US 63 Conn
0.4 mi·54 sec·US 63 Conn
Use the straight lane.
7
Take the exit
0.2 mi·31 sec
Toward I 70 East, US 40 East: Saint LouisUse the left lane.
8
Continue on I 70; US 40
88 mi·1 hr 44 min·Dwight D. Eisenhower Highway
Use the straight / slight right lanes.
9
Take the exit
0.3 mi·43 sec
Toward MO K: O'FallonUse the straight / slight right lanes.
10
Turn straight onto Drennen Parkway
150 ft·3 sec·Drennen Parkway
Toward MO K: O'Fallon
11
Keep slight right at fork onto Drennen Parkway
166 ft·5 sec·Drennen Parkway
Toward MO K: O'Fallon
12
Turn slight left
62 ft·2 sec
Toward MO K: O'Fallon
13
Continue on South Main Street
0.6 mi·1 min·South Main Street
14
Turn right
25 ft·1 sec
15
Arrive at destination
Trip Plan
Since this 2-hour and 14-minute journey is short, you have plenty of flexibility to plan your departure around your personal schedule. While no specific stops are mandated by the route, keep in mind that the turn-heavy nature of these local roads can make the drive feel longer than the mileage suggests. Ensure your vehicle is fueled up before you leave, as the $22 estimated cost is based on a direct, consistent drive. One practical tip is to check your navigation apps frequently for local traffic updates, as relying on surface streets means you are more susceptible to minor delays than you would be on a major interstate. Pacing yourself is easy here, so take advantage of the ability to stop whenever you need a break.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 73.7 miles from Macon, MO, or about 1h 24m into the drive.
The longest continuous stretch on this route runs about 88.2 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 32 miles or 36m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 73.7 miles or 1h 24m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 20m
Traffic, exits, and arrival timing usually matter more near O'Fallon, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Macon, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Macon, MO
This is one driving day of about 147.3 miles and 2h 53m.
Your first comfortable stop window is around 32 miles from Macon, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 88.2 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 10
5 decision points cluster between mile 0 and 146.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
4
0 mi into trip|~0m in|East Washington Street
Turn right onto East Washington Street
Navigation decision point
5
56.9 mi into trip|~1h 4m in
Take the exit toward MO PP, I 70, US 40: Kansas City, Saint Louis
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward MO PP, I 70, US 40: Kansas City, Saint L...
8
57.8 mi into trip|~1h 5m in
Take the exit toward I 70 East, US 40 East: Saint Louis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the left lane.
Toward I 70 East, US 40 East: Saint Louis
6
146.3 mi into trip|~2h 50m in
Take the exit toward MO K: O'Fallon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Toward MO K: O'Fallon
6
146.7 mi into trip|~2h 51m in|Drennen Parkway
Keep slight right at fork onto Drennen Parkway toward MO K: O'Fallon
Highway fork - watch signs carefully
Toward MO K: O'Fallon
Fuel & Cost
Regular Gas
$23.03 one way
$46.06 round trip
$3.97/gal25.4 MPG avg52 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$25.28
$50.57
premium
$4.89
$28.35
$56.69
diesel
$5.61
$32.52
$65.04
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$23
Meals
$25–$50
Total
$48–$73
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 51.5 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $15 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
44.2
0
$15.47
$7.07
Efficient EV
36.8
0
$12.89
$5.89
EV Truck/SUV
58.9
0
$20.62
$9.43
Gas CO2
52 kg
EV CO2
17 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 20, 2026
Origin
Macon, MO
Late night
in Macon on Tuesday
Local time
3:14 AM
CDT
Current temp
65°F
Unavailable
Live forecast
Destination
O'Fallon, MO
Late night
in O'Fallon on Tuesday
Local time
3:14 AM
CDT
Current temp
71°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
6 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
2h 53m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a turn-heavy, local-focused drive that keeps you engaged behind the wheel. Unlike a monotonous interstate haul, this route features zero highway miles, meaning your focus will shift frequently as you navigate local thoroughfares. The road profile is best described as a series of connected local segments rather than long, uninterrupted stretches. You will find yourself adjusting to varying road conditions throughout the 147.6-mile journey. Because the path relies entirely on surface streets, you should anticipate a more hands-on driving experience that requires your full attention compared to a cruise-controlled highway trip.
Only 0% highway — the rest is turn-by-turn surface driving.
15 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 88.2 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
5/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. You will hit about 10 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near East Washington Street.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 147.3 miles you will encounter 10 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (East Washington Street): Navigation decision point; at 56.9 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 57.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
896 ft542 ft
Total Climb
309 ft
Total Descent
630 ft
Highest Point
896 ft
~67.5 mi in
Elevation Range
353 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Macon, MO to O'Fallon, MO, road signs begin pointing toward Saint Louis along the way.
St. Charles, Missouri is outside of St. Louis on the bank of the Missouri River. It was Missouri's first state capital and was one of the first stops by Lewis and Clark on their journey to explore Louisiana Territory. The historic Main Street has largely been restored to its 1812-era appearance including gas lights a boardwalk and is lined with shops selling artwork, handicrafts, home decorations, antiques. There are also many restaurants.
Doable as a same-day drive at 2h 53m. Total distance: 147.3 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
2h 53m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (0%). Some complex stretches to watch for.
Scenic Drive
Mostly surface roads route profile.
Frequently Asked Questions
The longest stretch is about 88.2 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: near the start (East Washington Street): Navigation decision point; at 56.9 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 57.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes. A round trip is manageable in a single day if you plan a break at O'Fallon, MO before heading back.
