Spanning 426.8 miles across the Great Plains, your journey from Littlefield to San Antonio is a significant undertaking that typically takes about 6 hours and 42 minutes behind the wheel. Because this is a turn-heavy local drive rather than a straight interstate shot, you should plan on dedicating a full day to the trip. Budget approximately $64 for fuel to cover the distance safely. While the route remains within the Great Plains region for the duration, the transition from the high plains to the south requires focus and patience. It is best tackled as a single-day push if you are comfortable with local road navigation, though the intensity of the turns means you should be prepared for active driving.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
210.6 miles from Littlefield, TX
A natural place for your longest stop of the day
, about 3h 43m into the drive
.
Main Roads
Road
Distance
Duration
US Highway 84
73.9 mi
1h 14m
I 10
71.7 mi
1h 14m
Grassmeyer Street
41.9 mi
44m
US 84
40 mi
42m
US 83
40 mi
38m
State Highway 153
29.5 mi
33m
Ellis Street
29.4 mi
31m
East Highway 84
26.9 mi
26m
Longest stretch:
US Highway 84
— 73.9 mi, about 1h 14m
Turn-by-Turn Driving Directions
Step-by-step road directions between Littlefield, TX and San Antonio, TX.
1
Start on FM 54
0.4 mi·44 sec·East Waylon Jennings Boulevard
2
Turn slight right onto Loop 430
1.6 mi·2 min·Delano Avenue
Use the right lane.
3
Turn left onto US 84
34 mi·35 min·US 84
4
Merge onto US 84
4.0 mi·4 min·Avenue Q
Use the straight / right lanes.
5
Continue on US 84
4.8 mi·6 min·Slaton Road
6
Continue on US 84
6.9 mi·6 min·East Highway 84
7
Continue on US 84
4.5 mi·4 min·Trooper Jerry Don Davis Memorial Highway
8
Continue on US 84
20 mi·20 min·East Highway 84
9
Continue on US 84
1.0 mi·1 min·North US Highway 84
10
Turn left onto Spur 575
0.1 mi·16 sec·East 15th Street
11
Turn right onto TX 207
0.4 mi·37 sec·Ralls Road
12
Turn straight onto TX 207
1.1 mi·2 min·North Avenue F
13
At end of road, turn left onto US 84
74 mi·1 hr 14 min·US Highway 84
14
Keep slight left at fork onto US 84
6.5 mi·6 min·US 84
Toward I 20 East, US 84 East: Abilene
15
Take the exit
0.1 mi·18 sec
Exit 244Toward SH 70 South, SH 70 Business: Sweetwater, San Angelo
16
Turn slight left onto Southwest Georgia Avenue
0.1 mi·16 sec·Southwest Georgia Avenue
17
Turn right onto TX 70
0.7 mi·1 min·Lamar Street
18
Continue on TX 70
10 mi·10 min·State Highway 70
19
Turn left onto TX 153
29 mi·33 min·State Highway 153
20
Turn right onto FM 2111
12 mi·13 min·FM 2111
21
Turn left onto TX 158
6.3 mi·7 min·TX 158
22
At end of road, turn right onto US 67; US 83
387 ft·18 sec·Hutchings Avenue
23
Turn left onto US 83
17 mi·18 min·South 7th Street
Use the left lane.
24
Continue on US 83
42 mi·44 min·Grassmeyer Street
25
Continue on US 83
29 mi·31 min·Ellis Street
26
Take the exit onto US 83
40 mi·38 min·US 83
Toward I 10 East: San AntonioUse the left lane.
27
Continue on I 10
54 mi·54 min·I 10
Use the straight / slight right lanes.
28
Keep slight right at fork onto I 10; US 87
17 mi·19 min·I 10; US 87
Use the straight / slight right lanes.
29
Keep slight right at fork onto I 10; US 87
1.7 mi·2 min·McDermott Freeway
30
Take the exit
0.5 mi·1 min
Exit 569CToward Santa Rosa Street, DowntownUse the slight right lane.
31
Turn straight onto North Pecos-La Trinidad
0.2 mi·16 sec·North Pecos-La Trinidad
32
Keep slight right at fork onto North Pecos-La Trinidad
0.6 mi·1 min·North Pecos-La Trinidad
Use the straight lane.
33
Turn left onto Dolorosa Street
0.5 mi·55 sec·Dolorosa Street
Use the straight / left lanes.
34
Arrive at destination
Dolorosa Street
Trip Plan
For a drive of this length and complexity, getting an early start is essential to ensure you reach your destination before fatigue sets in. Plan for at least one dedicated stop to stretch your legs, as the continuous turns on local roads can be more taxing on your body than standard highway cruising. Since you are navigating local streets, keep your GPS handy and ensure your fuel tank is topped off at the start to avoid unexpected stops in remote sections. Given the $64 fuel cost, check your vehicle’s range early in the trip to budget your refueling stops effectively. Because this route lacks major highway stretches, remain alert to local traffic patterns and speed limit changes as you transition between the various segments of your journey.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 210.6 miles from Littlefield, TX, or about 3h 43m into the drive.
The longest continuous stretch on this route runs about 73.9 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 93 miles or 1h 40m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 210.6 miles or 3h 43m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 6h 19m
Traffic, exits, and arrival timing usually matter more near San Antonio, TX than in the middle of the route.
Before You Leave
+
Open the route before leaving Littlefield, TX so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
Day 1
Settle into the route from Littlefield, TX
This is one driving day of about 421.1 miles and 7h 24m.
Your first comfortable stop window is around 93 miles from Littlefield, TX.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on US Highway 84 for about 73.9 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 20
5 decision points cluster between mile 152.3 and 419.5 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
152.3 mi into trip|~2h 39m in|US 84
Keep slight left at fork onto US 84 toward I 20 East, US 84 East: Abilene
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 East, US 84 East: Abilene
6
158.8 mi into trip|~2h 46m in
Take the exit toward SH 70 South, SH 70 Business: Sweetwater, San Angelo
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 244
Toward SH 70 South, SH 70 Business: Sweetwater,...
6
218.4 mi into trip|~3h 52m in|US 83 / South 7th Street
Turn left onto US 83 / South 7th Street
Lane positioning matters here
Use the left lane.
8
306.1 mi into trip|~5h 26m in|US 83
Take the exit onto US 83 toward I 10 East: San Antonio
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the left lane.
Toward I 10 East: San Antonio
8
419.5 mi into trip|~7h 21m in
Take the exit toward Santa Rosa Street, Downtown
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 569C
Toward Santa Rosa Street, Downtown
Fuel & Cost
Regular Gas
$63.63 one way
$127.26 round trip
$3.84/gal25.4 MPG avg147 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.20
$69.65
$139.29
premium
$4.54
$75.18
$150.37
diesel
$5.61
$92.97
$185.95
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$64
Meals
$25–$50
Total
$89–$114
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 147.3 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $44 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
126.3
1
$44.22
$20.21
Efficient EV
105.3
1
$36.85
$16.84
EV Truck/SUV
168.4
2
$58.95
$26.95
Gas CO2
147 kg
EV CO2
49 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Littlefield, TX
Late night
in Littlefield on Sunday
Local time
5:03 AM
CDT
Current temp
84°F
Unavailable
Live forecast
Destination
San Antonio, TX
Late night
in San Antonio on Sunday
Local time
5:03 AM
CDT
Current temp
77°F
Unavailable
Live forecast
59°F
Sweetwater, TX
211 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
7 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
7h 24m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a very different experience from the typical high-speed interstate cruise, as this route relies entirely on local roads like Delano Avenue, Avenue Q, and Slaton Road. With a highway share of 0%, you won’t be dealing with the monotony of long, straight stretches; instead, you will encounter a turn-heavy environment that demands your constant attention. The longest stretch without a turn is 0 miles on Delano Avenue, highlighting the technical nature of the path. Navigating these local arteries means the road's personality is defined by frequent adjustments and a slower, more deliberate pace. You will find that the constant changes in direction keep the drive engaging, even if it adds to the overall mental effort required to reach San Antonio.
74% highway — fuel and pacing are the main things to plan.
34 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 73.9 mi on US Highway 84.
How Hard Is This Drive?
8/10
This is a straightforward highway drive that stays mostly on US Highway 84 and I 10. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 152.3 miles in near US 84.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 20 significant decision points across 421.1 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 152.3 miles (US 84): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 158.8 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 218.4 miles (US 83 / South 7th Street): Lane positioning matters here.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Littlefield, TX and San Antonio, TX, road signs point toward Sh 70 South, Sh 70 Business: Sweetwater and San Angelo.
San Antonio is the second largest city in the state of Texas and the 7th largest in the United States. It's the 24th largest metropolitan area in the country. Visited by more than 31 million annual visitors, San Antonio is a beautiful city at the axis of three different geological terrains: Hill Country, South Texas Plains and Prairie and Lakes. There's a lot to do in this city: fine art museums, historical missions and plenty of amusement parks in addition to great dining and lots of drinking. The culture and people are vibrant and interesting. San Antonio's downtown is one of the most lively in the nation.
Top landmarks
•Alamo Mission in San Antonio — historic place in San Antonio, Bexar County, Texas
•San Antonio Missions National Historical Park — historic district in San Antonio, Bexar County, Texas
•Fort Sam Houston — military base in San Antonio, Texas
Doable as a same-day drive at 7h 24m. Total distance: 421.1 miles.
Family Friendly
Moderate complexity with 2 natural rest stops along the way.
Solo Traveler
7h 24m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 73.9 miles on US Highway 84. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at San Antonio, TX before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 2 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 152.3 miles (US 84): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 158.8 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 218.4 miles (US 83 / South 7th Street): Lane positioning matters here.
Not recommended in a single day. At 7.4 hours each way, a round trip means 14.8 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at San Antonio, TX before the return drive.
