Spanning 572.5 miles across the Texas landscape, this journey from Anthony to San Antonio takes approximately 8 hours and 28 minutes of pure driving time. Because of the significant distance, we recommend breaking this trip into two days to ensure you stay alert and enjoy the transition across the Great Plains. You should budget about $85 for fuel to cover the full trek. Relying on local routes like South 1st Street, Franklin Street, and Antonio Street rather than major interstates defines this path. It is a substantial commitment that requires careful pacing to avoid fatigue, making it better suited for an overnight itinerary than a single-day push.
Trip Pace
Best split across 2 days
Treat the return leg as its own travel day rather than an afterthought.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
286.1 miles from Anthony, TX
A natural place for your longest stop of the day
, about 4h 43m into the drive
.
Main Roads
Road
Distance
Duration
I 10
555.7 mi
8h 57m
Camino Real de Tierra Adentro
11.6 mi
13m
McDermott Freeway
1.7 mi
2m
Franklin Street
0.8 mi
1m
North Pecos-La Trinidad
0.7 mi
1m
Antonio Street
0.5 mi
1m
Dolorosa Street
0.5 mi
<1m
South 1st Street
<0.1 mi
<1m
Longest stretch:
I 10
— 555.7 mi, about 8h 57m
Traffic on I-10
Hour-of-day weekday pattern from 44 FHWA count stations on your route.
Peak
4 PM
~1,388 veh/hr typical
· worst 1,773
Quietest
2 AM
~169 veh/hr
Peak-to-quiet ratio
8.2×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Anthony, TX and San Antonio, TX.
1
Start on Jefferson Street
75 ft·5 sec·Jefferson Street
2
Turn right onto South 1st Street
259 ft·16 sec·South 1st Street
3
Turn left onto FM 1905
0.8 mi·1 min·Franklin Street
4
Continue on FM 1905
0.5 mi·1 min·Antonio Street
5
Turn right onto South Desert Boulevard
172 ft·4 sec·South Desert Boulevard
6
Take the ramp
0.1 mi·19 sec
7
Merge onto I 10; US 85; US 180
12 mi·13 min·Camino Real de Tierra Adentro
Use the straight / slight right lanes.
8
Continue on I 10; US 180
175 mi·2 hr 53 min·I 10; US 180
Use the straight / slight right lanes.
9
Keep slight right at fork onto I 10
363 mi·5 hr 44 min·I 10
Use the straight / slight right lanes.
10
Keep slight right at fork onto I 10; US 87
17 mi·19 min·I 10; US 87
Use the straight / slight right lanes.
11
Keep slight right at fork onto I 10; US 87
1.7 mi·2 min·McDermott Freeway
12
Take the exit
0.5 mi·1 min
Exit 569CToward Santa Rosa Street, DowntownUse the slight right lane.
13
Turn straight onto North Pecos-La Trinidad
0.2 mi·16 sec·North Pecos-La Trinidad
14
Keep slight right at fork onto North Pecos-La Trinidad
0.6 mi·1 min·North Pecos-La Trinidad
Use the straight lane.
15
Turn left onto Dolorosa Street
0.5 mi·55 sec·Dolorosa Street
Use the straight / left lanes.
16
Arrive at destination
Dolorosa Street
Trip Plan
To manage the 572.5-mile distance effectively, plan for at least two intentional stops to stretch your legs and refuel. Since you are navigating local roads rather than high-speed highways, account for potential fluctuations in travel time that might exceed the base estimate of 8 hours and 28 minutes. Setting aside $85 for gas is a solid baseline, but keeping a little extra in your travel budget is a smart move for longer stints. We suggest splitting the trip into two days to keep your arrival in San Antonio stress-free. A helpful tip for this specific route is to verify your navigation settings to ensure you remain on the designated local thoroughfares of South 1st, Franklin, and Antonio streets throughout the journey.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
This drive is better paced as a 2-day trip.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 286.1 miles from Anthony, TX, or about 4h 43m into the drive.
The longest continuous stretch on this route runs about 555.7 miles.
Consider an overnight stop or starting very early.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 126 miles or 2h 8m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 286.1 miles or 4h 43m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Overnight split
Day 1 wrap after about 286.1 miles or 4h 43m
Stop before fatigue turns the last few hours into a grind. You want day two to start fresh, not just resumed.
Final approach
Final hour starts around 8h 17m
Traffic, exits, and arrival timing usually matter more near San Antonio, TX than in the middle of the route.
Before You Leave
+
Open the route before leaving Anthony, TX so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
+
Treat this as a 2-day road trip and book the overnight stop before the busiest arrival window.
Day 1
Settle into the route from Anthony, TX
Aim for roughly 286 miles and 4.7 hours of wheel time on this day.
Day 2
Finish the approach into San Antonio, TX
Aim for roughly 286 miles and 4.7 hours of wheel time on this day.
Your first comfortable stop window is around 126 miles from Anthony, TX.
This route usually feels better as a 2-day drive than as one long push.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on I 10 for about 555.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 11
5 decision points cluster between mile 188 and 571.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
188 mi into trip|~3h 10m in|I 10
Keep slight right at fork onto I 10
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
6
551.4 mi into trip|~8h 55m in|I 10; US 87
Keep slight right at fork onto I 10; US 87
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
8
570.5 mi into trip|~9h 16m in
Take the exit toward Santa Rosa Street, Downtown
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 569C
Toward Santa Rosa Street, Downtown
6
571.2 mi into trip|~9h 18m in|North Pecos-La Trinidad
Keep slight right at fork onto North Pecos-La Trinidad
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight lane.
6
571.7 mi into trip|~9h 19m in|Dolorosa Street
Turn left onto Dolorosa Street
Lane positioning matters here
Use the straight / left lanes.
Fuel & Cost
Regular Gas
$78.37 one way
$156.75 round trip
$3.48/gal25.4 MPG avg200 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$3.89
$87.54
$175.08
premium
$4.23
$95.18
$190.36
diesel
$4.80
$108.04
$216.08
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$78
Hotel (1n)
$80–$140
Meals
$50–$100
Total
$208–$318
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 200.2 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $60 in charging
· 2 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
171.7
2
$60.08
$27.47
Efficient EV
143.1
1
$50.07
$22.89
EV Truck/SUV
228.9
2
$80.11
$36.62
Gas CO2
200 kg
EV CO2
67 kg (67% less)
Plan for 2 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 16, 2026
Origin
Anthony, TX
Late night
in Anthony on Sunday
Local time
2:48 AM
MDT
Current temp
92°F
Slight Chance Showers And Thunderstorms
E 6 mph15% chanceLive forecast
Special Weather Statement
Special Weather Statement issued July 16 at 4:06PM CDT by NWS Midland/Odessa TX
Special Weather Statement
Special Weather Statement issued July 16 at 4:03PM CDT by NWS Midland/Odessa TX
Destination
San Antonio, TX
Late night
in San Antonio on Sunday
Local time
3:48 AM
CDT
Current temp
86°F
Chance Showers And Thunderstorms
SSE 10 mph39% chanceLive forecast
Special Weather Statement
Special Weather Statement issued July 16 at 4:06PM CDT by NWS Midland/Odessa TX
Special Weather Statement
Special Weather Statement issued July 16 at 4:03PM CDT by NWS Midland/Odessa TX
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
For long drives, weather on day two can matter just as much as conditions at departure, so check the whole travel window rather than only the first day.
Time zone
1 hour later
The destination clock does not match departure time, so double-check hotel check-in windows and late arrival plans.
Temperature spread
6 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
9h 20m on the road
This is long enough that the arrival forecast matters almost as much as departure conditions. Recheck both ends before you roll.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Chamizal National Memorial
National Memorial
Chamizal is more than just an urban park to recreate or enjoy a quiet afternoon. These grounds are a reminder of the harmonious settlement of a 100-year boundary dispute between the United States and...
Welcome to San Antonio Missions, a National Park Service site and the only UNESCO World Heritage Site in Texas. Each mission in the park is a center of community and has been since the early 1700s. Th...
9 mi from route
~22 min detour
Free
near mile 572.2
Lyndon B. Johnson National Historical Park tells the story of our 36th president beginning with his ancestors until his final resting place on his beloved LBJ Ranch. This entire "circle of life" gives...
28 mi from route
~70 min detour
Free
near mile 532.7
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a unique experience behind the wheel, as this route features 0% highway driving, relying instead on local roads that provide a different perspective of the Texas terrain. Navigating South 1st Street, Franklin Street, and Antonio Street means you will trade high-speed interstate monotony for a slower, more deliberate pace. The road's personality is defined by these local stretches, which demand your full attention and offer a steady rhythm rather than the quick, blurred vistas of a freeway. Since the entire journey stays within the Great Plains, you can anticipate consistent regional geography that unfolds gradually over your 8-hour and 28-minute travel time.
97% highway — fuel and pacing are the main things to plan.
16 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 555.7 mi on I 10.
How Hard Is This Drive?
7/10
This is a straightforward highway drive that stays mostly on I 10 and Camino Real de Tierra Adentro. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 188 miles in near I 10.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 11 significant decision points across 572.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 188 miles (I 10): Highway fork - watch signs carefully. Lane positioning matters here; at 551.4 miles (I 10; US 87): Highway fork - watch signs carefully. Lane positioning matters here; at 570.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
San Antonio is the second largest city in the state of Texas and the 7th largest in the United States. It's the 24th largest metropolitan area in the country. Visited by more than 31 million annual visitors, San Antonio is a beautiful city at the axis of three different geological terrains: Hill Country, South Texas Plains and Prairie and Lakes. There's a lot to do in this city: fine art museums, historical missions and plenty of amusement parks in addition to great dining and lots of drinking. The culture and people are vibrant and interesting. San Antonio's downtown is one of the most lively in the nation.
Top landmarks
•Alamo Mission in San Antonio — historic place in San Antonio, Bexar County, Texas
•San Antonio Missions National Historical Park — historic district in San Antonio, Bexar County, Texas
•Fort Sam Houston — military base in San Antonio, Texas
The longest stretch is about 555.7 miles on I 10. The full list of main roads is in the Roads section above.
Yes — a 2-day pace is more comfortable than one long haul. A sensible stopping point is after roughly 286 miles on day one.
Yes — we found about 62 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at San Antonio, TX before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 2 meaningful breaks. There are 62 rest areas along the route for bathroom stops.
The main spots that need attention: at 188 miles (I 10): Highway fork - watch signs carefully. Lane positioning matters here; at 551.4 miles (I 10; US 87): Highway fork - watch signs carefully. Lane positioning matters here; at 570.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Chamizal National Memorial, San Antonio Missions National Historical Park and Lyndon B Johnson National Historical Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 9.3 hours each way, a round trip means 18.7 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at San Antonio, TX before the return drive.
