Connecting Kansas City and St. Louis, this 248.3-mile journey across Missouri is a classic Midwest trek that typically takes about 4 hours and 46 minutes to complete. You can easily manage this as a single-day trip, making it an efficient way to traverse the state without needing an overnight stay. Expect to budget roughly $38 for fuel to cover the distance. Navigating via the Dwight D. Eisenhower Highway, U.S. Submarine Veterans' Memorial Highway, and the Avenue of the Saints, you will move through the heart of Missouri. Whether you are heading east or west, this route provides a direct link between the state's two major urban hubs.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
124.1 miles from Kansas City, MO
A natural place for your longest stop of the day
, about 2h 17m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
135.3 mi
2h 34m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Avenue of the Saints
27.7 mi
33m
George Brett Super Highway
6.9 mi
9m
Jack Buck Memorial Highway
5.8 mi
7m
Daniel Boone Expressway
5.7 mi
7m
Truman/Eisenhower Presidential Highway
5.6 mi
6m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
Longest stretch:
Dwight D. Eisenhower Highway
— 135.3 mi, about 2h 34m
Turn-by-Turn Driving Directions
Step-by-step road directions between Kansas City, MO and St. Louis, MO.
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
11
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
12
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
13
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
14
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
15
Continue on I 70; US 40
81 mi·1 hr 35 min·Dwight D. Eisenhower Highway
16
Take the exit onto US 40
0.3 mi·33 sec·US 40
Exit 210AToward I 64 East, US 40 East, US 61 South: Chesterfield
17
Merge onto I 64; US 40; US 61
28 mi·33 min·Avenue of the Saints
Use the straight / slight left lanes.
18
Continue on I 64; US 40
5.7 mi·7 min·Daniel Boone Expressway
Use the straight lane.
19
Continue on I 64; US 40
5.8 mi·7 min·Jack Buck Memorial Highway
Use the straight / slight right lanes.
20
Take the exit
0.2 mi·34 sec
Exit 39AToward 14th StreetUse the slight right lane.
21
Turn left onto South 14th Street
0.3 mi·42 sec·South 14th Street
Use the left lane.
22
Turn right onto Market Street
0.2 mi·25 sec·Market Street
23
Arrive at destination
Market Street
Trip Plan
Since this trip is roughly 5 hours, you have plenty of flexibility to plan your departure around your personal schedule. You should anticipate at least one necessary stop to stretch your legs and refuel during the 248.3-mile trek. Keep a close eye on your fuel gauge, as the $38 budget is an estimate that can fluctuate based on your vehicle's efficiency and local prices. Because this is a turn-heavy route, staying alert during the transitions between highways is essential for a smooth arrival. Use your single planned stop to break up the drive, ensuring you stay sharp while navigating the variety of roads connecting these two cities.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 124.1 miles from Kansas City, MO, or about 2h 17m into the drive.
The longest continuous stretch on this route runs about 135.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 55 miles or 1h 2m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 124.1 miles or 2h 17m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 50m
Traffic, exits, and arrival timing usually matter more near St. Louis, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Kansas City, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Kansas City, MO
This is one driving day of about 248.3 miles and 4h 46m.
Your first comfortable stop window is around 55 miles from Kansas City, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 135.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 10
5 decision points cluster between mile 0 and 247.5 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0 mi into trip|~0m in|East 12th Street
Turn right onto East 12th Street
Navigation decision point
5
0.3 mi into trip|~0m in
Take the ramp toward I 70 East, US 40 East
Multiple destination signs - pick the right one
Toward I 70 East, US 40 East
5
0.6 mi into trip|~1m in|I 70; US 24; US 40 / George Brett Super Highway
Merge onto I 70; US 24; US 40 / George Brett Super Highway
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
6
208.1 mi into trip|~3h 56m in|US 40
Take the exit onto US 40 toward I 64 East, US 40 East, US 61 South: Chesterfield
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 210A
Toward I 64 East, US 40 East, US 61 South: Ches...
7
247.5 mi into trip|~4h 45m in
Take the exit toward 14th Street
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 39A
Toward 14th Street
Fuel & Cost
Regular Gas
$38.82 one way
$77.64 round trip
$3.97/gal25.4 MPG avg87 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$42.62
$85.24
premium
$4.89
$47.78
$95.57
diesel
$5.61
$54.82
$109.64
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$39
Meals
$25–$50
Total
$64–$89
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 86.9 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $26 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
74.5
0
$26.07
$11.92
Efficient EV
62.1
0
$21.73
$9.93
EV Truck/SUV
99.3
1
$34.76
$15.89
Gas CO2
87 kg
EV CO2
29 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Kansas City, MO
Night
in Kansas City on Saturday
Local time
9:52 PM
CDT
Current temp
74°F
Unavailable
Live forecast
Destination
St. Louis, MO
Night
in St. Louis on Saturday
Local time
9:52 PM
CDT
Current temp
74°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
4h 46m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a turn-heavy local drive that demands your attention behind the wheel. While you will spend time on major thoroughfares, the route is defined by its mix of highway stretches and local road transitions. You will tackle a significant 135.3-mile segment along the Dwight D. Eisenhower Highway, which serves as the longest uninterrupted portion of your trip. With a highway share of 2, the road character shifts as you navigate through the regional landscape. Be prepared for a driving experience that feels more involved than a simple, monotonous interstate cruise.
Only 2% highway — the rest is turn-by-turn surface driving.
23 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 135.3 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
6/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. You will hit about 10 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near East 12th Street.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 248.3 miles you will encounter 10 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (East 12th Street): Navigation decision point; at 0.3 miles: Multiple destination signs - pick the right one; at 0.6 miles (I 70; US 24; US 40 / George Brett Super Highway): Merge point - match speed before joining. Lane positioning matters here.
Kansas City is a major Midwestern metropolitan area that spreads across the border of Missouri and Kansas. It is a city that tends to hide itself from tourists. Reputed to have more boulevards than Paris and more fountains than any other city in the world except for Rome, it can be a beautiful city, too. It is unique in that it is split down the middle by the state line of Kansas and Missouri.
The Gateway City of St. Louis is the epitome of the modern Midwestern metropolis. Missouri's second-largest city is vibrant but laid-back, populous but navigable, historic but still relevant. The city's planners have created an aesthetically beautiful city, with plenty of green space amidst buildings both old and new, framed by the majestic Mississippi and Missouri rivers. And capping it all is the world's tallest man-made monument, the beautiful and iconic Gateway Arch.
St. Louis is a city of culture and surprisingly inexpensive. Among American cities, only Washington, D.C. has more free attractions for tourists and residents alike. Hotels, restaurants, and even parking garages avoid the premium pricing common in other big cities. Although often overlooked, St. Louis can be an affordable, educational, and fun family getaway.
Doable as a same-day drive at 4h 46m. Total distance: 248.3 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 46m drive, comfortable solo distance.
Scenic Drive
Mostly surface roads route profile.
Frequently Asked Questions
The longest stretch is about 135.3 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at St. Louis, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: near the start (East 12th Street): Navigation decision point; at 0.3 miles: Multiple destination signs - pick the right one; at 0.6 miles (I 70; US 24; US 40 / George Brett Super Highway): Merge point - match speed before joining. Lane positioning matters here.
Possible but tiring. At 4.8 hours each way, an in-and-out day trip would put you behind the wheel for 9.6 hours — manageable with a long break at St. Louis, MO, but most travelers stay overnight.
