Jacksonville, FL to Myrtle Grove, FL is 361.7 miles and takes about 6h 39m via Ocean Street, State Street, and Kings Road, with a fuel budget near $55 and enough daylight to finish in a day. This route stays within Florida, offering a full day's drive without needing an overnight stay. Expect to navigate primarily on surface roads for the majority of the trip. With a single recommended stop, this drive is manageable for one day, but be prepared for a longer stretch of driving.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
180.8 miles from Jacksonville, FL
A natural place for your longest stop of the day
, about 3h 17m into the drive
.
Main Roads
Road
Distance
Duration
I 10
348.9 mi
6h 15m
East Fairfield Drive
2.9 mi
5m
Reubin O'Donovan Askew Parkway
2.7 mi
3m
Fairfield Drive
1.6 mi
3m
US 17
1.1 mi
1m
Lillian Highway
1 mi
2m
State Street
0.7 mi
1m
North 57th Avenue
0.4 mi
1m
Longest stretch:
I 10
— 348.9 mi, about 6h 15m
Traffic on I-10
Hour-of-day weekday pattern from 120 FHWA count stations on your route.
Peak
3 PM
~1,204 veh/hr typical
· worst 1,740
Quietest
2 AM
~150 veh/hr
Peak-to-quiet ratio
8×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 102 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Jacksonville, FL and Myrtle Grove, FL.
1
Start on US 17
210 ft·12 sec·Union Street
2
Turn left onto US 1; US 17; FL 228
281 ft·15 sec·Ocean Street
3
Turn left onto US 1; US 17; FL 228
0.7 mi·1 min·State Street
Use the straight / left lanes.
4
Continue on US 17; US 23; FL 228
0.3 mi·36 sec·Kings Road
5
Take the ramp onto US 17; FL 228
1.1 mi·1 min·US 17; FL 228
Toward I 95 South: JacksonvilleUse the straight / slight right lanes.
6
Take the exit
0.7 mi·1 min
Exit 351AToward I 10 West: Lake CityUse the straight / slight right lanes.
7
Merge onto I 10; US 17; FL 228
349 mi·6 hr 15 min·I 10; US 17; FL 228
Use the straight / slight left / slight right lanes.
8
Take the exit
0.9 mi·1 min
Exit 12Toward I 110 South: Pensacola, Pensacola BeachUse the straight / slight right lanes.
9
Merge onto I 110
2.7 mi·3 min·Reubin O'Donovan Askew Parkway
Use the straight / slight right lanes.
10
Take the exit
0.3 mi·39 sec
Exit 4Toward FL 295: Fairfield DriveUse the straight / slight right lanes.
11
Keep slight right at fork
0.1 mi·17 sec
Toward FL 295 South
12
Turn straight onto FL 295
2.9 mi·5 min·East Fairfield Drive
13
Continue on FL 727
1.6 mi·3 min·Fairfield Drive
14
Turn left onto North 57th Avenue
0.4 mi·1 min·North 57th Avenue
Use the left lane.
15
Turn right onto FL 298
1.0 mi·2 min·Lillian Highway
16
Turn right
44 ft·5 sec
17
Turn right
82 ft·5 sec
18
Arrive at destination
Trip Plan
Given the 6h 39m estimated duration and 361.7 miles, starting early in the morning is your best bet to complete this drive comfortably within daylight. Plan for at least one stop to break up the drive and refuel, as the fuel cost is estimated at $55. Since this is a single-day trip, you have flexibility, but be mindful that the entire route is on surface roads, which can slow your progress compared to highway driving. Keep an eye on your fuel gauge, especially as you get closer to Myrtle Grove, FL.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 180.8 miles from Jacksonville, FL, or about 3h 17m into the drive.
The longest continuous stretch on this route runs about 348.9 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 80 miles or 1h 29m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 180.8 miles or 3h 17m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 27m
Traffic, exits, and arrival timing usually matter more near Myrtle Grove, FL than in the middle of the route.
Before You Leave
+
Open the route before leaving Jacksonville, FL so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Jacksonville, FL
This is one driving day of about 361.7 miles and 6h 39m.
Your first comfortable stop window is around 80 miles from Jacksonville, FL.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 10 for about 348.9 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 13
5 decision points cluster between mile 2.1 and 360.2 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
7
2.1 mi into trip|~4m in
Take the exit toward I 10 West: Lake City
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Exit 351A
Toward I 10 West: Lake City
8
351.7 mi into trip|~6h 21m in
Take the exit toward I 110 South: Pensacola, Pensacola Beach
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 12
Toward I 110 South: Pensacola, Pensacola Beach
7
355.3 mi into trip|~6h 25m in
Take the exit toward FL 295: Fairfield Drive
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Exit 4
Toward FL 295: Fairfield Drive
6
355.6 mi into trip|~6h 26m in
Keep slight right at fork toward FL 295 South
Highway fork - watch signs carefully
Toward FL 295 South
6
360.2 mi into trip|~6h 35m in|North 57th Avenue
Turn left onto North 57th Avenue
Lane positioning matters here
Use the left lane.
Fuel & Cost
Regular Gas
$58.16 one way
$116.31 round trip
$4.08/gal25.4 MPG avg127 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.44
$63.25
$126.51
premium
$4.78
$68.04
$136.08
diesel
$6.18
$87.99
$175.98
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$58
Meals
$25–$50
Total
$83–$108
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 126.6 kg one way.
Prices: EIA weekly data, 2026-10-12.
Driving Electric?
About $38 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
108.5
1
$37.98
$17.36
Efficient EV
90.4
1
$31.65
$14.47
EV Truck/SUV
144.7
1
$50.64
$23.15
Gas CO2
127 kg
EV CO2
42 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Oct 17, 2026
Origin
Jacksonville, FL
Afternoon
in Jacksonville on Saturday
Local time
2:13 PM
EDT
Current temp
69°F
Mostly Cloudy
W 6 mph3% chanceLive forecast
Rip Current Statement
Rip Current Statement issued October 17 at 3:40AM EDT until October 20 at 2:00AM EDT by NWS Miami FL
Rip Current Statement
Rip Current Statement issued October 17 at 3:10AM EDT until October 18 at 2:00AM EDT by NWS Tallahassee FL
Destination
Myrtle Grove, FL
Afternoon
in Myrtle Grove on Saturday
Local time
1:13 PM
CDT
Current temp
54°F
Partly Cloudy
N 30 mph0% chanceLive forecast
Rip Current Statement
Rip Current Statement issued October 17 at 3:40AM EDT until October 20 at 2:00AM EDT by NWS Miami FL
Rip Current Statement
Rip Current Statement issued October 17 at 3:10AM EDT until October 18 at 2:00AM EDT by NWS Tallahassee FL
53°F
Quincy, FL
181 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
1 hour earlier
The destination clock does not match departure time, so double-check hotel check-in windows and late arrival plans.
Temperature spread
15 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 39m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Gulf Islands National Seashore
National Seashore
Millions of visitors are drawn to the Gulf of America for Gulf Islands National Seashore's emerald coast waters, magnificent white beaches, fertile marshes and historical landscapes. Come explore with...
8 mi from route
~21 min detour
$25
near mile 361.7
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This drive is entirely on surface roads, with a 0% highway share. You'll be navigating through towns and local areas for the entire 361.7 miles. Be prepared for frequent intersections and changes in speed limits as you pass through populated areas. The longest stretch without a significant break is not specified, but given the profile, expect consistent surface road conditions.
98% highway — fuel and pacing are the main things to plan.
18 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 348.9 mi on I 10.
How Hard Is This Drive?
7/10
This is a straightforward highway drive that stays mostly on I 10 and East Fairfield Drive. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 2.1 miles in.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 13 significant decision points across 361.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 2.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 351.7 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 355.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Jacksonville occupies one of the most coveted spots on the Atlantic coast. Set amongst abundant beaches and possessing an ideal subtropical climate, its crown jewel is the unique habitat and natural beauty of the St. Johns River. For this reason and more, "The River City" is a popular destination for vacationers looking for a laid-back Sunshine State escape.
Top landmarks
•Fort Caroline — fort in Florida managed by the National Park Service
•Museum of Contemporary Art Jacksonville — museum in Jacksonville, Florida
•Timucuan Ecological and Historic Preserve — wetlands in Florida (U.S.) managed by the National Park Service
Doable as a same-day drive at 6h 39m. Total distance: 361.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 39m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 348.9 miles on I 10. The full list of main roads is in the Roads section above.
Yes — we found about 31 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Myrtle Grove, FL before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 31 rest areas along the route for bathroom stops.
The main spots that need attention: at 2.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 351.7 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 355.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Yes — Gulf Islands National Seashore. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.7 hours each way, a round trip means 13.3 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Myrtle Grove, FL before the return drive.
