St. Petersburg, FL to Myrtle Grove, FL is 493.8 miles and takes about 9h 5m via I-75, I-275, and I-10, with a fuel budget near $86 and an overnight stop recommended. This trip keeps you within Florida for its entirety, primarily utilizing major interstate highways. Given the 9-hour estimated drive time, splitting this into two days is a sensible approach for a more relaxed pace. You'll encounter a high percentage of highway driving, making it a straightforward interstate cruise for most of the way.
Trip Pace
Best split across 2 days
Treat the return leg as its own travel day rather than an afterthought.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
246.9 miles from St. Petersburg, FL
A natural place for your longest stop of the day
, about 4h 33m into the drive
.
Main Roads
Road
Distance
Duration
I 10
283.4 mi
5h 3m
I 75
160.3 mi
2h 51m
I 275
37.7 mi
46m
East Fairfield Drive
2.9 mi
5m
Reubin O'Donovan Askew Parkway
2.7 mi
3m
Fairfield Drive
1.6 mi
3m
5th Avenue North
1.2 mi
2m
Lillian Highway
1 mi
2m
Longest stretch:
I 10
— 283.4 mi, about 5h 3m
Traffic on I-10
Hour-of-day weekday pattern from 54 FHWA count stations on your route.
Peak
3 PM
~1,226 veh/hr typical
· worst 1,701
Quietest
2 AM
~148 veh/hr
Peak-to-quiet ratio
8.3×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between St. Petersburg, FL and Myrtle Grove, FL.
1
Start on US 19
0.4 mi·1 min·34th Street South
2
Turn right onto FL 595
1.2 mi·2 min·5th Avenue North
3
Take the ramp
0.3 mi·49 sec
Toward I 275 North
4
Merge onto I 275
38 mi·46 min·I 275
Use the straight / slight right lanes.
5
Merge onto I 75
160 mi·2 hr 51 min·I 75
Use the straight / slight right lanes.
6
Take the exit
0.2 mi·15 sec
Exit 435Toward I 10: Jacksonville, TallahasseeUse the straight / slight right lanes.
7
Keep slight left at fork
0.3 mi·30 sec
Toward I 10 West: TallahasseeUse the slight left / slight right lanes.
8
Merge onto I 10
283 mi·5 hr 3 min·I 10
Use the straight / slight right lanes.
9
Take the exit
0.9 mi·1 min
Exit 12Toward I 110 South: Pensacola, Pensacola BeachUse the straight / slight right lanes.
10
Merge onto I 110
2.7 mi·3 min·Reubin O'Donovan Askew Parkway
Use the straight / slight right lanes.
11
Take the exit
0.3 mi·39 sec
Exit 4Toward FL 295: Fairfield DriveUse the straight / slight right lanes.
12
Keep slight right at fork
0.1 mi·17 sec
Toward FL 295 South
13
Turn straight onto FL 295
2.9 mi·5 min·East Fairfield Drive
14
Continue on FL 727
1.6 mi·3 min·Fairfield Drive
15
Turn left onto North 57th Avenue
0.4 mi·1 min·North 57th Avenue
Use the left lane.
16
Turn right onto FL 298
1.0 mi·2 min·Lillian Highway
17
Turn right
44 ft·5 sec
18
Turn right
82 ft·5 sec
19
Arrive at destination
Trip Plan
Given the 9h 5m estimated drive time, plan for an overnight stop to comfortably complete this 493.8-mile drive. A good point to break up the drive would be after approximately 4-5 hours of travel, allowing you to reach your destination refreshed the next day. Starting early in the morning will help you maximize daylight hours for driving. Keep an eye on your fuel levels, especially during the 283.4-mile stretch on I-10, as services can sometimes be further apart on longer interstate segments.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
This drive is better paced as a 2-day trip.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 246.9 miles from St. Petersburg, FL, or about 4h 33m into the drive.
The longest continuous stretch on this route runs about 283.4 miles.
Consider an overnight stop or starting very early.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 109 miles or 2h 5m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 246.9 miles or 4h 33m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Overnight split
Day 1 wrap after about 246.9 miles or 4h 33m
Stop before fatigue turns the last few hours into a grind. You want day two to start fresh, not just resumed.
Final approach
Final hour starts around 7h 53m
Traffic, exits, and arrival timing usually matter more near Myrtle Grove, FL than in the middle of the route.
Before You Leave
+
Open the route before leaving St. Petersburg, FL so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
+
Treat this as a 2-day road trip and book the overnight stop before the busiest arrival window.
Day 1
Settle into the route from St. Petersburg, FL
Aim for roughly 247 miles and 4.5 hours of wheel time on this day.
Day 2
Finish the approach into Myrtle Grove, FL
Aim for roughly 247 miles and 4.5 hours of wheel time on this day.
Your first comfortable stop window is around 109 miles from St. Petersburg, FL.
This route usually feels better as a 2-day drive than as one long push.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on I 10 for about 283.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 15
5 decision points cluster between mile 199.9 and 487.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
199.9 mi into trip|~3h 42m in
Take the exit toward I 10: Jacksonville, Tallahassee
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 435
Toward I 10: Jacksonville, Tallahassee
8
200.1 mi into trip|~3h 43m in
Keep slight left at fork toward I 10 West: Tallahassee
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left / slight right lanes.
Toward I 10 West: Tallahassee
8
483.8 mi into trip|~8h 47m in
Take the exit toward I 110 South: Pensacola, Pensacola Beach
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 12
Toward I 110 South: Pensacola, Pensacola Beach
7
487.4 mi into trip|~8h 51m in
Take the exit toward FL 295: Fairfield Drive
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Exit 4
Toward FL 295: Fairfield Drive
6
487.7 mi into trip|~8h 52m in
Keep slight right at fork toward FL 295 South
Highway fork - watch signs carefully
Toward FL 295 South
Fuel & Cost
Regular Gas
$74.75 one way
$149.50 round trip
$3.85/gal25.4 MPG avg173 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.22
$82.02
$164.04
premium
$4.55
$88.46
$176.91
diesel
$4.80
$93.24
$186.48
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$75
Hotel (1n)
$80–$140
Meals
$50–$100
Total
$205–$315
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 172.8 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $52 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
148.1
1
$51.85
$23.70
Efficient EV
123.5
1
$43.21
$19.75
EV Truck/SUV
197.5
2
$69.13
$31.60
Gas CO2
173 kg
EV CO2
58 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 16, 2026
Origin
St. Petersburg, FL
Morning
in St. Petersburg on Sunday
Local time
7:30 AM
EDT
Current temp
79°F
Scattered Showers And Thunderstorms
NW 5 to 12 mph43% chanceLive forecast
Special Weather Statement
Special Weather Statement issued July 16 at 6:35PM EDT by NWS Tallahassee FL
Special Weather Statement
Special Weather Statement issued July 16 at 6:26PM EDT by NWS Tallahassee FL
Destination
Myrtle Grove, FL
Morning
in Myrtle Grove on Sunday
Local time
6:30 AM
CDT
Current temp
95°F
Mostly Sunny
W 10 mph4% chanceLive forecast
Special Weather Statement
Special Weather Statement issued July 16 at 6:35PM EDT by NWS Tallahassee FL
Special Weather Statement
Special Weather Statement issued July 16 at 6:26PM EDT by NWS Tallahassee FL
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
For long drives, weather on day two can matter just as much as conditions at departure, so check the whole travel window rather than only the first day.
Time zone
1 hour earlier
The destination clock does not match departure time, so double-check hotel check-in windows and late arrival plans.
Temperature spread
16 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
9h 5m on the road
This is long enough that the arrival forecast matters almost as much as departure conditions. Recheck both ends before you roll.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Gulf Islands National Seashore
National Seashore
Millions of visitors are drawn to the Gulf of America for Gulf Islands National Seashore's emerald coast waters, magnificent white beaches, fertile marshes and historical landscapes. Come explore with...
8 mi from route
~21 min detour
$25
near mile 493.8
In May 1539, Conquistador Hernando de Soto’s army of soldiers, hired mercenaries, craftsmen, and clergy made landfall in Tampa Bay. They were met with fierce resistance of indigenous people protecting...
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
With 98% of this route on highways, expect continuous interstate cruising for the vast majority of your trip. The longest uninterrupted stretch you'll encounter is 283.4 miles on I-10. You'll notice a high density of exits and interchanges, particularly as you navigate through urban and suburban areas on I-75 and I-275 before transitioning to the more open cruising of I-10. Surface roads will only become prevalent in the final miles as you approach Myrtle Grove.
98% highway — fuel and pacing are the main things to plan.
19 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 283.4 mi on I 10.
How Hard Is This Drive?
9/10
This is a straightforward highway drive that stays mostly on I 10 and I 75. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 199.9 miles in.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 15 significant decision points across 493.8 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 199.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 200.1 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 483.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
275 ft38 ft
Total Climb
453 ft
Total Descent
452 ft
Highest Point
275 ft
~423.3 mi in
Elevation Range
236 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from St. Petersburg, FL to Myrtle Grove, FL, road signs begin pointing toward Tallahassee along the way.
Saint Petersburg sits at the base of the Tampa Bay peninsula in Pinellas County, Florida, and enjoys a more subdued social atmosphere than its larger cousin, Tampa. The city has tried to characterize the downtown as an arts and entertainments destination and you will find no shortage of arts and crafts stores, galleries, and museums along with cafes and boutique food shops all within a couple blocks of the Tampa Bay waterfront. With water on three sides of the city, St. Pete is a superb location for fishing, sailing, and wandering beaches.
Top landmarks
•Salvador Dalí Museum — art museum in St. Petersburg, Florida, United States
•Vinoy Park Hotel — historic hotel in St. Petersburg, Florida, USA
•Museum of Fine Arts, St. Petersburg, Florida, USA — museum in St. Petersburg, Florida
The longest stretch is about 283.4 miles on I 10. The full list of main roads is in the Roads section above.
Yes — a 2-day pace is more comfortable than one long haul. A sensible stopping point is after roughly 247 miles on day one.
Yes — we found about 1 rest area or service plaza within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Myrtle Grove, FL before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 2 meaningful breaks. There are 1 rest area along the route for bathroom stops.
The main spots that need attention: at 199.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 200.1 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 483.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Gulf Islands National Seashore and De Soto National Memorial. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 9.1 hours each way, a round trip means 18.2 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Myrtle Grove, FL before the return drive.
