Jacksonville, FL to North Key Largo, FL is 395.8 miles and takes about 7h 27m via I 95 and Florida's Turnpike, with a fuel budget near $68 and enough daylight to finish in a day. This trip stays within Florida, moving from the northern part of the state down to the Keys. The route is mostly highway driving, making it a straightforward option for a single-day trip. You'll want to be prepared for a solid chunk of time behind the wheel, but it's manageable if you get an early start.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
197.9 miles from Jacksonville, FL
A natural place for your longest stop of the day
, about 3h 37m into the drive
.
Main Roads
Road
Distance
Duration
I 95
219.5 mi
3h 57m
Florida's Turnpike
105.2 mi
1h 56m
Homestead Extension of Florida's Turnpike
47.1 mi
54m
Card Sound Road
16.5 mi
23m
CR 905
1.7 mi
2m
US 1
1.1 mi
2m
Dixie Highway
1 mi
1m
Okeechobee Road
0.5 mi
<1m
Longest stretch:
I 95
— 219.5 mi, about 3h 57m
Traffic on I-95
Hour-of-day weekday pattern from 71 FHWA count stations on your route.
Peak
4 PM
~3,498 veh/hr typical
· worst 4,230
Quietest
2 AM
~274 veh/hr
Peak-to-quiet ratio
12.8×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Jacksonville, FL and North Key Largo, FL.
1
Start on US 17
0.1 mi·20 sec·Union Street
2
Turn right onto Newnan Street
0.4 mi·1 min·Newnan Street
3
Turn right onto FL 228
0.1 mi·23 sec·East Forsyth Street
4
Turn left onto US 1; US 90
0.5 mi·1 min·Main Street
5
Take the ramp onto US 1; US 90
0.9 mi·2 min·US 1; US 90
Toward I 95 South
6
Keep slight right at fork onto US 1
0.2 mi·28 sec·US 1
Toward I 95, US 1 South, FL 5 South: Daytona Beach, Philips Highway
7
Keep slight left at fork
0.2 mi·26 sec
Toward I 95 South: Daytona BeachUse the straight lane.
8
Merge onto I 95
219 mi·3 hr 57 min·I 95
Use the straight / slight right lanes.
9
Take the exit
0.5 mi·58 sec
Exit 129Toward FL 70: Okeechobee, Fort PierceUse the straight / slight right lanes.
10
Keep slight right at fork
492 ft·12 sec
Toward FL 70 West: OkeechobeeUse the right lane.
11
Merge onto FL 70
0.5 mi·57 sec·Okeechobee Road
12
Take the ramp
0.2 mi·35 sec
Use the left / uturn lanes.
13
Keep slight left at fork
0.5 mi·1 min
Toward Miami, Florida's Turnpike SouthUse the left lane.
14
Merge onto Florida's Turnpike
105 mi·1 hr 56 min·Florida's Turnpike
Use the straight / slight right lanes.
15
Take the exit onto Homestead Extension of Florida's Turnpike
0.2 mi·20 sec·Homestead Extension of Florida's Turnpike
Toward Florida's Turnpike Toll South, HomesteadUse the straight / slight right lanes.
16
Keep slight left at fork onto Homestead Extension of Florida's Turnpike
47 mi·54 min·Homestead Extension of Florida's Turnpike
Toward HomesteadUse the straight / slight right lanes.
17
Keep slight left at fork
0.6 mi·1 min
18
Merge onto US 1
1.0 mi·1 min·Dixie Highway
Use the left lane.
19
Turn left onto Card Sound Road
17 mi·23 min·Card Sound Road
Use the left lane.
20
Turn right onto CR 905
1.7 mi·2 min·CR 905
21
Arrive at destination
CR 905
Trip Plan
To make the most of this 7.5-hour drive, aim to depart from Jacksonville early in the morning, ideally before 8:00 AM, to avoid potential traffic as you head south. With a recommended one-day drive, plan for one or two brief stops for fuel and a quick break, perhaps around the halfway point. Keep an eye on your fuel gauge, as the longest stretch without a major town could be a factor depending on your vehicle's efficiency. The Homestead Extension of Florida's Turnpike will be your final major road before reaching North Key Largo.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 197.9 miles from Jacksonville, FL, or about 3h 37m into the drive.
The longest continuous stretch on this route runs about 219.5 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 87 miles or 1h 37m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 197.9 miles or 3h 37m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 6h 11m
Traffic, exits, and arrival timing usually matter more near North Key Largo, FL than in the middle of the route.
Before You Leave
+
Open the route before leaving Jacksonville, FL so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
Day 1
Settle into the route from Jacksonville, FL
This is one driving day of about 395.8 miles and 7h 27m.
Your first comfortable stop window is around 87 miles from Jacksonville, FL.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on I 95 for about 219.5 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 19
5 decision points cluster between mile 2.3 and 328.9 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
2.3 mi into trip|~5m in
Keep slight left at fork toward I 95 South: Daytona Beach
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight lane.
Toward I 95 South: Daytona Beach
8
221.9 mi into trip|~4h 3m in
Take the exit toward FL 70: Okeechobee, Fort Pierce
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 129
Toward FL 70: Okeechobee, Fort Pierce
7
222.4 mi into trip|~4h 4m in
Keep slight right at fork toward FL 70 West: Okeechobee
Highway fork - watch signs carefully. Lane positioning matters here
Use the right lane.
Toward FL 70 West: Okeechobee
8
223.2 mi into trip|~4h 6m in
Keep slight left at fork toward Miami, Florida's Turnpike South
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the left lane.
Toward Miami, Florida's Turnpike South
7
328.9 mi into trip|~6h 3m in|Homestead Extension of Florida's Turnpike
Take the exit onto Homestead Extension of Florida's Turnpike toward Florida's Turnpike Toll South, Homestead
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward Florida's Turnpike Toll South, Homestead
Fuel & Cost
Regular Gas
$63.00 one way
$126.00 round trip
$4.04/gal25.4 MPG avg139 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.41
$68.67
$137.35
premium
$4.74
$73.91
$147.82
diesel
$5.35
$83.37
$166.73
Estimated Tolls: $10.18
Florida's Turnpike
(105.2 mi)$7.36
Homestead Extension
(47.1 mi)$2.82
Toll estimates based on average 2024-2025 rates. EZ-Pass/SunPass discounts may lower the actual cost.
Estimated Trip Cost (one way, 1 person)
Fuel
$63
Tolls
$10
Meals
$25–$50
Total
$98–$123
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 138.5 kg one way.
Prices: EIA weekly data, 2026-06-01.
Driving Electric?
About $42 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
118.7
1
$41.56
$19.00
Efficient EV
99
1
$34.63
$15.83
EV Truck/SUV
158.3
1
$55.41
$25.33
Gas CO2
138 kg
EV CO2
46 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jun 1, 2026
Origin
Jacksonville, FL
Evening
in Jacksonville on Wednesday
Local time
5:47 PM
EDT
Current temp
74°F
Chance Showers And Thunderstorms
SW 2 to 7 mph30% chanceLive forecast
Rip Current Statement
Rip Current Statement issued May 31 at 11:16AM EDT until June 2 at 2:00AM EDT by NWS Tallahassee FL
Destination
North Key Largo, FL
Evening
in North Key Largo on Wednesday
Local time
5:47 PM
EDT
Current temp
79°F
Slight Chance Showers And Thunderstorms
SW 5 mph13% chanceLive forecast
Rip Current Statement
Rip Current Statement issued May 31 at 11:16AM EDT until June 2 at 2:00AM EDT by NWS Tallahassee FL
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
5 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
7h 27m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Fort Matanzas National Monument
National Monument
Fort Matanzas National Monument preserves the fortified coquina watchtower, completed in 1742, which defended the southern approach to the Spanish military settlement of St. Augustine. It also protect...
5 mi from route
~13 min detour
Free
near mile 54.6
Built by the Spanish in St. Augustine to defend Florida and the Atlantic trade route, Castillo de San Marcos National Monument preserves the oldest masonry fortification in the continental United Stat...
Discover a dynamic barrier island shaped by dunes, coastal hammocks, and Mosquito Lagoon. Walk among ancient Timucua shell mounds and connect with thousands of years of human history. Immerse yourself...
9 mi from route
~22 min detour
$25
near mile 122.8
Within sight of Miami, yet worlds away, Biscayne protects a rare combination of aquamarine waters, emerald islands, and fish-bejeweled coral reefs. Evidence of 10,000 years of human history is here to...
12 mi from route
~29 min detour
Free
near mile 368.5
Established in 1947 as the first national park created for its biodiversity, Everglades National Park protects 1.5 million acres of wetland, forest, and marine habitats and the native plants and anima...
28 mi from route
~69 min detour
$35
near mile 382.2
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a predominantly highway experience, with 95% of the 395.8 miles on major roadways like I 95 and Florida's Turnpike. The longest continuous stretch on the highway is 219.5 miles, primarily on I 95, meaning you'll encounter relatively few turns for a significant portion of the drive. You'll transition to surface roads as you approach your destination, but the bulk of the travel involves high-speed cruising with frequent exits and services.
95% highway — fuel and pacing are the main things to plan.
21 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 219.5 mi on I 95.
How Hard Is This Drive?
9/10
This is a straightforward highway drive that stays mostly on I 95 and Florida's Turnpike. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 2.3 miles in.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 395.8 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 2.3 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 221.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 222.4 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Elevation Profile
Mostly flat terrain
35 ft6 ft
Total Climb
45 ft
Total Descent
55 ft
Highest Point
35 ft
~28.3 mi in
Elevation Range
29 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Jacksonville, FL and North Key Largo, FL, road signs point toward Fort Pierce, Miami, Florida's Turnpike South, Florida's Turnpike Toll South and Homestead.
Fort Pierce
221.9 mi in|~4h 3m
Miami
223.2 mi in|~4h 6m
Florida's Turnpike South
223.2 mi in|~4h 6m
Florida's Turnpike Toll South
328.9 mi in|~6h 3m|via Homestead Extension of Florida's Turnpike
Homestead
328.9 mi in|~6h 3m|via Homestead Extension of Florida's Turnpike
Jacksonville occupies one of the most coveted spots on the Atlantic coast. Set amongst abundant beaches and possessing an ideal subtropical climate, its crown jewel is the unique habitat and natural beauty of the St. Johns River. For this reason and more, "The River City" is a popular destination for vacationers looking for a laid-back Sunshine State escape.
Top landmarks
•Fort Caroline — fort in Florida managed by the National Park Service
•Museum of Contemporary Art Jacksonville — museum in Jacksonville, Florida
•Timucuan Ecological and Historic Preserve — wetlands in Florida (U.S.) managed by the National Park Service
Doable as a same-day drive at 7h 27m. Total distance: 395.8 miles.
Family Friendly
Moderate complexity with 2 natural rest stops along the way.
Solo Traveler
7h 27m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 219.5 miles on I 95. The full list of main roads is in the Roads section above.
Expect about $10.18 in tolls one way, starting with Florida's Turnpike. Most Northeast and Midwest toll agencies accept E-ZPass; in the West and Texas, transponders like TxTag or FasTrak apply. If you do not have a transponder, cashless tolling plates will mail a bill to the vehicle's registered address — usually with a surcharge, so a rental-car toll pass is often cheaper than paying by mail.
Yes — we found about 29 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at North Key Largo, FL before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 2 meaningful breaks. There are 29 rest areas along the route for bathroom stops.
The main spots that need attention: at 2.3 miles: Highway fork - watch signs carefully. Lane positioning matters here; at 221.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 222.4 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Yes — Fort Matanzas National Monument, Castillo de San Marcos National Monument and Canaveral National Seashore (5 total within detour distance). See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 7.5 hours each way, a round trip means 14.9 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at North Key Largo, FL before the return drive.
