Planning a trip from Harrisburg, PA to Neshannock, PA? This drive covers 243 miles and is estimated to take around 4 hours and 53 minutes. You'll primarily be on the Keystone Shortway and US 22, with a relatively low 17% highway share. With a fuel cost estimate of $40, this route is easily manageable as a single-day trip. The overall feel is more of a turn-heavy local drive, so don't expect a high-speed interstate experience. This journey stays within the Northeast region, making it a straightforward transit through Pennsylvania.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
121.5 miles from Harrisburg, PA
A natural place for your longest stop of the day
, about 2h 36m into the drive
.
Main Roads
Road
Distance
Duration
Keystone Shortway
107.2 mi
1h 54m
North Cameron Street
53.1 mi
1h 5m
US 22
24.5 mi
32m
Mount Nittany Expressway
17.5 mi
21m
Port Matilda Highway
10.1 mi
14m
Philipsburg Bigler Highway
7.1 mi
8m
Sharon-Mercer Road
4.2 mi
6m
Woodland Bigler Highway
2.8 mi
3m
Longest stretch:
Keystone Shortway
— 107.2 mi, about 1h 54m
Turn-by-Turn Driving Directions
Step-by-step road directions between Harrisburg, PA and Neshannock, PA.
1
Start on North 7th Street
89 ft·3 sec·North 7th Street
2
Enter roundabout onto North 7th Street
81 ft·2 sec·North 7th Street
3
Continue on North 7th Street
0.5 mi·1 min·North 7th Street
4
Turn right onto Maclay Street
0.4 mi·54 sec·Maclay Street
5
Turn left onto US 22
53 mi·1 hr 5 min·North Cameron Street
Use the left lane.
6
Keep slight left at fork onto US 22; US 322
24 mi·32 min·US 22; US 322
Toward US 22 West, US 322 West: Mount Union, State College
7
Continue on US 322; PA 144 Truck
2.6 mi·4 min·Boal Avenue
Use the straight / right lanes.
8
Continue on US 322; PA 144 Truck
18 mi·21 min·Mount Nittany Expressway
9
Keep slight right at fork onto US 322
1.0 mi·1 min·28th Division Highway
Exit 62Toward US 322 West: Philipsburg
10
Continue on US 322
10 mi·14 min·Port Matilda Highway
Use the straight lane.
11
Continue on US 322
1.0 mi·2 min·Railroad Street
12
Turn right onto US 322; PA 53
0.1 mi·10 sec·North Centre Street
13
Continue on US 322; PA 53
0.3 mi·25 sec·North Front Street
14
Continue on US 322
7.1 mi·8 min·Philipsburg Bigler Highway
15
Continue on US 322
2.8 mi·3 min·Woodland Bigler Highway
16
Turn right onto PA 970
1.6 mi·2 min·Shawville Highway
Use the straight lane.
17
Take the exit
0.3 mi·40 sec
18
Merge onto I 80
107 mi·1 hr 54 min·Keystone Shortway
19
Take the exit
0.2 mi·23 sec
Exit 15Toward US 19: Mercer
20
Keep slight right at fork
240 ft·7 sec
21
Turn straight onto US 19
2.2 mi·4 min·South Erie Street
Use the straight / right lanes.
22
Turn left onto US 62; PA 258
0.4 mi·54 sec·West Market Street
Use the left lane.
23
Continue on US 62
2.3 mi·3 min·Sharon-Mercer Road
24
Continue on US 62
1.4 mi·2 min·West Market Street
25
Continue on US 62
1.9 mi·2 min·Sharon-Mercer Road
26
Continue on US 62
0.8 mi·1 min·West Market Street
27
Continue on US 62
1.9 mi·2 min·East State Street
28
Turn left onto South Neshannock Road
1.5 mi·2 min·South Neshannock Road
29
Arrive at destination
South Neshannock Road
Trip Plan
For this 243-mile journey, a single day is definitely feasible, with a projected driving time of under 5 hours. Aim to depart in the morning to maximize daylight and allow for a relaxed pace, especially given the 'turn-heavy' nature of the drive. You have one recommended stop, so plan it strategically along the Keystone Shortway for a break. Keep an eye on your fuel, as the estimated cost is $40, and it’s wise to top off before heading into any longer stretches. The flexibility of this drive means you can adjust your timing as needed.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 121.5 miles from Harrisburg, PA, or about 2h 36m into the drive.
The longest continuous stretch on this route runs about 107.2 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 53 miles or 1h 6m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 121.5 miles or 2h 36m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h
Traffic, exits, and arrival timing usually matter more near Neshannock, PA than in the middle of the route.
Before You Leave
+
Open the route before leaving Harrisburg, PA so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Harrisburg, PA
This is one driving day of about 243 miles and 4h 53m.
Your first comfortable stop window is around 53 miles from Harrisburg, PA.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Keystone Shortway for about 107.2 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 14
5 decision points cluster between mile 0 and 232.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0 mi into trip|~0m in|North 7th Street
Enter roundabout onto North 7th Street
Roundabout - know your exit number before entering
6
54 mi into trip|~1h 8m in|US 22; US 322
Keep slight left at fork onto US 22; US 322 toward US 22 West, US 322 West: Mount Union, State College
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 22 West, US 322 West: Mount Union, St...
6
98.7 mi into trip|~2h 6m in|US 322 / 28th Division Highway
Keep slight right at fork onto US 322 / 28th Division Highway toward US 322 West: Philipsburg
Highway fork - watch signs carefully
Exit 62
Toward US 322 West: Philipsburg
5
122.8 mi into trip|~2h 37m in
Take the exit
Exit ramp - move to the correct lane early
6
232.7 mi into trip|~4h 38m in|US 62; PA 258 / West Market Street
Turn left onto US 62; PA 258 / West Market Street
Lane positioning matters here
Use the left lane.
Fuel & Cost
Regular Gas
$40.29 one way
$80.57 round trip
$4.21/gal25.4 MPG avg85 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.61
$44.12
$88.25
premium
$4.93
$47.13
$94.25
diesel
$5.61
$53.65
$107.30
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$40
Meals
$25–$50
Total
$65–$90
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 85 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $26 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
72.9
0
$25.51
$11.66
Efficient EV
60.8
0
$21.26
$9.72
EV Truck/SUV
97.2
1
$34.02
$15.55
Gas CO2
85 kg
EV CO2
28 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Harrisburg, PA
Morning
in Harrisburg on Sunday
Local time
6:20 AM
EDT
Current temp
64°F
Unavailable
Live forecast
Destination
Neshannock, PA
Morning
in Neshannock on Sunday
Local time
6:20 AM
EDT
Current temp
69°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
5 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 53m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Carlisle Federal Indian Boarding School National Monument
National Monument
More than 7,800 children from 140 Tribes went to the Carlisle School from 1879 to 1918. The National Park Service will collaborate with families, affiliated Tribal Nations, the US Army, historians, an...
The Appalachian Trail is a 2,190+ mile long public footpath that traverses the scenic, wooded, pastoral, wild, and culturally resonant lands of the Appalachian Mountains. Conceived in 1921, built by p...
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route offers a 'turn-heavy local drive' profile, meaning you'll experience a good amount of transitions and possibly slower speeds on local roads. With only a 17% highway share, much of your time will be spent on roads like North Cameron Street and US 22, interspersed with the Keystone Shortway. The longest uninterrupted stretch you'll encounter is 107.2 miles on the Keystone Shortway, providing a significant period of consistent travel. Be prepared for varied road conditions and speeds as you navigate between these segments.
Only 17% highway — the rest is turn-by-turn surface driving.
29 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 107.2 mi on Keystone Shortway.
How Hard Is This Drive?
7/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near North 7th Street.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 14 significant decision points across 243 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: near the start (North 7th Street): Roundabout - know your exit number before entering; at 54 miles (US 22; US 322): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 98.7 miles (US 322 / 28th Division Highway): Highway fork - watch signs carefully.
Elevation Profile
Gently rolling terrain
2,053 ft332 ft
Total Climb
2,682 ft
Total Descent
1,888 ft
Highest Point
2,053 ft
~104.2 mi in
Elevation Range
1,721 ft
Notable High Points
1,665 ft at ~69.4 miles+564 ft prominence
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Harrisburg, PA to Neshannock, PA, road signs begin pointing toward State College along the way.
Harrisburg is the capital and 4th-largest metropolitan area of Pennsylvania, with a metro population of 592,000 people in 2020. Harrisburg is known as the host city of the Pennsylvania Farm Show, the largest free indoor agriculture exposition in the United States, the largest annual outdoor sports show in North America, an auto show, which features a large static display of new and classic cars, and Motorama, a two-day event consisting of a car show, motocross racing, and remote control car racing.
Doable as a same-day drive at 4h 53m. Total distance: 243 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 53m drive, comfortable solo distance.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 107.2 miles on Keystone Shortway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Neshannock, PA before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: near the start (North 7th Street): Roundabout - know your exit number before entering; at 54 miles (US 22; US 322): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 98.7 miles (US 322 / 28th Division Highway): Highway fork - watch signs carefully.
Yes — Carlisle Federal Indian Boarding School National Monument and Appalachian National Scenic Trail. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.9 hours each way, an in-and-out day trip would put you behind the wheel for 9.8 hours — manageable with a long break at Neshannock, PA, but most travelers stay overnight.
