Harrisburg to Greenville is 209.7 miles and takes about 4h 28m via Keystone Shortway and US 22, with a fuel budget near $35 and enough daylight to finish in a day. This trip stays within Pennsylvania, traveling from the Northeast region to the Northeast region. The route primarily utilizes surface roads, so expect a more leisurely pace compared to a full interstate drive. With only one recommended stop and a manageable duration, it's a straightforward option for a single-day excursion.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
104.9 miles from Harrisburg, PA
A natural place for your longest stop of the day
, about 2h 15m into the drive
.
Main Roads
Road
Distance
Duration
Keystone Shortway
60.1 mi
1h 4m
North Cameron Street
53.1 mi
1h 5m
US 22
24.5 mi
32m
Mount Nittany Expressway
17.5 mi
21m
Port Matilda Highway
10.1 mi
14m
PA 68
8.9 mi
13m
Main Street
8.5 mi
12m
Philipsburg Bigler Highway
7.1 mi
8m
Longest stretch:
Keystone Shortway
— 60.1 mi, about 1h 4m
Traffic on I-80
Hour-of-day weekday pattern from 8 FHWA count stations on your route.
Peak
3 PM
~1,036 veh/hr typical
· worst 1,332
Quietest
2 AM
~180 veh/hr
Peak-to-quiet ratio
5.8×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Harrisburg, PA and Greenville, PA.
1
Start on North 7th Street
89 ft·3 sec·North 7th Street
2
Enter roundabout onto North 7th Street
81 ft·2 sec·North 7th Street
3
Continue on North 7th Street
0.5 mi·1 min·North 7th Street
4
Turn right onto Maclay Street
0.4 mi·54 sec·Maclay Street
5
Turn left onto US 22
53 mi·1 hr 5 min·North Cameron Street
Use the left lane.
6
Keep slight left at fork onto US 22; US 322
24 mi·32 min·US 22; US 322
Toward US 22 West, US 322 West: Mount Union, State College
7
Continue on US 322; PA 144 Truck
2.6 mi·4 min·Boal Avenue
Use the straight / right lanes.
8
Continue on US 322; PA 144 Truck
18 mi·21 min·Mount Nittany Expressway
9
Keep slight right at fork onto US 322
1.0 mi·1 min·28th Division Highway
Exit 62Toward US 322 West: Philipsburg
10
Continue on US 322
10 mi·14 min·Port Matilda Highway
Use the straight lane.
11
Continue on US 322
1.0 mi·2 min·Railroad Street
12
Turn right onto US 322; PA 53
0.1 mi·10 sec·North Centre Street
13
Continue on US 322; PA 53
0.3 mi·25 sec·North Front Street
14
Continue on US 322
7.1 mi·8 min·Philipsburg Bigler Highway
15
Continue on US 322
2.8 mi·3 min·Woodland Bigler Highway
16
Turn right onto PA 970
1.6 mi·2 min·Shawville Highway
Use the straight lane.
17
Take the exit
0.3 mi·40 sec
18
Merge onto I 80
60 mi·1 hr 4 min·Keystone Shortway
19
Take the exit
0.2 mi·24 sec
Toward PA 68: Sligo, Clarion
20
Keep slight left at fork
277 ft·13 sec
21
Turn left onto PA 68
8.9 mi·13 min·PA 68
22
Turn left onto PA 68
4.5 mi·6 min·Colrain Street
23
Continue on PA 68
8.5 mi·12 min·Main Street
24
Continue on PA 68
0.4 mi·38 sec·Kellys Way
25
Turn left onto PA 68
266 ft·4 sec·Clarion Street
26
Continue on PA 68
2.2 mi·4 min·Sergeant Carl F. Curran II Bridge
27
Turn left onto Kittanning Hollow Road
1.9 mi·7 min·Kittanning Hollow Road
28
Turn right onto T650
63 ft·2 sec·Holder Hill Road
29
Arrive at destination
T650
Trip Plan
To make the most of this 4-hour drive, consider departing Harrisburg early in the morning to take advantage of lighter traffic. With a total distance of 209.7 miles and only one recommended stop, you have flexibility in pacing. Keep an eye on your fuel gauge, especially as you transition to surface roads, where gas stations might be less frequent than on major interstates. The estimated fuel cost is around $35, so plan accordingly. Since this is easily a one-day trip, you can afford to be spontaneous with brief stops if you see something of interest along US 22.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 104.9 miles from Harrisburg, PA, or about 2h 15m into the drive.
The longest continuous stretch on this route runs about 60.1 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 46 miles or 58m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 104.9 miles or 2h 15m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 30m
Traffic, exits, and arrival timing usually matter more near Greenville, PA than in the middle of the route.
Before You Leave
+
Open the route before leaving Harrisburg, PA so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Harrisburg, PA
This is one driving day of about 209.7 miles and 4h 28m.
Your first comfortable stop window is around 46 miles from Harrisburg, PA.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Keystone Shortway for about 60.1 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 16
5 decision points cluster between mile 0 and 183.2 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0 mi into trip|~0m in|North 7th Street
Enter roundabout onto North 7th Street
Roundabout - know your exit number before entering
6
54 mi into trip|~1h 8m in|US 22; US 322
Keep slight left at fork onto US 22; US 322 toward US 22 West, US 322 West: Mount Union, State College
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward US 22 West, US 322 West: Mount Union, St...
6
98.7 mi into trip|~2h 6m in|US 322 / 28th Division Highway
Keep slight right at fork onto US 322 / 28th Division Highway toward US 322 West: Philipsburg
Highway fork - watch signs carefully
Exit 62
Toward US 322 West: Philipsburg
5
122.8 mi into trip|~2h 37m in
Take the exit
Exit ramp - move to the correct lane early
5
183.2 mi into trip|~3h 42m in
Take the exit toward PA 68: Sligo, Clarion
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward PA 68: Sligo, Clarion
Fuel & Cost
Regular Gas
$33.44 one way
$66.87 round trip
$4.05/gal25.4 MPG avg73 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.48
$37.00
$74.01
premium
$4.81
$39.69
$79.39
diesel
$4.80
$39.60
$79.19
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$33
Meals
$25–$50
Total
$58–$83
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 73.4 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $22 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
62.9
0
$22.02
$10.07
Efficient EV
52.4
0
$18.35
$8.39
EV Truck/SUV
83.9
1
$29.36
$13.42
Gas CO2
73 kg
EV CO2
25 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 19, 2026
Origin
Harrisburg, PA
Late night
in Harrisburg on Monday
Local time
3:20 AM
EDT
Current temp
69°F
Showers And Thunderstorms Likely
W 6 to 9 mph59% chanceLive forecast
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued July 18 at 8:12PM EDT until July 18 at 8:15PM EDT by NWS Pittsburgh PA
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued July 18 at 8:12PM EDT until July 18 at 8:15PM EDT by NWS Pittsburgh PA
Destination
Greenville, PA
Late night
in Greenville on Monday
Local time
3:20 AM
EDT
Current temp
60°F
Showers And Thunderstorms then Mostly Cloudy
NW 7 mph85% chanceLive forecast
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued July 18 at 8:12PM EDT until July 18 at 8:15PM EDT by NWS Pittsburgh PA
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued July 18 at 8:12PM EDT until July 18 at 8:15PM EDT by NWS Pittsburgh PA
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
9 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 28m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Carlisle Federal Indian Boarding School National Monument
National Monument
More than 7,800 children from 140 Tribes went to the Carlisle School from 1879 to 1918. The National Park Service will collaborate with families, affiliated Tribal Nations, the US Army, historians, an...
The Appalachian Trail is a 2,190+ mile long public footpath that traverses the scenic, wooded, pastoral, wild, and culturally resonant lands of the Appalachian Mountains. Conceived in 1921, built by p...
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This drive features a highway share of 24%, meaning you'll spend most of your time on surface roads. You'll encounter the longest stretch of continuous driving on the Keystone Shortway for 60.1 miles. Expect to transition from more direct highway segments to surface roads, which often means more local traffic and intersections to navigate. The profile of the route suggests a generally consistent driving experience without significant elevation changes.
Only 24% highway — the rest is turn-by-turn surface driving.
29 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 60.1 mi on Keystone Shortway.
How Hard Is This Drive?
6/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. You will hit about 16 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near North 7th Street.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 209.7 miles you will encounter 16 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (North 7th Street): Roundabout - know your exit number before entering; at 54 miles (US 22; US 322): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 98.7 miles (US 322 / 28th Division Highway): Highway fork - watch signs carefully.
Elevation Profile
Gently rolling terrain
2,185 ft332 ft
Total Climb
2,549 ft
Total Descent
1,617 ft
Highest Point
2,185 ft
~134.8 mi in
Elevation Range
1,853 ft
Notable High Points
2,163 ft at ~104.9 miles+575 ft prominence
2,185 ft at ~134.8 miles+597 ft prominence
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Harrisburg, PA and Greenville, PA, road signs point toward State College and Clarion.
Harrisburg is the capital and 4th-largest metropolitan area of Pennsylvania, with a metro population of 592,000 people in 2020. Harrisburg is known as the host city of the Pennsylvania Farm Show, the largest free indoor agriculture exposition in the United States, the largest annual outdoor sports show in North America, an auto show, which features a large static display of new and classic cars, and Motorama, a two-day event consisting of a car show, motocross racing, and remote control car racing.
Top landmarks
•Pennsylvania State Capitol — state capitol building of the U.S. state of Pennsylvania
•Cathedral of Saint Patrick — cathedral of the Catholic Church in downtown Harrisburg, Pennsylvania, United St...
•Harrisburg Transportation Center — intermodal station in Harrisburg, Pennsylvania
Doable as a same-day drive at 4h 28m. Total distance: 209.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 28m drive, comfortable solo distance.
Scenic Drive
Mostly surface roads route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 60.1 miles on Keystone Shortway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Greenville, PA before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: near the start (North 7th Street): Roundabout - know your exit number before entering; at 54 miles (US 22; US 322): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 98.7 miles (US 322 / 28th Division Highway): Highway fork - watch signs carefully.
Yes — Carlisle Federal Indian Boarding School National Monument and Appalachian National Scenic Trail. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.5 hours each way, an in-and-out day trip would put you behind the wheel for 9.0 hours — manageable with a long break at Greenville, PA, but most travelers stay overnight.
