This 219.7-mile drive from Greenwood, MO to O'Fallon, MO is a manageable one-day trip, taking approximately 3 hours and 18 minutes. You'll navigate primarily local roads, including Southeast Ranson Road and Southeast Todd George Parkway, with a segment on US 50 West. With a fuel cost estimated at $33 and only one recommended stop, this route offers a straightforward journey through the Midwest. The 'turn-heavy local drive' profile suggests you'll be making frequent adjustments, so plan for a more engaged driving experience rather than a simple highway cruise. It's a practical choice if you're looking for an efficient way to connect these two Missouri communities without extensive highway time.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
108.6 miles from Greenwood, MO
A natural place for your longest stop of the day
, about 2h 3m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
142.5 mi
2h 42m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
MO 291
9.3 mi
12m
Southeast Ranson Road
2.4 mi
4m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi
1m
Truman/Eisenhower Presidential Highway
1.1 mi
1m
North Ranson Road
1 mi
2m
Longest stretch:
Dwight D. Eisenhower Highway
— 142.5 mi, about 2h 42m
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenwood, MO and O'Fallon, MO.
1
Start on North Ranson Road
1.0 mi·2 min·North Ranson Road
2
Continue on Southeast Ranson Road
2.4 mi·4 min·Southeast Ranson Road
3
Continue on Southeast Todd George Parkway
0.1 mi·21 sec·Southeast Todd George Parkway
4
Turn left
0.2 mi·33 sec
Toward US 50 West: Raytown, Kansas CityUse the left lane.
5
Merge onto US 50
0.8 mi·1 min·US 50
6
Take the exit
0.2 mi·26 sec
Toward MO 291 North: Hamblen Road, IndependenceUse the straight / slight right lanes.
7
Turn slight right
212 ft·5 sec
8
Turn straight onto MO 291
9.3 mi·12 min·MO 291
9
Take the exit
0.4 mi·44 sec
Exit 16BToward I 70 East: Saint LouisUse the slight right lane.
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
13
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
14
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
15
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
16
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
17
Continue on I 70; US 40
88 mi·1 hr 44 min·Dwight D. Eisenhower Highway
Use the straight / slight right lanes.
18
Take the exit
0.3 mi·43 sec
Toward MO K: O'FallonUse the straight / slight right lanes.
19
Turn straight onto Drennen Parkway
150 ft·3 sec·Drennen Parkway
Toward MO K: O'Fallon
20
Keep slight right at fork onto Drennen Parkway
166 ft·5 sec·Drennen Parkway
Toward MO K: O'Fallon
21
Turn slight left
62 ft·2 sec
Toward MO K: O'Fallon
22
Continue on South Main Street
0.6 mi·1 min·South Main Street
23
Turn right
25 ft·1 sec
24
Arrive at destination
Trip Plan
Given the 3-hour and 18-minute duration, this 219.7-mile trip is best tackled in a single day. Aim to depart early to avoid potential local traffic congestion, especially as you navigate the numerous turns. With an estimated fuel cost of $33 and only one stop suggested, you can be quite flexible with your timing. Keep an eye on your GPS, as the 'turn-heavy local drive' profile means constant vigilance is needed to follow the correct sequence of roads like Southeast Ranson Road and Southeast Todd George Parkway. Having a full tank of gas before you leave Greenwood, MO, will ensure you're prepared for the entire journey without needing to search for fuel.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 108.6 miles from Greenwood, MO, or about 2h 3m into the drive.
The longest continuous stretch on this route runs about 142.5 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 48 miles or 58m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 108.6 miles or 2h 3m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 24m
Traffic, exits, and arrival timing usually matter more near O'Fallon, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Greenwood, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Greenwood, MO
This is one driving day of about 217.2 miles and 4h 12m.
Your first comfortable stop window is around 48 miles from Greenwood, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 142.5 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 10
5 decision points cluster between mile 3.6 and 216.6 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
3.6 mi into trip|~7m in
Turn left toward US 50 West: Raytown, Kansas City
Lane positioning matters here. Multiple destination signs - pick the right one
Use the left lane.
Toward US 50 West: Raytown, Kansas City
7
4.6 mi into trip|~8m in
Take the exit toward MO 291 North: Hamblen Road, Independence
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward MO 291 North: Hamblen Road, Independence
7
14.2 mi into trip|~21m in
Take the exit toward I 70 East: Saint Louis
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 16B
Toward I 70 East: Saint Louis
6
216.2 mi into trip|~4h 9m in
Take the exit toward MO K: O'Fallon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Toward MO K: O'Fallon
6
216.6 mi into trip|~4h 10m in|Drennen Parkway
Keep slight right at fork onto Drennen Parkway toward MO K: O'Fallon
Highway fork - watch signs carefully
Toward MO K: O'Fallon
Fuel & Cost
Regular Gas
$33.96 one way
$67.91 round trip
$3.97/gal25.4 MPG avg76 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$37.28
$74.57
premium
$4.89
$41.80
$83.60
diesel
$5.61
$47.96
$95.91
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$34
Meals
$25–$50
Total
$59–$84
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 76 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $23 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
65.2
0
$22.81
$10.43
Efficient EV
54.3
0
$19.01
$8.69
EV Truck/SUV
86.9
1
$30.41
$13.90
Gas CO2
76 kg
EV CO2
25 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Greenwood, MO
Late night
in Greenwood on Sunday
Local time
2:49 AM
CDT
Current temp
55°F
Unavailable
Live forecast
Destination
O'Fallon, MO
Late night
in O'Fallon on Sunday
Local time
2:49 AM
CDT
Current temp
57°F
Unavailable
Live forecast
74°F
Columbia, MO
109 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 12m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a 'turn-heavy local drive' on this route, with zero highway percentage. This means your journey will be characterized by numerous turns and changes in direction as you utilize roads like Southeast Ranson Road and Southeast Todd George Parkway. While there isn't a 'longest stretch' noted, the absence of highway driving suggests a consistent pace dictated by local traffic and road conditions. This type of route often allows for a more intimate feel of the landscape between the two points, contrasting sharply with the high-speed monotony of interstate travel. Be prepared for a more interactive driving experience that requires constant attention to navigation.
Only 5% highway — the rest is turn-by-turn surface driving.
24 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 142.5 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
7/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 3.6 miles in.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 10 significant decision points across 217.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 3.6 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 4.6 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 14.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 12m. Total distance: 217.2 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 12m drive, comfortable solo distance.
Scenic Drive
Mostly surface roads route profile.
Frequently Asked Questions
The longest stretch is about 142.5 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at O'Fallon, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 3.6 miles: Lane positioning matters here. Multiple destination signs - pick the right one; at 4.6 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 14.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Possible but tiring. At 4.2 hours each way, an in-and-out day trip would put you behind the wheel for 8.4 hours — manageable with a long break at O'Fallon, MO, but most travelers stay overnight.
