Traveling from Greenville to Hattiesburg spans 208.8 miles and takes approximately 4 hours and 23 minutes of driving time. Because this journey fits comfortably into a single day, you won't need to worry about booking an overnight stay unless you prefer a slower pace. You will primarily navigate via Highway 49 South, with transitions through North Martin Luther King Drive and Jerry Clower Boulevard. Expect to budget roughly $32 for fuel to complete the trip. Since both cities are located within the Southeast region of Mississippi, the drive offers a consistent look at the state's geography. It is a straightforward route that works well for travelers looking to get from the Delta region down toward the Pine Belt without a complicated itinerary.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
104.4 miles from Greenville, MS
A natural place for your longest stop of the day
, about 2h 11m into the drive
.
Main Roads
Road
Distance
Duration
Highway 49 South
80.3 mi
1h 37m
North Martin Luther King Drive
46.2 mi
55m
Jerry Clower Boulevard
38.8 mi
47m
US 82
15.8 mi
19m
US 49
12.8 mi
17m
MS 182
9.2 mi
13m
Old Highway 42
1.8 mi
3m
North Main Street
1.2 mi
2m
Longest stretch:
Highway 49 South
— 80.3 mi, about 1h 37m
Turn-by-Turn Driving Directions
Step-by-step road directions between Greenville, MS and Hattiesburg, MS.
1
Start on MS 814
10 ft·7 sec·South Broadway Street
2
Turn left onto Main Street
0.9 mi·2 min·Main Street
3
Turn left onto MS 182
9.2 mi·13 min·MS 182
4
Turn left onto US 82; US 278
16 mi·19 min·US 82; US 278
Use the straight lane.
5
Turn right onto US 49W
46 mi·55 min·North Martin Luther King Drive
6
Keep slight right at fork onto US 49W
0.5 mi·53 sec·US 49W
Toward US 49 South: Jackson
7
Merge onto US 49
39 mi·47 min·Jerry Clower Boulevard
8
Take the exit onto US 49
4.9 mi·5 min·US 49
9
Keep slight left at fork onto US 49
3.8 mi·5 min·US 49
10
Merge onto I 20; I 55; US 49
1.1 mi·1 min·I 20; I 55; US 49
11
Keep slight right at fork onto I 20; US 49
347 ft·4 sec·I 20; US 49
Toward Meridian, Hattiesburg
12
Take the exit onto US 49
0.6 mi·42 sec·US 49
Toward Hattiesburg
13
Keep slight right at fork onto US 49
0.7 mi·1 min·US 49
Toward Richland, Hattiesburg
14
Merge onto US 49
80 mi·1 hr 37 min·Highway 49 South
Use the straight lane.
15
Continue on US 49; MS 42
0.4 mi·35 sec·US 49; MS 42
Use the straight lane.
16
Continue on US 49; MS 42
2.4 mi·4 min·US 49; MS 42
Use the straight lane.
17
Turn left onto Old Highway 42
1.8 mi·3 min·Old Highway 42
Use the left lane.
18
Turn right onto North Main Street
1.2 mi·2 min·North Main Street
Use the straight / right lanes.
19
Turn left onto Batson Street
154 ft·8 sec·Batson Street
20
Turn right
329 ft·25 sec
21
At end of road, turn right onto US 11
98 ft·4 sec·East Pine Street
22
Arrive at destination
US 11
Trip Plan
Planning your departure for the morning is your best bet to ensure you arrive in Hattiesburg with plenty of daylight to spare. Given the four-plus hour duration, scheduling at least one stop is recommended to break up the monotony of the highway stretches. Because you are only looking at a single stop, use your fuel budget of $32 to keep your tank topped off during that break, especially when transitioning off the longer 80.3-mile stretch of Highway 49. Flexibility is a major advantage here, as the manageable length allows you to adjust your pace based on traffic or personal preference. Keep a close eye on your navigation when moving through the local sections of Greenville to ensure a smooth start to your trek.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 104.4 miles from Greenville, MS, or about 2h 11m into the drive.
The longest continuous stretch on this route runs about 80.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 46 miles or 59m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 104.4 miles or 2h 11m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 33m
Traffic, exits, and arrival timing usually matter more near Hattiesburg, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Greenville, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Greenville, MS
This is one driving day of about 208.8 miles and 4h 23m.
Your first comfortable stop window is around 46 miles from Greenville, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Highway 49 South for about 80.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 17
5 decision points cluster between mile 72.1 and 205.6 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
72.1 mi into trip|~1h 31m in|US 49W
Keep slight right at fork onto US 49W toward US 49 South: Jackson
Highway fork - watch signs carefully
Toward US 49 South: Jackson
6
121.2 mi into trip|~2h 32m in|I 20; US 49
Keep slight right at fork onto I 20; US 49 toward Meridian, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Meridian, Hattiesburg
6
121.8 mi into trip|~2h 32m in|US 49
Keep slight right at fork onto US 49 toward Richland, Hattiesburg
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward Richland, Hattiesburg
5
122.6 mi into trip|~2h 34m in|US 49 / Highway 49 South
Merge onto US 49 / Highway 49 South
Merge point - match speed before joining. Lane positioning matters here
Use the straight lane.
5
205.6 mi into trip|~4h 16m in|Old Highway 42
Turn left onto Old Highway 42
Lane positioning matters here
Use the left lane.
Fuel & Cost
Regular Gas
$31.53 one way
$63.07 round trip
$3.84/gal25.4 MPG avg73 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.21
$34.62
$69.23
premium
$4.56
$37.48
$74.95
diesel
$5.61
$46.10
$92.20
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$32
Meals
$25–$50
Total
$57–$82
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 73.1 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $22 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
62.6
0
$21.92
$10.02
Efficient EV
52.2
0
$18.27
$8.35
EV Truck/SUV
83.5
1
$29.23
$13.36
Gas CO2
73 kg
EV CO2
24 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 14, 2026
Origin
Greenville, MS
Late night
in Greenville on Sunday
Local time
3:03 AM
CDT
Current temp
77°F
Unavailable
Live forecast
Destination
Hattiesburg, MS
Late night
in Hattiesburg on Sunday
Local time
3:03 AM
CDT
Current temp
86°F
Sunny
S 10 mph0% chanceLive forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
9 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 23m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Medgar and Myrlie Evers Home National Monument
National Monument
Medgar and Myrlie Evers were partners in the civil rights struggle. The assassination of Medgar Evers in the carport of their home on June 12, 1963, was the first murder of a nationally significant le...
3 mi from route
~7 min detour
Free
near mile 115.2
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This trip features a mixed drive profile, offering a blend of fast-paced highway segments and local navigation. With 58% of the journey spent on highways, you will experience varied road conditions rather than a monotonous interstate grind. Your longest uninterrupted stretch occurs on Highway 49 South, where you will cover 80.3 miles at a time. The transition between different road types requires you to stay alert as you move from local thoroughfares like Jerry Clower Boulevard onto the primary highway arteries. You should anticipate a dynamic driving experience that shifts in intensity as you move through different traffic environments along the 208.8-mile path.
58% highway, the rest on surface roads — varied driving throughout.
22 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 80.3 mi on Highway 49 South.
How Hard Is This Drive?
8/10
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 72.1 miles in near US 49W.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 17 significant decision points across 208.8 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 72.1 miles (US 49W): Highway fork - watch signs carefully; at 121.2 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 121.8 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
379 ft107 ft
Total Climb
308 ft
Total Descent
270 ft
Highest Point
379 ft
~164.1 mi in
Elevation Range
272 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Greenville, MS and Hattiesburg, MS, road signs point toward Meridian and Richland.
Greenville is a city in Washington County, Mississippi, United States. The population was 30,000 in 2020, making it the ninth largest city in the state. It is the county seat of Washington County.
Doable as a same-day drive at 4h 23m. Total distance: 208.8 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 23m drive, comfortable solo distance.
Scenic Drive
Mixed highway & surface route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 80.3 miles on Highway 49 South. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Hattiesburg, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 72.1 miles (US 49W): Highway fork - watch signs carefully; at 121.2 miles (I 20; US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 121.8 miles (US 49): Highway fork - watch signs carefully. Multiple destination signs - pick the right one.
Yes — Medgar and Myrlie Evers Home National Monument. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.4 hours each way, an in-and-out day trip would put you behind the wheel for 8.8 hours — manageable with a long break at Hattiesburg, MS, but most travelers stay overnight.
