Altoona, PA to Blairsville, PA is 54.3 miles and takes about 1h 16m via US 22, with a fuel budget near $9 and enough daylight to finish in a day. This drive stays within Pennsylvania, offering a relatively short journey through the Northeast region. The route is primarily on US 22, also known as the William Penn Highway, which provides a direct connection between these two towns. With a drive time under two hours and minimal stops recommended, it's a straightforward trip suitable for a single day. Consider this route if you need a quick and efficient transit between Altoona and Blairsville without extensive detours.