Origin
Tupelo, MS
Morning in Tupelo on Tuesday
Local time
7:21 AM
CDT
Current temp
79°F
Unavailable
Live forecast
Trip from Tupelo, MS to Glendale, MS
Pin this tripCompiled and reviewed by the US Trip Planner planning team at COD Solutions Oy · Last reviewed Apr 21, 2026 · Editorial standards
Drive Time
4h 22m
Distance
227.4 mi
366 km
Drive Score
8/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$34
one way
EV Charging
Unknown
Best Time to Leave
4 AM
4h 9m
★
6 AM
4h 23m
8 AM
4h 49m
10 AM
4h 32m
12 PM
4h 29m
3 PM
4h 33m
5 PM
4h 48m
8 PM
4h 15m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Tupelo, MS
Wikimedia Commons
Glendale, MS
大 董
Trip Overview
This 227.4-mile drive from Tupelo, Mississippi, to Glendale, Mississippi, is best tackled in a single day, taking approximately 4 hours and 22 minutes. You'll primarily be on I-59 and US Highway 45 Alternate, with 94% of the journey on highways, making it a straightforward, highway-focused trip. With an estimated fuel cost of $34, it's an economical option for a quick getaway within the Southeast region. This route is designed for efficient travel, allowing you to cover a good distance without needing an overnight stop.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
113.7 miles from Tupelo, MS
A natural place for your longest stop of the day , about 2h 15m into the drive .
Main Roads
| Road | Distance | Duration |
|---|---|---|
| I 59 | 78 mi | 1h 24m |
| US Highway 45 Aiternate | 60.6 mi | 1h 9m |
| US Highway 45 Alternate | 54.7 mi | 1h 6m |
| Martin Luther King Drive | 8.7 mi | 10m |
| I 20 | 8.1 mi | 9m |
| US 45 ALT | 7.2 mi | 8m |
| US 45 | 3.9 mi | 4m |
| Martin Luther King, Junior Drive | 2.3 mi | 2m |
Longest stretch:
I 59
— 78 mi, about 1h 24m
Turn-by-Turn Driving Directions
Step-by-step road directions between Tupelo, MS and Glendale, MS.
1
Start on North Spring Street
68 ft
·
5 sec
·
North Spring Street
2
Turn right onto Court Street
317 ft
·
16 sec
·
Court Street
3
Turn right onto North Front Street
287 ft
·
15 sec
·
North Front Street
4
Turn left onto East Main Street
0.5 mi
·
1 min
·
East Main Street
Use the left lane.
5
Take the ramp
0.4 mi
·
55 sec
6
Merge onto US 45; MS 6
1.0 mi
·
1 min
·
Martin Luther King Drive
7
Continue on US 45; MS 6
2.3 mi
·
2 min
·
Martin Luther King, Junior Drive
8
Continue on US 45; US 278
7.7 mi
·
8 min
·
Martin Luther King Drive
9
Continue on US 45 ALT
1.4 mi
·
1 min
·
US 45 ALT
10
Continue on US 45 ALT
2.2 mi
·
2 min
·
US 45 ALT
11
Continue on US 45 ALT
1.5 mi
·
1 min
·
US 45 ALT
12
Continue on US 45 ALT
0.7 mi
·
49 sec
·
US 45 ALT
13
Continue on US 45 ALT
1.4 mi
·
1 min
·
US 45 ALT
14
Continue on US 45 ALT
55 mi
·
1 hr 6 min
·
US Highway 45 Alternate
Use the straight lane.
15
Continue on US 45
61 mi
·
1 hr 9 min
·
US Highway 45 Aiternate
16
Keep slight right at fork onto US 45
3.9 mi
·
4 min
·
US 45
17
Take the exit
0.5 mi
·
1 min
Toward I 59 South, I 20 West: Meridian
18
Merge onto I 20; I 59
6.3 mi
·
7 min
·
I 20; I 59
Use the straight / slight right lanes.
19
Continue on I 20; I 59; US 80
1.8 mi
·
2 min
·
I 20; I 59; US 80
Use the straight lane.
20
Keep slight left at fork onto I 59
78 mi
·
1 hr 24 min
·
I 59
Toward I 59 South: Laurel, New Orleans
Use the slight left / slight right lanes.
21
Take the exit
0.6 mi
·
1 min
Toward MS 42 East: Evelyn Gandy Parkway, Petal
Use the straight / slight right lanes.
22
Turn left onto MS 42
1.8 mi
·
2 min
·
Evelyn Gandy Parkway
Use the straight lane.
23
Turn right onto Glendale Avenue
246 ft
·
8 sec
·
Glendale Avenue
24
Arrive at destination
Glendale Avenue
Trip Plan
Given the 4-hour 22-minute duration, departing Tupelo in the morning is ideal to arrive in Glendale with plenty of daylight. You'll have one main stretch of 78 miles on I-59 where stops are less frequent, so ensure you're fueled up before embarking on that segment. While you can complete this 227.4-mile trip in one day, the flexibility of a shorter duration means you can take your time and make brief stops if needed. Keep an eye on your fuel gauge, as the estimated cost is $34, and plan your refills accordingly, especially before merging onto longer highway stretches.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 113.7 miles from Tupelo, MS, or about 2h 15m into the drive.
The longest continuous stretch on this route runs about 78 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 50 miles or 1h 1m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 113.7 miles or 2h 15m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 37m
Traffic, exits, and arrival timing usually matter more near Glendale, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Tupelo, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Tupelo, MS
This is one driving day of about 227.4 miles and 4h 22m.
Your first comfortable stop window is around 50 miles from Tupelo, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 59 for about 78 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Mid-route town
Meal stop
114 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 50 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 113.7 miles from Tupelo, MS, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before I 59 if your tank is already low. That segment runs about 78 miles.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Heads-up: tricky spots
5 of 115 decision points cluster between mile 0 and 225.6 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0 mi into trip
|
~0m in
|
Court Street
Turn right onto Court Street
Navigation decision point
5
0.1 mi into trip
|
~0m in
|
East Main Street
Turn left onto East Main Street
Lane positioning matters here
Use the left lane.
8
147 mi into trip
|
~2h 54m in
|
I 59
Keep slight left at fork onto I 59 toward I 59 South: Laurel, New Orleans
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 59 South: Laurel, New Orleans
7
225 mi into trip
|
~4h 18m in
Take the exit toward MS 42 East: Evelyn Gandy Parkway, Petal
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward MS 42 East: Evelyn Gandy Parkway, Petal
6
225.6 mi into trip
|
~4h 20m in
|
MS 42 / Evelyn Gandy Parkway
Turn left onto MS 42 / Evelyn Gandy Parkway
Lane positioning matters here
Use the straight lane.
Fuel & Cost
Regular Gas
$34.34 one way
$68.69 round trip
$3.84/gal
25.4 MPG avg
80 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.21 | $37.70 | $75.40 |
| premium | $4.56 | $40.82 | $81.63 |
| diesel | $5.61 | $50.21 | $100.41 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$34
Meals
$25–$50
Total
$59–$84
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 79.6 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $24 in charging · 0 stops · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 68.2 | 0 | $23.88 | $10.92 |
| Efficient EV | 56.9 | 0 | $19.90 | $9.10 |
| EV Truck/SUV | 91 | 1 | $31.84 | $14.55 |
Gas CO2
80 kg
EV CO2
27 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Destination
Glendale, MS
Morning in Glendale on Tuesday
Local time
7:21 AM
CDT
Current temp
59°F
Unavailable
Live forecast
82°F
Meridian, MS
114 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
20 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 22m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
What kind of drive is this?
Expect a predominantly highway experience on this route, with 94% of your travel occurring on high-speed roads like I-59 and US Highway 45 Alternate. The longest uninterrupted stretch you'll encounter is 78 miles on I-59, offering a chance to settle into a rhythm. While largely highway-focused, be aware that US Highway 45 Alternate may present a slightly different driving feel as you transition. Overall, this drive is characterized by its efficiency and ease of navigation for most of its 227.4 miles.
94% highway — fuel and pacing are the main things to plan.
24 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 78 mi on I 59.
How Hard Is This Drive?
7/10
This is a straightforward highway drive that stays mostly on I 59 and US Highway 45 Aiternate. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near Court Street.
Driving Effort
7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 11 significant decision points across 227.4 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: near the start (Court Street): Navigation decision point; at 0.1 miles (East Main Street): Lane positioning matters here; at 147 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from Tupelo, MS to Glendale, MS, road signs begin pointing toward New Orleans along the way.
New Orleans
147 mi in
|
~2h 54m
|
via I 59
About the Cities
Starting in Tupelo, MS
Full guide →Tupelo is a city in Northeast Mississippi that is known best for being the birthplace of Elvis Presley.
City content from Wikivoyage (CC BY-SA 4.0) and Wikidata (CC0).
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 22m. Total distance: 227.4 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 22m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (94%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 78 miles on I 59. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Glendale, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: near the start (Court Street): Navigation decision point; at 0.1 miles (East Main Street): Lane positioning matters here; at 147 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Possible but tiring. At 4.4 hours each way, an in-and-out day trip would put you behind the wheel for 8.8 hours — manageable with a long break at Glendale, MS, but most travelers stay overnight.
How this page is built
Compiled by the US Trip Planner planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, and EIA for fuel prices. See our methodology for refresh cadence and limitations.
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