Embarking on a journey from Tupelo, MS to De Lisle, MS covers approximately 309.7 miles, with an estimated driving time of 6 hours and 2 minutes. This drive is best suited for a single day, making it a manageable road trip without requiring an overnight stop. You'll primarily navigate on I-59, US Highway 45 Alternate, and US 49, with highways making up 95% of the route. Expect a fuel cost around $47 for this trip. The drive flows smoothly through the Southeast region, offering a straightforward highway-focused experience.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
154.9 miles from Tupelo, MS
A natural place for your longest stop of the day
, about 3h 2m into the drive
.
Main Roads
Road
Distance
Duration
I 59
88.7 mi
1h 36m
US Highway 45 Aiternate
60.6 mi
1h 9m
US 49
57.6 mi
1h 8m
US Highway 45 Alternate
54.7 mi
1h 6m
I 10
8.9 mi
9m
Martin Luther King Drive
8.7 mi
10m
I 20
8.1 mi
9m
US 45 ALT
7.2 mi
8m
Longest stretch:
I 59
— 88.7 mi, about 1h 36m
Traffic on I-59
Hour-of-day weekday pattern from 12 FHWA count stations on your route.
Peak
4 PM
~976 veh/hr typical
· worst 1,182
Quietest
2 AM
~88 veh/hr
Peak-to-quiet ratio
11.1×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Tupelo, MS and De Lisle, MS.
1
Start on North Spring Street
68 ft·5 sec·North Spring Street
2
Turn right onto Court Street
317 ft·16 sec·Court Street
3
Turn right onto North Front Street
287 ft·15 sec·North Front Street
4
Turn left onto East Main Street
0.5 mi·1 min·East Main Street
Use the left lane.
5
Take the ramp
0.4 mi·55 sec
6
Merge onto US 45; MS 6
1.0 mi·1 min·Martin Luther King Drive
7
Continue on US 45; MS 6
2.3 mi·2 min·Martin Luther King, Junior Drive
8
Continue on US 45; US 278
7.7 mi·8 min·Martin Luther King Drive
9
Continue on US 45 ALT
1.4 mi·1 min·US 45 ALT
10
Continue on US 45 ALT
2.2 mi·2 min·US 45 ALT
11
Continue on US 45 ALT
1.5 mi·1 min·US 45 ALT
12
Continue on US 45 ALT
0.7 mi·49 sec·US 45 ALT
13
Continue on US 45 ALT
1.4 mi·1 min·US 45 ALT
14
Continue on US 45 ALT
55 mi·1 hr 6 min·US Highway 45 Alternate
Use the straight lane.
15
Continue on US 45
61 mi·1 hr 9 min·US Highway 45 Aiternate
16
Keep slight right at fork onto US 45
3.9 mi·4 min·US 45
17
Take the exit
0.5 mi·1 min
Toward I 59 South, I 20 West: Meridian
18
Merge onto I 20; I 59
6.3 mi·7 min·I 20; I 59
Use the straight / slight right lanes.
19
Continue on I 20; I 59; US 80
1.8 mi·2 min·I 20; I 59; US 80
Use the straight lane.
20
Keep slight left at fork onto I 59
89 mi·1 hr 36 min·I 59
Toward I 59 South: Laurel, New OrleansUse the slight left / slight right lanes.
21
Take the exit onto US 98
3.2 mi·4 min·US 98
Toward US 98 East: Lucedale, MobileUse the straight / slight right lanes.
22
Take the exit
0.3 mi·44 sec
Toward US 49: Wiggins, Gulfport, Mississippi Gulf CoastUse the straight / slight right lanes.
23
Keep slight left at fork
0.2 mi·27 sec
Toward Multi Purpose Center, HattiesburgUse the slight left / slight right lanes.
24
Turn right onto US 49
58 mi·1 hr 8 min·US 49
Use the straight lane.
25
Take the exit
0.5 mi·58 sec
Toward I 10 West: New Orleans
26
Merge onto I 10
8.9 mi·9 min·I 10
27
Take the exit
0.3 mi·36 sec
Toward Menge Avenue
28
Keep slight left at fork
128 ft·4 sec
29
Turn left onto Firetower Road
224 ft·4 sec·Firetower Road
30
Continue on Menge Avenue
1.5 mi·3 min·Menge Avenue
31
Turn right onto Cuevas-Delisle Road
1.6 mi·3 min·Cuevas-Delisle Road
32
Turn left onto Ball Park Road
69 ft·3 sec·Ball Park Road
33
Arrive at destination
Ball Park Road
Trip Plan
To make the most of this 6-hour drive, consider an early morning departure from Tupelo to avoid potential traffic. With only one recommended stop, you have flexibility in pacing your journey; however, keep in mind the longest stretch is nearly 89 miles, so plan accordingly. The fuel cost is estimated at $47, so ensure your tank is full before leaving Tupelo, as services can be more spread out on highway stretches. Given the route's highway-centric nature, staying alert for speed limit changes and any potential construction on I-59, US 45 Alternate, or US 49 is advisable.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 154.9 miles from Tupelo, MS, or about 3h 2m into the drive.
The longest continuous stretch on this route runs about 88.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 68 miles or 1h 22m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 154.9 miles or 3h 2m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 53m
Traffic, exits, and arrival timing usually matter more near De Lisle, MS than in the middle of the route.
Before You Leave
+
Open the route before leaving Tupelo, MS so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Tupelo, MS
This is one driving day of about 309.7 miles and 6h 2m.
Your first comfortable stop window is around 68 miles from Tupelo, MS.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 59 for about 88.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 19
5 decision points cluster between mile 147 and 239.4 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
147 mi into trip|~2h 54m in|I 59
Keep slight left at fork onto I 59 toward I 59 South: Laurel, New Orleans
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward I 59 South: Laurel, New Orleans
7
235.7 mi into trip|~4h 30m in|US 98
Take the exit onto US 98 toward US 98 East: Lucedale, Mobile
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 98 East: Lucedale, Mobile
7
238.9 mi into trip|~4h 34m in
Take the exit toward US 49: Wiggins, Gulfport, Mississippi Gulf Coast
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward US 49: Wiggins, Gulfport, Mississippi Gu...
9
239.2 mi into trip|~4h 35m in
Keep slight left at fork toward Multi Purpose Center, Hattiesburg
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Toward Multi Purpose Center, Hattiesburg
6
239.4 mi into trip|~4h 35m in|US 49
Turn right onto US 49
Lane positioning matters here
Use the straight lane.
Fuel & Cost
Regular Gas
$42.99 one way
$85.98 round trip
$3.53/gal25.4 MPG avg108 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$3.95
$48.10
$96.20
premium
$4.29
$52.30
$104.59
diesel
$4.80
$58.48
$116.95
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$43
Meals
$25–$50
Total
$68–$93
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 108.4 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $33 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
92.9
1
$32.52
$14.87
Efficient EV
77.4
0
$27.10
$12.39
EV Truck/SUV
123.9
1
$43.36
$19.82
Gas CO2
108 kg
EV CO2
36 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 17, 2026
Origin
Tupelo, MS
Late night
in Tupelo on Sunday
Local time
4:40 AM
CDT
Current temp
95°F
Slight Chance Showers And Thunderstorms
WNW 10 mph15% chanceLive forecast
Special Weather Statement
Special Weather Statement issued July 17 at 1:35PM CDT by NWS Jackson MS
Destination
De Lisle, MS
Late night
in De Lisle on Sunday
Local time
4:40 AM
CDT
Current temp
96°F
Mostly Sunny
W 5 mph3% chanceLive forecast
Special Weather Statement
Special Weather Statement issued July 17 at 1:35PM CDT by NWS Jackson MS
73°F
Newton, MS
155 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 2m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Tupelo National Battlefield
National Battlefield
In July, 1864, federal forces, including men from the United States Colored Troops, marched into Tupelo, Mississippi. Disorganized Confederate soldiers fought fiercely but could not overpower the fede...
The Natchez Trace National Scenic Trail is five sections of hiking trail running roughly parallel to the 444-mile long Natchez Trace Parkway scenic motor road. The foot trails total more than 60 miles...
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route is predominantly a highway-focused drive, with 95% of your journey taking place on major roadways. You'll encounter the longest uninterrupted stretch of 88.7 miles on I-59, which sets a consistent pace for a significant portion of the trip. While largely interstate, the inclusion of US Highway 45 Alternate and US 49 offers slight variations in the driving experience. Overall, expect a clear path with limited deviations, making for an efficient travel day.
95% highway — fuel and pacing are the main things to plan.
33 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 88.7 mi on I 59.
How Hard Is This Drive?
9/10
This is a straightforward highway drive that stays mostly on I 59 and US Highway 45 Aiternate. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 147 miles in near I 59.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 309.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 147 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 235.7 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 238.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Elevation Profile
Mostly flat terrain
503 ft18 ft
Total Climb
416 ft
Total Descent
675 ft
Highest Point
503 ft
~177 mi in
Elevation Range
485 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Tupelo, MS and De Lisle, MS, road signs point toward New Orleans, Mobile, Gulfport, Mississippi Gulf Coast, Multi Purpose Center and Hattiesburg.
New Orleans
147 mi in|~2h 54m|via I 59
Mobile
235.7 mi in|~4h 30m|via US 98
Gulfport
238.9 mi in|~4h 34m
Mississippi Gulf Coast
238.9 mi in|~4h 34m
Multi Purpose Center
239.2 mi in|~4h 35m
Hattiesburg
239.2 mi in|~4h 35m
Detours Along the Way
Tagged by where each one fits in your drive — first break, midpoint, final stretch.
Doable as a same-day drive at 6h 2m. Total distance: 309.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 2m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 88.7 miles on I 59. The full list of main roads is in the Roads section above.
Yes — we found about 11 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at De Lisle, MS before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 11 rest areas along the route for bathroom stops.
The main spots that need attention: at 147 miles (I 59): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 235.7 miles (US 98): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 238.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Tupelo National Battlefield and Natchez Trace National Scenic Trail. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.0 hours each way, a round trip means 12.1 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at De Lisle, MS before the return drive.
