St. Louis to Oregon County is 210.3 miles and takes about 4 hours 28 minutes via US 67 and I 55, with a fuel budget near $33 and enough daylight to finish in a day. This trip stays within Missouri, taking you from the Midwest's urban edge into its heartland. With 86% highway driving, it's a straightforward path, ideal if you're looking for an efficient way to cover ground. Plan for a single day of travel, but know you have some flexibility given the relatively short distance.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
105.1 miles from St. Louis, MO
A natural place for your longest stop of the day
, about 2h 3m into the drive
.
Main Roads
Road
Distance
Duration
US 67
81.4 mi
1h 33m
I 55
32.7 mi
37m
US 60
27.7 mi
32m
MO 19
25.9 mi
38m
North Main Street
25.8 mi
37m
MO 34
13.4 mi
19m
South Tucker Boulevard
1.3 mi
3m
US 160
0.6 mi
<1m
Longest stretch:
US 67
— 81.4 mi, about 1h 33m
Turn-by-Turn Driving Directions
Step-by-step road directions between St. Louis, MO and Oregon County, MO.
1
Start on Market Street
86 ft·4 sec·Market Street
2
Turn left onto South Tucker Boulevard
1.3 mi·3 min·South Tucker Boulevard
Use the left lane.
3
Turn straight onto Gravois Avenue
0.3 mi·46 sec·Gravois Avenue
4
Take the ramp
0.1 mi·15 sec
Toward I 55 South: MemphisUse the left lane.
5
Merge onto I 55
33 mi·37 min·I 55
Use the straight / slight right lanes.
6
Take the exit
0.2 mi·19 sec
Exit 174BToward US 67 South: Farmington, Poplar Bluff
7
Keep slight left at fork
0.1 mi·17 sec
8
Enter roundabout onto US 67
30 ft·0 sec·US 67
9
Continue on US 67
81 mi·1 hr 33 min·US 67
10
Take the exit
0.2 mi·21 sec
11
Turn right
116 ft·3 sec
12
Turn right onto MO 34
13 mi·19 min·MO 34
13
Continue on MO 34; MO 49
26 mi·37 min·North Main Street
14
Turn right onto US 60
28 mi·32 min·US 60
15
Turn left onto MO 19
26 mi·38 min·MO 19
16
Turn left onto US 160; MO 19
0.6 mi·57 sec·US 160; MO 19
17
Continue on Tucker Creek Road
0.5 mi·1 min·Tucker Creek Road
18
Arrive at destination
Tucker Creek Road
Trip Plan
To make the most of this 4-hour, 28-minute drive, aim to depart St. Louis in the morning to ensure you have ample daylight for your arrival in Oregon County. With only one recommended stop, the 81.4-mile stretch on US 67 is the longest continuous driving segment, so consider planning your fuel and rest break just before or after this section. The $33 fuel estimate is based on the total mileage, so keep an eye on your gauge, especially after leaving more populated areas. Since this is a single-day trip, you can adjust your pace as needed.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 105.1 miles from St. Louis, MO, or about 2h 3m into the drive.
The longest continuous stretch on this route runs about 81.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 46 miles or 55m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 105.1 miles or 2h 3m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 34m
Traffic, exits, and arrival timing usually matter more near Oregon County, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving St. Louis, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from St. Louis, MO
This is one driving day of about 210.3 miles and 4h 28m.
Your first comfortable stop window is around 46 miles from St. Louis, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 67 for about 81.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 12
5 decision points cluster between mile 1.7 and 34.8 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
7
1.7 mi into trip|~4m in
Take the ramp toward I 55 South: Memphis
Lane positioning matters here
Use the left lane.
Toward I 55 South: Memphis
5
1.8 mi into trip|~4m in|I 55
Merge onto I 55
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
6
34.5 mi into trip|~42m in
Take the exit toward US 67 South: Farmington, Poplar Bluff
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 174B
Toward US 67 South: Farmington, Poplar Bluff
5
34.6 mi into trip|~42m in
Keep slight left at fork
Highway fork - watch signs carefully
5
34.8 mi into trip|~42m in|US 67
Enter roundabout onto US 67
Roundabout - know your exit number before entering
Fuel & Cost
Regular Gas
$35.08 one way
$70.16 round trip
$4.24/gal25.4 MPG avg74 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.61
$38.13
$76.25
premium
$5.26
$43.54
$87.08
diesel
$6.18
$51.16
$102.32
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$35
Meals
$25–$50
Total
$60–$85
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 73.6 kg one way.
Prices: EIA weekly data, 2026-10-12.
Driving Electric?
About $22 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
63.1
0
$22.08
$10.09
Efficient EV
52.6
0
$18.40
$8.41
EV Truck/SUV
84.1
1
$29.44
$13.46
Gas CO2
74 kg
EV CO2
25 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Oct 18, 2026
Origin
St. Louis, MO
Morning
in St. Louis on Sunday
Local time
8:32 AM
CDT
Current temp
38°F
Clear
S 2 mph0% chanceLive forecast
Destination
Oregon County, MO
Morning
in Oregon County on Sunday
Local time
8:32 AM
CDT
Current temp
35°F
Clear
NE 3 mph0% chanceLive forecast
81°F
Ironton, MO
105 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
3 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 28m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Gateway Arch National Park
National Park
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
Established by 1750, Ste. Geneviève was the first permanent European settlement in Missouri. Early French Canadian settlers were drawn here by the rich agricultural land known as Le Grand Champ (the B...
25 mi from route
~62 min detour
Free
near mile 50.8
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route is primarily highway driving, with 86% of the 210.3 miles on major roads like I 55 and US 67. You'll experience a long stretch of 81.4 miles on US 67 before transitioning to more rural roads. Expect a consistent flow of traffic and frequent exits on the initial highway segments before the landscape opens up. The transition from highway to surface roads happens around mile 180.
86% highway — fuel and pacing are the main things to plan.
18 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 81.4 mi on US 67.
How Hard Is This Drive?
4/10
This is a straightforward highway drive that stays mostly on US 67 and I 55. There are only a few real navigation decisions along the way. The trickiest moment comes around 1.7 miles in.
Driving Effort4/10
Easy - simple navigation with a manageable amount of wheel time
Balances navigation complexity with total wheel time.
This is a straightforward 4h 28m drive. You will face about 12 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
The main spots that need attention: at 1.7 miles: Lane positioning matters here; at 1.8 miles (I 55): Merge point - match speed before joining. Lane positioning matters here; at 34.5 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Elevation Profile
Gently rolling terrain
916 ft410 ft
Total Climb
1,316 ft
Total Descent
1,017 ft
Highest Point
916 ft
~195.3 mi in
Elevation Range
506 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
On the drive from St. Louis, MO to Oregon County, MO, road signs begin pointing toward Poplar Bluff along the way.
The Gateway City of St. Louis is the epitome of the modern Midwestern metropolis. Missouri's second-largest city is vibrant but laid-back, populous but navigable, historic but still relevant. The city's planners have created an aesthetically beautiful city, with plenty of green space amidst buildings both old and new, framed by the majestic Mississippi and Missouri rivers. And capping it all is the world's tallest man-made monument, the beautiful and iconic Gateway Arch.
St. Louis is a city of culture and surprisingly inexpensive. Among American cities, only Washington, D.C. has more free attractions for tourists and residents alike. Hotels, restaurants, and even parking garages avoid the premium pricing common in other big cities. Although often overlooked, St. Louis can be an affordable, educational, and fun family getaway.
Top landmarks
•Gateway Arch — monument in St. Louis, Missouri
•Missouri Botanical Garden — non-profit organization in the USA
•Gateway Arch National Park — American National Park in St. Louis, Missouri
The longest stretch is about 81.4 miles on US 67. The full list of main roads is in the Roads section above.
Yes — we found about 3 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: at 1.7 miles: Lane positioning matters here; at 1.8 miles (I 55): Merge point - match speed before joining. Lane positioning matters here; at 34.5 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Yes — Gateway Arch National Park and Ste. Geneviève National Historical Park. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.5 hours each way, an in-and-out day trip would put you behind the wheel for 8.9 hours — manageable with a long break at Oregon County, MO, but most travelers stay overnight.
