Seguin, TX to Amarillo, TX is 537.9 miles and takes about 9h 30m via I 10 and US 84, with a fuel budget near $78 and enough daylight to finish in a day. This is a long-haul drive that will take you across the vast plains of Texas. While you'll start in the Great Plains region and end in the same region, the landscape shifts subtly as you head north. Consider this a direct route for getting from point A to point B efficiently, best tackled over two days to avoid fatigue.
Trip Pace
Best split across 2 days
Treat the return leg as its own travel day rather than an afterthought.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
268.9 miles from Seguin, TX
A natural place for your longest stop of the day
, about 4h 50m into the drive
.
Main Roads
Road
Distance
Duration
I 10
113.2 mi
1h 51m
Marshall Formby Memorial Highway
109.9 mi
1h 51m
US 84
74.5 mi
1h 14m
Frisco Avenue
41.9 mi
44m
State Highway 153
29.5 mi
33m
North Main Street
29.3 mi
30m
Anderson Loop
20.4 mi
22m
Highway 84
20 mi
19m
Longest stretch:
I 10
— 113.2 mi, about 1h 51m
Traffic on I-10
Hour-of-day weekday pattern from 40 FHWA count stations on your route.
Peak
4 PM
~1,124 veh/hr typical
· worst 1,604
Quietest
2 AM
~177 veh/hr
Peak-to-quiet ratio
6.4×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Seguin, TX and Amarillo, TX.
1
Start on US 90 Alt
2.1 mi·4 min·West Court Street
Use the straight / right lanes.
2
Continue on FM 464
1.0 mi·1 min·FM 464
Use the straight / right lanes.
3
Take the ramp
0.3 mi·41 sec
Toward I 10 West, TX 130 South
4
Merge onto I 10; TX 130
2.1 mi·2 min·I 10; TX 130
Use the straight / slight right lanes.
5
Continue on I 10; US 90; TX 130
9.4 mi·9 min·I 10; US 90; TX 130
Use the straight / slight right lanes.
6
Keep slight left at fork onto I 10; US 90; TX 130
1.9 mi·1 min·I 10; US 90; TX 130
7
Take the exit
0.1 mi·14 sec
Exit 591Toward TX 1518: SchertzUse the straight / slight right lanes.
8
Turn straight onto Interstate 10 East
0.1 mi·21 sec·Interstate 10 East
9
Turn right onto FM 1518
5.4 mi·9 min·Farm-to-Market Road 1518
10
At end of road, turn left onto FM 78
2.0 mi·3 min·Gordon A Blake Highway
11
Turn left
0.2 mi·21 sec
12
Take the ramp
265 ft·6 sec
Toward Loop 1604 North
13
Merge onto Loop 1604
20 mi·22 min·Anderson Loop
Use the straight / slight right lanes.
14
Take the exit
0.2 mi·20 sec
Toward Frontage RoadUse the straight / slight right lanes.
15
Turn straight onto North Loop 1604 West
0.2 mi·25 sec·North Loop 1604 West
16
Turn right onto Interstate 10 West
0.3 mi·24 sec·Interstate 10 West
17
Take the ramp
0.2 mi·19 sec
Toward I 10 West, US 87 North
18
Merge onto I 10; US 87
1.1 mi·1 min·I 10; US 87
Use the straight / slight right lanes.
19
Keep slight right at fork onto I 10; US 87
99 mi·1 hr 37 min·I 10; US 87
Use the straight / slight left lanes.
20
Take the exit onto US 83
0.3 mi·44 sec·US 83
Exit 456Toward US 83 North, US 377: Junction, Menard
21
Turn right onto US 83; US 377
29 mi·30 min·North Main Street
Use the right lane.
22
Continue on US 83
42 mi·44 min·Frisco Avenue
23
Continue on US 83
17 mi·18 min·Roberts Avenue
24
Turn right onto US 67; US 83
387 ft·18 sec·Hutchings Avenue
Use the right lane.
25
Turn left onto TX 158
6.3 mi·7 min·North Broadway Street
Use the left lane.
26
Turn right onto FM 2111
12 mi·13 min·FM 2111
27
Turn left onto TX 153
29 mi·33 min·State Highway 153
28
Keep slight right at fork onto TX 153
19 ft·0 sec·State Highway 153
29
Turn right onto TX 70
10 mi·10 min·State Highway 70
30
Continue on TX 70
0.8 mi·1 min·Lamar Street
31
Turn left onto Northwest Georgia Avenue
0.1 mi·16 sec·Northwest Georgia Avenue
32
Take the ramp
340 ft·8 sec
Toward I 20 West: Midland
33
Merge onto I 20; US 84
6.0 mi·5 min·I 20; US 84
34
Take the exit onto US 84
0.3 mi·19 sec·US 84
Exit 238AToward US 84 West: Snyder, Lubbock
35
Keep slight left at fork onto US 84
74 mi·1 hr 14 min·US 84
36
Turn right onto Loop 46
1.0 mi·1 min·South Avenue F
37
Keep slight left at fork onto TX 207
0.1 mi·10 sec·North Avenue F
38
Turn straight onto TX 207
0.4 mi·38 sec·Ralls Road
39
Turn left onto Spur 575
0.1 mi·17 sec·East 15th Street
40
Turn right onto US 84
1.0 mi·1 min·North US Highway 84
41
Continue on US 84
20 mi·19 min·Highway 84
42
Continue on US 84
4.6 mi·4 min·Trooper Jerry Don Davis Memorial Highway
43
Continue on US 84
6.8 mi·6 min·East Highway 84
44
Continue on US 84
4.5 mi·5 min·Slaton Road
45
Take the exit
0.2 mi·26 sec
46
Turn slight right onto Interstate 27
321 ft·6 sec·Interstate 27
47
Take the ramp
0.2 mi·31 sec
48
Merge onto I 27; US 87
110 mi·1 hr 51 min·Marshall Formby Memorial Highway
49
Continue on I 27; US 60; US 87
13 mi·15 min·Canyon Expressway
Use the straight / right lanes.
50
Keep slight left at fork onto US 87
0.9 mi·2 min·US 87
Toward US 87 NorthUse the slight left / slight right lanes.
51
Keep slight right at fork onto US 87; Original US Route 66
0.7 mi·1 min·South Fillmore Street
Use the straight / right lanes.
52
Turn right onto I 40 Business; Original US Route 66; US 60
105 ft·1 sec·East Amarillo Boulevard
53
Arrive at destination
I 40 Business; Original US Route 66; US 60
Trip Plan
For this 9.5-hour drive, it's highly recommended to split it over two days. Aim to leave early to maximize your daylight hours on the first day. With two recommended stops, you can plan for roughly every 3-4 hours of driving. Keep an eye on your fuel levels, especially during the longer stretches; the $78 fuel estimate should help you budget. A good place to break up the drive would be around the halfway point, giving you a solid 4.5-5 hours of driving each day.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
This drive is better paced as a 2-day trip.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 268.9 miles from Seguin, TX, or about 4h 50m into the drive.
The longest continuous stretch on this route runs about 113.2 miles.
Consider an overnight stop or starting very early.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 118 miles or 2h 8m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 268.9 miles or 4h 50m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Overnight split
Day 1 wrap after about 268.9 miles or 4h 50m
Stop before fatigue turns the last few hours into a grind. You want day two to start fresh, not just resumed.
Final approach
Final hour starts around 8h 25m
Traffic, exits, and arrival timing usually matter more near Amarillo, TX than in the middle of the route.
Before You Leave
+
Open the route before leaving Seguin, TX so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
+
Treat this as a 2-day road trip and book the overnight stop before the busiest arrival window.
Day 1
Settle into the route from Seguin, TX
Aim for roughly 269 miles and 4.8 hours of wheel time on this day.
Day 2
Finish the approach into Amarillo, TX
Aim for roughly 269 miles and 4.8 hours of wheel time on this day.
Your first comfortable stop window is around 118 miles from Seguin, TX.
This route usually feels better as a 2-day drive than as one long push.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on I 10 for about 113.2 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 39
5 decision points cluster between mile 16.8 and 536.3 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
7
16.8 mi into trip|~20m in
Take the exit toward TX 1518: Schertz
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Exit 591
Toward TX 1518: Schertz
6
45.1 mi into trip|~56m in
Take the exit toward Frontage Road
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Toward Frontage Road
6
47.1 mi into trip|~59m in|I 10; US 87
Keep slight right at fork onto I 10; US 87
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight left lanes.
6
145.8 mi into trip|~2h 36m in|US 83
Take the exit onto US 83 toward US 83 North, US 377: Junction, Menard
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 456
Toward US 83 North, US 377: Junction, Menard
7
536.3 mi into trip|~9h 26m in|US 87
Keep slight left at fork onto US 87 toward US 87 North
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight left / slight right lanes.
Toward US 87 North
Fuel & Cost
Regular Gas
$73.68 one way
$147.35 round trip
$3.48/gal25.4 MPG avg188 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$3.89
$82.29
$164.59
premium
$4.23
$89.47
$178.95
diesel
$4.80
$101.57
$203.13
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$74
Hotel (1n)
$80–$140
Meals
$50–$100
Total
$204–$314
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 188.2 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $56 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
161.4
1
$56.48
$25.82
Efficient EV
134.5
1
$47.07
$21.52
EV Truck/SUV
215.2
2
$75.31
$34.43
Gas CO2
188 kg
EV CO2
63 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 16, 2026
Origin
Seguin, TX
Late night
in Seguin on Monday
Local time
1:45 AM
CDT
Current temp
87°F
Chance Showers And Thunderstorms
SSE 10 mph31% chanceLive forecast
Flash Flood Warning
Flash Flood Warning issued July 16 at 4:47PM CDT until July 16 at 7:45PM CDT by NWS Midland/Odessa TX
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued July 16 at 4:46PM CDT until July 16 at 5:30PM CDT by NWS Shreveport LA
Destination
Amarillo, TX
Late night
in Amarillo on Monday
Local time
1:45 AM
CDT
Current temp
87°F
Slight Chance Showers And Thunderstorms
SE 10 mph10% chanceLive forecast
Flash Flood Warning
Flash Flood Warning issued July 16 at 4:47PM CDT until July 16 at 7:45PM CDT by NWS Midland/Odessa TX
Severe Thunderstorm Warning
Severe Thunderstorm Warning issued July 16 at 4:46PM CDT until July 16 at 5:30PM CDT by NWS Shreveport LA
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
For long drives, weather on day two can matter just as much as conditions at departure, so check the whole travel window rather than only the first day.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
Very similar conditions
Both ends of the route are sitting at about the same temperature right now.
Road read
9h 30m on the road
This is long enough that the arrival forecast matters almost as much as departure conditions. Recheck both ends before you roll.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
San Antonio Missions National Historical Park
National Historical Park
Welcome to San Antonio Missions, a National Park Service site and the only UNESCO World Heritage Site in Texas. Each mission in the park is a center of community and has been since the early 1700s. Th...
18 mi from route
~44 min detour
Free
near mile 18.5
13,000 years ago, Alibates Flint was used by mammoth hunters as a source of flint for tools. Learn how important this site was to the survival, commerce, and culture of the people of the High Plains.
26 mi from route
~66 min detour
Free
near mile 537.9
Lyndon B. Johnson National Historical Park tells the story of our 36th president beginning with his ancestors until his final resting place on his beloved LBJ Ranch. This entire "circle of life" gives...
27 mi from route
~67 min detour
Free
near mile 74.2
Set within the wide‑open Texas Plains, Lake Meredith National Recreation Area offers a peaceful retreat in the heart of rugged grasslands. Over thousands of years, the Canadian River carved dramatic 2...
29 mi from route
~72 min detour
Free
near mile 537.9
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route is 54% highway, meaning you'll spend a good portion of your time on interstates. The longest continuous stretch on a highway is 113.2 miles on I 10. After the interstate sections, you'll transition to US 84, which offers a more rural cruising experience. Expect more frequent exits and potentially slower speeds as you leave the interstate behind.
54% highway, the rest on surface roads — varied driving throughout.
53 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 113.2 mi on I 10.
How Hard Is This Drive?
10/10
At 9h 30m, this is a long-haul route where pacing matters more than any single turn. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 16.8 miles in.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 39 significant decision points across 537.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 16.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 45.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 47.1 miles (I 10; US 87): Highway fork - watch signs carefully. Lane positioning matters here.
Elevation Profile
Hilly terrain with moderate elevation changes
3,670 ft529 ft
Total Climb
3,538 ft
Total Descent
397 ft
Highest Point
3,670 ft
~537.9 mi in
Elevation Range
3,141 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Seguin, TX and Amarillo, TX, road signs point toward Menard and Lubbock.
Long-haul drive route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 113.2 miles on I 10. The full list of main roads is in the Roads section above.
Yes — a 2-day pace is more comfortable than one long haul. A sensible stopping point is after roughly 269 miles on day one.
Yes — we found about 43 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Amarillo, TX before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 2 meaningful breaks. There are 43 rest areas along the route for bathroom stops.
The main spots that need attention: at 16.8 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 45.1 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 47.1 miles (I 10; US 87): Highway fork - watch signs carefully. Lane positioning matters here.
Yes — San Antonio Missions National Historical Park, Alibates Flint Quarries National Monument and Lyndon B Johnson National Historical Park (4 total within detour distance). See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 9.5 hours each way, a round trip means 19.0 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Amarillo, TX before the return drive.
