San Antonio, TX to West Odessa, TX is 347.7 miles and takes about 6h 5m via I 10 and US 385, with a fuel budget near $53 and enough daylight to finish in a day. This drive primarily stays within the Great Plains region, offering a straightforward path across Texas. Given its mostly highway profile and single-day recommendation, it's a practical choice for those needing to cover ground efficiently. You'll spend most of your time on the interstate, making it a relatively predictable transit.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
173.9 miles from San Antonio, TX
A natural place for your longest stop of the day
, about 2h 51m into the drive
.
Main Roads
Road
Distance
Duration
I 10
247.5 mi
3h 56m
US 385
47.2 mi
53m
Farm to Market Road 305
18.1 mi
26m
McDermott Freeway
12.8 mi
14m
Southwest Loop 338
6.8 mi
8m
West University Boulevard
5.2 mi
7m
US 190
4 mi
5m
South Burleson Avenue
2.3 mi
3m
Longest stretch:
I 10
— 247.5 mi, about 3h 56m
Turn-by-Turn Driving Directions
Step-by-step road directions between San Antonio, TX and West Odessa, TX.
1
Start on Dolorosa Street
143 ft·4 sec·Dolorosa Street
2
Continue on West Market Street
0.2 mi·28 sec·West Market Street
3
Turn left onto Navarro Street
0.8 mi·1 min·Navarro Street
4
Enter roundabout onto San Pedro Avenue
85 ft·1 sec·San Pedro Avenue
5
Continue on San Pedro Avenue
0.5 mi·1 min·San Pedro Avenue
6
Turn left onto West Cypress Street
0.1 mi·10 sec·West Cypress Street
Use the left lane.
7
Turn straight onto East Fredericksburg Road
1.2 mi·2 min·East Fredericksburg Road
8
Turn right onto Interstate 10 West
0.1 mi·13 sec·Interstate 10 West
9
Take the ramp
0.1 mi·13 sec
Toward I 10 West, US 87 North
10
Merge onto I 10; US 87
13 mi·14 min·McDermott Freeway
Use the straight / slight right lanes.
11
Keep slight right at fork onto I 10; US 87
247 mi·3 hr 56 min·I 10; US 87
Use the straight / slight left lanes.
12
Take the exit
0.2 mi·29 sec
Exit 307Toward US 190, FM 305: Iraan, McCamey
13
Continue on I 10 Service Road
0.1 mi·18 sec·I 10 Service Road
14
Turn right onto US 190
4.0 mi·5 min·US 190
15
Turn left onto FM 305
18 mi·26 min·Farm to Market Road 305
16
Continue on FM 305
2.3 mi·3 min·South Burleson Avenue
17
Continue on US 385
47 mi·53 min·US 385
18
Turn left onto Loop 338
6.8 mi·8 min·Southwest Loop 338
19
Take the exit
0.1 mi·14 sec
Toward FM 2020
20
Keep slight left at fork
0.2 mi·24 sec
Toward FM 2020
21
Keep slight left at fork
149 ft·9 sec
22
Turn left onto FM 2020
5.2 mi·7 min·West University Boulevard
23
Turn right
79 ft·5 sec
24
Turn right
97 ft·7 sec
25
Arrive at destination
Trip Plan
For this 6-hour drive, leaving San Antonio in the morning will allow you to reach West Odessa with ample daylight. With only one recommended stop and a fuel cost around $53, this route is manageable for a single day. The 247.5-mile segment on I 10 is quite long, so consider a brief break before or during that stretch to stay alert. Pay attention to the transition from I 10 to US 385, as this is where the road type changes and you'll want to be prepared for slower speeds and potentially more local traffic.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 173.9 miles from San Antonio, TX, or about 2h 51m into the drive.
The longest continuous stretch on this route runs about 247.5 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 76 miles or 1h 18m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 173.9 miles or 2h 51m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 53m
Traffic, exits, and arrival timing usually matter more near West Odessa, TX than in the middle of the route.
Before You Leave
+
Open the route before leaving San Antonio, TX so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from San Antonio, TX
This is one driving day of about 347.7 miles and 6h 5m.
Your first comfortable stop window is around 76 miles from San Antonio, TX.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 10 for about 247.5 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 16
5 decision points cluster between mile 1.6 and 342.3 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
1.6 mi into trip|~3m in|West Cypress Street
Turn left onto West Cypress Street
Lane positioning matters here
Use the left lane.
5
3.1 mi into trip|~5m in
Take the ramp toward I 10 West, US 87 North
Multiple destination signs - pick the right one
Toward I 10 West, US 87 North
6
16.1 mi into trip|~20m in|I 10; US 87
Keep slight right at fork onto I 10; US 87
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight left lanes.
6
263.5 mi into trip|~4h 17m in
Take the exit toward US 190, FM 305: Iraan, McCamey
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 307
Toward US 190, FM 305: Iraan, McCamey
6
342.3 mi into trip|~5h 56m in
Keep slight left at fork toward FM 2020
Highway fork - watch signs carefully
Toward FM 2020
Fuel & Cost
Regular Gas
$52.54 one way
$105.08 round trip
$3.84/gal25.4 MPG avg122 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.20
$57.51
$115.01
premium
$4.54
$62.08
$124.16
diesel
$5.61
$76.77
$153.54
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$53
Meals
$25–$50
Total
$78–$103
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 121.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $37 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
104.3
1
$36.51
$16.69
Efficient EV
86.9
0
$30.42
$13.91
EV Truck/SUV
139.1
1
$48.68
$22.25
Gas CO2
122 kg
EV CO2
41 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 20, 2026
Origin
San Antonio, TX
Morning
in San Antonio on Tuesday
Local time
6:23 AM
CDT
Current temp
61°F
Showers And Thunderstorms
ENE 10 mph79% chanceLive forecast
Flash Flood Warning
Flash Flood Warning issued April 20 at 3:22PM CDT until April 20 at 6:00PM CDT by NWS Austin/San Antonio TX
Fire Weather Watch
Fire Weather Watch issued April 20 at 2:28PM CDT until April 22 at 9:00PM CDT by NWS Amarillo TX
Destination
West Odessa, TX
Morning
in West Odessa on Tuesday
Local time
6:23 AM
CDT
Current temp
62°F
Partly Sunny
SE 15 mph6% chanceLive forecast
Flash Flood Warning
Flash Flood Warning issued April 20 at 3:22PM CDT until April 20 at 6:00PM CDT by NWS Austin/San Antonio TX
Fire Weather Watch
Fire Weather Watch issued April 20 at 2:28PM CDT until April 22 at 9:00PM CDT by NWS Amarillo TX
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 5m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
San Antonio Missions National Historical Park
National Historical Park
Welcome to San Antonio Missions, a National Park Service site and the only UNESCO World Heritage Site in Texas. Each mission in the park is a center of community and has been since the early 1700s. Th...
Lyndon B. Johnson National Historical Park tells the story of our 36th president beginning with his ancestors until his final resting place on his beloved LBJ Ranch. This entire "circle of life" gives...
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a drive that is 90% highway, meaning you'll be on high-speed roads for the vast majority of the 347.7 miles. The longest continuous stretch on I 10 spans 247.5 miles, so you'll experience extended periods of rural cruising without many exit interruptions. The transition from the interstate to surface roads like US 385 and Farm to Market Road 305 will occur later in your trip, signaling a change in pace as you approach West Odessa.
90% highway — fuel and pacing are the main things to plan.
25 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 247.5 mi on I 10.
How Hard Is This Drive?
6/10
This is a straightforward highway drive that stays mostly on I 10 and US 385. You will hit about 16 points where you need to pay attention to lane position or signs. The trickiest moment comes around 1.6 miles in near West Cypress Street.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 347.7 miles you will encounter 16 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 1.6 miles (West Cypress Street): Lane positioning matters here; at 3.1 miles: Multiple destination signs - pick the right one; at 16.1 miles (I 10; US 87): Highway fork - watch signs carefully. Lane positioning matters here.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between San Antonio, TX and West Odessa, TX, road signs point toward Fm 305: Iraan and Mccamey.
San Antonio is the second largest city in the state of Texas and the 7th largest in the United States. It's the 24th largest metropolitan area in the country. Visited by more than 31 million annual visitors, San Antonio is a beautiful city at the axis of three different geological terrains: Hill Country, South Texas Plains and Prairie and Lakes. There's a lot to do in this city: fine art museums, historical missions and plenty of amusement parks in addition to great dining and lots of drinking. The culture and people are vibrant and interesting. San Antonio's downtown is one of the most lively in the nation.
Top landmarks
•Alamo Mission in San Antonio — historic place in San Antonio, Bexar County, Texas
•San Antonio Missions National Historical Park — historic district in San Antonio, Bexar County, Texas
•Fort Sam Houston — military base in San Antonio, Texas
Doable as a same-day drive at 6h 5m. Total distance: 347.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 5m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 247.5 miles on I 10. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at West Odessa, TX before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 1.6 miles (West Cypress Street): Lane positioning matters here; at 3.1 miles: Multiple destination signs - pick the right one; at 16.1 miles (I 10; US 87): Highway fork - watch signs carefully. Lane positioning matters here.
Yes — San Antonio Missions National Historical Park and Lyndon B Johnson National Historical Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.1 hours each way, a round trip means 12.2 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at West Odessa, TX before the return drive.
