Saint Clair Rest Area (Westbound)
0.1 mi from route
Trip from Saint Charles, MO to Humansville, MO
Pin this tripCompiled and reviewed by the US Trip Planner planning team at COD Solutions Oy · Last reviewed Jun 3, 2026 · Editorial standards
Drive Time
4h 36m
Distance
226.8 mi
365 km
Drive Score
9/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$38
one way
EV Charging
Unknown
Best Time to Leave
4 AM
4h 23m
★
6 AM
4h 36m
8 AM
5h 3m
10 AM
4h 46m
12 PM
4h 43m
3 PM
4h 47m
5 PM
5h 2m
8 PM
4h 28m
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Saint Charles, MO
Wikimedia Commons
Humansville, MO
Mikhail Nilov
Trip Overview
Saint Charles, MO to Humansville, MO is 226.8 miles and takes about 4h 36m via Henry Shaw Ozark Corridor, with a fuel budget near $35 and enough daylight to finish in a day. This trip stays within Missouri, taking you from the Midwest region to another part of the Midwest. The drive features a mix of highway and surface roads, offering a straightforward path through the state. It's a solid option for a single-day trip, allowing you to reach your destination without needing an overnight stop.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
113.4 miles from Saint Charles, MO
A natural place for your longest stop of the day , about 2h 12m into the drive .
Main Roads
| Road | Distance | Duration |
|---|---|---|
| Henry Shaw Ozark Corridor | 143 mi | 2h 35m |
| MO 32 | 42.8 mi | 1h 1m |
| MO 13 | 11.9 mi | 13m |
| I 270 | 10.9 mi | 13m |
| West Commercial Street | 4.3 mi | 6m |
| I 70 | 2.7 mi | 3m |
| Dougherty Ferry Road | 2.5 mi | 4m |
| MO 123 | 2.4 mi | 4m |
Longest stretch:
Henry Shaw Ozark Corridor
— 143 mi, about 2h 35m
Traffic on I-70
Hour-of-day weekday pattern from 11 FHWA count stations on your route.
Peak
4 PM
~6,589 veh/hr typical
Quietest
2 AM
~547 veh/hr
Peak-to-quiet ratio
12×
busier at peak than in the quiet hours
12a
6a
noon
6p
11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Saint Charles, MO and Humansville, MO.
1
Start on North Second Street
0.2 mi
·
38 sec
·
North Second Street
2
Turn right onto Jefferson Street
0.2 mi
·
44 sec
·
Jefferson Street
3
Turn left onto MO 94
1.1 mi
·
2 min
·
South Fifth Street
Use the straight / right lanes.
4
Take the ramp
0.2 mi
·
14 sec
Toward I 70 East
Use the left / straight lanes.
5
Merge onto I 70
2.7 mi
·
3 min
·
I 70
6
Take the exit
0.2 mi
·
12 sec
Exit 232
Toward I 270: Chicago, Memphis
Use the slight right lane.
7
Keep slight right at fork
0.4 mi
·
33 sec
Toward I 270 South: Memphis
Use the slight right lane.
8
Continue on this road
0.1 mi
·
10 sec
·
this road
Exit 232
Toward I 270 South: Memphis
9
Merge onto I 270
11 mi
·
13 min
·
I 270
Use the straight lane.
10
Take the exit
0.3 mi
·
28 sec
Exit 8
Toward Dougherty Ferry Road
Use the slight right lane.
11
Turn right onto Dougherty Ferry Road
2.5 mi
·
4 min
·
Dougherty Ferry Road
Use the straight lane.
12
Continue on Forest Avenue
1.0 mi
·
2 min
·
Forest Avenue
13
Turn left onto MO 141
0.7 mi
·
1 min
·
MO 141
14
Take the exit
105 ft
·
3 sec
15
Turn right onto North Highway Drive
0.1 mi
·
14 sec
·
North Highway Drive
16
Take the ramp
0.2 mi
·
13 sec
Toward I 44 West, US 50 West: Rolla
17
Merge onto I 44; US 50
143 mi
·
2 hr 35 min
·
Henry Shaw Ozark Corridor
Use the straight lane.
18
Take the exit
0.2 mi
·
20 sec
Exit 129
Toward MO 32, MO 5, MO 64: Hartville
19
Turn right onto MO 5; MO 32; MO 64
1.0 mi
·
1 min
·
South Jefferson Avenue
20
Turn left onto West Commercial Street
4.3 mi
·
6 min
·
West Commercial Street
Use the left lane.
21
Continue on MO 32
43 mi
·
1 hr 1 min
·
MO 32
22
Take the ramp
0.3 mi
·
39 sec
Toward MO 13 North: Humansville
23
Merge onto MO 13
12 mi
·
13 min
·
MO 13
24
Turn right onto MO 123; MO 13 Business
2.4 mi
·
4 min
·
MO 123; MO 13 Business
25
Turn left onto MO 13 Business
475 ft
·
10 sec
·
East Tilden Street
26
Arrive at destination
MO 13 Business
Trip Plan
For this 4h 36m drive, consider leaving Saint Charles in the morning to give yourself plenty of daylight for the 226.8 miles. With only one recommended stop, you have flexibility in pacing. Keep an eye on your fuel gauge, especially during the 143-mile stretch on the Henry Shaw Ozark Corridor, as services might be more spread out. The fuel cost is estimated at $35, so plan accordingly. Since this is a single-day trip, you can depart at your leisure and still arrive comfortably.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 113.4 miles from Saint Charles, MO, or about 2h 12m into the drive.
The longest continuous stretch on this route runs about 143 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 50 miles or 1h 3m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 113.4 miles or 2h 12m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 39m
Traffic, exits, and arrival timing usually matter more near Humansville, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Saint Charles, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Saint Charles, MO
This is one driving day of about 226.8 miles and 4h 36m.
Your first comfortable stop window is around 50 miles from Saint Charles, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Henry Shaw Ozark Corridor for about 143 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Mid-route town
Meal stop
113 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
Pacing Suggestions
Fuel and coffee
A short stop after about 50 miles helps settle the day before fatigue starts building.
Meal break
The midpoint is around 113.4 miles from Saint Charles, MO, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before Henry Shaw Ozark Corridor if your tank is already low. That segment runs about 143 miles.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
Stops Along Your Drive
Picked by where they fit in your drive — first break, midpoint reset, final stretch.
Flying J Travel Center
0.1 mi from route
Road Ranger
0.1 mi from route
Mr. Fuel
0.1 mi from route
Truck Parking
0.1 mi from route
Truck Parking
0.1 mi from route
Saint Clair Rest Area (Eastbound)
0.1 mi from route
QuikTrip
0.1 mi from route
Pilot Travel Center
0.2 mi from route
TA
0.2 mi from route
Love's Travel Stop
0.2 mi from route
B&D Auto/Truck Plaza
1.3 mi from route
Love's Travel Stop
1.9 mi from route
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 195 decision points cluster between mile 0.4 and 163.8 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
0.4 mi into trip
|
~1m in
|
MO 94 / South Fifth Street
Turn left onto MO 94 / South Fifth Street
Lane positioning matters here
Use the straight / right lanes.
8
4.3 mi into trip
|
~7m in
Take the exit toward I 270: Chicago, Memphis
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 232
Toward I 270: Chicago, Memphis
7
4.5 mi into trip
|
~8m in
Keep slight right at fork toward I 270 South: Memphis
Highway fork - watch signs carefully. Lane positioning matters here
Use the slight right lane.
Toward I 270 South: Memphis
7
16 mi into trip
|
~22m in
Take the exit toward Dougherty Ferry Road
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 8
Toward Dougherty Ferry Road
6
163.8 mi into trip
|
~3h 6m in
Take the exit toward MO 32, MO 5, MO 64: Hartville
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 129
Toward MO 32, MO 5, MO 64: Hartville
Fuel & Cost
Regular Gas
$37.71 one way
$75.42 round trip
$4.22/gal
25.4 MPG avg
79 kg CO2
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.60 | $41.07 | $82.15 |
| premium | $5.18 | $46.28 | $92.56 |
| diesel | $5.35 | $47.77 | $95.54 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$38
Meals
$25–$50
Total
$63–$88
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 79.4 kg one way. Prices: EIA weekly data, 2026-06-01.
Driving Electric?
About $24 in charging · 0 stops · 66% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 68 | 0 | $23.81 | $10.89 |
| Efficient EV | 56.7 | 0 | $19.85 | $9.07 |
| EV Truck/SUV | 90.7 | 1 | $31.75 | $14.52 |
Gas CO2
79 kg
EV CO2
27 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Origin
Saint Charles, MO
Afternoon in Saint Charles on Wednesday
Local time
3:46 PM
CDT
Current temp
84°F
Partly Sunny then Isolated Showers And Thunderstorms
SE 6 mph
17% chance
Live forecast
Special Weather Statement
Special Weather Statement issued May 31 at 11:35AM CDT by NWS Springfield MO
Special Weather Statement
Special Weather Statement issued May 31 at 11:12AM CDT by NWS Springfield MO
Destination
Humansville, MO
Afternoon in Humansville on Wednesday
Local time
3:46 PM
CDT
Current temp
87°F
Sunny then Slight Chance Showers And Thunderstorms
S 10 mph
19% chance
Live forecast
Special Weather Statement
Special Weather Statement issued May 31 at 11:35AM CDT by NWS Springfield MO
Special Weather Statement
Special Weather Statement issued May 31 at 11:12AM CDT by NWS Springfield MO
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
3 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 36m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Gateway Arch National Park
National Park
Gateway Arch National Park commemorates President Jefferson’s vision of a continental nation, the individuals and cultural groups who helped shape its history, St. Louis’ role in westward expansion, a...
14 mi from route
~36 min detour
$19
near mile 15.6
View on nps.gov
Park data from the National Park Service API. Alerts update every 2 hours.
What kind of drive is this?
About 31% of this 226.8-mile drive is on highways. You'll experience the longest continuous stretch on the Henry Shaw Ozark Corridor, covering 143 miles. After the highway portion concludes, you'll transition to MO 32 and MO 13, which are surface roads. Expect a change from higher-speed cruising to more rural driving as you leave the main highway.
31% highway, the rest on surface roads — varied driving throughout.
26 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 143 mi on Henry Shaw Ozark Corridor.
How Hard Is This Drive?
8/10
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.4 miles in near MO 94 / South Fifth Street.
Driving Effort
8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 19 significant decision points across 226.8 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.4 miles (MO 94 / South Fifth Street): Lane positioning matters here; at 4.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 4.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Elevation Profile
Mostly flat terrain
1,236 ft
491 ft
Total Climb
838 ft
Total Descent
368 ft
Highest Point
1,236 ft
~162 mi in
Elevation Range
745 ft
About the Cities
Starting in Saint Charles, MO
Full guide →Founded 1765
St. Charles, Missouri is outside of St. Louis on the bank of the Missouri River. It was Missouri's first state capital and was one of the first stops by Lewis and Clark on their journey to explore Louisiana Territory. The historic Main Street has largely been restored to its 1812-era appearance including gas lights a boardwalk and is lined with shops selling artwork, handicrafts, home decorations, antiques. There are also many restaurants.
Top landmarks
- • First Missouri State Capitol State Historic Site — historic site in Missouri, United States
- • African Church — church building in Missouri, United States of America
- • Frenchtown Historic District — historic district in St. Charles County, Missouri
Arriving in Humansville, MO
Full guide →City content from Wikivoyage (CC BY-SA 4.0) and Wikidata (CC0).
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 36m. Total distance: 226.8 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 36m drive, comfortable solo distance.
Scenic Drive
Mixed highway & surface route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 143 miles on Henry Shaw Ozark Corridor. The full list of main roads is in the Roads section above.
Yes — we found about 13 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Humansville, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 13 rest areas along the route for bathroom stops.
The main spots that need attention: at 0.4 miles (MO 94 / South Fifth Street): Lane positioning matters here; at 4.3 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 4.5 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Yes — Gateway Arch National Park. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.6 hours each way, an in-and-out day trip would put you behind the wheel for 9.2 hours — manageable with a long break at Humansville, MO, but most travelers stay overnight.
How this page is built
Compiled by the US Trip Planner planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, EIA for fuel prices, USGS 3DEP for elevation, NPS for national parks, and FHWA TMAS for hourly traffic volumes. See our methodology for refresh cadence and limitations.
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