Origin
Odessa, TX
Morning in Odessa on Tuesday
Local time
6:10 AM
CDT
Current temp
84°F
Unavailable
Compiled and reviewed by the US Trip Planner planning team at COD Solutions Oy · Last reviewed Apr 21, 2026 · Editorial standards
Drive Time
4h 32m
Distance
259.6 mi
418 km
Drive Score
9/10
Great drive
Same Day?
Yes, doable
Fuel Cost
$39
one way
EV Charging
Unknown
Estimated drive times based on typical traffic patterns. Actual times may vary with weather, construction, and real-time conditions.
Odessa, TX
Wikimedia Commons
Amarillo, TX
Wikimedia Commons
Odessa to Amarillo is 259.6 miles and takes about 4h 32m via Marshall Formby Memorial Highway and North US Highway 87, with a fuel budget near $39 and enough daylight to finish in a day. This trip stays within the Great Plains region, moving from one part of Texas to another. The route offers a mix of highway cruising and surface roads, making for a straightforward drive. Given its duration and distance, this is a manageable one-day trip, allowing for flexibility in your departure time.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
129.8 miles from Odessa, TX
A natural place for your longest stop of the day , about 2h 16m into the drive .
| Road | Distance | Duration |
|---|---|---|
| Marshall Formby Memorial Highway | 111.1 mi | 1h 52m |
| North US Highway 87 | 51.2 mi | 51m |
| State Highway 349 | 47 mi | 47m |
| Canyon Expressway | 13.5 mi | 15m |
| Nadine and Tom Craddick Highway | 12.5 mi | 12m |
| Tahoka Highway | 4.4 mi | 4m |
| Sergeant Michael Naylor Memorial Highway | 3.1 mi | 3m |
| East 2nd Street | 2.6 mi | 4m |
Step-by-step road directions between Odessa, TX and Amarillo, TX.
Start on US 385
Turn right onto I 20 Bus
Continue on I 20 Bus
Turn left onto Northeast Loop 338
Keep slight left at fork onto Northeast Loop 338
Merge onto Loop 338
Take the exit
Turn straight onto State Highway 191 East
Take the ramp
Merge onto TX 191
Continue on TX 191
Take the exit
Turn straight onto State Highway 191
Turn slight left onto TX 349; FM 1788
Keep slight right at fork onto TX 349
At end of road, turn left onto TX 349
At end of road, turn left onto US 87; US 180
Continue on US 87; US 180
Continue on US 87; US 180
Continue on US 87
Continue on US 87
Continue on I 27; US 87
Continue on I 27; US 87
Continue on I 27; US 60; US 87
Keep slight left at fork onto US 87
Keep slight right at fork onto US 87; Original US Route 66
Turn right onto I 40 Business; Original US Route 66; US 60
Arrive at destination
With a total drive time of just over 4.5 hours, this route is easily completed in a single day, so you can leave whenever it suits your schedule. The estimated fuel cost is around $39, which is helpful for budgeting. Plan for one stop to break up the 259.6 miles, perhaps after the longest stretch of 111.1 miles on Marshall Formby Memorial Highway. Keep an eye on your fuel gauge, especially as you transition from highway to surface roads, as services might be less frequent in certain sections.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 57 miles or 1h 3m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 129.8 miles or 2h 16m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 40m
Traffic, exits, and arrival timing usually matter more near Amarillo, TX than in the middle of the route.
Open the route before leaving Odessa, TX so your first major turns are already loaded.
Leave with enough water and a charging cable within reach, not packed away.
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Odessa, TX
This is one driving day of about 259.6 miles and 4h 32m.
Rest stops, refuel points, and overnight suggestions along this route.
Mid-route town
Meal stop
130 mi into the route
Best for: Lunch, fuel, and a longer reset
This sits close to the middle of the route, so it works well for the longest stop of the day.
A short stop after about 57 miles helps settle the day before fatigue starts building.
The midpoint is around 129.8 miles from Odessa, TX, which is a good place for a longer meal and fuel stop.
Before the longest stretch
Fuel checkTop up before Marshall Formby Memorial Highway if your tank is already low. That segment runs about 111.1 miles.
These stop ideas are pacing suggestions — the exact town or exit can change with traffic, hotel plans, and fuel range.
5 decision points cluster between mile 4.1 and 258.9 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
Keep slight left at fork onto Northeast Loop 338
Highway fork - watch signs carefully
Merge onto Loop 338 / Ray C. Stoker, Jr. Memorial Highway
Merge point - match speed before joining. Lane positioning matters here
Take the exit
Exit ramp - move to the correct lane early. Lane positioning matters here
Keep slight left at fork onto US 87 toward US 87 North
Highway fork - watch signs carefully. Lane positioning matters here
Keep slight right at fork onto US 87; Original US Route 66 / South Fillmore Street
Highway fork - watch signs carefully. Lane positioning matters here
Regular Gas
$39.23 one way
$78.45 round trip
| Fuel Type | $/gal | One Way | Round Trip |
|---|---|---|---|
| midgrade | $4.20 | $42.94 | $85.87 |
| premium | $4.54 | $46.35 | $92.70 |
| diesel | $5.61 | $57.32 | $114.63 |
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$39
Meals
$25–$50
Total
$64–$89
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 90.8 kg one way. Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $27 in charging · 0 stops · 67% less CO2
| Vehicle Type | kWh | Stops | DC Fast | Home Charge |
|---|---|---|---|---|
| Average EV | 77.9 | 0 | $27.26 | $12.46 |
| Efficient EV | 64.9 | 0 | $22.72 | $10.38 |
| EV Truck/SUV | 103.8 | 1 | $36.34 | $16.61 |
Gas CO2
91 kg
EV CO2
30 kg (67% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Current conditions at both ends of the drive.
Origin
Morning in Odessa on Tuesday
Local time
6:10 AM
CDT
Current temp
84°F
Unavailable
Destination
Morning in Amarillo on Tuesday
Local time
6:10 AM
CDT
Current temp
76°F
Unavailable
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
You'll spend about 45% of this 259.6-mile drive on main highways. The longest continuous stretch on a highway is 111.1 miles along Marshall Formby Memorial Highway. After that, expect a mix of highway and surface roads for the remainder of the journey. This means you'll experience some rural cruising with fewer exits and then transition to roads with more local traffic and intersections.
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 4.1 miles in near Northeast Loop 338.
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 14 significant decision points across 259.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 4.1 miles (Northeast Loop 338): Highway fork - watch signs carefully; at 4.2 miles (Loop 338 / Ray C. Stoker, Jr. Memorial Highway): Merge point - match speed before joining. Lane positioning matters here; at 5.5 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Founded 1881
Odessa is a city of 120,000 people (2018) in West Texas, 20 mi (32 km) west of its sister city, Midland. Much of the major industry in the area is oil- and gas-related. As such, the Midland/Odessa area is colloquially known as the petroplex. Many of the attractions you will find in the area are in Midland, so if you're visiting Odessa, the Midland article deserves a look as well. It's also notable as the fountainhead for the Friday Night Lights media franchise, which began with a 1990 book that explored football at the city's Permian High School, later followed by a movie that was mostly faithful to the book, and then a TV series that was a looser adaptation.
Top landmarks
Amarillo, which means "yellow" in Spanish, is the center of the Texas Panhandle at the edge of the Great Plains.
City content from Wikivoyage (CC BY-SA 4.0) and Wikidata (CC0).
Weekend Trip
Doable as a same-day drive at 4h 32m. Total distance: 259.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 32m drive, comfortable solo distance.
Compiled by the US Trip Planner planning team at COD Solutions Oy from open government datasets — OSRM over OpenStreetMap for geometry, and EIA for fuel prices. See our methodology for refresh cadence and limitations.
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