Traveling from Murphy to San Antonio covers 323.3 miles of Texas landscape, typically requiring about 4 hours and 46 minutes of time behind the wheel. Because this journey stays within the Great Plains region, you won't experience drastic shifts in geography, though the transition from the DFW metro area toward the heart of the state is significant. Budgeting roughly $48 for fuel is a smart move for this one-day trek. While you could technically complete the drive in a single day, the turn-heavy nature of the local roads means you should stay alert throughout the journey. It is a straightforward trip that relies on local navigation rather than high-speed highway travel, making it a manageable, albeit demanding, day trip for most drivers.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
148.2 miles from Murphy, TX
A natural place for your longest stop of the day
, about 2h 41m into the drive
.
Step-by-step road directions between Murphy, TX and San Antonio, TX.
1
Start on FM 2551
0.2 mi·29 sec·North Murphy Road
2
Turn right onto FM 544
0.7 mi·1 min·West FM 544
Use the right lane.
3
Continue on 14th Street
0.9 mi·1 min·14th Street
Use the left lane.
4
Continue on East Plano Parkway
2.6 mi·4 min·East Plano Parkway
5
Turn left onto Jupiter Road
0.3 mi·33 sec·Jupiter Road
Use the left lane.
6
Turn slight right
167 ft·7 sec
7
Turn straight onto TX 190
0.5 mi·44 sec·President George Bush Highway
8
Take the ramp
0.3 mi·34 sec
Toward PGBT Toll West
9
Merge onto PGBT
0.3 mi·17 sec·President George Bush Turnpike
10
Take the exit
0.2 mi·35 sec
Use the straight / slight right lanes.
11
Keep slight left at fork
0.6 mi·1 min
Toward US 75 South: DallasUse the slight left lane.
12
Merge onto US 75
15 mi·16 min·North Central Expressway
Use the straight / right lanes.
13
Take the exit
501 ft·12 sec
Exit 284CToward Downtown, Good-Latimer ExpresswayUse the slight left lane.
14
Continue on North Central Expressway
0.7 mi·1 min·North Central Expressway
Use the left / straight lanes.
15
Turn right onto Elm Street
304 ft·10 sec·Elm Street
16
Turn left onto North Pearl Expressway
0.2 mi·28 sec·North Pearl Expressway
Use the straight lane.
17
Turn right onto Young Street
0.1 mi·19 sec·Young Street
18
Turn left onto South Harwood Street
315 ft·8 sec·South Harwood Street
Use the left lane.
19
Turn right onto Canton Street
0.4 mi·47 sec·Canton Street
20
Take the ramp
0.3 mi·38 sec
Toward I 30 West
21
Keep slight left at fork
0.1 mi·14 sec
Toward I 35E South, I 35E North: Waco, Denton
22
Keep slight left at fork
221 ft·5 sec
Toward I 35E North, I 35E South: Denton, WacoUse the straight / slight right lanes.
23
Keep slight left at fork
0.4 mi·30 sec
Toward I 35E South: WacoUse the left / right lanes.
24
Continue on I 35E
0.5 mi·44 sec·South R L Thornton Freeway
25
Continue on I 35E
89 mi·1 hr 31 min·South R L Thornton Freeway
Exit 426Toward Dallas ZooUse the straight / slight right lanes.
26
Continue on I 35; US 77
6.6 mi·7 min·North Jack Kultgen Expressway
Use the straight / slight right lanes.
27
Continue on I 35
38 mi·39 min·Purple Heart Trail
Use the straight / slight right lanes.
28
Keep slight left at fork onto I 35
56 mi·58 min·I 35
Use the straight / slight right lanes.
29
Keep slight left at fork onto I 35; US 290
50 mi·54 min·Purple Heart Trail
Toward 32nd Street, Dean Keeton StreetUse the slight left lane.
30
Continue on I 35
1.7 mi·1 min·Interstate Highway 35
Use the straight / slight right lanes.
31
Continue on I 35
12 mi·12 min·Purple Heart Trail
Use the straight / slight right lanes.
32
Continue on I 35
10.0 mi·11 min·North Pan Am Expressway
Use the straight / slight right lanes.
33
Keep slight left at fork onto I 35
6.4 mi·8 min·North Pan Am Expressway
Toward I 35 SouthUse the straight / slight right lanes.
34
Keep slight left at fork onto I 35
0.6 mi·41 sec·North Pan Am Expressway
Toward I 35 South: Lower Level, LaredoUse the slight left lane.
35
Take the exit
0.1 mi·16 sec
Exit 157AToward Lexington Avenue, Main Avenue, San Pedro AvenueUse the slight right lane.
36
Turn straight onto East Elmira Street
526 ft·17 sec·East Elmira Street
Use the left / straight lanes.
37
Turn left onto North Main Avenue
0.2 mi·18 sec·North Main Avenue
Use the left / straight lanes.
38
Enter roundabout onto Navarro Street
159 ft·3 sec·Navarro Street
39
Continue on Navarro Street
111 ft·2 sec·Navarro Street
40
Keep slight right at fork onto North Main Avenue
0.4 mi·51 sec·North Main Avenue
Use the slight left / slight right lanes.
41
Turn right onto West Travis Street
222 ft·10 sec·West Travis Street
42
Turn left onto North Flores Street
0.2 mi·20 sec·North Flores Street
43
Continue on Military Plaza
392 ft·15 sec·Military Plaza
44
Turn left onto Dolorosa Street
327 ft·8 sec·Dolorosa Street
45
Arrive at destination
Dolorosa Street
Trip Plan
To keep your 4-hour and 46-minute drive as smooth as possible, plan for at least one dedicated stop to stretch your legs and reset. Since the route is entirely local, departing early in the morning can help you avoid local traffic congestion that often slows down surface streets. Keep a close eye on your fuel gauge, as the $48 estimate can fluctuate based on idling in heavy traffic along the local road segments. Because the route lacks long highway stretches, build in extra time for the frequent turns and stop-and-go sections you will encounter. A great tip for this specific trip is to download your navigation maps offline before leaving Murphy, as reliance on local roads can sometimes lead to spotty reception in certain stretches.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 148.2 miles from Murphy, TX, or about 2h 41m into the drive.
The longest continuous stretch on this route runs about 99.6 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 65 miles or 1h 15m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 148.2 miles or 2h 41m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 4h 22m
Traffic, exits, and arrival timing usually matter more near San Antonio, TX than in the middle of the route.
Before You Leave
+
Open the route before leaving Murphy, TX so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Murphy, TX
This is one driving day of about 296.3 miles and 5h 23m.
Your first comfortable stop window is around 65 miles from Murphy, TX.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Purple Heart Trail for about 99.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 30
5 decision points cluster between mile 22 and 295.1 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
22 mi into trip|~28m in
Take the exit toward Downtown, Good-Latimer Expressway
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Exit 284C
Toward Downtown, Good-Latimer Expressway
9
24.1 mi into trip|~32m in
Keep slight left at fork toward I 35E North, I 35E South: Denton, Waco
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 35E North, I 35E South: Denton, Waco
8
214.7 mi into trip|~3h 51m in|I 35; US 290 / Purple Heart Trail
Keep slight left at fork onto I 35; US 290 / Purple Heart Trail toward 32nd Street, Dean Keeton Street
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Toward 32nd Street, Dean Keeton Street
8
294.6 mi into trip|~5h 20m in|I 35 / North Pan Am Expressway
Keep slight left at fork onto I 35 / North Pan Am Expressway toward I 35 South: Lower Level, Laredo
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Toward I 35 South: Lower Level, Laredo
8
295.1 mi into trip|~5h 21m in
Take the exit toward Lexington Avenue, Main Avenue, San Pedro Avenue
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 157A
Toward Lexington Avenue, Main Avenue, San Pedro...
Fuel & Cost
Regular Gas
$44.77 one way
$89.54 round trip
$3.84/gal25.4 MPG avg104 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.20
$49.01
$98.01
premium
$4.54
$52.90
$105.80
diesel
$5.61
$65.42
$130.84
Estimated Tolls: $1.32
Central Expressway
(16.2 mi)$1.30
President George Bush Turnpike
(0.3 mi)$0.02
Toll estimates based on average 2024-2025 rates. EZ-Pass/SunPass discounts may lower the actual cost.
Estimated Trip Cost (one way, 1 person)
Fuel
$45
Tolls
$1
Meals
$25–$50
Total
$71–$96
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 103.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $31 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
88.9
1
$31.11
$14.22
Efficient EV
74.1
0
$25.93
$11.85
EV Truck/SUV
118.5
1
$41.48
$18.96
Gas CO2
104 kg
EV CO2
35 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Murphy, TX
Late night
in Murphy on Sunday
Local time
2:30 AM
CDT
Current temp
59°F
Unavailable
Live forecast
Destination
San Antonio, TX
Late night
in San Antonio on Sunday
Local time
2:30 AM
CDT
Current temp
77°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
18 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
5h 23m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Waco Mammoth National Monument
National Monument
Standing as tall as 14 feet and weighing 20,000 pounds, Columbian mammoths roamed across what is present-day Texas thousands of years ago. Today, the fossil specimens represent the nation's first and...
4 mi from route
~11 min detour
Free
near mile 112.4
Welcome to San Antonio Missions, a National Park Service site and the only UNESCO World Heritage Site in Texas. Each mission in the park is a center of community and has been since the early 1700s. Th...
9 mi from route
~22 min detour
Free
near mile 296.3
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a highly technical experience on this route, as it relies entirely on local roads like FM 544, 14th Street, and East Plano Parkway rather than major interstates. With a highway share of 0%, this is a turn-heavy local drive that demands your full attention at every intersection. You will not find long, monotonous stretches of high-speed cruising here; in fact, the longest uninterrupted stretch on FM 544 is 0 miles, meaning you are constantly navigating turns and changing conditions. This setup creates a very different experience than a typical interstate haul, requiring you to remain engaged with your GPS and surroundings for the entire 323.3-mile duration.
64% highway — fuel and pacing are the main things to plan.
45 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 99.6 mi on Purple Heart Trail.
How Hard Is This Drive?
9/10
This is a straightforward highway drive that stays mostly on Purple Heart Trail and South R L Thornton Freeway. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 22 miles in.
Driving Effort9/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 30 significant decision points across 296.3 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 22 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 24.1 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 214.7 miles (I 35; US 290 / Purple Heart Trail): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Murphy, TX and San Antonio, TX, road signs point toward Downtown, Denton, Waco and Dallas Zoo.
San Antonio is the second largest city in the state of Texas and the 7th largest in the United States. It's the 24th largest metropolitan area in the country. Visited by more than 31 million annual visitors, San Antonio is a beautiful city at the axis of three different geological terrains: Hill Country, South Texas Plains and Prairie and Lakes. There's a lot to do in this city: fine art museums, historical missions and plenty of amusement parks in addition to great dining and lots of drinking. The culture and people are vibrant and interesting. San Antonio's downtown is one of the most lively in the nation.
Top landmarks
•Alamo Mission in San Antonio — historic place in San Antonio, Bexar County, Texas
•San Antonio Missions National Historical Park — historic district in San Antonio, Bexar County, Texas
•Fort Sam Houston — military base in San Antonio, Texas
Doable as a same-day drive at 5h 23m. Total distance: 296.3 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
5h 23m drive, comfortable solo distance.
Frequently Asked Questions
The longest stretch is about 99.6 miles on Purple Heart Trail. The full list of main roads is in the Roads section above.
Expect about $1.32 in tolls one way, starting with Central Expressway. Most Northeast and Midwest toll agencies accept E-ZPass; in the West and Texas, transponders like TxTag or FasTrak apply. If you do not have a transponder, cashless tolling plates will mail a bill to the vehicle's registered address — usually with a surcharge, so a rental-car toll pass is often cheaper than paying by mail.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at San Antonio, TX before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 22 miles: Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 24.1 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 214.7 miles (I 35; US 290 / Purple Heart Trail): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Yes — Waco Mammoth National Monument and San Antonio Missions National Historical Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 5.4 hours each way, a round trip means 10.8 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at San Antonio, TX before the return drive.
