Traveling from Mission to Houston covers 368.6 miles and typically takes about 5 hours and 38 minutes. Because this is a turn-heavy local drive rather than a straight interstate shot, you should plan on this being a full-day commitment. Budgeting roughly $55 for fuel will get you across the Great Plains region from the Rio Grande Valley toward the Gulf Coast area. While you could technically push through in one day, the persistent navigation required by local roads makes it a demanding journey. It is a practical trek for those who prefer navigating through the heart of South Texas rather than sticking to high-speed corridors.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
178.3 miles from Mission, TX
A natural place for your longest stop of the day
, about 3h 24m into the drive
.
Main Roads
Road
Distance
Duration
US Highway 59 South
88.6 mi
1h 38m
US 281
57.1 mi
1h
I 69C
47 mi
51m
US 77
37.6 mi
44m
United States Highway 77
33 mi
37m
Southwest Freeway
32.6 mi
37m
East Main Street
26.2 mi
30m
I 2
8 mi
9m
Longest stretch:
US Highway 59 South
— 88.6 mi, about 1h 38m
Turn-by-Turn Driving Directions
Step-by-step road directions between Mission, TX and Houston, TX.
1
Start on US 83 Bus
134 ft·9 sec·East Tom Landry Street
2
Turn left onto TX 107
1.1 mi·1 min·North Conway Avenue
3
Turn left onto US 83 Exwy Service Road
155 ft·3 sec·US 83 Exwy Service Road
4
Continue on East Expressway 83
0.6 mi·1 min·East Expressway 83
5
Take the ramp
0.4 mi·46 sec
Toward I 2 East, US 83 East
6
Merge onto I 2; US 83
8.0 mi·9 min·I 2; US 83
Use the straight / slight right lanes.
7
Take the exit
1.0 mi·1 min
Exit 416BToward I 69C North, US 281: Edinburg
8
Continue on I 69C
22 mi·23 min·I 69C
Use the straight / slight right lanes.
9
Continue on US 281
57 mi·1 hr·US 281
10
Keep slight right at fork onto I 69C; US 281
25 mi·28 min·I 69C; US 281
11
Take the exit
0.4 mi·1 min
12
Continue on US 281 Business
2.2 mi·3 min·US 281 Business
13
Turn right onto FM 1352
0.5 mi·57 sec·Cecilia Street
14
Turn left onto FM 665
345 ft·7 sec·Old Kingsville Road
15
Turn slight right onto FM 665
1.3 mi·2 min·South Cameron Street
16
Turn right onto TX 44; TX 359
452 ft·5 sec·East Front Street
17
Continue on TX 44; TX 359
26 mi·30 min·East Main Street
Use the straight lane.
18
Take the exit onto TX 44
0.6 mi·1 min·TX 44
19
Turn left onto North US Highway 77
1.0 mi·2 min·North US Highway 77
Use the left lane.
20
Take the ramp
0.2 mi·30 sec
Toward County Road 44
21
Merge onto I 69E; US 77
4.7 mi·5 min·U.S. Highway 77
22
Merge onto I 37; US 77; I 69E
1.4 mi·1 min·I 37; US 77; I 69E
23
Keep slight left at fork
0.8 mi·50 sec
24
Continue on I 37; US 77; I 69E
463 ft·5 sec·I 37; US 77; I 69E
25
Take the exit onto US 77
38 mi·44 min·US 77
Toward Sinton, Victoria
26
Turn slight right onto US 77
33 mi·37 min·United States Highway 77
27
Keep slight left at fork onto Spur 91
1.5 mi·1 min·Spur 91
28
Merge onto US 59
89 mi·1 hr 38 min·US Highway 59 South
29
Take the exit
0.3 mi·37 sec
30
Continue on 59 Northbound Frontage Road
1.6 mi·2 min·59 Northbound Frontage Road
31
Continue on this road
0.4 mi·58 sec·this road
32
Continue on US 59 Northbound Frontage Road
2.0 mi·4 min·US 59 Northbound Frontage Road
33
Continue on Southwest Freeway Frontage Road
1.3 mi·2 min·Southwest Freeway Frontage Road
34
Take the ramp
0.2 mi·31 sec
Toward I 69 North, US 59 North
35
Merge onto I 69; US 59
33 mi·37 min·Southwest Freeway
Use the straight / slight right lanes.
36
Keep slight left at fork
0.9 mi·1 min
Toward Richmond Avenue, Downtown via Louisiana StreetUse the slight left lane.
37
Take the exit
155 ft·3 sec
Toward Downtown, Louisiana StreetUse the straight / slight right lanes.
38
Continue on Louisiana Street
1.9 mi·4 min·Louisiana Street
Use the straight / left lanes.
39
Arrive at destination
Louisiana Street
Trip Plan
To make the most of your 368.6-mile journey, try to depart early in the morning to avoid the fatigue that can set in during a turn-heavy local drive. You should plan for at least one dedicated stop to break up the 5-hour and 38-minute duration, as the lack of high-speed highway segments can make the time behind the wheel feel longer. Keep a close eye on your fuel gauge, as the $55 estimate assumes steady driving, which can vary depending on local traffic patterns and stop-and-go navigation. Since this route lacks the efficiency of a major highway, stay flexible with your arrival time and prioritize comfort over speed to ensure a safe arrival in Houston.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 178.3 miles from Mission, TX, or about 3h 24m into the drive.
The longest continuous stretch on this route runs about 88.6 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 78 miles or 1h 26m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 178.3 miles or 3h 24m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 37m
Traffic, exits, and arrival timing usually matter more near Houston, TX than in the middle of the route.
Before You Leave
+
Open the route before leaving Mission, TX so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Mission, TX
This is one driving day of about 356.6 miles and 6h 53m.
Your first comfortable stop window is around 78 miles from Mission, TX.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US Highway 59 South for about 88.6 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 24
5 decision points cluster between mile 2.1 and 354.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
2.1 mi into trip|~3m in|I 2; US 83
Merge onto I 2; US 83
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
6
10 mi into trip|~13m in
Take the exit toward I 69C North, US 281: Edinburg
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 416B
Toward I 69C North, US 281: Edinburg
5
146.5 mi into trip|~2h 46m in|North US Highway 77
Turn left onto North US Highway 77
Lane positioning matters here
Use the left lane.
8
353.8 mi into trip|~6h 48m in
Keep slight left at fork toward Richmond Avenue, Downtown via Louisiana Street
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Toward Richmond Avenue, Downtown via Louisiana...
7
354.7 mi into trip|~6h 49m in
Take the exit toward Downtown, Louisiana Street
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward Downtown, Louisiana Street
Fuel & Cost
Regular Gas
$53.88 one way
$107.77 round trip
$3.84/gal25.4 MPG avg125 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.20
$58.98
$117.96
premium
$4.54
$63.67
$127.34
diesel
$5.61
$78.73
$157.47
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$54
Meals
$25–$50
Total
$79–$104
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 124.8 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $37 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
107
1
$37.44
$17.12
Efficient EV
89.2
1
$31.20
$14.26
EV Truck/SUV
142.6
1
$49.92
$22.82
Gas CO2
125 kg
EV CO2
42 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 18, 2026
Origin
Mission, TX
Late night
in Mission on Tuesday
Local time
3:07 AM
CDT
Current temp
74°F
Mostly Cloudy
SSE 14 mph0% chanceLive forecast
Special Weather Statement
Special Weather Statement issued April 18 at 2:50AM CDT by NWS San Angelo TX
Wind Advisory
Wind Advisory issued April 18 at 2:47AM CDT until April 18 at 1:00PM CDT by NWS San Angelo TX
Destination
Houston, TX
Late night
in Houston on Tuesday
Local time
3:07 AM
CDT
Current temp
71°F
Mostly Cloudy
S 5 to 10 mph8% chanceLive forecast
Special Weather Statement
Special Weather Statement issued April 18 at 2:50AM CDT by NWS San Angelo TX
Wind Advisory
Wind Advisory issued April 18 at 2:47AM CDT until April 18 at 1:00PM CDT by NWS San Angelo TX
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
3 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 53m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a hands-on driving experience as this route relies heavily on North Conway Avenue, US 83, and East Expressway 83. Unlike a monotonous interstate slog, this path is characterized by frequent turns and local transitions that keep you fully engaged behind the wheel. The highway share is 0 percent, meaning you will spend your time navigating through local infrastructure rather than cruising at high speeds on major interstates. With no long, uninterrupted stretches on North Conway Avenue, you should prepare for a drive that demands constant focus and frequent adjustments to your speed and direction.
89% highway — fuel and pacing are the main things to plan.
39 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 88.6 mi on US Highway 59 South.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on US Highway 59 South and US 281. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 2.1 miles in near I 2; US 83.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 24 significant decision points across 356.6 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 2.1 miles (I 2; US 83): Merge point - match speed before joining. Lane positioning matters here; at 10 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 146.5 miles (North US Highway 77): Lane positioning matters here.
Elevation Profile
Mostly flat terrain
201 ft35 ft
Total Climb
245 ft
Total Descent
352 ft
Highest Point
201 ft
~118.9 mi in
Elevation Range
166 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Mission, TX and Houston, TX, road signs point toward County Road 44, Sinton and Victoria.
Houston is a sprawling port city in Southeastern Texas. An oil boom and continuing international immigration has brought explosive growth to the city, and it is now the fifth largest metropolitan area in the United States and the most diverse large city since 2021. While at first glance, the city appears to be a 9-5 central business district surrounded by a sea of suburbs and strip malls, there are many hidden gems to be discovered.
Top landmarks
•Museum of Fine Arts, Houston — art museum in Houston, Texas
•Astrodome — historic place in Houston, Harris County, Texas
•Rothko Chapel — building in Houston, Harris County, Texas
Doable as a same-day drive at 6h 53m. Total distance: 356.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 53m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 88.6 miles on US Highway 59 South. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Houston, TX before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 2.1 miles (I 2; US 83): Merge point - match speed before joining. Lane positioning matters here; at 10 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one; at 146.5 miles (North US Highway 77): Lane positioning matters here.
Not recommended in a single day. At 6.9 hours each way, a round trip means 13.8 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Houston, TX before the return drive.
