Traveling from Mifflinburg to Pittsburgh covers 182.9 miles of Pennsylvania terrain, typically requiring about 3 hours and 25 minutes of driving time. Because this route relies on local roads rather than interstates, it is best suited for a single-day trip rather than an overnight journey. You should budget approximately $29 for fuel to complete the transit between these two Northeast locations. Navigating through Penns Valley Road and Main Street offers a direct, albeit non-highway, connection across the state. It is a straightforward trip that rewards those who prefer backroad driving over the monotony of major expressways.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
91.4 miles from Mifflinburg, PA
A natural place for your longest stop of the day
, about 2h into the drive
.
Main Roads
Road
Distance
Duration
William Penn Highway
61.2 mi
1h 25m
I 99
33.8 mi
36m
Mount Nittany Expressway
16.8 mi
20m
Penns Valley Road
15.3 mi
22m
Penn-Lincoln Parkway East
13.5 mi
18m
Admiral Peary Highway
13.4 mi
19m
Old Turnpike Road
10.8 mi
16m
Earlystown Road
6.8 mi
10m
Longest stretch:
William Penn Highway
— 61.2 mi, about 1h 25m
Turn-by-Turn Driving Directions
Step-by-step road directions between Mifflinburg, PA and Pittsburgh, PA.
1
Start on PA 45
0.8 mi·1 min·Chestnut Street
2
Continue on PA 45
4.5 mi·6 min·Old Turnpike Road
3
Continue on PA 45
1.0 mi·1 min·Main Street
4
Continue on PA 45
6.3 mi·9 min·Old Turnpike Road
5
Continue on PA 45
3.1 mi·4 min·Penns Valley Road
6
Continue on PA 45
1.1 mi·1 min·Mountain Avenue
7
Continue on PA 45
4.5 mi·6 min·Penns Valley Road
8
Continue on PA 45
1.1 mi·1 min·East Aaron Square
9
Continue on PA 45
1.6 mi·3 min·East Main Street
10
Continue on PA 45
7.7 mi·11 min·Penns Valley Road
11
Continue on PA 45
2.8 mi·4 min·Penns Valley Pike
12
Continue on PA 45
6.8 mi·10 min·Earlystown Road
13
Take the ramp
0.4 mi·49 sec
14
Merge onto US 322; PA 144 Truck
17 mi·20 min·Mount Nittany Expressway
15
Keep slight left at fork onto I 99; US 220
34 mi·36 min·I 99; US 220
Toward I 99 South, US 220 South: Port Matilda, Altoona
16
Take the exit
0.8 mi·1 min
Toward US 22: Ebensburg, Hollidaysburg
17
Continue on this road
0.5 mi·43 sec·this road
18
Continue on US 22
16 mi·19 min·William Penn Highway
19
Continue on US 22
13 mi·19 min·Admiral Peary Highway
Use the straight lane.
20
Continue on US 22
45 mi·1 hr 6 min·William Penn Highway
Use the straight / right lanes.
21
Keep slight right at fork onto I 376; US 22
13 mi·18 min·Penn-Lincoln Parkway East
Toward I 376 West, US 22 West: PittsburghUse the slight left lane.
22
Take the exit
0.2 mi·38 sec
Exit 71BToward Second AvenueUse the straight / slight right lanes.
23
Turn straight onto Second Avenue
0.3 mi·41 sec·Second Avenue
24
At end of road, turn right onto Ross Street
0.2 mi·32 sec·Ross Street
25
Turn left onto Fifth Avenue
352 ft·10 sec·Fifth Avenue
26
Turn right onto Grant Street
513 ft·21 sec·Grant Street
Use the right lane.
27
Arrive at destination
Grant Street
Trip Plan
Since this is a 3-hour and 25-minute commitment without the benefit of high-speed highways, planning your departure time is essential to avoid fatigue. Aim to leave early in the morning to maximize daylight, as the technical nature of these local roads can be more taxing after dark. With only one recommended stop, you have plenty of flexibility to stretch your legs whenever you find a convenient spot along your route. Keep a close eye on your fuel gauge, as the $29 budget is a baseline that can fluctuate depending on your vehicle's efficiency on these stop-and-go stretches. Because you are avoiding major highways, ensure your GPS is updated to navigate the frequent turns on Penns Valley Road effectively.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 91.4 miles from Mifflinburg, PA, or about 2h into the drive.
The longest continuous stretch on this route runs about 61.2 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 40 miles or 1h 1m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 91.4 miles or 2h in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 20m
Traffic, exits, and arrival timing usually matter more near Pittsburgh, PA than in the middle of the route.
Before You Leave
+
Open the route before leaving Mifflinburg, PA so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Mifflinburg, PA
This is one driving day of about 182.7 miles and 4h 9m.
Your first comfortable stop window is around 40 miles from Mifflinburg, PA.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on William Penn Highway for about 61.2 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 8
5 decision points cluster between mile 58.6 and 182.6 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
58.6 mi into trip|~1h 24m in|I 99; US 220
Keep slight left at fork onto I 99; US 220 toward I 99 South, US 220 South: Port Matilda, Altoona
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 99 South, US 220 South: Port Matilda,...
8
168.4 mi into trip|~3h 48m in|I 376; US 22 / Penn-Lincoln Parkway East
Keep slight right at fork onto I 376; US 22 / Penn-Lincoln Parkway East toward I 376 West, US 22 West: Pittsburgh
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left lane.
Toward I 376 West, US 22 West: Pittsburgh
7
181.9 mi into trip|~4h 6m in
Take the exit toward Second Avenue
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Exit 71B
Toward Second Avenue
6
182.4 mi into trip|~4h 8m in|Ross Street
At end of road, turn right onto Ross Street
Complex interchange - multiple decisions in a short stretch
7
182.6 mi into trip|~4h 8m in|Grant Street
Turn right onto Grant Street
Lane positioning matters here
Use the right lane.
Fuel & Cost
Regular Gas
$30.29 one way
$60.58 round trip
$4.21/gal25.4 MPG avg64 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.61
$33.17
$66.35
premium
$4.93
$35.43
$70.86
diesel
$5.61
$40.34
$80.68
Estimated Tolls: $0.75
Old Turnpike Road
(10.8 mi)$0.75
Toll estimates based on average 2024-2025 rates. EZ-Pass/SunPass discounts may lower the actual cost.
Estimated Trip Cost (one way, 1 person)
Fuel
$30
Tolls
$1
Meals
$25–$50
Total
$56–$81
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 63.9 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $19 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
54.8
0
$19.18
$8.77
Efficient EV
45.7
0
$15.99
$7.31
EV Truck/SUV
73.1
0
$25.58
$11.69
Gas CO2
64 kg
EV CO2
21 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 20, 2026
Origin
Mifflinburg, PA
Morning
in Mifflinburg on Tuesday
Local time
9:52 AM
EDT
Current temp
61°F
Unavailable
Live forecast
Destination
Pittsburgh, PA
Morning
in Pittsburgh on Tuesday
Local time
9:52 AM
EDT
Current temp
69°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
8 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 9m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Johnstown Flood National Memorial
National Memorial
The South Fork Dam failed on Friday, May 31, 1889, and unleashed 20,000,000 tons of water that devastated Johnstown, PA. The flood killed 2,209 people but it brought the nation and the world together...
8 mi from route
~20 min detour
Free
near mile 113.4
On Tuesday morning, September 11, 2001, the U.S. came under attack when four commercial airliners were hijacked and used to strike targets on the ground. Nearly 3,000 people tragically lost their live...
27 mi from route
~67 min detour
Free
near mile 119.7
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
Expect a turn-heavy local drive that keeps you actively engaged behind the wheel. With a 0% highway share, you will spend the entire 182.9 miles navigating surface streets and local corridors like Old Turnpike Road. There is no long-distance interstate cruising here; in fact, the longest stretch on any single road is 0 miles on Old Turnpike Road, indicating frequent turns and transitions. This route prioritizes local connectivity over speed, making for a technical drive that requires your full attention. You will find that the road's personality remains consistent, favoring winding local paths over high-speed transit.
41% highway, the rest on surface roads — varied driving throughout.
27 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 61.2 mi on William Penn Highway.
How Hard Is This Drive?
5/10
This route mixes highway mileage with some local-road sections near the start or finish. You will hit about 8 points where you need to pay attention to lane position or signs. The trickiest moment comes around 58.6 miles in near I 99; US 220.
Driving Effort5/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 182.7 miles you will encounter 8 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 58.6 miles (I 99; US 220): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 168.4 miles (I 376; US 22 / Penn-Lincoln Parkway East): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 181.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Mifflinburg, PA and Pittsburgh, PA, road signs point toward Altoona and Hollidaysburg.
The pleasure of Pittsburgh remains a well-kept secret. Though not built up by reputation, the city's unique combination of bridges, steep hills, and broad rivers make it one of the most naturally scenic cities in the country. Cheap food and beer abound in this true sports town and the locals are amazingly friendly. A city of about 303,000 (2021) in Allegheny County, at the center of a metro area of about 2.4 million in southwestern Pennsylvania, Pittsburgh is situated at the confluence of three rivers: the Monongahela and Allegheny Rivers, which meet to form the Ohio River. The city's unique terrain has resulted in an unusual city design and a hodge-podge of unique neighborhood "pockets" with diverse ethnic and architectural heritage.
Top landmarks
•Carnegie Museum of Natural History — natural history museum in Pittsburgh, Pennsylvania, United States
•Allegheny Observatory — historic observatory of the University of Pittsburgh
•Carnegie Museum of Art — museum in Pittsburgh, Pennsylvania
Doable as a same-day drive at 4h 9m. Total distance: 182.7 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 9m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (41%). Some complex stretches to watch for.
Scenic Drive
Mixed highway & surface route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 61.2 miles on William Penn Highway. The full list of main roads is in the Roads section above.
Expect about $0.75 in tolls one way, starting with Old Turnpike Road. Most Northeast and Midwest toll agencies accept E-ZPass; in the West and Texas, transponders like TxTag or FasTrak apply. If you do not have a transponder, cashless tolling plates will mail a bill to the vehicle's registered address — usually with a surcharge, so a rental-car toll pass is often cheaper than paying by mail.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: at 58.6 miles (I 99; US 220): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 168.4 miles (I 376; US 22 / Penn-Lincoln Parkway East): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 181.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Yes — Johnstown Flood National Memorial and Flight 93 National Memorial. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.2 hours each way, an in-and-out day trip would put you behind the wheel for 8.3 hours — manageable with a long break at Pittsburgh, PA, but most travelers stay overnight.
