This 218.2-mile journey from Liberty, MO to O'Fallon, MO will take approximately 4 hours and 13 minutes. Primarily following the Dwight D. Eisenhower Highway and U.S. Submarine Veterans' Memorial Highway, this route is best suited for a single day trip, with an estimated fuel cost of $34. You'll experience a 'turn-heavy local drive' feel for much of the way, making it a straightforward trip within the Midwest. This drive offers a practical way to get from point A to point B without extensive planning.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
109.1 miles from Liberty, MO
A natural place for your longest stop of the day
, about 2h 5m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
142.5 mi
2h 42m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
MO 291
14 mi
20m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi
1m
Truman/Eisenhower Presidential Highway
1.5 mi
1m
South Leonard Street
0.6 mi
1m
South Main Street
0.6 mi
1m
Longest stretch:
Dwight D. Eisenhower Highway
— 142.5 mi, about 2h 42m
Turn-by-Turn Driving Directions
Step-by-step road directions between Liberty, MO and O'Fallon, MO.
1
Start on East Kansas Street
182 ft·12 sec·East Kansas Street
2
Turn right onto South Missouri Street
490 ft·27 sec·South Missouri Street
3
Turn left onto East Mill Street
377 ft·11 sec·East Mill Street
4
Turn right onto South Leonard Street
0.6 mi·1 min·South Leonard Street
5
Take the ramp
147 ft·2 sec
6
Merge onto MO 291
14 mi·20 min·MO 291
7
Take the exit
0.3 mi·49 sec
Exit 16BToward I 70 East: Saint LouisUse the right lane.
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
11
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
12
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
13
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
14
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
15
Continue on I 70; US 40
88 mi·1 hr 44 min·Dwight D. Eisenhower Highway
Use the straight / slight right lanes.
16
Take the exit
0.3 mi·43 sec
Toward MO K: O'FallonUse the straight / slight right lanes.
17
Turn straight onto Drennen Parkway
150 ft·3 sec·Drennen Parkway
Toward MO K: O'Fallon
18
Keep slight right at fork onto Drennen Parkway
166 ft·5 sec·Drennen Parkway
Toward MO K: O'Fallon
19
Turn slight left
62 ft·2 sec
Toward MO K: O'Fallon
20
Continue on South Main Street
0.6 mi·1 min·South Main Street
21
Turn right
25 ft·1 sec
22
Arrive at destination
Trip Plan
With a total duration of just over 4 hours, this 218.2-mile trip is easily manageable in one day. Consider departing in the morning to maximize daylight and take advantage of potentially lighter traffic. The route has one recommended stop, so plan for a break around the halfway point. Keep an eye on your fuel gauge, as the estimated cost is $34, and be prepared for the 'turn-heavy' nature of the drive, especially as you get closer to your destination in O'Fallon. A specific tip: familiarize yourself with the MO 291 segment, as it's a key artery for this particular journey.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 109.1 miles from Liberty, MO, or about 2h 5m into the drive.
The longest continuous stretch on this route runs about 142.5 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 48 miles or 59m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 109.1 miles or 2h 5m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 26m
Traffic, exits, and arrival timing usually matter more near O'Fallon, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Liberty, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Liberty, MO
This is one driving day of about 218.2 miles and 4h 13m.
Your first comfortable stop window is around 48 miles from Liberty, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 142.5 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 11
5 decision points cluster between mile 0 and 217.6 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0 mi into trip|~0m in|South Missouri Street
Turn right onto South Missouri Street
Navigation decision point
5
0.1 mi into trip|~0m in|East Mill Street
Turn left onto East Mill Street
Navigation decision point
7
14.9 mi into trip|~23m in
Take the exit toward I 70 East: Saint Louis
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the right lane.
Exit 16B
Toward I 70 East: Saint Louis
6
217.2 mi into trip|~4h 11m in
Take the exit toward MO K: O'Fallon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Toward MO K: O'Fallon
6
217.6 mi into trip|~4h 12m in|Drennen Parkway
Keep slight right at fork onto Drennen Parkway toward MO K: O'Fallon
Highway fork - watch signs carefully
Toward MO K: O'Fallon
Fuel & Cost
Regular Gas
$34.11 one way
$68.23 round trip
$3.97/gal25.4 MPG avg76 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$37.45
$74.91
premium
$4.89
$41.99
$83.98
diesel
$5.61
$48.18
$96.35
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$34
Meals
$25–$50
Total
$59–$84
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 76.3 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $23 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
65.5
0
$22.91
$10.47
Efficient EV
54.6
0
$19.09
$8.73
EV Truck/SUV
87.3
1
$30.55
$13.96
Gas CO2
76 kg
EV CO2
26 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Liberty, MO
Late night
in Liberty on Sunday
Local time
12:59 AM
CDT
Current temp
56°F
Unavailable
Live forecast
Destination
O'Fallon, MO
Late night
in O'Fallon on Sunday
Local time
12:59 AM
CDT
Current temp
57°F
Unavailable
Live forecast
55°F
New Franklin, MO
109 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 13m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a 'turn-heavy local drive' profile for most of this 218.2-mile route. While 6% of the drive utilizes highway travel, the majority involves navigating local roads and highways like MO 291. Your longest uninterrupted stretch will be 142.5 miles on the Dwight D. Eisenhower Highway, offering a period of more consistent travel before transitioning back to more frequent turns. This road personality suggests you'll be more engaged with the driving, with frequent changes in direction and speed.
Only 6% highway — the rest is turn-by-turn surface driving.
22 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 142.5 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
6/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. You will hit about 11 points where you need to pay attention to lane position or signs. The trickiest moment comes early in the drive near South Missouri Street.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 218.2 miles you will encounter 11 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (South Missouri Street): Navigation decision point; at 0.1 miles (East Mill Street): Navigation decision point; at 14.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 4h 13m. Total distance: 218.2 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 13m drive, comfortable solo distance.
Scenic Drive
Mostly surface roads route profile.
Frequently Asked Questions
The longest stretch is about 142.5 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at O'Fallon, MO before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: near the start (South Missouri Street): Navigation decision point; at 0.1 miles (East Mill Street): Navigation decision point; at 14.9 miles: Exit ramp - move to the correct lane early. Lane positioning matters here.
Possible but tiring. At 4.2 hours each way, an in-and-out day trip would put you behind the wheel for 8.5 hours — manageable with a long break at O'Fallon, MO, but most travelers stay overnight.
