Traveling from Hereford to San Antonio covers 496.7 miles across the Texas Great Plains. You should plan for a driving time of approximately 7 hours and 34 minutes, making this a long but manageable single-day commitment for most drivers. Because the route relies on local roads like West 1st Street, South 25 Mile Avenue, and North Main Street rather than high-speed interstates, it demands your full attention behind the wheel. Expect to budget roughly $74 for fuel to complete the journey. While it is possible to finish the trip in one day, the turn-heavy nature of the drive makes it a significant undertaking that requires careful pacing.
Trip Pace
Best split across 2 days
Treat the return leg as its own travel day rather than an afterthought.
Break Rhythm
2 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
242.8 miles from Hereford, TX
A natural place for your longest stop of the day
, about 4h 25m into the drive
.
Main Roads
Road
Distance
Duration
US Highway 84
73.9 mi
1h 14m
I 10
71.7 mi
1h 14m
US 385
42.4 mi
44m
Grassmeyer Street
41.9 mi
44m
US 84
40 mi
42m
US 83
40 mi
38m
State Highway 153
29.5 mi
33m
Ellis Street
29.4 mi
31m
Longest stretch:
US Highway 84
— 73.9 mi, about 1h 14m
Turn-by-Turn Driving Directions
Step-by-step road directions between Hereford, TX and San Antonio, TX.
1
Start on this road
242 ft·19 sec·this road
2
Turn right onto US 60
0.5 mi·35 sec·West 1st Street
3
Turn left onto US 385
21 mi·31 min·South 25 Mile Avenue
4
Turn right onto US 385
21 mi·22 min·US 385
5
Turn straight onto North Main Street
0.1 mi·11 sec·North Main Street
6
Continue on US 385
5.8 mi·5 min·US 385
7
Turn straight onto US 385
16 mi·16 min·US 385
8
At end of road, turn left onto US 385; Loop 430
2.3 mi·3 min·East Delano Avenue
Use the left lane.
9
Turn left onto US 84
34 mi·35 min·US 84
10
Merge onto US 84
4.0 mi·4 min·Avenue Q
Use the straight / right lanes.
11
Continue on US 84
4.8 mi·6 min·Slaton Road
12
Continue on US 84
6.9 mi·6 min·East Highway 84
13
Continue on US 84
4.5 mi·4 min·Trooper Jerry Don Davis Memorial Highway
14
Continue on US 84
20 mi·20 min·East Highway 84
15
Continue on US 84
1.0 mi·1 min·North US Highway 84
16
Turn left onto Spur 575
0.1 mi·16 sec·East 15th Street
17
Turn right onto TX 207
0.4 mi·37 sec·Ralls Road
18
Turn straight onto TX 207
1.1 mi·2 min·North Avenue F
19
At end of road, turn left onto US 84
74 mi·1 hr 14 min·US Highway 84
20
Keep slight left at fork onto US 84
6.5 mi·6 min·US 84
Toward I 20 East, US 84 East: Abilene
21
Take the exit
0.1 mi·18 sec
Exit 244Toward SH 70 South, SH 70 Business: Sweetwater, San Angelo
22
Turn slight left onto Southwest Georgia Avenue
0.1 mi·16 sec·Southwest Georgia Avenue
23
Turn right onto TX 70
0.7 mi·1 min·Lamar Street
24
Continue on TX 70
10 mi·10 min·State Highway 70
25
Turn left onto TX 153
29 mi·33 min·State Highway 153
26
Turn right onto FM 2111
12 mi·13 min·FM 2111
27
Turn left onto TX 158
6.3 mi·7 min·TX 158
28
At end of road, turn right onto US 67; US 83
387 ft·18 sec·Hutchings Avenue
29
Turn left onto US 83
17 mi·18 min·South 7th Street
Use the left lane.
30
Continue on US 83
42 mi·44 min·Grassmeyer Street
31
Continue on US 83
29 mi·31 min·Ellis Street
32
Take the exit onto US 83
40 mi·38 min·US 83
Toward I 10 East: San AntonioUse the left lane.
33
Continue on I 10
54 mi·54 min·I 10
Use the straight / slight right lanes.
34
Keep slight right at fork onto I 10; US 87
17 mi·19 min·I 10; US 87
Use the straight / slight right lanes.
35
Keep slight right at fork onto I 10; US 87
1.7 mi·2 min·McDermott Freeway
36
Take the exit
0.5 mi·1 min
Exit 569CToward Santa Rosa Street, DowntownUse the slight right lane.
37
Turn straight onto North Pecos-La Trinidad
0.2 mi·16 sec·North Pecos-La Trinidad
38
Keep slight right at fork onto North Pecos-La Trinidad
0.6 mi·1 min·North Pecos-La Trinidad
Use the straight lane.
39
Turn left onto Dolorosa Street
0.5 mi·55 sec·Dolorosa Street
Use the straight / left lanes.
40
Arrive at destination
Dolorosa Street
Trip Plan
Given the 7 hour and 34 minute duration, departing early in the morning is your best strategy to avoid fatigue during the final leg of the trip. Plan for at least two stops along the way to stretch your legs and break up the repetitive nature of local road navigation. Since this route utilizes city-focused streets like North Main Street, keep a close watch on local traffic patterns and changing speed limits. Budgeting $74 for fuel is a solid baseline, but keep a little extra set aside for potential fluctuations depending on your vehicle's efficiency. Because the route is entirely local, use your navigation tools proactively to manage the numerous turns required to reach San Antonio.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
This drive is better paced as a 2-day trip.
Plan roughly 2 meaningful breaks for fuel, food, and rest.
The halfway point lands around 242.8 miles from Hereford, TX, or about 4h 25m into the drive.
The longest continuous stretch on this route runs about 73.9 miles.
Consider an overnight stop or starting very early.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 107 miles or 2h 4m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 242.8 miles or 4h 25m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Overnight split
Day 1 wrap after about 242.8 miles or 4h 25m
Stop before fatigue turns the last few hours into a grind. You want day two to start fresh, not just resumed.
Final approach
Final hour starts around 7h 37m
Traffic, exits, and arrival timing usually matter more near San Antonio, TX than in the middle of the route.
Before You Leave
+
Open the route before leaving Hereford, TX so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
+
Treat this as a 2-day road trip and book the overnight stop before the busiest arrival window.
Day 1
Settle into the route from Hereford, TX
Aim for roughly 243 miles and 4.4 hours of wheel time on this day.
Day 2
Finish the approach into San Antonio, TX
Aim for roughly 243 miles and 4.4 hours of wheel time on this day.
Your first comfortable stop window is around 107 miles from Hereford, TX.
This route usually feels better as a 2-day drive than as one long push.
Plan about 2 real breaks rather than only quick fuel stops.
The longest stretch is on US Highway 84 for about 73.9 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 23
5 decision points cluster between mile 64.2 and 484 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
7
64.2 mi into trip|~1h 17m in|US 385; Loop 430 / East Delano Avenue
At end of road, turn left onto US 385; Loop 430 / East Delano Avenue
Lane positioning matters here
Use the left lane.
6
216.9 mi into trip|~3h 57m in|US 84
Keep slight left at fork onto US 84 toward I 20 East, US 84 East: Abilene
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 20 East, US 84 East: Abilene
6
223.3 mi into trip|~4h 3m in
Take the exit toward SH 70 South, SH 70 Business: Sweetwater, San Angelo
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 244
Toward SH 70 South, SH 70 Business: Sweetwater,...
8
370.7 mi into trip|~6h 44m in|US 83
Take the exit onto US 83 toward I 10 East: San Antonio
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the left lane.
Toward I 10 East: San Antonio
8
484 mi into trip|~8h 38m in
Take the exit toward Santa Rosa Street, Downtown
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 569C
Toward Santa Rosa Street, Downtown
Fuel & Cost
Regular Gas
$73.39 one way
$146.78 round trip
$3.84/gal25.4 MPG avg170 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.20
$80.33
$160.66
premium
$4.54
$86.72
$173.44
diesel
$5.61
$107.24
$214.47
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$73
Hotel (1n)
$80–$140
Meals
$50–$100
Total
$203–$313
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 169.9 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $51 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
145.7
1
$51.00
$23.31
Efficient EV
121.4
1
$42.50
$19.43
EV Truck/SUV
194.3
2
$68.00
$31.08
Gas CO2
170 kg
EV CO2
57 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 14, 2026
Origin
Hereford, TX
Late night
in Hereford on Tuesday
Local time
4:24 AM
CDT
Current temp
77°F
Unavailable
Live forecast
Destination
San Antonio, TX
Late night
in San Antonio on Tuesday
Local time
4:24 AM
CDT
Current temp
85°F
Mostly Cloudy
SSE 5 to 15 mph3% chanceLive forecast
Wind Advisory
Wind Advisory issued April 14 at 6:30AM CDT until April 14 at 9:00PM CDT by NWS Amarillo TX
Red Flag Warning
Red Flag Warning issued April 14 at 6:28AM CDT until April 14 at 9:00PM CDT by NWS Amarillo TX
85°F
Roscoe, TX
243 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
For long drives, weather on day two can matter just as much as conditions at departure, so check the whole travel window rather than only the first day.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
8 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
8h 42m on the road
This is long enough that the arrival forecast matters almost as much as departure conditions. Recheck both ends before you roll.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
San Antonio Missions National Historical Park
National Historical Park
Welcome to San Antonio Missions, a National Park Service site and the only UNESCO World Heritage Site in Texas. Each mission in the park is a center of community and has been since the early 1700s. Th...
9 mi from route
~22 min detour
Free
near mile 485.7
Lyndon B. Johnson National Historical Park tells the story of our 36th president beginning with his ancestors until his final resting place on his beloved LBJ Ranch. This entire "circle of life" gives...
26 mi from route
~66 min detour
Free
near mile 435.4
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This journey is defined by its turn-heavy local road profile, offering a much different experience than a standard interstate cruise. With a 0% highway share, you will be navigating local arteries for the entire 496.7-mile duration. The route requires consistent engagement, as you transition between local streets rather than maintaining a steady pace on a controlled-access road. You should be prepared for a slower, more deliberate driving pace compared to major highways. Staying alert is essential, as the lack of highway stretches means you will encounter frequent shifts in road geometry as you move through the Great Plains.
73% highway — fuel and pacing are the main things to plan.
40 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 73.9 mi on US Highway 84.
How Hard Is This Drive?
8/10
This is a straightforward highway drive that stays mostly on US Highway 84 and I 10. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 64.2 miles in near US 385; Loop 430 / East Delano Avenue.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 23 significant decision points across 485.7 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 64.2 miles (US 385; Loop 430 / East Delano Avenue): Lane positioning matters here; at 216.9 miles (US 84): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 223.3 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Hereford, TX and San Antonio, TX, road signs point toward Sh 70 South, Sh 70 Business: Sweetwater and San Angelo.
San Antonio is the second largest city in the state of Texas and the 7th largest in the United States. It's the 24th largest metropolitan area in the country. Visited by more than 31 million annual visitors, San Antonio is a beautiful city at the axis of three different geological terrains: Hill Country, South Texas Plains and Prairie and Lakes. There's a lot to do in this city: fine art museums, historical missions and plenty of amusement parks in addition to great dining and lots of drinking. The culture and people are vibrant and interesting. San Antonio's downtown is one of the most lively in the nation.
Top landmarks
•Alamo Mission in San Antonio — historic place in San Antonio, Bexar County, Texas
•San Antonio Missions National Historical Park — historic district in San Antonio, Bexar County, Texas
•Fort Sam Houston — military base in San Antonio, Texas
The longest stretch is about 73.9 miles on US Highway 84. The full list of main roads is in the Roads section above.
Yes — a 2-day pace is more comfortable than one long haul. A sensible stopping point is after roughly 243 miles on day one.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at San Antonio, TX before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 2 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 64.2 miles (US 385; Loop 430 / East Delano Avenue): Lane positioning matters here; at 216.9 miles (US 84): Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 223.3 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Yes — San Antonio Missions National Historical Park and Lyndon B Johnson National Historical Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 8.7 hours each way, a round trip means 17.4 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at San Antonio, TX before the return drive.
