Des Plaines, IL to Murphysboro, IL is 348.9 miles and takes about 6h 39m via I 57 and Tri-State Tollway, with a fuel budget near $62 and enough daylight to finish in a day. This Midwest to Midwest drive keeps you primarily on major highways, making it a straightforward trip within Illinois. With a recommended 1 day for the drive, it's suitable for a single push or a relaxed half-day trip. Expect consistent travel conditions as you head south, largely on tollways and interstates. This route offers efficiency for reaching your destination in southern Illinois.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
174.5 miles from Des Plaines, IL
A natural place for your longest stop of the day
, about 3h 20m into the drive
.
Main Roads
Road
Distance
Duration
I 57
254.2 mi
4h 34m
Ken Gray Expressway
32.7 mi
35m
Tri-State Tollway
28.3 mi
35m
Russell Street
11.3 mi
15m
Herrin Road
6.6 mi
9m
Cicero Avenue
4.9 mi
7m
East Herrin Street
3.1 mi
5m
South Des Plaines River Road
1.8 mi
3m
Longest stretch:
I 57
— 254.2 mi, about 4h 34m
Traffic on I-57
Hour-of-day weekday pattern from 16 FHWA count stations on your route.
Peak
3 PM
~1,006 veh/hr typical
· worst 1,239
Quietest
3 AM
~158 veh/hr
Peak-to-quiet ratio
6.4×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 51 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Des Plaines, IL and Murphysboro, IL.
1
Start on Henry Avenue
0.1 mi·25 sec·Henry Avenue
2
Turn right onto South Des Plaines River Road
1.8 mi·3 min·South Des Plaines River Road
Use the left lane.
3
Take the ramp
0.4 mi·55 sec
Toward I 294 South: Indiana
4
Merge onto I 294
11 mi·14 min·Tri-State Tollway
Use the straight / slight right lanes.
5
Keep slight left at fork onto I 294
4.8 mi·5 min·Tri-State Tollway
6
Keep slight right at fork onto I 294
3.5 mi·4 min·Tri-State Tollway
Use the straight / slight right lanes.
7
Continue on I 294
0.9 mi·1 min·Mile-Long Bridge
8
Continue on I 294
8.5 mi·10 min·Tri-State Tollway
Use the straight / slight right lanes.
9
Take the exit
0.2 mi·28 sec
Exit 12 B-AToward IL 50 South, IL 83: Cicero Avenue, 127th StreetUse the straight / slight right lanes.
10
Keep slight left at fork
0.5 mi·1 min
Exit 12AToward IL 50 South: Cicero AvenueUse the straight lane.
11
Turn straight onto IL 50; IL 83
4.9 mi·7 min·Cicero Avenue
Use the left lane.
12
Turn left onto 167th Street
0.2 mi·26 sec·167th Street
Use the left lane.
13
Take the ramp
0.6 mi·1 min
Toward I 57 South: Kankakee, I-80
14
Merge onto I 57
188 mi·3 hr 23 min·I 57
Use the straight / slight right lanes.
15
Keep slight left at fork onto I 57
66 mi·1 hr 10 min·I 57
Toward I 57 South: Memphis
16
Keep slight right at fork onto I 57
33 mi·35 min·Ken Gray Expressway
17
Take the exit
0.3 mi·38 sec
Toward Johnston City, Herrin
18
Turn right onto Herrin Road
3.1 mi·4 min·Herrin Road
19
Continue on East Herrin Street
3.1 mi·5 min·East Herrin Street
20
Continue on Herrin Road
3.5 mi·5 min·Herrin Road
21
Enter roundabout onto Cambria Road
35 ft·0 sec·Cambria Road
22
Continue on Cambria Road
1.5 mi·2 min·Cambria Road
23
Turn left onto IL 149
11 mi·15 min·Russell Street
24
Turn left onto IL 13; IL 127; IL 149
0.9 mi·1 min·North 2nd Street
25
Turn right onto IL 127; IL 149
0.6 mi·1 min·Walnut Street
26
Turn right onto North 11th Street
65 ft·2 sec·North 11th Street
27
Arrive at destination
North 11th Street
Trip Plan
To make the most of this 6h 39m drive, consider leaving early in the morning to maximize daylight and avoid potential afternoon traffic. The route is designed for a single day, so you can push through or plan for a single, brief stop. Keep an eye on your fuel gauge, especially during the 254.2-mile stretch on I 57, as services can sometimes be spaced out on long highway segments. Your estimated fuel cost is around $62, so budget accordingly. The transition from highway to surface roads will likely occur in the final stretch, so be prepared for a change in speed and traffic patterns as you approach Murphysboro.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 174.5 miles from Des Plaines, IL, or about 3h 20m into the drive.
The longest continuous stretch on this route runs about 254.2 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 77 miles or 1h 34m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 174.5 miles or 3h 20m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 23m
Traffic, exits, and arrival timing usually matter more near Murphysboro, IL than in the middle of the route.
Before You Leave
+
Open the route before leaving Des Plaines, IL so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Des Plaines, IL
This is one driving day of about 348.9 miles and 6h 39m.
Your first comfortable stop window is around 77 miles from Des Plaines, IL.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 57 for about 254.2 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 18
5 decision points cluster between mile 0.1 and 31.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0.1 mi into trip|~0m in|South Des Plaines River Road
Turn right onto South Des Plaines River Road
Lane positioning matters here
Use the left lane.
5
2.3 mi into trip|~4m in|I 294 / Tri-State Tollway
Merge onto I 294 / Tri-State Tollway
Merge point - match speed before joining. Lane positioning matters here
Use the straight / slight right lanes.
6
18.6 mi into trip|~25m in|I 294 / Tri-State Tollway
Keep slight right at fork onto I 294 / Tri-State Tollway
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
8
31.5 mi into trip|~41m in
Take the exit toward IL 50 South, IL 83: Cicero Avenue, 127th Street
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 12 B-A
Toward IL 50 South, IL 83: Cicero Avenue, 127th...
8
31.7 mi into trip|~41m in
Keep slight left at fork toward IL 50 South: Cicero Avenue
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight lane.
Exit 12A
Toward IL 50 South: Cicero Avenue
Fuel & Cost
Regular Gas
$51.52 one way
$103.05 round trip
$3.75/gal25.4 MPG avg122 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.14
$56.88
$113.76
premium
$4.72
$64.78
$129.56
diesel
$4.80
$65.88
$131.76
Estimated Tolls: $1.70
Tri-state Tollway
(28.3 mi)$1.70
Toll estimates based on average 2024-2025 rates. EZ-Pass/SunPass discounts may lower the actual cost.
Estimated Trip Cost (one way, 1 person)
Fuel
$52
Tolls
$2
Meals
$25–$50
Total
$78–$103
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 122.1 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $37 in charging
· 1 stop
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
104.7
1
$36.63
$16.75
Efficient EV
87.2
0
$30.53
$13.96
EV Truck/SUV
139.6
1
$48.85
$22.33
Gas CO2
122 kg
EV CO2
41 kg (66% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 17, 2026
Origin
Des Plaines, IL
Late night
in Des Plaines on Sunday
Local time
1:59 AM
CDT
Current temp
74°F
Smoke
0 mph8% chanceLive forecast
Flood Warning
Flood Warning issued July 16 at 8:29PM CDT until July 18 at 7:00PM CDT by NWS Lincoln IL
Flood Warning
Flood Warning issued July 16 at 8:29PM CDT until July 19 at 1:00PM CDT by NWS Lincoln IL
Destination
Murphysboro, IL
Late night
in Murphysboro on Sunday
Local time
1:59 AM
CDT
Current temp
90°F
Chance Showers And Thunderstorms
W 1 to 5 mph33% chanceLive forecast
Flood Warning
Flood Warning issued July 16 at 8:29PM CDT until July 18 at 7:00PM CDT by NWS Lincoln IL
Flood Warning
Flood Warning issued July 16 at 8:29PM CDT until July 19 at 1:00PM CDT by NWS Lincoln IL
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
16 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 39m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Pullman National Historical Park
National Historical Park
In a growing Chicago neighborhood, diverse people and stories intertwined. All were seeking opportunity. Some succeeded. Others were limited—by race, gender, or economic status. Their stories came tog...
9 mi from route
~23 min detour
Free
near mile 36.1
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
You'll be on highways for about 82% of this 348.9-mile trip. The longest continuous stretch you'll encounter is 254.2 miles on I 57. After the main highway sections, you'll transition to surface roads for the remainder of the drive. Expect a consistent flow of traffic and numerous exits along the interstate segments.
82% highway — fuel and pacing are the main things to plan.
27 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 254.2 mi on I 57.
How Hard Is This Drive?
8/10
This is a straightforward highway drive that stays mostly on I 57 and Ken Gray Expressway. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 0.1 miles in near South Des Plaines River Road.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 18 significant decision points across 348.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 0.1 miles (South Des Plaines River Road): Lane positioning matters here; at 2.3 miles (I 294 / Tri-State Tollway): Merge point - match speed before joining. Lane positioning matters here; at 18.6 miles (I 294 / Tri-State Tollway): Highway fork - watch signs carefully. Lane positioning matters here.
Elevation Profile
Mostly flat terrain
808 ft418 ft
Total Climb
446 ft
Total Descent
660 ft
Highest Point
808 ft
~49.8 mi in
Elevation Range
390 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Des Plaines, IL and Murphysboro, IL, road signs point toward Johnston City and Herrin.
Des Plaines is in Chicagoland. It is an inner-ring, northwest suburb of Chicago with two distinct portions: a suburban northern portion reminiscient of other, nearby northwest suburbs (including Niles, Park Ridge, and Mount Prospect), as well as a built-up southern portion with the businesses, hotels, and other amenities of the O'Hare Airport corridor (much like Rosemont, Chicago's O'Hare neighborhood, and Elk Grove Village).
Top landmarks
•McDonald's #1 Store Museum — former McDonald's spot
Doable as a same-day drive at 6h 39m. Total distance: 348.9 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 39m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 254.2 miles on I 57. The full list of main roads is in the Roads section above.
Expect about $1.70 in tolls one way, starting with Tri-state Tollway. Most Northeast and Midwest toll agencies accept E-ZPass; in the West and Texas, transponders like TxTag or FasTrak apply. If you do not have a transponder, cashless tolling plates will mail a bill to the vehicle's registered address — usually with a surcharge, so a rental-car toll pass is often cheaper than paying by mail.
Yes — we found about 45 rest areas or service plazas within a short detour of the route (from OpenStreetMap). See the Rest Stops tab under Nearby Places for locations and mile markers. Plan to stretch, use the bathroom, and top off fluids every 2–3 hours on longer drives.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Murphysboro, IL before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. There are 45 rest areas along the route for bathroom stops.
The main spots that need attention: at 0.1 miles (South Des Plaines River Road): Lane positioning matters here; at 2.3 miles (I 294 / Tri-State Tollway): Merge point - match speed before joining. Lane positioning matters here; at 18.6 miles (I 294 / Tri-State Tollway): Highway fork - watch signs carefully. Lane positioning matters here.
Yes — Pullman National Historical Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 6.7 hours each way, a round trip means 13.3 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Murphysboro, IL before the return drive.
