This 97.8-mile drive from Cary to Winston-Salem, North Carolina, is easily manageable as a single-day trip, taking approximately 1 hour and 58 minutes. You'll primarily travel on the Dan K. Moore Freeway and I-40, with a portion on Salem Parkway. With an estimated fuel cost of around $15, this is an economical option for getting between these two Southeast region cities. The mixed drive profile suggests a varied experience on the road, not a monotonous journey. Consider this a straightforward and efficient route for your North Carolina travels.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Midpoint
48.9 miles from Cary, NC
A natural place for your longest stop of the day
, about 59m into the drive
.
Main Roads
Road
Distance
Duration
Dan K. Moore Frwy
59.8 mi
1h 9m
I 40
20.3 mi
24m
Salem Parkway
13.4 mi
16m
North Harrison Avenue
3.3 mi
5m
South Main Street
0.4 mi
<1m
Chapel Hill Road
0.1 mi
<1m
North Academy Street
<0.1 mi
<1m
North Main Street
—
—
Some road-level metrics are being recalculated.
Longest stretch:
Dan K. Moore Frwy
— 59.8 mi, about 1h 9m
Turn-by-Turn Driving Directions
Step-by-step road directions between Cary, NC and Winston-Salem, NC.
1
Start on North Academy Street
24 ft·5 sec·North Academy Street
2
Turn right onto Chapel Hill Road
0.1 mi·18 sec·Chapel Hill Road
3
Turn right onto SR 1652
3.3 mi·5 min·North Harrison Avenue
Use the straight / right lanes.
4
Take the ramp
0.4 mi·41 sec
5
Merge onto I 40
60 mi·1 hr 9 min·Dan K. Moore Frwy.
Use the straight / slight right lanes.
6
Keep slight right at fork onto I 40
7.7 mi·9 min·I 40
Use the straight / slight left lanes.
7
Keep slight right at fork onto I 40; US 220
13 mi·15 min·I 40; US 220
Use the straight lane.
8
Keep slight right at fork onto US 421
13 mi·16 min·Salem Parkway
Exit 206Toward US 421 North: KernersvilleUse the straight lane.
9
Take the exit
0.2 mi·28 sec
Exit 233AToward Main StreetUse the slight right lane.
10
Turn slight right onto South Main Street
0.4 mi·44 sec·South Main Street
Use the straight lane.
11
Arrive at destination
North Main Street
Trip Plan
Given the short duration of under two hours, this trip offers great flexibility; you can depart whenever it suits you best. Since there are no designated stops, plan your own breaks as needed, perhaps midway through the drive on I-40. Keep an eye on your fuel gauge, especially during the longest stretch on the Dan K. Moore Freeway, as services can be spaced out. With a fuel cost estimated at $15, it's a budget-friendly journey, so you can focus on enjoying the drive itself.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
You may only need one short stretch break if traffic stays light.
The halfway point lands around 48.9 miles from Cary, NC, or about 59m into the drive.
The longest continuous stretch on this route runs about 59.8 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 22 miles or 28m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 48.9 miles or 59m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 1h 36m
Traffic, exits, and arrival timing usually matter more near Winston-Salem, NC than in the middle of the route.
Before You Leave
+
Open the route before leaving Cary, NC so your first major turns are already loaded.
Day 1
Settle into the route from Cary, NC
This is one driving day of about 97.8 miles and 1h 58m.
Your first comfortable stop window is around 22 miles from Cary, NC.
This route can stay practical as a one-day drive if traffic stays reasonable.
The longest stretch is on Dan K. Moore Frwy for about 59.8 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 9
5 decision points cluster between mile 0 and 97.2 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
0 mi into trip|~0m in|Chapel Hill Road
Turn right onto Chapel Hill Road
Navigation decision point
6
63.6 mi into trip|~1h 16m in|I 40
Keep slight right at fork onto I 40
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight left lanes.
6
71.2 mi into trip|~1h 25m in|I 40; US 220
Keep slight right at fork onto I 40; US 220
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight lane.
8
83.8 mi into trip|~1h 40m in|US 421 / Salem Parkway
Keep slight right at fork onto US 421 / Salem Parkway toward US 421 North: Kernersville
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight lane.
Exit 206
Toward US 421 North: Kernersville
7
97.2 mi into trip|~1h 56m in
Take the exit toward Main Street
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 233A
Toward Main Street
Fuel & Cost
Regular Gas
$15.29 one way
$30.59 round trip
$3.97/gal25.4 MPG avg34 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.34
$16.72
$33.44
premium
$4.70
$18.10
$36.20
diesel
$5.61
$21.59
$43.19
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$15
Meals
$25–$50
Total
$40–$65
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 34.2 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $10 in charging
· 0 stops
· 68% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
29.3
0
$10.27
$4.69
Efficient EV
24.5
0
$8.56
$3.91
EV Truck/SUV
39.1
0
$13.69
$6.26
Gas CO2
34 kg
EV CO2
11 kg (68% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 20, 2026
Origin
Cary, NC
Late night
in Cary on Tuesday
Local time
5:19 AM
EDT
Current temp
77°F
Unavailable
Live forecast
Destination
Winston-Salem, NC
Late night
in Winston-Salem on Tuesday
Local time
5:19 AM
EDT
Current temp
58°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
19 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
1h 58m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a mixed drive on this route, with about 34% of your journey on highways. The longest uninterrupted stretch you'll encounter is 59.8 miles on the Dan K. Moore Freeway, offering a good opportunity to settle into a rhythm. As you progress, the landscape will transition, with highway segments giving way to other road types as you approach your destination. This blend means you won't be stuck on one type of road for the entire trip, providing a dynamic driving experience.
34% highway, the rest on surface roads — varied driving throughout.
11 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 59.8 mi on Dan K. Moore Frwy.
How Hard Is This Drive?
7/10
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes early in the drive near Chapel Hill Road.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 97.8 miles you will encounter 9 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: near the start (Chapel Hill Road): Navigation decision point; at 63.6 miles (I 40): Highway fork - watch signs carefully. Lane positioning matters here; at 71.2 miles (I 40; US 220): Highway fork - watch signs carefully. Lane positioning matters here.
Cary is a town in the Research Triangle of North Carolina. It is primarily a fast-growing suburb of Raleigh, the state capital, but has developed some economic gravity of its own. Cary is known throughout the area for having a very high population of non-native residents. The name of the city is jokingly referred to as standing for Containment/Concentration Area for Relocated Yankees.
Winston-Salem is a city in North Carolina. It has an approximate population of 251,000 (2022). Winston-Salem is one of three cities that make up the Piedmont Triad; the others are Greensboro and High Point.
Top landmarks
•Old Salem — historic district and open-air museum in Winston-Salem, North Carolina, U.S.A.
•Reynolds Building — historic skyscraper in Winston-Salem, North Carolina, U.S.A.
•Home Moravian Church — church building in Winston-Salem, North Carolina
Doable as a same-day drive at 1h 58m. Total distance: 97.8 miles.
Family Friendly
Moderate complexity with 0 natural rest stops along the way.
Solo Traveler
1h 58m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (34%). Some complex stretches to watch for.
Scenic Drive
Mixed highway & surface route profile.
Frequently Asked Questions
The longest stretch is about 59.8 miles on Dan K. Moore Frwy. The full list of main roads is in the Roads section above.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Winston-Salem, NC before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Yes. At under 2 hours behind the wheel, this works well for families — plan one quick stop if you have younger kids.
The main spots that need attention: near the start (Chapel Hill Road): Navigation decision point; at 63.6 miles (I 40): Highway fork - watch signs carefully. Lane positioning matters here; at 71.2 miles (I 40; US 220): Highway fork - watch signs carefully. Lane positioning matters here.
Yes. A round trip is manageable in a single day if you plan a break at Winston-Salem, NC before heading back.
