Traveling from the coast to the Piedmont is straightforward with this 235.3-mile journey connecting Wilmington to Winston-Salem. Expect to spend about 4 hours and 28 minutes behind the wheel, making this a very manageable single-day trip. You will spend roughly half of your time on highways, primarily utilizing the Michael Jordan Highway, I-40, and the Salem Parkway. Budgeting around $38 for fuel should cover your travel costs, leaving you plenty of time to explore once you arrive. Since both cities are located within the Southeast region of North Carolina, the transition between them feels like a natural progression across the state. Whether you are heading inland for business or leisure, this route offers a reliable path that fits perfectly into a one-day itinerary.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
117.6 miles from Wilmington, NC
A natural place for your longest stop of the day
, about 2h 10m into the drive
.
Main Roads
Road
Distance
Duration
Michael Jordan Highway
107.3 mi
1h 55m
I 40
106.4 mi
2h 3m
Salem Parkway
13.4 mi
16m
Martin Luther King Jr Parkway
4.7 mi
6m
South 3rd Street
1.7 mi
3m
North College Road
1.2 mi
1m
South Main Street
0.4 mi
<1m
North Main Street
—
—
Some road-level metrics are being recalculated.
Longest stretch:
Michael Jordan Highway
— 107.3 mi, about 1h 55m
Turn-by-Turn Driving Directions
Step-by-step road directions between Wilmington, NC and Winston-Salem, NC.
1
Start on US 17 Business
1.7 mi·3 min·South 3rd Street
Use the straight / right lanes.
2
Keep slight right at fork onto Martin Luther King Jr Parkway
4.7 mi·6 min·Martin Luther King Jr Parkway
Use the straight lane.
3
Turn left onto US 117; NC 132
1.2 mi·1 min·North College Road
Use the left lane.
4
Continue on I 40; US 117; NC 132
107 mi·1 hr 55 min·Michael Jordan Highway
5
Keep slight left at fork onto I 40
86 mi·1 hr 38 min·I 40
Use the straight / slight right lanes.
6
Keep slight right at fork onto I 40
7.7 mi·9 min·I 40
Use the straight / slight left lanes.
7
Keep slight right at fork onto I 40; US 220
13 mi·15 min·I 40; US 220
Use the straight lane.
8
Keep slight right at fork onto US 421
13 mi·16 min·Salem Parkway
Exit 206Toward US 421 North: KernersvilleUse the straight lane.
9
Take the exit
0.2 mi·28 sec
Exit 233AToward Main StreetUse the slight right lane.
10
Turn slight right onto South Main Street
0.4 mi·44 sec·South Main Street
Use the straight lane.
11
Arrive at destination
North Main Street
Trip Plan
Planning your departure is key to keeping this 4-hour and 28-minute drive stress-free. Since the trip is relatively short, you have the flexibility to leave whenever suits your schedule, though aiming for off-peak hours will help you navigate the highway sections more comfortably. You only need to build in one primary stop to stay refreshed throughout the 235.3-mile trek. Because you are traveling across a significant portion of North Carolina, keep a close eye on your fuel gauge before starting the 107.3-mile stretch on the Michael Jordan Highway to ensure you don't run low in a less populated area. Taking this methodical approach to your pacing ensures that you arrive in Winston-Salem feeling energized rather than drained by the time in the driver's seat.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 117.6 miles from Wilmington, NC, or about 2h 10m into the drive.
The longest continuous stretch on this route runs about 107.3 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 52 miles or 1h in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 117.6 miles or 2h 10m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 37m
Traffic, exits, and arrival timing usually matter more near Winston-Salem, NC than in the middle of the route.
Before You Leave
+
Open the route before leaving Wilmington, NC so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Wilmington, NC
This is one driving day of about 235.3 miles and 4h 28m.
Your first comfortable stop window is around 52 miles from Wilmington, NC.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Michael Jordan Highway for about 107.3 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 8
5 decision points cluster between mile 1.7 and 234.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
6
1.7 mi into trip|~3m in|Martin Luther King Jr Parkway
Keep slight right at fork onto Martin Luther King Jr Parkway
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight lane.
6
114.9 mi into trip|~2h 7m in|I 40
Keep slight left at fork onto I 40
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight right lanes.
6
201 mi into trip|~3h 46m in|I 40
Keep slight right at fork onto I 40
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight left lanes.
8
221.3 mi into trip|~4h 11m in|US 421 / Salem Parkway
Keep slight right at fork onto US 421 / Salem Parkway toward US 421 North: Kernersville
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight lane.
Exit 206
Toward US 421 North: Kernersville
7
234.7 mi into trip|~4h 27m in
Take the exit toward Main Street
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 233A
Toward Main Street
Fuel & Cost
Regular Gas
$36.80 one way
$73.59 round trip
$3.97/gal25.4 MPG avg82 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.34
$40.23
$80.47
premium
$4.70
$43.55
$87.10
diesel
$5.61
$51.95
$103.90
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$37
Meals
$25–$50
Total
$62–$87
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 82.3 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $25 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
70.6
0
$24.71
$11.29
Efficient EV
58.8
0
$20.59
$9.41
EV Truck/SUV
94.1
1
$32.94
$15.06
Gas CO2
82 kg
EV CO2
28 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 15, 2026
Origin
Wilmington, NC
Morning
in Wilmington on Sunday
Local time
10:21 AM
EDT
Current temp
52°F
Unavailable
Live forecast
Destination
Winston-Salem, NC
Morning
in Winston-Salem on Sunday
Local time
10:21 AM
EDT
Current temp
42°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
10 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 28m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Moores Creek National Battlefield
National Battlefield
In the early morning hours of February 27, 1776, Loyalist forces charged across a partially dismantled Moores Creek Bridge. Beyond the bridge, nearly 1,000 North Carolina Patriots waited quietly with...
14 mi from route
~34 min detour
Free
near mile 24.3
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This trip offers a mixed driving profile that keeps you engaged as you transition from the coast toward the interior. With a highway share of 53%, you will spend a good portion of your time maintaining a steady pace, particularly during the longest stretch of 107.3 miles on the Michael Jordan Highway. The road conditions change as you move off the main interstate segments and transition into the local infrastructure of the Salem Parkway. You will find that the drive balances high-speed efficiency with the necessity of navigating various road types. It is a functional drive that requires your attention, shifting from open stretches to the more structured traffic patterns you encounter as you approach Winston-Salem.
53% highway, the rest on surface roads — varied driving throughout.
11 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 107.3 mi on Michael Jordan Highway.
How Hard Is This Drive?
7/10
This route mixes highway mileage with some local-road sections near the start or finish. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 1.7 miles in near Martin Luther King Jr Parkway.
Driving Effort7/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 8 significant decision points across 235.3 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 1.7 miles (Martin Luther King Jr Parkway): Highway fork - watch signs carefully. Lane positioning matters here; at 114.9 miles (I 40): Highway fork - watch signs carefully. Lane positioning matters here; at 201 miles (I 40): Highway fork - watch signs carefully. Lane positioning matters here.
Wilmington is a city in the southeastern part of North Carolina. It is the county seat of New Hanover County, and home to the University of North Carolina at Wilmington, the U.S.S. North Carolina Battleship Memorial, the Cape Fear Museum, Airlie Gardens, and a large historic district. It is convenient to nearby beaches, and is a relatively short drive from the Triangle (Raleigh, Durham, and Chapel Hill), Charlotte, Myrtle Beach, SC, and the I-95 corridor.
Winston-Salem is a city in North Carolina. It has an approximate population of 251,000 (2022). Winston-Salem is one of three cities that make up the Piedmont Triad; the others are Greensboro and High Point.
Doable as a same-day drive at 4h 28m. Total distance: 235.3 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
4h 28m drive, comfortable solo distance.
Scenic Drive
Mixed highway & surface route profile with national parks nearby.
Frequently Asked Questions
The longest stretch is about 107.3 miles on Michael Jordan Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Winston-Salem, NC before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 1.7 miles (Martin Luther King Jr Parkway): Highway fork - watch signs carefully. Lane positioning matters here; at 114.9 miles (I 40): Highway fork - watch signs carefully. Lane positioning matters here; at 201 miles (I 40): Highway fork - watch signs carefully. Lane positioning matters here.
Yes — Moores Creek National Battlefield. See the National Parks section for detour distances and tips on detours.
Possible but tiring. At 4.5 hours each way, an in-and-out day trip would put you behind the wheel for 9.0 hours — manageable with a long break at Winston-Salem, NC, but most travelers stay overnight.
