Cameron, MO to O'Fallon, MO is 238.1 miles and takes about 4h 46m via Dwight D. Eisenhower Highway, with a fuel budget near $37 and enough daylight to finish in a day. This trip stays within Missouri, traversing the Midwest region. With most of the drive on surface roads, expect a more relaxed pace than a pure interstate sprint. It's a solid one-day trip, perfect if you're looking for a straightforward drive between these two points without needing an overnight stop.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
119.1 miles from Cameron, MO
A natural place for your longest stop of the day
, about 2h 27m into the drive
.
Main Roads
Road
Distance
Duration
Dwight D. Eisenhower Highway
109.9 mi
2h 7m
U.S. Submarine Veterans' Memorial Highway
54.4 mi
58m
Main Street
45.2 mi
1h 1m
North Walnut Street
13.1 mi
17m
MO 116
10.6 mi
13m
Sheriff Roger I. Wilson Memorial Highway
1.9 mi
2m
Highway Patrol Sgt. Benjamin Booth Memorial Highway
1.6 mi
1m
South Main Street
0.6 mi
1m
Longest stretch:
Dwight D. Eisenhower Highway
— 109.9 mi, about 2h 7m
Traffic on I-70
Hour-of-day weekday pattern from 20 FHWA count stations on your route.
Peak
3 PM
~2,319 veh/hr typical
· worst 2,912
Quietest
1 AM
~234 veh/hr
Peak-to-quiet ratio
9.9×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 105 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Cameron, MO and O'Fallon, MO.
1
Start on West 2nd Street
0.3 mi·1 min·West 2nd Street
2
At end of road, turn right onto I 35 Business; US 69
13 mi·17 min·North Walnut Street
3
Enter roundabout onto MO 116
221 ft·3 sec·MO 116
4
Continue on MO 116
11 mi·13 min·MO 116
5
Turn right onto MO 13
45 mi·1 hr 1 min·Main Street
6
Take the exit
0.2 mi·23 sec
Toward I 70 East, US 40 East: Columbia
7
Merge onto I 70; US 40
20 mi·21 min·Dwight D. Eisenhower Highway
8
Continue on I 70; US 40
32 mi·34 min·U.S. Submarine Veterans' Memorial Highway
9
Keep slight left at fork onto I 70
22 mi·24 min·U.S. Submarine Veterans' Memorial Highway
10
Continue on I 70; US 40
1.8 mi·2 min·Dwight D. Eisenhower Highway
11
Continue on I 70; US 40
1.6 mi·1 min·Highway Patrol Sgt. Benjamin Booth Memorial Highway
12
Continue on I 70; US 40
1.9 mi·2 min·Sheriff Roger I. Wilson Memorial Highway
13
Continue on I 70; US 40
88 mi·1 hr 44 min·Dwight D. Eisenhower Highway
Use the straight / slight right lanes.
14
Take the exit
0.3 mi·43 sec
Toward MO K: O'FallonUse the straight / slight right lanes.
15
Turn straight onto Drennen Parkway
150 ft·3 sec·Drennen Parkway
Toward MO K: O'Fallon
16
Keep slight right at fork onto Drennen Parkway
166 ft·5 sec·Drennen Parkway
Toward MO K: O'Fallon
17
Turn slight left
62 ft·2 sec
Toward MO K: O'Fallon
18
Continue on South Main Street
0.6 mi·1 min·South Main Street
19
Turn right
25 ft·1 sec
20
Arrive at destination
Trip Plan
Given the 4h 46m duration, starting your drive in the morning is ideal to allow for a comfortable pace and potential brief stops. The route includes only one suggested stop, so plan your breaks strategically. Keep an eye on your fuel gauge, especially during the 109.9-mile stretch on the Dwight D. Eisenhower Highway, as services might be less frequent. With a fuel cost estimated around $37, budgeting for gas is straightforward. This is a manageable one-day drive, so you have the flexibility to depart when it suits you best.
Morning Departure
An early start around 7-8 AM gets you there with plenty of daylight left.
Evening Departure
A late afternoon start means arriving after dark. Morning is better.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 119.1 miles from Cameron, MO, or about 2h 27m into the drive.
The longest continuous stretch on this route runs about 109.9 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 52 miles or 1h 10m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 119.1 miles or 2h 27m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 3h 54m
Traffic, exits, and arrival timing usually matter more near O'Fallon, MO than in the middle of the route.
Before You Leave
+
Open the route before leaving Cameron, MO so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Cameron, MO
This is one driving day of about 238.1 miles and 4h 46m.
Your first comfortable stop window is around 52 miles from Cameron, MO.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Dwight D. Eisenhower Highway for about 109.9 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 10
5 decision points cluster between mile 0.3 and 237.5 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
4
0.3 mi into trip|~1m in|I 35 Business; US 69 / North Walnut Street
At end of road, turn right onto I 35 Business; US 69 / North Walnut Street
Navigation decision point
4
13.4 mi into trip|~18m in|MO 116
Enter roundabout onto MO 116
Roundabout - know your exit number before entering
7
69.1 mi into trip|~1h 33m in
Take the exit toward I 70 East, US 40 East: Columbia
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward I 70 East, US 40 East: Columbia
6
237.1 mi into trip|~4h 44m in
Take the exit toward MO K: O'Fallon
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the straight / slight right lanes.
Toward MO K: O'Fallon
6
237.5 mi into trip|~4h 45m in|Drennen Parkway
Keep slight right at fork onto Drennen Parkway toward MO K: O'Fallon
Highway fork - watch signs carefully
Toward MO K: O'Fallon
Fuel & Cost
Regular Gas
$39.72 one way
$79.44 round trip
$4.24/gal25.4 MPG avg83 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.61
$43.17
$86.33
premium
$5.26
$49.30
$98.60
diesel
$6.18
$57.92
$115.84
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$40
Meals
$25–$50
Total
$65–$90
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 83.3 kg one way.
Prices: EIA weekly data, 2026-10-12.
Driving Electric?
About $25 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
71.4
0
$25.00
$11.43
Efficient EV
59.5
0
$20.83
$9.52
EV Truck/SUV
95.2
1
$33.33
$15.24
Gas CO2
83 kg
EV CO2
28 kg (66% less)
Plan for 0 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Oct 18, 2026
Origin
Cameron, MO
Morning
in Cameron on Monday
Local time
7:34 AM
CDT
Current temp
65°F
Sunny
S 6 to 12 mph0% chanceLive forecast
Destination
O'Fallon, MO
Morning
in O'Fallon on Monday
Local time
7:34 AM
CDT
Current temp
69°F
Sunny
S 0 to 6 mph0% chanceLive forecast
77°F
Lincoln, MO
119 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
4 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
4h 46m on the road
An early start around 7-8 AM gets you there with plenty of daylight left.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This route is mostly surface roads, meaning you'll spend less than half the time on highways. The Dwight D. Eisenhower Highway accounts for the longest continuous stretch at 109.9 miles. Expect to transition from highway cruising to navigating local streets as you get closer to O'Fallon. The significant portion on surface roads suggests you'll encounter more traffic lights and varied speed limits.
Only 4% highway — the rest is turn-by-turn surface driving.
20 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 109.9 mi on Dwight D. Eisenhower Highway.
How Hard Is This Drive?
4/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. There are only a few real navigation decisions along the way. The trickiest moment comes around 0.3 miles in near I 35 Business; US 69 / North Walnut Street.
Driving Effort4/10
Easy - simple navigation with a manageable amount of wheel time
Balances navigation complexity with total wheel time.
This is a straightforward 4h 46m drive. You will face about 10 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
The main spots that need attention: at 0.3 miles (I 35 Business; US 69 / North Walnut Street): Navigation decision point; at 13.4 miles (MO 116): Roundabout - know your exit number before entering; at 69.1 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
St. Charles, Missouri is outside of St. Louis on the bank of the Missouri River. It was Missouri's first state capital and was one of the first stops by Lewis and Clark on their journey to explore Louisiana Territory. The historic Main Street has largely been restored to its 1812-era appearance including gas lights a boardwalk and is lined with shops selling artwork, handicrafts, home decorations, antiques. There are also many restaurants.
The longest stretch is about 109.9 miles on Dwight D. Eisenhower Highway. The full list of main roads is in the Roads section above.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
Yes, with realistic expectations. Build in a stop roughly every 2 hours, have snacks and activities ready, and check the Nearby Places tabs for kid-friendly stops along the way.
The main spots that need attention: at 0.3 miles (I 35 Business; US 69 / North Walnut Street): Navigation decision point; at 13.4 miles (MO 116): Roundabout - know your exit number before entering; at 69.1 miles: Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one.
Possible but tiring. At 4.8 hours each way, an in-and-out day trip would put you behind the wheel for 9.6 hours — manageable with a long break at O'Fallon, MO, but most travelers stay overnight.
