If you are planning a quick trek from Andrews to Florence, South Carolina, expect a straightforward journey covering approximately 63.5 miles. You should budget about 1 hour and 32 minutes of drive time for this trip, which is easily manageable as a one-day excursion. With a fuel cost estimate of $10, it is an economical route that requires no overnight stops along the way. You will navigate through the Southeast region, transitioning between smaller local roads and larger corridors. Since there are no formal stops scheduled, this route is best suited for those looking to reach their destination efficiently rather than those seeking a scenic tour.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Midpoint
31.7 miles from Andrews, SC
A natural place for your longest stop of the day
, about 43m into the drive
.
Main Roads
Road
Distance
Duration
US Highway 521
17.4 mi
19m
South Ron McNair Boulevard
15.2 mi
24m
North Williamsburg County Highway
10.6 mi
13m
South Irby Street
7 mi
9m
Martin Luther King Jr Avenue
6.1 mi
10m
South Church Street
2.7 mi
5m
Eastland Avenue
1.6 mi
3m
East Main Street
1.3 mi
2m
Longest stretch:
US Highway 521
— 17.4 mi, about 19m
Turn-by-Turn Driving Directions
Step-by-step road directions between Andrews, SC and Florence, SC.
1
Start on US 521 Bus
1.0 mi·1 min·East Main Street
2
Continue on US 521
17 mi·19 min·US Highway 521
3
Turn right onto SC 377
6.1 mi·10 min·Martin Luther King Jr Avenue
4
At end of road, turn right onto SC 261
0.3 mi·32 sec·East Main Street
5
Turn left onto County Road S-45-186
1.6 mi·3 min·Eastland Avenue
6
Turn left onto Dennis Avenue
0.3 mi·46 sec·Dennis Avenue
7
At end of road, turn right onto US 52
11 mi·13 min·North Williamsburg County Highway
8
Continue on US 52
15 mi·24 min·South Ron McNair Boulevard
9
Continue on US 52
7.0 mi·9 min·South Irby Street
10
Turn right onto US 301
1.3 mi·2 min·Freedom Boulevard
11
Turn left onto South Church Street
2.7 mi·5 min·South Church Street
12
Turn left
57 ft·4 sec
Use the left lane.
13
Turn slight left
126 ft·14 sec
14
At end of road, turn left
44 ft·5 sec
15
Turn right
50 ft·3 sec
16
Arrive at destination
Trip Plan
Because this is a relatively short drive, you have the flexibility to depart at your convenience without worrying about extensive pre-trip planning. Since there are no designated stops on this 63.5-mile route, make sure you are fueled up and ready to go before you leave Andrews to avoid unnecessary delays. Keep a close eye on your navigation as you transition between US Highway 521 and the various county highways, as the frequent turns can be easy to miss. Given the turn-heavy nature of the drive, staying alert is your best strategy for a smooth transition into Florence. Aim to complete the trip during daylight hours to better manage the local road segments.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
You may only need one short stretch break if traffic stays light.
The halfway point lands around 31.7 miles from Andrews, SC, or about 43m into the drive.
The longest continuous stretch on this route runs about 17.4 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 14 miles or 16m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 31.7 miles or 43m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 1h 17m
Traffic, exits, and arrival timing usually matter more near Florence, SC than in the middle of the route.
Before You Leave
+
Open the route before leaving Andrews, SC so your first major turns are already loaded.
Day 1
Settle into the route from Andrews, SC
This is one driving day of about 63.5 miles and 1h 32m.
Your first comfortable stop window is around 14 miles from Andrews, SC.
This route can stay practical as a one-day drive if traffic stays reasonable.
The longest stretch is on US Highway 521 for about 17.4 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 10
5 decision points cluster between mile 24.5 and 63.5 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
5
24.5 mi into trip|~32m in|SC 261 / East Main Street
At end of road, turn right onto SC 261 / East Main Street
Navigation decision point
5
26.6 mi into trip|~37m in|US 52 / North Williamsburg County Highway
At end of road, turn right onto US 52 / North Williamsburg County Highway
Navigation decision point
5
63.4 mi into trip|~1h 32m in
Turn left
Lane positioning matters here
Use the left lane.
5
63.5 mi into trip|~1h 32m in
At end of road, turn left
Navigation decision point
5
63.5 mi into trip|~1h 32m in
Turn right
Navigation decision point
Fuel & Cost
Regular Gas
$9.93 one way
$19.86 round trip
$3.97/gal25.4 MPG avg22 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.34
$10.86
$21.72
premium
$4.70
$11.75
$23.51
diesel
$5.61
$14.02
$28.04
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$10
Meals
$25–$50
Total
$35–$60
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 22.2 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $7 in charging
· 0 stops
· 68% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
19.1
0
$6.67
$3.05
Efficient EV
15.9
0
$5.56
$2.54
EV Truck/SUV
25.4
0
$8.89
$4.06
Gas CO2
22 kg
EV CO2
7 kg (68% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 14, 2026
Origin
Andrews, SC
Morning
in Andrews on Tuesday
Local time
6:34 AM
EDT
Current temp
85°F
Sunny
SW 6 mph0% chanceLive forecast
Destination
Florence, SC
Morning
in Florence on Tuesday
Local time
6:34 AM
EDT
Current temp
88°F
Sunny
SW 8 mph0% chanceLive forecast
85°F
Lake City, SC
32 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
3 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
1h 32m on the road
The weather snapshot is not static. If you are leaving later, give both cities one more quick forecast check before departure.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
Expect a turn-heavy local drive that demands your full attention behind the wheel. The route relies on a combination of US Highway 521, South Ron McNair Boulevard, and North Williamsburg County Highway to reach your destination. Only 27% of your travel occurs on highways, meaning you will spend the majority of your time navigating local roads. Your longest uninterrupted stretch is 17.4 miles on US Highway 521, offering a brief period of consistent travel before the road profile shifts again. Because of the frequent turns, the pace remains steady and practical rather than fast-paced.
Only 27% highway — the rest is turn-by-turn surface driving.
16 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 17.4 mi on US Highway 521.
How Hard Is This Drive?
3/10
Expect a hands-on drive with frequent turns and local roads rather than long highway stretches. There are only a few real navigation decisions along the way. The trickiest moment comes around 24.5 miles in near SC 261 / East Main Street.
Driving Effort3/10
Easy - simple navigation with a manageable amount of wheel time
Balances navigation complexity with total wheel time.
This is a straightforward 1h 32m drive. You will face about 10 decision points, but nothing that requires special attention if you follow navigation.
Where does it get tricky?
The main spots that need attention: at 24.5 miles (SC 261 / East Main Street): Navigation decision point; at 26.6 miles (US 52 / North Williamsburg County Highway): Navigation decision point; at 63.4 miles: Lane positioning matters here.
Florence is a city in the Pee Dee Country Region of South Carolina. It was the site of the Florence Stockade, a Confederate POW camp, notably bad but still maybe not as bad as Andersonville, then a railroad hub, and nowadays a regional center for medical care and manufacturing, including as it sits at the terminus for I-20. Even though it got started rather late, in 1871, it's more or less the hub for northeastern South Carolina, aka Pee Dee Country.
The longest stretch is about 17.4 miles on US Highway 521. The full list of main roads is in the Roads section above.
Yes. At under 2 hours behind the wheel, this works well for families — plan one quick stop if you have younger kids.
The main spots that need attention: at 24.5 miles (SC 261 / East Main Street): Navigation decision point; at 26.6 miles (US 52 / North Williamsburg County Highway): Navigation decision point; at 63.4 miles: Lane positioning matters here.
Yes. A round trip is manageable in a single day if you plan a break at Florence, SC before heading back.
