Saint Joseph, IN to Knox, IN is 133.5 miles and takes about 2h 36m via I 65 and I 69, with a fuel budget near $21 and enough daylight to finish in a day. This is a straightforward, highway-focused drive primarily within Indiana, making it a convenient option for a single-day trip. You'll spend most of your time on major interstates, so expect a consistent pace. Given the relatively short duration, this route is ideal if you're looking for an efficient way to travel between these two points without significant detours.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
66.8 miles from Saint Joseph, IN
A natural place for your longest stop of the day
, about 1h 18m into the drive
.
Main Roads
Road
Distance
Duration
I 65
86.7 mi
1h 33m
Dwight D Eisenhower Highway
25.1 mi
27m
I 69
7.1 mi
8m
US 31
2.9 mi
4m
Perry Crossing Road
2.7 mi
6m
South Emerson Avenue
2.5 mi
4m
State Road 111
1.8 mi
3m
McCullum
1 mi
1m
Longest stretch:
I 65
— 86.7 mi, about 1h 33m
Turn-by-Turn Driving Directions
Step-by-step road directions between Saint Joseph, IN and Knox, IN.
1
Start on Grant Line Road
233 ft·4 sec·Grant Line Road
2
Continue on State Road 111
1.8 mi·3 min·State Road 111
3
Turn right onto SR 60
0.2 mi·24 sec·State Road 60
4
Turn left onto Perry Crossing Road
2.7 mi·6 min·Perry Crossing Road
5
Turn left onto US 31
2.9 mi·4 min·US 31
6
Turn left onto Memphis-Blue Lick Road
0.6 mi·1 min·Memphis-Blue Lick Road
7
Take the ramp
0.3 mi·33 sec
8
Merge onto I 65
87 mi·1 hr 33 min·I 65
9
Take the exit
0.4 mi·47 sec
Exit 103Toward Southport RoadUse the slight right lane.
10
Turn slight right
176 ft·4 sec
11
Turn straight onto East Southport Road
0.2 mi·26 sec·East Southport Road
12
Turn left onto South Emerson Avenue
2.5 mi·4 min·South Emerson Avenue
Use the left lane.
13
Take the ramp
0.5 mi·58 sec
14
Merge onto I 69; I 74; I 465
2.3 mi·2 min·I 69; I 74; I 465
15
Continue on I 69; I 465
4.9 mi·5 min·I 69; I 465
16
Take the exit
0.8 mi·1 min
Exit 44BToward I 70 East: DaytonUse the slight right lane.
17
Merge onto I 70
25 mi·27 min·Dwight D Eisenhower Highway
18
Take the exit
0.4 mi·43 sec
Exit 115Toward SR 109: Wilkinson, Knightstown
19
Turn right onto SR 109
1.0 mi·1 min·McCullum
20
Turn right onto South Grant City Road
0.4 mi·1 min·South Grant City Road
21
Arrive at destination
South Grant City Road
Trip Plan
Given the 2h 36m duration, this trip is easily completed in a single day, so you have flexibility with your departure time. Plan for one stop to break up the drive, especially since the longest stretch on I 65 is nearly 87 miles. Keep an eye on fuel, as the estimated cost is $21, and ensure you're comfortable with the interstate driving for the bulk of the trip. A good tip is to check for any potential construction or traffic delays on I 65 before you leave, as it's your primary artery for a significant portion of the journey.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 66.8 miles from Saint Joseph, IN, or about 1h 18m into the drive.
The longest continuous stretch on this route runs about 86.7 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 29 miles or 38m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 66.8 miles or 1h 18m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 8m
Traffic, exits, and arrival timing usually matter more near Knox, IN than in the middle of the route.
Before You Leave
+
Open the route before leaving Saint Joseph, IN so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Saint Joseph, IN
This is one driving day of about 133.5 miles and 2h 36m.
Your first comfortable stop window is around 29 miles from Saint Joseph, IN.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on I 65 for about 86.7 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 13
5 decision points cluster between mile 1.8 and 131.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
4
1.8 mi into trip|~3m in|SR 60 / State Road 60
Turn right onto SR 60 / State Road 60
Navigation decision point
7
95.2 mi into trip|~1h 49m in
Take the exit toward Southport Road
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 103
Toward Southport Road
6
95.8 mi into trip|~1h 50m in|South Emerson Avenue
Turn left onto South Emerson Avenue
Lane positioning matters here
Use the left lane.
7
105.8 mi into trip|~2h 3m in
Take the exit toward I 70 East: Dayton
Exit ramp - move to the correct lane early. Lane positioning matters here
Use the slight right lane.
Exit 44B
Toward I 70 East: Dayton
6
131.7 mi into trip|~2h 33m in
Take the exit toward SR 109: Wilkinson, Knightstown
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Exit 115
Toward SR 109: Wilkinson, Knightstown
Fuel & Cost
Regular Gas
$20.87 one way
$41.74 round trip
$3.97/gal25.4 MPG avg47 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.36
$22.92
$45.83
premium
$4.89
$25.69
$51.38
diesel
$5.61
$29.48
$58.95
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$21
Meals
$25–$50
Total
$46–$71
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 46.7 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $14 in charging
· 0 stops
· 66% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
40.1
0
$14.02
$6.41
Efficient EV
33.4
0
$11.68
$5.34
EV Truck/SUV
53.4
0
$18.69
$8.54
Gas CO2
47 kg
EV CO2
16 kg (66% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 14, 2026
Origin
Saint Joseph, IN
Morning
in Saint Joseph on Sunday
Local time
10:57 AM
EDT
Current temp
42°F
Unavailable
Live forecast
Destination
Knox, IN
Morning
in Knox on Sunday
Local time
10:57 AM
EDT
Current temp
71°F
Unavailable
Live forecast
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
29 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
2h 36m on the road
Use the two city cards together: check the sky where you start, then compare it with the local time and temperature at arrival.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This route is largely defined by its 72% highway share, meaning you'll be on high-speed interstates for the majority of your journey. The longest stretch without a major change in direction or road type is 86.7 miles on I 65. Expect a consistent, if not monotonous, driving experience as you cover ground efficiently. While the profile is highway-focused, there will be transitions between different interstate segments, so remain aware of signage.
72% highway — fuel and pacing are the main things to plan.
21 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 86.7 mi on I 65.
How Hard Is This Drive?
6/10
This is a straightforward highway drive that stays mostly on I 65 and Dwight D Eisenhower Highway. You will hit about 13 points where you need to pay attention to lane position or signs. The trickiest moment comes around 1.8 miles in near SR 60 / State Road 60.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 133.5 miles you will encounter 13 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 1.8 miles (SR 60 / State Road 60): Navigation decision point; at 95.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 95.8 miles (South Emerson Avenue): Lane positioning matters here.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 2h 36m. Total distance: 133.5 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
2h 36m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (72%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 86.7 miles on I 65. The full list of main roads is in the Roads section above.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Knox, IN before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 1.8 miles (SR 60 / State Road 60): Navigation decision point; at 95.2 miles: Exit ramp - move to the correct lane early. Lane positioning matters here; at 95.8 miles (South Emerson Avenue): Lane positioning matters here.
Yes. A round trip is manageable in a single day if you plan a break at Knox, IN before heading back.
