Roxboro, NC to Greenville, NC is 128.6 miles and takes about 2h 46m via US 264, with a fuel budget near $20 and enough daylight to finish in a day. This trip stays within North Carolina, connecting two points in the Southeast region. The route offers a mixed highway and surface road experience, making it a straightforward drive for a single day. With only one recommended stop and a relatively short duration, this is a practical option for getting from point A to point B without significant time commitment.
Trip Pace
Same-day drive is realistic
A same-day return is realistic if you keep stops short.
Break Rhythm
1 planned break
A short stop every 2 to 3 hours is enough for this drive.
Midpoint
64.3 miles from Roxboro, NC
A natural place for your longest stop of the day
, about 1h 34m into the drive
.
Main Roads
Road
Distance
Duration
US 264
55.9 mi
59m
Martin Luther King Junior Avenue
13.6 mi
19m
Zebulon Road
10.5 mi
11m
NC 96
9.6 mi
14m
US 158
7.2 mi
10m
Dennys Store Road
6 mi
8m
Old Roxboro Road
5.5 mi
8m
South Cross Street
4.9 mi
8m
Longest stretch:
US 264
— 55.9 mi, about 59m
Turn-by-Turn Driving Directions
Step-by-step road directions between Roxboro, NC and City of Greenville, NC.
1
Start on Depot Street
0.4 mi·1 min·Depot Street
2
Continue on Mountain Road
1.8 mi·2 min·Mountain Road
3
Continue on State Road 1536
0.8 mi·1 min·State Road 1536
4
Continue on Allensville Road
2.4 mi·3 min·Allensville Road
5
Continue on Dennys Store Road
6.0 mi·8 min·Dennys Store Road
6
Continue on Old Roxboro Road
5.5 mi·8 min·Old Roxboro Road
7
At end of road, turn left onto US 158
7.2 mi·10 min·US 158
8
Turn right onto Ivey Day Road
0.2 mi·34 sec·Ivey Day Road
9
Turn right onto Oxford Loop
1.3 mi·1 min·Oxford Loop
Use the straight / right lanes.
10
Continue on West Industry Drive
2.1 mi·2 min·West Industry Drive
Use the straight / right lanes.
11
Turn right onto NC 96
14 mi·19 min·Martin Luther King Junior Avenue
Use the straight lane.
12
Turn left onto NC 96
9.6 mi·14 min·NC 96
13
Turn left onto NC 96
0.3 mi·57 sec·West Main Street
14
Turn right onto NC 96
4.9 mi·8 min·South Cross Street
15
Enter roundabout onto NC 96
135 ft·1 sec·Zebulon Road
16
Continue on NC 96
1.2 mi·1 min·Zebulon Road
17
Keep slight left at fork onto NC 96
9.3 mi·10 min·Zebulon Road
18
Continue on NC 96
0.8 mi·1 min·North Arendell Avenue
19
Take the exit
0.2 mi·29 sec
Toward US 64 East, US 264 East
20
Merge onto US 64; US 264
0.5 mi·32 sec·US 64; US 264
21
Keep slight right at fork onto US 264
56 mi·59 min·US 264
22
Turn straight onto Stantonsburg Road
1.5 mi·2 min·Stantonsburg Road
Toward Greenville, Downtown
23
Turn right onto West Arlington Boulevard
2.4 mi·4 min·West Arlington Boulevard
24
Turn left onto South Evans Street
0.4 mi·35 sec·South Evans Street
25
Arrive at destination
South Evans Street
Trip Plan
Given the 2 hour and 46 minute duration, leaving Roxboro in the morning should give you plenty of daylight to reach Greenville. The route has a suggested one stop, so consider breaking up the drive on US 264, perhaps around the 55.9-mile mark if you need a stretch. Keep an eye on your fuel, as the estimated cost is around $20, and plan your fill-up accordingly. Since this is a single-day trip, you have flexibility to depart later if needed, but an earlier start ensures a relaxed arrival.
Morning Departure
Leave by 9 AM and you'll arrive before lunch.
Evening Departure
Even a 4 PM departure gets you there before dark in summer.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 64.3 miles from Roxboro, NC, or about 1h 34m into the drive.
The longest continuous stretch on this route runs about 55.9 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 28 miles or 41m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 64.3 miles or 1h 34m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 2h 18m
Traffic, exits, and arrival timing usually matter more near City of Greenville, NC than in the middle of the route.
Before You Leave
+
Open the route before leaving Roxboro, NC so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Roxboro, NC
This is one driving day of about 128.6 miles and 2h 46m.
Your first comfortable stop window is around 28 miles from Roxboro, NC.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on US 264 for about 55.9 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 15
5 decision points cluster between mile 17 and 67.7 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
4
17 mi into trip|~25m in|US 158
At end of road, turn left onto US 158
Navigation decision point
5
24.4 mi into trip|~36m in|Oxford Loop
Turn right onto Oxford Loop
Lane positioning matters here
Use the straight / right lanes.
5
27.9 mi into trip|~41m in|NC 96 / Martin Luther King Junior Avenue
Turn right onto NC 96 / Martin Luther King Junior Avenue
Lane positioning matters here
Use the straight lane.
4
51.1 mi into trip|~1h 15m in|NC 96 / West Main Street
Turn left onto NC 96 / West Main Street
Navigation decision point
6
67.7 mi into trip|~1h 38m in
Take the exit toward US 64 East, US 264 East
Exit ramp - move to the correct lane early. Multiple destination signs - pick the right one
Toward US 64 East, US 264 East
Fuel & Cost
Regular Gas
$20.11 one way
$40.22 round trip
$3.97/gal25.4 MPG avg45 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.34
$21.99
$43.98
premium
$4.70
$23.80
$47.60
diesel
$5.61
$28.39
$56.79
No toll roads detected on this route.
Estimated Trip Cost (one way, 1 person)
Fuel
$20
Meals
$25–$50
Total
$45–$70
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 45 kg one way.
Prices: EIA weekly data, 2026-04-13.
Driving Electric?
About $14 in charging
· 0 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
38.6
0
$13.50
$6.17
Efficient EV
32.2
0
$11.25
$5.14
EV Truck/SUV
51.4
0
$18.00
$8.23
Gas CO2
45 kg
EV CO2
15 kg (67% less)
This trip is well within single-charge range for most EVs. No charging stops needed if you start fully charged.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 20, 2026
Origin
Roxboro, NC
Morning
in Roxboro on Tuesday
Local time
7:08 AM
EDT
Current temp
38°F
Clear
NW 2 to 7 mph0% chanceLive forecast
Special Weather Statement
Special Weather Statement issued April 19 at 9:30PM EDT by NWS Greenville-Spartanburg SC
Special Weather Statement
Special Weather Statement issued April 19 at 9:27PM EDT by NWS Raleigh NC
Destination
City of Greenville, NC
Morning
in City of Greenville on Tuesday
Local time
7:08 AM
EDT
Current temp
40°F
Mostly Clear
NW 2 mph0% chanceLive forecast
Special Weather Statement
Special Weather Statement issued April 19 at 9:30PM EDT by NWS Greenville-Spartanburg SC
Special Weather Statement
Special Weather Statement issued April 19 at 9:27PM EDT by NWS Raleigh NC
76°F
Youngsville, NC
64 mi in
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
2 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
2h 46m on the road
The weather snapshot is not static. If you are leaving later, give both cities one more quick forecast check before departure.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This 128.6-mile drive is about 57% highway, meaning you'll spend a good portion of your time on faster roads. The longest stretch without a significant change in road type is 55.9 miles on US 264. You'll transition from highway driving to surface streets as you approach your destination. Expect to notice more frequent exits and potential for merging traffic as you get closer to Greenville.
57% highway, the rest on surface roads — varied driving throughout.
25 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 55.9 mi on US 264.
How Hard Is This Drive?
6/10
This route mixes highway mileage with some local-road sections near the start or finish. You will hit about 15 points where you need to pay attention to lane position or signs. The trickiest moment comes around 17 miles in near US 158.
Driving Effort6/10
Moderate - straightforward overall, but long enough or busy enough to require pacing
Balances navigation complexity with total wheel time.
This drive requires moderate attention. Across 128.6 miles you will encounter 15 spots where lane choice or exit timing matters. Not difficult for experienced highway drivers, but worth previewing the tricky sections before you go.
Where does it get tricky?
The main spots that need attention: at 17 miles (US 158): Navigation decision point; at 24.4 miles (Oxford Loop): Lane positioning matters here; at 27.9 miles (NC 96 / Martin Luther King Junior Avenue): Lane positioning matters here.
Who Is This Route For?
Weekend Trip
Doable as a same-day drive at 2h 46m. Total distance: 128.6 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
2h 46m drive, comfortable solo distance.
First-Time Driver
Mostly highway driving (57%). Some complex stretches to watch for.
Frequently Asked Questions
The longest stretch is about 55.9 miles on US 264. The full list of main roads is in the Roads section above.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at City of Greenville, NC before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 17 miles (US 158): Navigation decision point; at 24.4 miles (Oxford Loop): Lane positioning matters here; at 27.9 miles (NC 96 / Martin Luther King Junior Avenue): Lane positioning matters here.
Yes. A round trip is manageable in a single day if you plan a break at City of Greenville, NC before heading back.
