Panama City, FL to Miami, FL is 579.9 miles and takes about 10h 55m via Florida's Turnpike and I-75, with a fuel budget near $92 and an overnight recommendation. This long-distance drive spans across the entire state of Florida, taking you from the Panhandle region down to South Florida. With a 99% highway share, expect a consistent pace for most of the journey, making it ideal for those who prefer covering ground efficiently. Consider breaking this trip into two days to enjoy the drive without feeling rushed.
Trip Pace
Best split across 2 days
Treat the return leg as its own travel day rather than an afterthought.
Break Rhythm
3 planned breaks
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
289.9 miles from Panama City, FL
A natural place for your longest stop of the day
, about 5h 35m into the drive
.
Main Roads
Road
Distance
Duration
Florida's Turnpike
264.2 mi
4h 46m
I 10
121.5 mi
2h 10m
I 75
107.2 mi
1h 54m
FL 20
28.4 mi
39m
US 231
24.1 mi
32m
FL 12
18.1 mi
24m
I 95
9 mi
11m
Greensboro Highway
2.2 mi
3m
Longest stretch:
Florida's Turnpike
— 264.2 mi, about 4h 46m
Traffic on I-10
Hour-of-day weekday pattern from 26 FHWA count stations on your route.
Peak
4 PM
~1,501 veh/hr typical
· worst 2,043
Quietest
2 AM
~173 veh/hr
Peak-to-quiet ratio
8.7×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Panama City, FL and Miami, FL.
1
Start on Luverne Avenue
429 ft·26 sec·Luverne Avenue
2
Turn left onto East 7th Street
228 ft·14 sec·East 7th Street
3
Turn right onto US 231
1.0 mi·2 min·Harrison Avenue
4
Continue on US 231
1.6 mi·2 min·US 231
5
Continue on US 231
1.3 mi·2 min·US 231
6
Continue on US 231
21 mi·27 min·US 231
7
Turn right onto FL 20
28 mi·39 min·FL 20
8
Turn left onto FL 12
18 mi·24 min·FL 12
9
Turn right onto FL 12; CR 270
0.6 mi·1 min·Selman Street
10
Continue on FL 12
2.2 mi·3 min·Greensboro Highway
11
Take the ramp
0.5 mi·1 min
Toward I 10 East: Tallahassee
12
Merge onto I 10
121 mi·2 hr 10 min·I 10
Use the straight / slight right lanes.
13
Take the exit
0.4 mi·37 sec
Exit 296AToward I-75 South: Tampa
14
Merge onto I 75
107 mi·1 hr 54 min·I 75
Use the straight lane.
15
Take the exit onto Florida's Turnpike
264 mi·4 hr 46 min·Florida's Turnpike
Exit 328Toward Florida's Turnpike South, OrlandoUse the slight left / straight lanes.
16
Take the exit
0.3 mi·42 sec
Toward I 95, US 441, SR 826 West
17
Keep slight left at fork
0.8 mi·1 min
Toward I 95, US 441
18
Keep slight left at fork
0.1 mi·18 sec
Toward I 95 SouthUse the straight / slight left lanes.
19
Merge onto I 95
9.0 mi·11 min·I 95
Use the straight / slight right lanes.
20
Take the exit
0.4 mi·1 min
Exit 3BToward Northwest 8th Street, Port of MiamiUse the straight / slight right lanes.
21
Turn left onto Northwest 8th Street
0.4 mi·1 min·Northwest 8th Street
Use the straight / left lanes.
22
Turn right onto North Miami Avenue
0.5 mi·1 min·North Miami Avenue
Use the straight / right lanes.
23
Arrive at destination
North Miami Avenue
Trip Plan
Given the 10h 55m estimated duration, planning for an overnight stop is highly recommended to avoid an excessively long day of driving. Aim to depart Panama City in the morning to maximize daylight for your first leg. The longest stretch, 264.2 miles on Florida's Turnpike, means you'll want to ensure you have ample fuel before entering it. With 3 recommended stops, you can easily break up the drive into two manageable days, perhaps stopping around the central Florida region.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
This drive is better paced as a 2-day trip.
Plan roughly 3 meaningful breaks for fuel, food, and rest.
The halfway point lands around 289.9 miles from Panama City, FL, or about 5h 35m into the drive.
The longest continuous stretch on this route runs about 264.2 miles.
Consider an overnight stop or starting very early.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 128 miles or 2h 41m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 289.9 miles or 5h 35m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Overnight split
Day 1 wrap after about 289.9 miles or 5h 35m
Stop before fatigue turns the last few hours into a grind. You want day two to start fresh, not just resumed.
Final approach
Final hour starts around 9h 44m
Traffic, exits, and arrival timing usually matter more near Miami, FL than in the middle of the route.
Before You Leave
+
Open the route before leaving Panama City, FL so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
+
Pick one backup stop option before the midpoint in case traffic changes your pacing.
+
Treat this as a 2-day road trip and book the overnight stop before the busiest arrival window.
Day 1
Settle into the route from Panama City, FL
Aim for roughly 290 miles and 5.5 hours of wheel time on this day.
Day 2
Finish the approach into Miami, FL
Aim for roughly 290 miles and 5.5 hours of wheel time on this day.
Your first comfortable stop window is around 128 miles from Panama City, FL.
This route usually feels better as a 2-day drive than as one long push.
Plan about 3 real breaks rather than only quick fuel stops.
The longest stretch is on Florida's Turnpike for about 264.2 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 16
5 decision points cluster between mile 304 and 579.3 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
8
304 mi into trip|~5h 50m in|Florida's Turnpike
Take the exit onto Florida's Turnpike toward Florida's Turnpike South, Orlando
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / straight lanes.
Exit 328
Toward Florida's Turnpike South, Orlando
6
568.5 mi into trip|~10h 37m in
Keep slight left at fork toward I 95, US 441
Highway fork - watch signs carefully. Multiple destination signs - pick the right one
Toward I 95, US 441
7
569.3 mi into trip|~10h 39m in
Keep slight left at fork toward I 95 South
Highway fork - watch signs carefully. Lane positioning matters here
Use the straight / slight left lanes.
Toward I 95 South
8
578.5 mi into trip|~10h 51m in
Take the exit toward Northwest 8th Street, Port of Miami
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 3B
Toward Northwest 8th Street, Port of Miami
6
579.3 mi into trip|~10h 53m in|North Miami Avenue
Turn right onto North Miami Avenue
Lane positioning matters here
Use the straight / right lanes.
Fuel & Cost
Regular Gas
$87.78 one way
$175.57 round trip
$3.85/gal25.4 MPG avg203 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.22
$96.32
$192.65
premium
$4.55
$103.88
$207.76
diesel
$4.80
$109.50
$218.99
Estimated Tolls: $18.49
Florida's Turnpike
(264.2 mi)$18.49
Toll estimates based on average 2024-2025 rates. EZ-Pass/SunPass discounts may lower the actual cost.
Estimated Trip Cost (one way, 1 person)
Fuel
$88
Tolls
$18
Hotel (1n)
$80–$140
Meals
$50–$100
Total
$236–$346
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 202.9 kg one way.
Prices: EIA weekly data, 2026-07-13.
Driving Electric?
About $61 in charging
· 2 stops
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
174
2
$60.89
$27.84
Efficient EV
145
1
$50.74
$23.20
EV Truck/SUV
232
2
$81.19
$37.11
Gas CO2
203 kg
EV CO2
68 kg (67% less)
Plan for 2 charging stops, roughly every 270 miles. Allow 25-40 minutes per stop at a DC fast charger.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Jul 16, 2026
Origin
Panama City, FL
Late night
in Panama City on Sunday
Local time
3:22 AM
CDT
Current temp
89°F
Sunny
W 15 mph6% chanceLive forecast
Special Weather Statement
Special Weather Statement issued July 16 at 5:07PM EDT by NWS Miami FL
Rip Current Statement
Rip Current Statement issued July 16 at 11:29AM EDT until July 17 at 4:00AM EDT by NWS Melbourne FL
Destination
Miami, FL
Late night
in Miami on Sunday
Local time
4:22 AM
EDT
Current temp
92°F
Isolated Showers And Thunderstorms
SE 10 mph19% chanceLive forecast
Special Weather Statement
Special Weather Statement issued July 16 at 5:07PM EDT by NWS Miami FL
Rip Current Statement
Rip Current Statement issued July 16 at 11:29AM EDT until July 17 at 4:00AM EDT by NWS Melbourne FL
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
For long drives, weather on day two can matter just as much as conditions at departure, so check the whole travel window rather than only the first day.
Time zone
1 hour later
The destination clock does not match departure time, so double-check hotel check-in windows and late arrival plans.
Temperature spread
3 degrees warmer at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
10h 55m on the road
This is long enough that the arrival forecast matters almost as much as departure conditions. Recheck both ends before you roll.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
National Parks Near This Route
Worth a detour if your schedule allows.
Biscayne National Park
National Park
Within sight of Miami, yet worlds away, Biscayne protects a rare combination of aquamarine waters, emerald islands, and fish-bejeweled coral reefs. Evidence of 10,000 years of human history is here to...
20 mi from route
~49 min detour
Free
near mile 579.9
Park data from the National Park Service API. Alerts update every 2 hours.
More Details
What kind of drive is this?
This route is predominantly a highway experience, with 99% of the drive on major interstates and turnpikes. You'll encounter the longest uninterrupted stretch of 264.2 miles on Florida's Turnpike, so be prepared for extended periods of steady driving. While the majority is fast-paced highway, the transition between I-10, I-75, and Florida's Turnpike offers slight shifts in the road's character as you navigate different parts of the state. Expect a consistent, efficient journey designed for covering distance.
99% highway — fuel and pacing are the main things to plan.
23 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 264.2 mi on Florida's Turnpike.
How Hard Is This Drive?
8/10
This is a straightforward highway drive that stays mostly on Florida's Turnpike and I 10. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 304 miles in near Florida's Turnpike.
Driving Effort8/10
Demanding - plan breaks and stay ahead of the key maneuvers
Balances navigation complexity with total wheel time.
This is a demanding drive. With 16 significant decision points across 579.9 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 304 miles (Florida's Turnpike): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 568.5 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 569.3 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Elevation Profile
Mostly flat terrain
225 ft6 ft
Total Climb
341 ft
Total Descent
363 ft
Highest Point
225 ft
~82.8 mi in
Elevation Range
219 ft
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Panama City, FL and Miami, FL, road signs point toward Florida's Turnpike South and Orlando.
Miami is a major city in the southeastern United States and the second most populous city in Florida. The Greater Miami metropolitan area is the largest in the state with an estimated population just under 6.1 million (2021), which makes it the 9th most populous metro area in the United States.
Although tourists generally consider Miami Beach to be part of Miami, it is its own municipality. Miami Beach sits on a barrier island east of Miami and Biscayne Bay. It is home to lots of beach resorts, and is one of the most popular spring break party destinations in the world. This article only covers the city of Miami, not Miami Beach.
Top landmarks
•Little Havana — neighborhood in Miami, Florida
•Vizcaya Museum and Gardens — historic estate on Biscayne Bay; Coconut Grove neighborhood of Miami, Florida
The longest stretch is about 264.2 miles on Florida's Turnpike. The full list of main roads is in the Roads section above.
Yes — a 2-day pace is more comfortable than one long haul. A sensible stopping point is after roughly 290 miles on day one.
Expect about $18.49 in tolls one way, starting with Florida's Turnpike. Most Northeast and Midwest toll agencies accept E-ZPass; in the West and Texas, transponders like TxTag or FasTrak apply. If you do not have a transponder, cashless tolling plates will mail a bill to the vehicle's registered address — usually with a surcharge, so a rental-car toll pass is often cheaper than paying by mail.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Miami, FL before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 3 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 304 miles (Florida's Turnpike): Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one; at 568.5 miles: Highway fork - watch signs carefully. Multiple destination signs - pick the right one; at 569.3 miles: Highway fork - watch signs carefully. Lane positioning matters here.
Yes — Biscayne National Park. See the National Parks section for detour distances and tips on detours.
Not recommended in a single day. At 10.9 hours each way, a round trip means 21.8 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Miami, FL before the return drive.
