Middlesex, NY to Manhattan, NY is 299.2 miles and takes about 6h 16m via Keystone Shortway and Southern Tier Expressway, with a fuel budget near $49 and enough daylight to finish in a day. This trip stays within New York, connecting the Northeast region from a more rural starting point to the bustling Northeast destination of Manhattan. With a recommended one-day drive, it's a straightforward transit, mostly on highways, making it a practical option for getting from upstate to the city. You'll find it's a manageable distance for a single day's travel.
Trip Pace
Same-day drive is realistic
A same-day return is possible, but it will make for a full day on the road.
Break Rhythm
1 planned break
Plan on a short reset every 3 to 4 hours to stay fresh behind the wheel.
Midpoint
149.6 miles from Middlesex, NY
A natural place for your longest stop of the day
, about 3h 12m into the drive
.
Main Roads
Road
Distance
Duration
Keystone Shortway
80 mi
1h 37m
Southern Tier Expressway
63.8 mi
1h 15m
I 81
53.4 mi
1h 3m
NY 14
38.1 mi
53m
I 380
23.6 mi
25m
State Route 364
11.7 mi
17m
Christopher Columbus Highway
5.5 mi
5m
Henry Hudson Parkway
4.2 mi
6m
Longest stretch:
Keystone Shortway
— 80 mi, about 1h 37m
Traffic on I-80
Hour-of-day weekday pattern from 168 FHWA count stations on your route.
Peak
3 PM
~4,210 veh/hr typical
· worst 4,900
Quietest
1 AM
~430 veh/hr
Peak-to-quiet ratio
9.8×
busier at peak than in the quiet hours
12a6anoon6p11p
Averaged across 52 weeks of 2023 FHWA Travel Monitoring Analysis System data. Weekday hours only (Mon–Fri).
Turn-by-Turn Driving Directions
Step-by-step road directions between Middlesex, NY and Manhattan, NY.
1
Start on NY 364
28 ft·6 sec·Water Street
2
Continue on NY 245; NY 364
360 ft·6 sec·NY 245; NY 364
3
Keep slight right at fork onto NY 364
12 mi·17 min·State Route 364
4
Continue on NY 364
0.4 mi·32 sec·Maple Avenue
5
Continue on North Avenue
1.1 mi·2 min·North Avenue
6
Turn left onto NY 54
277 ft·7 sec·Clinton Street
7
Continue on NY 54
4.0 mi·5 min·State Highway 54
8
Merge onto NY 14
38 mi·53 min·NY 14
Use the straight / right lanes.
9
Continue on North Main Street
1.3 mi·2 min·North Main Street
10
Take the ramp onto NY 13
0.2 mi·28 sec·NY 13
11
Merge onto I 86; NY 17; NY 13
64 mi·1 hr 15 min·Southern Tier Expressway
12
Keep slight right at fork onto I 81
53 mi·1 hr 3 min·I 81
Toward I 81 South: ScrantonUse the straight lane.
13
Keep slight right at fork onto US 6
0.8 mi·1 min·US 6
Exit 187Toward I 84 East, I 380 South, US 6 East: Carbondale, Mt PoconoUse the slight left / slight right lanes.
14
Continue on I 84; I 380
3.7 mi·4 min·I 84; I 380
Toward I 84 East, I 380 South: Mount Pocono, MilfordUse the straight lane.
15
Keep slight right at fork onto I 380
24 mi·25 min·I 380
Exit 4Toward I 380 South: Mount Pocono
16
Keep slight left at fork
1.0 mi·1 min
Exit 1BToward I 80 East: Stroudsburg
17
Merge onto I 80
80 mi·1 hr 37 min·Keystone Shortway
Use the straight / right lanes.
18
Keep slight right at fork onto I 80
5.5 mi·5 min·Christopher Columbus Highway
Toward I 95: George Washington Bridge Lower LevelUse the slight right lane.
19
Keep slight left at fork
0.3 mi·23 sec
Toward I 95 North: George Washington Bridge, New York CityUse the straight / slight right lanes.
20
Keep slight right at fork
0.4 mi·38 sec
Exit 70A-BToward Leonia, TeaneckUse the slight right lane.
21
Turn right
0.2 mi·35 sec
Exit 70AToward LeoniaUse the straight / slight right lanes.
22
Turn straight onto CR 56
454 ft·9 sec·Degraw Avenue
23
Continue on CR 56
1.1 mi·2 min·Fort Lee Road
Use the straight / right lanes.
24
Continue on CR 56
469 ft·13 sec·Main Street
25
Take the ramp
472 ft·12 sec
Toward George Washington Bridge
26
Merge onto US 1; US 9; US 46
0.3 mi·28 sec·Bergen Boulevard
Use the straight / slight right lanes.
27
Take the exit
312 ft·4 sec
Toward George Washington Bridge Upper Level
28
Merge onto I 95 EXPR
0.3 mi·20 sec·I 95 EXPR
Use the straight / slight right lanes.
29
Keep slight left at fork onto I 95 EXPR
0.8 mi·1 min·I 95 EXPR
30
Continue on I 95; US 1; US 9
0.5 mi·45 sec·George Washington Bridge (upper level)
31
Take the exit onto US 9
0.1 mi·13 sec·US 9
Exit 1AToward NY 9A: Henry Hudson Parkway, West 178th StreetUse the straight / slight right lanes.
32
Keep slight right at fork
0.3 mi·42 sec
Toward NY 9A: Henry Hudson ParkwayUse the straight / slight right lanes.
33
Keep slight left at fork
0.4 mi·47 sec
Toward NY 9A South: Henry Hudson Parkway, DowntownUse the straight lane.
34
Merge onto HH; NY 9A
4.2 mi·6 min·Henry Hudson Parkway
Use the straight / slight right lanes.
35
Take the exit
0.2 mi·27 sec
Toward Boat Basin, Metropolitan Museum of Art, American Museum of Natural History, Children's Museum Of Manhattan, JCC in Manhattan, Lincoln Center, New York Historical Society, New York Institute of TechnologyUse the straight / slight right lanes.
36
Continue on West 79th Street
0.2 mi·51 sec·West 79th Street
Use the straight / right lanes.
37
Turn left onto Broadway
0.4 mi·56 sec·Broadway
38
Turn right onto West 86th Street
0.4 mi·1 min·West 86th Street
39
Continue on 86th Street Transverse
0.2 mi·35 sec·86th Street Transverse
Toward East SideUse the straight / left lanes.
40
Arrive at destination
86th Street Transverse
Trip Plan
Given this is a 6h 16m drive, leaving Middlesex, NY in the morning is ideal to make the most of daylight. You can comfortably complete this trip in one day, with only one recommended stop, allowing for flexibility. Keep an eye on your fuel levels, especially during the 80-mile stretch on the Keystone Shortway, as services might be less frequent. Your estimated fuel cost is around $49, so factor that into your budget. As you approach Manhattan, be prepared for increased traffic and more complex navigation.
Morning Departure
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Evening Departure
This is a long drive — plan for a morning departure or consider splitting it into two days.
You can normally do this drive in one day.
Plan roughly 1 meaningful break for fuel, food, and rest.
The halfway point lands around 149.6 miles from Middlesex, NY, or about 3h 12m into the drive.
The longest continuous stretch on this route runs about 80 miles.
This is a comfortable same-day trip.
Departure
Before you leave
Start with fuel, water, and navigation already sorted so the first hour feels easy.
First stop
Around 66 miles or 1h 33m in
Use this first pause for coffee, a restroom break, and a quick traffic check ahead.
Halfway reset
Around 149.6 miles or 3h 12m in
This is the best place for your longest stop, a real meal, and a full fuel check.
Final approach
Final hour starts around 5h 5m
Traffic, exits, and arrival timing usually matter more near Manhattan, NY than in the middle of the route.
Before You Leave
+
Open the route before leaving Middlesex, NY so your first major turns are already loaded.
+
Leave with enough water and a charging cable within reach, not packed away.
+
Check your fuel range against the first long segment, especially if you are starting outside city service areas.
Day 1
Settle into the route from Middlesex, NY
This is one driving day of about 299.2 miles and 6h 16m.
Your first comfortable stop window is around 66 miles from Middlesex, NY.
This route can stay practical as a one-day drive if traffic stays reasonable.
Plan about 1 real break rather than only quick fuel stops.
The longest stretch is on Keystone Shortway for about 80 miles.
Where to Stop
Rest stops, refuel points, and overnight suggestions along this route.
Place data sourced from public business listings. Hours and availability may vary.
Heads-up: tricky spots
5 of 29
5 decision points cluster between mile 174.1 and 293.2 — GPS handles the exact turns, but know they're coming. Your lane choice matters more than the turn itself.
9
174.1 mi into trip|~3h 41m in|US 6
Keep slight right at fork onto US 6 toward I 84 East, I 380 South, US 6 East: Carbondale, Mt Pocono
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight left / slight right lanes.
Exit 187
Toward I 84 East, I 380 South, US 6 East: Carbo...
8
288.6 mi into trip|~5h 57m in
Keep slight left at fork toward I 95 North: George Washington Bridge, New York City
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Toward I 95 North: George Washington Bridge, Ne...
9
288.9 mi into trip|~5h 57m in
Keep slight right at fork toward Leonia, Teaneck
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the slight right lane.
Exit 70A-B
Toward Leonia, Teaneck
8
292.8 mi into trip|~6h 4m in|US 9
Take the exit onto US 9 toward NY 9A: Henry Hudson Parkway, West 178th Street
Exit ramp - move to the correct lane early. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight / slight right lanes.
Exit 1A
Toward NY 9A: Henry Hudson Parkway, West 178th...
8
293.2 mi into trip|~6h 5m in
Keep slight left at fork toward NY 9A South: Henry Hudson Parkway, Downtown
Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one
Use the straight lane.
Toward NY 9A South: Henry Hudson Parkway, Downt...
Fuel & Cost
Regular Gas
$48.63 one way
$97.25 round trip
$4.13/gal25.4 MPG avg105 kg CO2
Fuel Type
$/gal
One Way
Round Trip
midgrade
$4.47
$52.63
$105.26
premium
$4.87
$57.32
$114.64
diesel
$5.40
$63.64
$127.29
Estimated Tolls: $16.00
George Washington Bridge
$16.00
Toll estimates based on average 2024-2025 rates. EZ-Pass/SunPass discounts may lower the actual cost.
Estimated Trip Cost (one way, 1 person)
Fuel
$49
Tolls
$16
Meals
$25–$50
Total
$90–$115
Rough estimate based on US averages. Hotel $80–$140/night, meals $25–$50/day.
Estimated CO2 emission: 104.7 kg one way.
Prices: EIA weekly data, 2026-04-20.
Station data from NREL Alternative Fuel Stations database.
Driving Electric?
About $31 in charging
· 1 stop
· 67% less CO2
Vehicle Type
kWh
Stops
DC Fast
Home Charge
Average EV
89.8
1
$31.42
$14.36
Efficient EV
74.8
0
$26.18
$11.97
EV Truck/SUV
119.7
1
$41.89
$19.15
Gas CO2
105 kg
EV CO2
35 kg (67% less)
Plan for 1 charging stop. A 30-minute DC fast charge mid-route should be enough to complete the trip comfortably.
DC fast charging avg $0.35/kWh. Home charging avg $0.16/kWh. US grid CO2: 0.39 kg/kWh.
Travel Intel
Current conditions at both ends of the drive.
Forecast as of Apr 26, 2026
Origin
Middlesex, NY
Late night
in Middlesex on Sunday
Local time
1:59 AM
EDT
Current temp
42°F
Unavailable
Live forecast
Destination
Manhattan, NY
Late night
in Manhattan on Sunday
Local time
1:59 AM
EDT
Current temp
41°F
Rain Showers
E 9 mph98% chanceLive forecast
Flood Warning
Flood Warning issued April 25 at 8:05PM EDT until April 26 at 11:00AM EDT by NWS Buffalo NY
Flood Warning
Flood Warning issued April 25 at 1:03PM EDT by NWS Binghamton NY
Seasonal Notes
Summer travel usually means heavier construction, hotter rest stops, and busier weekend traffic around major cities.
Winter travel shortens daylight, so a route that looks manageable on paper can feel much longer after dark.
Holiday weekends tend to make both departure and arrival windows slower than the raw route time suggests.
Time zone
Same local time
Origin and destination are on the same clock, so arrival timing is easier to judge at a glance.
Temperature spread
1 degrees cooler at arrival
A meaningful temperature swing is a good cue to rethink layers, water, and how soon you want to arrive.
Road read
6h 16m on the road
Start early — leave by 6-7 AM to arrive at a reasonable hour.
Weather data from the National Weather Service. Conditions may change; check closer to your travel date.
More Details
What kind of drive is this?
This drive is primarily on highways, with 68% of the 299.2 miles on such roads. You'll encounter a longest stretch of 80 miles on the Keystone Shortway before transitioning to other expressways. Expect a good amount of highway cruising, with a higher density of exits as you approach your destination. The 32% on surface roads will likely involve more local traffic and varied speed limits.
68% highway — fuel and pacing are the main things to plan.
40 navigation steps total — most of the decisions cluster near the start and finish.
Longest single stretch: 80 mi on Keystone Shortway.
How Hard Is This Drive?
10/10
This is a straightforward highway drive that stays mostly on Keystone Shortway and Southern Tier Expressway. This route has several spots where lane changes, forks, or exits need your full attention. The trickiest moment comes around 174.1 miles in near US 6.
Driving Effort10/10
High effort - long or complex enough to need steady focus all day
Balances navigation complexity with total wheel time.
This is a demanding drive. With 29 significant decision points across 299.2 miles, you will need to stay alert - especially through interchange areas and urban stretches. Consider splitting it into segments if you are not comfortable with fast highway navigation.
Where does it get tricky?
The main spots that need attention: at 174.1 miles (US 6): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 288.6 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 288.9 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Towns Mentioned on Route Signs
Based on OSRM destination-sign hints, not a full list of every settlement the road passes.
Between Middlesex, NY and Manhattan, NY, road signs point toward Mt Pocono and Milford.
Wall Street. Madison Avenue. 34th Street. Broadway. Times Square. Manhattan is so well known that even the names of its streets have become iconic and understood the world over. This long, thin island is only one of New York City's five boroughs, but it's Manhattan that has the concrete canyons and the inimitable skyline; Manhattan that has the world's brightest theater district; Manhattan that has Central Park, Rockefeller Center, the Empire State Building, and the Met; and Manhattan that includes iconic neighborhoods like Harlem, the Upper East Side, Times Square, and Greenwich Village.
The rest of New York City has much to see and do, but it's Manhattan that represents the city—and sometimes the entire United States—to the world. You could spend a month on this tiny island and still not see all there is to see.
Top landmarks
•Empire State Building — skyscraper located in Midtown Manhattan, New York City, USA
Doable as a same-day drive at 6h 16m. Total distance: 299.2 miles.
Family Friendly
Moderate complexity with 1 natural rest stops along the way.
Solo Traveler
6h 16m drive, plan rest stops for pacing.
Frequently Asked Questions
The longest stretch is about 80 miles on Keystone Shortway. The full list of main roads is in the Roads section above.
Expect about $16.00 in tolls one way, starting with George Washington Bridge. Most Northeast and Midwest toll agencies accept E-ZPass; in the West and Texas, transponders like TxTag or FasTrak apply. If you do not have a transponder, cashless tolling plates will mail a bill to the vehicle's registered address — usually with a surcharge, so a rental-car toll pass is often cheaper than paying by mail.
We did not find dedicated rest areas on this route. For a drive this long, plan bathroom and stretch breaks around gas stations, fast-food stops, or small-town downtowns — check the Nearby Places section for options.
It helps. This route has a higher-than-average number of complex decision points, which get harder in the dark. If the last hour of the trip is on surface roads or mountain grades, aim to arrive at Manhattan, NY before sunset when you can. Check the Trip Plan for departure windows that land you in daylight.
Only with planning. This is a long drive for kids — consider splitting it into two days rather than pushing through. Plan at least 1 meaningful breaks. Dedicated rest areas are limited, so plan gas or food stops as your bathroom breaks.
The main spots that need attention: at 174.1 miles (US 6): Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 288.6 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one; at 288.9 miles: Highway fork - watch signs carefully. Lane positioning matters here. Multiple destination signs - pick the right one.
Not recommended in a single day. At 6.3 hours each way, a round trip means 12.6 hours of driving — that is an unsafe level of fatigue for most drivers. Plan at least one night at Manhattan, NY before the return drive.
